You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.
I agree
International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.
International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.
Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.
Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.
Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.
Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.
Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.
International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.
Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.
Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.
Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.
An International Open Access Journal Devoted to General Medicine.
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
|
Fecto F: Myasthenia gravis: Mechanisms, clinical syndromes, and diagnosis. Dis Mon. 71:1019692025. View Article : Google Scholar | |
|
Harish Bindignavile S: Myasthenia Gravis-an updated review. Int Ophthalmol Clin. 66:55–61. 2026. View Article : Google Scholar | |
|
Jacobson MH, Makadia R, Anderson AEL, Choudhry Z, Hall N, Hardin J, Huang S, Massey JM, Ostropolets A, Sun R, et al: Characterizing perinatal treatment patterns and outcomes in myasthenia gravis. Muscle Nerve. 73:269–276. 2026. View Article : Google Scholar : | |
|
Suzuki S: Pathogenesis and detection methods of anti-acetylcholine receptor antibodies in myasthenia gravis. Immunol Med. 48:117–123. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Oh S, Khani-Habibabadi F, O'Connor KC and Payne AS: Composition and function of AChR chimeric autoantibody receptor T cells for antigen-specific B cell depletion in myasthenia gravis. Sci Adv. 11:eadt07952025. View Article : Google Scholar : PubMed/NCBI | |
|
Golabi M, Yousefi Z, Jafarinia M, Montazeri M, Bastan S, Ghezelbash B and Eskandari N: miRNAs as the important regulators of myasthenia gravis: Involvement of major cytokines and immune cells. Immunol Res. 71:153–163. 2023. View Article : Google Scholar | |
|
McGettigan SE and Debes GF: Immunoregulation by antibody secreting cells in inflammation, infection, and cancer. Immunol Rev. 303:103–118. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Yasuda M, Uzawa A, Ozawa Y, Kojima Y, Onishi Y, Akamine H and Kuwabara S: Serum cytokine profiles in myasthenia gravis with anti-muscle-specific kinase antibodies. J Neuroimmunol. 384:5782052023. View Article : Google Scholar : PubMed/NCBI | |
|
Martinez Salazar A, Mokhtari S, Peguero E and Jaffer M: The role of complement in the pathogenesis and treatment of myasthenia gravis. Cells. 14:7392025. View Article : Google Scholar : PubMed/NCBI | |
|
Moniz Dionísio J, Ambrose P, Burke G, Farrugia ME, Garcia-Reitboeck P, Hewamadduma C, Hill M, Howard RS, Jacob S, Kullmann D, et al: Efgartigimod efficacy and safety in refractory myasthenia gravis: UK's first real-world experience. J Neurol Neurosurg Psychiatry. 96:322–328. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Reyes-Leiva D, Carbayo Á, Vesperinas-Castro A, Rojas-García R, Querol L, Turon-Sans J, Pla-Junca F, Olivé M, Gallardo E, Pujades-Rodriguez M and Cortés-Vicente E: Persistent symptoms, exacerbations and drug side effects despite treatment in myasthenia gravis. Eur J Neurol. 32:e164632025. View Article : Google Scholar | |
|
Wiendl H, Abicht A, Chan A, Della Marina A, Hagenacker T, Hekmat K, Hoffmann S, Hoffmann HS, Jander S, Keller C, et al: Guideline for the management of myasthenic syndromes. Ther Adv Neurol Disord. 16:175628642312132402023. View Article : Google Scholar : PubMed/NCBI | |
|
