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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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April-2026 Volume 57 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Review Open Access

Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)

  • Authors:
    • Lu Xu
    • Wei Jiang
    • Lin Song
    • Jing Wang
    • Jiangquan Yu
    • Ruiqiang Zheng

  • View Affiliations / Copyright

    Affiliations: Department of Critical Care Medicine, The Yangzhou Clinical College of Xuzhou Medical University, Yangzhou, Jiangsu 225001, P.R. China, Department of Critical Care Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 78
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    Published online on: January 30, 2026
       https://doi.org/10.3892/ijmm.2026.5749
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Abstract

Sepsis is a life‑threatening clinical syndrome characterized by a dysregulated host immune response to infection, with its pathogenesis closely linked to the aberrant activation and dysfunction of various immune cells. The kidney is among the most vulnerable organs in sepsis. The development of acute kidney injury (AKI) in sepsis, referred to as sepsis‑associated AKI (SA‑AKI), is often associated with significantly increased mortality. Despite its clinical impact, specific and effective therapies for SA‑AKI remain scarce. Increasing evidence highlights that complex intrarenal inflammatory processes, primarily driven by diverse immune cell populations, are central to the onset and progression of SA‑AKI. The present review provides a comprehensive analysis of the roles of both innate and adaptive immune cells, such as macrophages, neutrophils, dendritic cells, natural killer cells, natural killer T (NKT) cells, B cells and T cells, in SA‑AKI and explores potential therapeutic strategies, offering a theoretical foundation and insights for the development of more effective prevention and treatment approaches.

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Copy and paste a formatted citation
Spandidos Publications style
Xu L, Jiang W, Song L, Wang J, Yu J and Zheng R: <p>Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)</p>. Int J Mol Med 57: 78, 2026.
APA
Xu, L., Jiang, W., Song, L., Wang, J., Yu, J., & Zheng, R. (2026). <p>Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)</p>. International Journal of Molecular Medicine, 57, 78. https://doi.org/10.3892/ijmm.2026.5749
MLA
Xu, L., Jiang, W., Song, L., Wang, J., Yu, J., Zheng, R."<p>Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)</p>". International Journal of Molecular Medicine 57.4 (2026): 78.
Chicago
Xu, L., Jiang, W., Song, L., Wang, J., Yu, J., Zheng, R."<p>Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)</p>". International Journal of Molecular Medicine 57, no. 4 (2026): 78. https://doi.org/10.3892/ijmm.2026.5749
Copy and paste a formatted citation
x
Spandidos Publications style
Xu L, Jiang W, Song L, Wang J, Yu J and Zheng R: <p>Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)</p>. Int J Mol Med 57: 78, 2026.
APA
Xu, L., Jiang, W., Song, L., Wang, J., Yu, J., & Zheng, R. (2026). <p>Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)</p>. International Journal of Molecular Medicine, 57, 78. https://doi.org/10.3892/ijmm.2026.5749
MLA
Xu, L., Jiang, W., Song, L., Wang, J., Yu, J., Zheng, R."<p>Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)</p>". International Journal of Molecular Medicine 57.4 (2026): 78.
Chicago
Xu, L., Jiang, W., Song, L., Wang, J., Yu, J., Zheng, R."<p>Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)</p>". International Journal of Molecular Medicine 57, no. 4 (2026): 78. https://doi.org/10.3892/ijmm.2026.5749
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