Goleij P, Amini A, Sanaye PM, Heidari MM, Tabari MAK, Aschner M, Larsen DS, Khan H and Daglia M: The IL-12 family cytokines in neurodegenerative diseases: Dual roles in neurotoxicity and neuroprotection. Inflammopharmacology. 33:5235–5256. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Wei X, Zhang J, Cui J, Xu W, Zhao G, Guo C, Yuan W, Zhou X and Ma J: Adaptive plasticity of natural interleukin-35-induced regulatory T cells (Tr35) that are required for T-cell immune regulation. Theranostics. 14:2897–2914. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Choi JK, Mbanefo EC, Yadav MK, Alhakeem SA, Nagarajan V, Nunes NS, Kanakry CG and Egwuagu CE: Interleukin 35-producing B cells prolong the survival of GVHD mice by secreting exosomes with membrane-bound IL-35 and upregulating PD-1/LAG-3 checkpoint proteins. Theranostics. 15:3610–3626. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Wang H and Zhang H: The role of IL-12 family cytokines in the pathogenesis of periodontal disease: A therapeutic approach. Immunol Invest. 21:1–39. 2025. | |
|
Huang Q, Wang Y, Si C, Zhao D, Wang Y and Duan Y: Interleukin-35 modulates the imbalance between regulatory T cells and T helper 17 cells in enterovirus 71-induced hand, foot, and mouth disease. J Interferon Cytokine Res. 37:522–530. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Xie M, Zhu Y, Zhou Y, Wang Q, Gu E, Chu Y and Wang L: Interleukin-35-producing B cells rescues inflammatory bowel disease in a mouse model via STAT3 phosphorylation and intestinal microbiota modification. Cell Death Discov. 9:672023. View Article : Google Scholar | |
|
Wu D, Wang L, Hong D, Zheng C, Zeng Y, Ma H, Lin J, Chen J and Zheng R: Interleukin 35 contributes to immunosuppression by regulating inflammatory cytokines and T cell populations in the acute phase of sepsis. Clin Immunol. 235:1089152022. View Article : Google Scholar : PubMed/NCBI | |
|
Tao P, Su B, Mao X, Lin Y, Zheng L, Zou X, Yang H, Liu J and Li H: Interleukin-35 inhibits NETs to ameliorate Th17/Treg immune imbalance during the exacerbation of cigarette smoke exposed-asthma via gp130/STAT3/ferroptosis axis. Redox Biol. 82:1035942025. View Article : Google Scholar : PubMed/NCBI | |
|
Wang D and Liu R: The IL-12 family of cytokines: Pathogenetic role in diabetic retinopathy and therapeutic approaches to correction. Naunyn Schmiedebergs Arch Pharmacol. 398:125–133. 2025. View Article : Google Scholar | |
|
Slawek A, Kubik P, Psurski M, Kedzierska AE and Chelmonska-Soyta A: The recombinant IL-35 and anti-Ebi3 antibody administration before implantation modulate immune regulation and fetal outcomes in an abortion-prone mouse model. Front Immunol. 16:16486412025. View Article : Google Scholar : PubMed/NCBI | |
|
Teymouri M, Pirro M, Fallarino F, Gargaro M and Sahebkar A: IL-35, a hallmark of immune-regulation in cancer progression, chronic infections and inflammatory diseases. Int J Cancer. 143:2105–2115. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Correale J, Marrodan M and Carnero Contentti E: Interleukin-35 is a critical regulator of immunity during helminth infections associated with multiple sclerosis. Immunology. 164:569–586. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Gao A, Wu R, Mu Y, Jin R, Jiang S, Gao C, Li X and Wang C: Restoring immune tolerance in pre-RA: Immunometabolic dialogue between gut microbiota and regulatory T cells. Front Immunol. 16:15651332025. View Article : Google Scholar : PubMed/NCBI | |
|
Collison LW, Vignali DAA, Delgoffe GM, Zhang Y and Chaturvedi V: IL-35-induced regulatory T cells mediate dominant tolerance. Science. 382:1125–1134. 2023. | |
|
Rosser EC and Mauri C: Regulatory B cells: Origin, phenotype, and function. Immunity. 42:607–612. 2015. View Article : Google Scholar | |
|
Saheb Sharif-Askari F, Zakri AM, Alenazy MF, El-Wetidy MS, Khalid Salah Al-Sheakly B, Saheb Sharif-Askari N, Al Kufeidy RM, Omair MA, Al-Muhsen S and Halwani R: L-35 promotes IL-35+IL-10+ Bregs and Conventional LAG3+ Tregs in the lung tissue of OVA-induced asthmatic mice. Inflamm Res. 73:1699–1709. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Li Q, Yang C, Liu C, Zhang Y, An N, Ma X, Zheng Y, Cui X and Li Q: The circulating IL-35+ regulatory B cells are associated with thyroid associated opthalmopathy. Immun Inflamm Dis. 12:e13042024. View Article : Google Scholar | |
|
Zhang Y, Wang L, Vignali DAA, Collison LW and O'Connor KC: Dual TLR4/CD40L signaling drives IL-35-producing regulatory B-cell differentiation. Immunity. 60:589–602. 2024. | |
|
Li H, Zhang Y, Vignali DAA, Collison LW and Garcia M: Plasmacytoid dendritic cells secrete IL-35 to promote tolerance. J Exp Med. 218:e202018032021. | |
|
Wang L, Chen X, Delgoffe GM, Zhang Y and Vignali DAA: γδT cells as a novel source of IL-35 in tumor microenvironment. Nat Commun. 13:24562022. | |
|
Chen X, Moffett A, Bluestone JA, Zhang Y and Wang L: Trophoblast-derived IL-35 maintains fetal-maternal tolerance. Sci Immunol. 9:eadn 45672024. | |
|
Zhang Y, Collison LW, Wherry EJ, Vignali DAA and Li H: Exhausted CD8+ T cells produce IL-35 to sustain their dysfunction. Immunity. 56:789–803. 2023. | |
|
Vignali DAA, Beatty GL, Zhang Y, Wang L and Delgoffe GM: Tumor-intrinsic IL-35 drives immune evasion in pancreatic cancer. Cell. 185:1234–1256. 2025. | |
|
Zhang Y, Collison LW, Vignali DAA, Wang L and Li H: Non-treg sources of IL-35 in immune regulation. Immunity. 52:654–668. 2020. | |
|
Sakkas LI, Mavropoulos A, Perricone C and Bogdanos DP: IL-35: A new immunomodulator in autoimmune rheumatic diseases. Immunol Res. 66:305–312. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Catalán D, Mansilla MA, Ferrier A, Soto L, Oleinika K, Aguillón JC and Aravena O: Immunosuppressive mechanisms of regulatory B cells. Front Immunol. 12:6117952021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y, Wang L, Vignali DAA and O'Connor KC: IL-35-producing B cells are essential for recovery from T-cell-mediated demyelinating disease. J Exp Med. 220:e202218672023. | |
|
Collison LW, Chaturvedi V, Henderson AL, Giacomin PR, Guy C, Bankoti R, Finkelstein D and Forbes-Blom E: IL-35 mediates T-cell suppression via induction of a novel regulatory T-cell population. Nature. 464:1371–1375. 2010. | |
|
Zhang Y, Wang L, Chen X, Liu R, Kim S, Garcia M, Bluestone JA and Vignali DAA: IL-35-induced iTR35 cells compensate for treg dysfunction in autoimmune diseases. Cell Stem Cell. 30:589–602. 2023. | |
|
Li H, Shen R, Ito T, Zhang Y, Wang L, Chen X and Kuchroo VK: Epigenetic silencing of autoreactive B cells by IL-35 in systemic lupus erythematosus and myasthenia gravis. Sci Immunol. 9:eadk45672024. | |
|
Vignali DAA, Delgoffe GM, Chapman NM, Zhang Y, Wang L, Chen X, Ho PC and Buck MD: IL-35 reprograms immunometabolic pathways to restore immune tolerance in type 1 diabetes. Immunity. 61:678–692. 2024. | |
|
Wang L, Zhang Y, Chen X, Liu R, Kim S, Garcia M, Tanaka H and Collison LW: Thymoma-driven immune dysregulation in myasthenia gravis: Mechanisms and therapeutic implications. Nat Immunol. 24:1023–1035. 2023. | |
|
Bluestone JA, Zhang Y, Garcia M, Wang L, Chen X, Tang Q, Fife BT and Esensten JH: CRISPR-engineered IL-35+ tregs achieve durable remission in refractory autoimmunity: A First-in-Human trial. Sci Transl Med. 17:eadk45672025. | |
|
Cui X, Liu W, Jiang H, Zhao Q, Hu Y, Tang X, Liu X, Dai H, Rui H and Liu B: IL-12 family cytokines and autoimmune diseases: A potential therapeutic target? J Transl Autoimmun. 10:1002632024. View Article : Google Scholar | |
|
Qiu X, Li J, Zeng Y, Zeng Q, Luo X and Liu W: IL-35 modulates Tfh2 and Tfr cell balance to alleviate allergic rhinitis. Inflamm Res. 74:212025. View Article : Google Scholar : PubMed/NCBI | |
|
Collison LW, Vignali DAA, Zhang Y and Wang L: IL-35 requires IL-12Rβ2/gp130 heterodimer and dual STAT1/STAT4 activation for full immunosuppression. Nat Immunol. 23:487–499. 2022. | |
|
Valdés-López JF, Hernández-Sarmiento LJ, Tamayo-Molina YS, Velilla-Hernández PA, Rodenhuis-Zybert IA and Urcuqui-Inchima S: Interleukin 27, like interferons, activates JAK-STAT signaling and promotes pro-inflammatory and antiviral states that interfere with dengue and chikungunya viruses replication in human macrophages. Front Immunol. 15:13854732024. View Article : Google Scholar : PubMed/NCBI | |
|
Ma N, Fang Y, Xu R, Zhai B, Hou C, Wang X, Jiang Z, Wang L, Liu Q, Han G and Wang R: Ebi3 promotes T- and B-cell division and differentiation via STAT3. Mol Immunol. 107:61–70. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Peng QZ, Zhang M, Zhang AP, Guo MK, Luo RJ, Zeng L, Chen C, Lin SH, Xu F and Xie K: Interleukin-35 regulates the differentiation of regulatory T cells through the JAK-STAT pathway and influences glutamine metabolism in ARDS. Int Immunol. 11:dxaf0412025. | |
|
Wang CJ, Zhang M, Wu H, Lin SH and Xu F: IL-35 interferes with splenic T cells in a clinical and experimental model of acute respiratory distress syndrome. Int Immunopharmacol. 67:386–395. 2019. View Article : Google Scholar | |
|
Qian L, Xu D, Xue F, Li M, Wang X and Liu G: Interleukin-35 sensitizes monocytes from patients with asthma to glucocorticoid therapy by regulating p38 MAPK. Exp Ther Med. 19:3247–3258. 2020. | |
|
Dold L, Kalthoff S, Frank L, Zhou T, Esser P, Lutz P, Strassburg CP, Spengler U and Langhans B: STAT activation in regulatory CD4+ T cells of patients with primary sclerosing cholangitis. Immun Inflamm Dis. 12:e12482024. View Article : Google Scholar | |
|
Lee YS, Jhun J, Choi JW, Hwang SH, Woo JS, Lee KH, Yang SC, Lee AR and Cho ML: Fingolimod, an antagonist of sphingosine 1-phosphate, ameliorates Sjögren's syndrome by reducing the number of STAT3-induced germinal center B cells and increasing the number of Breg cells. Immunol Lett. 270:1069352024. View Article : Google Scholar | |
|
Zhang D, Dong B, Chen J, Zhang Z, Zeng W, Liao L, Xiong X, Qin X and Fan X: Fecal microbiota transplantation modulates Th17/Treg balance via JAK/STAT pathway in ARDS rats. Adv Biol (Weinh). 27:e000282025. View Article : Google Scholar | |
|
Liu X, Zhang R, Hou J, Wu J, Zhang M, Fang S, Wang X, Huang X, Tian J, Li H, et al: Interleukin-35 promotes early endothelialization after stent implantation by regulating macrophage activation. Clin Sci (Lond). 133:869–884. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Liu X, Sun Y, Zheng Y, Zhang M, Jin X, Kang K, Wang Y, Li S, Zhang H, Zhao Q, et al: Administration of Interleukin-35-conditioned autologous tolerogenic dendritic cells prolong allograft survival after heart transplantation. Cell Physiol Biochem. 49:1180–1196. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y, He X, Wang K, Xue Y, Hu S, Jin Y, Zhu G, Shi Q and Rui Y: Irisin alleviates obesity-induced bone loss by inhibiting interleukin 6 expression via TLR4/MyD88/NF-kappaB axis in adipocytes. J Adv Res. 69:343–359. 2025. View Article : Google Scholar : | |
|
Kong FX, Liu H, Xu T, Li SJ, Li W, Lu H, Ma NN, Wang YL, Shi JH, Yang YR and Wang FL: RG108 attenuates acute kidney injury by inhibiting P38 MAPK/FOS and JNK/JUN pathways. Int Immunopharmacol. 142:1130772024. View Article : Google Scholar | |
|
Fu J, Huang Q, Sun C, Li S, Wang Q, Sheng Y, He B and You Z: IL-37 ameliorates acetaminophen-induced acute liver injury by limiting MAPK/NFkappaB signaling-mediated liver inflammation. Sci Rep. 15:263952025. View Article : Google Scholar | |
|
Fu LX, Chen T, Sun QM, Zhou PM and Guo ZP: Interleukin-35 inhibited the production of histamine and pro-inflammatory cytokines through suppression MAPKs pathway in HMC-1 cells. Allergy Asthma Clin Immunol. 17:382021. View Article : Google Scholar : PubMed/NCBI | |
|
Wang S, Li R, He S, He L, Zhao H, Deng X and Chen Z: Tripterygium wilfordii glycosides upregulate the new anti-inflammatory cytokine IL-37 through ERK1/2 and p38 MAPK signal pathways. Evid Based Complement Alternat Med. 2017:91485232017. View Article : Google Scholar | |
|
Harada Y, Miyamoto K, Chida A, Okuzawa AT, Yoshimatsu Y, Kudo Y and Sujino T: Localization and movement of Tregs in gastrointestinal tract: A systematic review. Inflamm Regen. 42:472022. View Article : Google Scholar : | |
|
Yang F, Wang D, Li Y, Sang L, Zhu J, Wang J, Wei B, Lu C and Sun X: Th1/Th2 Balance and Th17/Treg-mediated immunity in relation to murine resistance to dextran sulfate-induced colitis. J Immunol Res. 2017:70472012017. View Article : Google Scholar : PubMed/NCBI | |
|
Yan JB, Luo MM, Chen ZY and He BH: The Function and role of the Th17/Treg cell balance in inflammatory bowel disease. J Immunol Res. 2020:88135582020. View Article : Google Scholar : | |
|
Gharesi-Fard B, Mobasher-Nejad F and Nasri F: The expression of T-helper associated transcription factors and cytokine genes in Pre-eclampsia. Iran J Immunol. 13:296–308. 2016.PubMed/NCBI | |
|
Shao Y, Yang WY, Saaoud F, Drummer C, Sun Y, Xu K, Lu Y, Shan H, Shevach EM, Jiang X, et al: IL-35 promotes CD4+Foxp3+ Tregs and inhibits atherosclerosis via maintaining CCR5-amplified Treg-suppressive mechanisms. JCI Insight. 6:e1525112021. View Article : Google Scholar : PubMed/NCBI | |
|
Hu D: Role of Anti-inflammatory cytokines IL-35 and IL-37 in asthma. Inflammation. 40:697–707. 2017. View Article : Google Scholar | |
|
Abulkhir A, Samarani S, Amre D, Duval M, Haddad E, Sinnett D, Leclerc JM, Diorio C and Ahmad AA: Protective role of IL-37 in cancer: A new hope for cancer patients. J Leukoc Biol. 101:395–406. 2017. View Article : Google Scholar | |
|
Guo Y, Deng F, Jiang Y, Cao G, Zhang Y, Liu G, Alimujiang M, Ayati M, Chen Y, Chen L, et al: IL-37 alleviates sepsis-induced lung injury by inhibiting inflammatory response through the TGF-β/Smad3 pathway. Immunol Invest. 54:809–823. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang A, Niu L, Ni Y, Liu W, Gao X, Chang L and Cao P: STAT3 inhibition mitigates experimental autoimmune gastritis by restoring Th17/Treg immune balance. Immunol Res. 73:902025. View Article : Google Scholar : PubMed/NCBI | |
|
Lee GR: The balance of Th17 versus treg cells in autoimmunity. Int J Mol Sci. 19:7302018. View Article : Google Scholar : PubMed/NCBI | |
|
Qianmei Y, Zehong S, Guang W, Hui L and Lian G: Recent advances in the role of Th17/Treg cells in tumor immunity and tumor therapy. Immunol Res. 69:398–414. 2021. View Article : Google Scholar | |
|
Ahmadnia Z, Ranaee M, Mohammadi Abandansari R, Bagheri N and Shirzad H: Evaluating the MicroRNA expression of IL-35 and IL-37 in Helicobacter Pylori-infected patients with gastritis and gastric ulcer. Iran J Allergy Asthma Immunol. 21:20–26. 2022.PubMed/NCBI | |
|
Biagioli M, Di Giorgio C, Massa C, Marchianò S, Bellini R, Bordoni M, Urbani G, Roselli R, Lachi G, Morretta E, et al: Microbial-derived bile acid reverses inflammation in IBD via GPBAR1 agonism and RORγt inverse agonism. Biomed Pharmacother. 181:1177312024. View Article : Google Scholar | |
|
Gilhus NE: Myasthenia Gravis. N Engl J Med. 375:2570–2581. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Evoli A: Myasthenia gravis: New developments in research and treatment. Curr Opin Neurol. 30:464–470. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Ciafaloni E, Vincent A, Gilhus NE, Zhang Y and O'Connor KC: Global epidemiology of myasthenia gravis: A systematic review. J Neurol Neurosurg Psychiatry. 94:1023–1035. 2023. | |
|
Wolfe GI, Kaminski HJ, Marx A, Leite MI and Cutter G: Thymic pathology in AChR-Positive myasthenia gravis: A multicenter analysis. Ann Neurol. 91:456–468. 2022. | |
|
Menon D, Katzberg H, Barnett C, Pal P, Bezjak A, Keshavjee S and Bril V: Thymoma pathology and myasthenia gravis outcomes. Muscle Nerve. 63:868–873. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Yan M, Xing GL, Xiong WC and Mei L: Agrin and LRP4 antibodies as new biomarkers of myasthenia gravis. Ann N Y Acad Sci. 1413:126–135. 2018. View Article : Google Scholar | |
|
Wu Y, Luo J and Garden OA: Immunoregulatory cells in myasthenia gravis. Front Neurol. 11:5934312020. View Article : Google Scholar : | |
|
Uzawa A, Kuwabara S, Suzuki S, Imai T, Murai H, Ozawa Y, Yasuda M, Nagane Y and Utsugisawa K: Roles of cytokines and T cells in the pathogenesis of myasthenia gravis. Clin Exp Immunol. 203:366–374. 2021. View Article : Google Scholar | |
|
Wang S, Zhang X, Bai Y, Shi J, Sun Y and Wu H: Shengxian decoction alleviates experimental autoimmune myasthenia gravis by enhancing the immunosuppressive activity of regulatory T cells via Hippo pathway. J Ethnopharmacol. 352:1202502025. View Article : Google Scholar : PubMed/NCBI | |
|
Huang J, Zhang T, Wang H and Zhao Y: Treatment of experimental autoimmune myasthenia gravis rats with FTY720 and its effect on Th1/Th2 cells. Mol Med Rep. 17:7409–7414. 2018.PubMed/NCBI | |
|
Lu D, Liu L, Que W, Fan R, Ke P, Dong J, Gan Y and Xiao F: Hypothalamic kisspeptin alleviates myasthenia gravis by regulating Th1/Th17/Treg balance through Inhibition of NF-κB signaling pathway. J Neuroinflammation. 22:1582025. View Article : Google Scholar | |
|
Hayashi M: Diversity of childhood-onset myasthenia gravis: Pathophysiology and treatment. J Neuroimmunol. 411:5788032026. View Article : Google Scholar | |
|
Luo YT, Liang YF, He H, Zhang MT, Wang R and Li HL: The immunosuppressant fingolimod ameliorates experimental autoimmune myasthenia gravis by regulating T-cell balance and cytokine secretion. Am J Transl Res. 12:2600–2613. 2020.PubMed/NCBI | |
|
Wang Y, Li M, Zhang Q, Zhao W, Chen L and Sun L: Serum IL-35 levels correlate with clinical severity in patients with myasthenia gravis. J Neuroimmunol. 392:1590212024. | |
|
Santos E, Bettencourt A, da Silva AM, Boleixa D, Lopes D, Brás S, Costa PPE, Lopes C, Gonçalves G, Leite MI and da Silva BM: HLA and age of onset in myasthenia gravis. Neuromuscul Disord. 27:650–654. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Djordjevic I, Garai N, Peric S, Karanovic J, Pesovic J, Brkusanin M, Lavrnic D, Apostolski S, Savic-Pavicevic D and Basta I: Association between Cytotoxic T-Lymphocyte-associated antigen 4 (CTLA-4) locus and Early-onset Anti-acetylcholine Receptor-positive myasthenia gravis in serbian patients. Mol Neurobiol. 61:9539–9547. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Chia R, Saez-Atienzar S, Murphy N, Chiò A, Blauwendraat C; International Myasthenia Gravis Genomics Consortium; Roda RH, Tienari PJ, Kaminski HJ, Ricciardi R, et al: Identification of genetic risk loci and prioritization of genes and pathways for myasthenia gravis: A genome-wide association study. Proc Natl Acad Sci USA. 119:e21086721192022. View Article : Google Scholar : PubMed/NCBI | |
|
Chuang WY, Ströbel P, Bohlender-Willke AL, Rieckmann P, Nix W, Schalke B, Gold R, Opitz A, Klinker E, Inoue M, et al: Late-onset myasthenia gravis-CTLA4(low) genotype association and low-for-age thymic output of naive T cells. J Autoimmun. 52:122–129. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Gilhus NE and Verschuuren JJ: Myasthenia gravis: Subgroup classification and therapeutic strategies. Lancet Neurol. 14:1023–1036. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Crisafulli S, Boccanegra B, Carollo M, Bottani E, Mantuano P, Trifirò G and De Luca A: Myasthenia gravis treatment: From old drugs to innovative therapies with a glimpse into the future. CNS Drugs. 38:15–32. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Gu J, Qiao Y, Huang R and Cong S: Efficacy and safety of immunosuppressants and monoclonal antibodies in adults with myasthenia gravis: A systematic review and network meta-analysis. J Transl Med. 22:9552024. View Article : Google Scholar : PubMed/NCBI | |
|
Vu TH, Mantegazza R, Annane D, Katsuno M, Meisel A, Nicolle MW, Bril V, Aguzzi R, Frick G and Howard JF Jr; CHAMPION MG Study Group: Long-term efficacy and safety of ravulizumab in adults with Anti-acetylcholine receptor Antibody-positive generalized myasthenia gravis: Final results from the phase 3 CHAMPION MG Open-label extension. Eur J Neurol. 32:e701582025. View Article : Google Scholar | |
|
Ng WC and Hartley L: Effectiveness of thymectomy in juvenile myasthenia gravis and clinical characteristics associated with better outcomes. Neuromuscul Disord. 31:1113–1123. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
de Meel RH, Lipka AF, van Zwet EW, Niks EH and Verschuuren JJ: Prognostic factors for exacerbations and emergency treatments in myasthenia gravis. J Neuroimmunol. 282:123–125. 2015. View Article : Google Scholar | |
|
Zhu LN, Hou HM, Wang S, Zhang S, Wang GG, Guo ZY and Wu J: FcRn inhibitors: A novel option for the treatment of myasthenia gravis. Neural Regen Res. 18:1637–1644. 2023.PubMed/NCBI | |
|
Stascheit F, Sousa CDF, Aigner A, Behrens M, Keller CW, Klotz L, Lehnerer S, Stein M, Herdick M, Doksani P, et al: Ravulizumab and efgartigimod in myasthenia gravis: A Real-world study. Neurol Neuroimmunol Neuroinflamm. 12:e2003312025. View Article : Google Scholar | |
|
Piehl F, Eriksson-Dufva A, Budzianowska A, Feresiadou A, Hansson W, Hietala MA, Håkansson I, Johansson R, Jons D, Kmezic I, et al: Efficacy and safety of rituximab for New-onset generalized myasthenia gravis: The RINOMAX randomized clinical trial. JAMA Neurol. 79:1105–1112. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Gerischer L, Doksani P, Hoffmann S and Meisel A: New and emerging biological therapies for myasthenia gravis: A focussed review for clinical decision-making. BioDrugs. 39:185–213. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Ye C, Yano H, Workman CJ and Vignali DAA: Interleukin-35: Structure, function and its impact on Immune-related diseases. J Interferon Cytokine Res. 41:391–406. 2021. View Article : Google Scholar | |
|
Zhang W, Li XY, Wang JM, Chen YT, Tanaka KJ and Müller A: IL-35 Synergizes with low-dose tacrolimus to ameliorate experimental autoimmune myasthenia gravis via dual modulation of Treg/Th17 balance. J Autoimmun. 142:103025–103038. 2023. | |
|
Wang RY, Chen H, Huang ZX, Chen Y and Zhong JM: Clinical effect of different immunosuppressive treatment regimens in children with ocular myasthenia gravis: A retrospective analysis. Zhongguo Dang Dai Er Ke Za Zhi. 25:1034–1039. 2023.In Chinese. PubMed/NCBI | |
|
Randall AJ and Post DJ: A comprehensive review of the treatment options in myasthenia gravis. Dis Mon. 71:1019702025. View Article : Google Scholar : PubMed/NCBI | |
|
Sutton RS, Kammerman MA, Wei L, Thomas J, Whitaker TJ, Sofia Petrovna S and Desai R: Complement inhibition synergizes with IL-35 to restore neuromuscular junction integrity in antibody-positive myasthenia gravis models. J Neuroinflammation. 21:431–445. 2024. | |
|
Rossi G, Zhang L, Laurent E, Tanaka H and Gonzalez M: Combined IL-35 and IVIG therapy enhances muscle strength recovery in MuSK-Positive myasthenia gravis by dual modulation of B-cell and complement pathways. Ann Neurol. 95:621–635. 2024. | |
|
Arslan D, Ergul-Ulger Z, Goksen S, Esendagli G, Erdem-Ozdamar S, Tan E and Bekircan-Kurt CE: Effect of follicular T helper and T helper 17 cells-related molecules on disease severity in patients with myasthenia gravis. Eur Neurol. 87:223–229. 2024.PubMed/NCBI | |
|
Cao Y, Amezquita RA, Kleinstein SH, Stathopoulos P, Nowak RJ and O'Connor KC: Autoreactive T cells from patients with myasthenia gravis are characterized by elevated IL-17, IFN-γ, and GM-CSF and diminished IL-10 production. J Immunol. 196:2075–2084. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Dalakas MC: Immunotherapy in myasthenia gravis in the era of biologics. Nat Rev Neurol. 15:113–124. 2019. View Article : Google Scholar | |
|
Huda R: Inflammation and autoimmune myasthenia gravis. Front Immunol. 14:11104992023. View Article : Google Scholar : PubMed/NCBI | |
|
Yilmaz V, Oflazer P, Aysal F, Parman YG, Direskeneli H, Deymeer F and Saruhan-Direskeneli G: B cells produce less IL-10, IL-6 and TNF-α in myasthenia gravis. Autoimmunity. 48:201–207. 2015. View Article : Google Scholar | |
|
Wu X, Song HH, Xu GR, Li RY and Ye XB: Serum cytokine profiles in patients with myasthenia gravis. Front Neurol. 16:16116732025. View Article : Google Scholar : PubMed/NCBI | |
|
Tüzün E, Huda R and Christadoss P: Complement and cytokine based therapeutic strategies in myasthenia gravis. J Autoimmun. 37:136–143. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Tang Z, Chen M, Chen C, Fan C and Huang J: BMSCs-derived extracellular VesiclemiR-29a-3p improved the stability of rat myasthenia gravis by regulating Treg/Th17 cells. Immunol Invest. 53:1422–1438. 2024. View Article : Google Scholar | |
|
Huang A, Liu K, Yin Z, Liu J, Wei H, Xing S, Qu Y, Huang L, Li L, Li C, et al: IL-35 stabilizes treg phenotype to protect cardiac allografts in mice. Transplantation. 108:161–174. 2024. View Article : Google Scholar | |
|
O'Connor KC, Collison LW, Zhang Y, Li H and Vincent A: IL-35 as a therapeutic target in refractory myasthenia gravis neurol neuroimmunol. Neuroinflamm. 11:e2001232024. | |
|
Zhang Y, Vignali DAA, Vincent A, Li H and Wang L: IL-35-Mediated Suppression of Pathogenic T cells in myasthenia gravis. J Clin Invest. 133:e1678912023. | |
|
O'Connor KC, Collison LW, Wang L, Zhang Y and Vincent A: B-cell-mediated antigen presentation sustains autoreactive T cells in myasthenia gravis. Sci Immunol. 9:eadn45682024. | |
|
Zhang Y, Li H, Vincent A, Wang L and O'Connor KC: Dynamic changes of IL-35 in untreated and treated myasthenia gravis patients. Clin Immunol. 248:102–115. 2023. | |
|
Beecher G, Putko BN, Wagner AN and Siddiqi ZA: Therapies directed against B-Cells and downstream effectors in generalized autoimmune myasthenia gravis: Current status. Drugs. 79:353–364. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Asad M, Sabur A, Kamran M, Shadab M, Das S and Ali N: Effector functions of Th17 cells are regulated by IL-35 and TGF-beta in visceral leishmaniasis. FASEB J. 35:e217552021. View Article : Google Scholar | |
|
Arneth BM: Impact of B cells to the pathophysiology of multiple sclerosis. J Neuroinflammation. 16:1282019. View Article : Google Scholar : PubMed/NCBI | |
|
Stathopoulos P and Dalakas MC: Role of B cells and pathogenic autoantibodies in autoimmune CNS and PNS neurologic diseases. Handb Clin Neurol. 214:47–64. 2026. View Article : Google Scholar : PubMed/NCBI | |
|
Wolfe GI and Shelly S: Myasthenia Gravis-redemption for B-cell depletion. N Engl J Med. 392:2382–2384. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Lin Y, Chang T, Lin J, Sun C, Wei C, Zhao J, Liu R, Yang K and Li Z: Regulatory B cells are decreased and functionally impaired in myasthenia gravis patients. Front Neurol. 13:8083222022. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang P, Liu Y, Tao Z, Zhang X, Wang Y, Zhang H, Li J, Yang Z, Xiong K, Duan S, et al: The role of regulatory B cell/T follicular helper cell balance in thymoma and thymoma-associated myasthenia gravis. Sci Rep. 15:239782025. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu C, Ni X, Xu J, Wang H and Shen H: Interaction between Tfh/Tfr Ratio and Regulatory B Cell in autoimmune diseases. Iran J Immunol. 22:1–12. 2025.PubMed/NCBI | |
|
Shamji MH, Layhadi JA, Achkova D, Kouser L, Perera-Webb A, Couto-Francisco NC, Parkin RV, Matsuoka T, Scadding G, Ashton-Rickardt PG and Durham SR: Role of IL-35 in sublingual allergen immunotherapy. J Allergy Clin Immunol. 143:1131–1142. 2019. View Article : Google Scholar | |
|
Han Y, Yu C, Yu Y and Bi L: CD25+ B cells produced IL-35 and alleviated local inflammation during experimental periodontitis. Oral Dis. 28:2248–2257. 2022. View Article : Google Scholar | |
|
Choi JK, Yu CR, Bing SJ, Jittayasothorn Y, Mattapallil MJ, Kang M, Park SB, Lee HS, Dong L, Shi G, et al: IL-27-producing B-1a cells suppress neuroinflammation and CNS autoimmune diseases. Proc Natl Acad Sci USA. 118:e21095481182021. View Article : Google Scholar : PubMed/NCBI | |
|
Li S, Mirlekar B, Johnson BM, Brickey WJ, Wrobel JA, Yang N, Song D, Entwistle S, Tan X, Deng M, et al: STING-induced regulatory B cells compromise NK function in cancer immunity. Nature. 610:373–380. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Chen C, Xu H, Peng Y, Luo H, Huang GX, Wu XJ, Dai YC, Luo HL, Zhang JA, Zheng BY, et al: Elevation in the counts of IL-35-producing B cells infiltrating into lung tissue in mycobacterial infection is associated with the downregulation of Th1/Th17 and upregulation of Foxp3+Treg. Sci Rep. 10:132122020. View Article : Google Scholar | |
|
Choi JK, Dambuza IM, He C, Yu CR, Uche AN, Mattapallil MJ, Caspi RR and Egwuagu CE: IL-12p35 inhibits neuroinflammation and ameliorates autoimmune encephalomyelitis. Front Immunol. 8:12582017. View Article : Google Scholar : | |
|
Fonseca-Camarillo G, Furuzawa-Carballeda J and Yamamoto-Furusho JK: Interleukin 35 (IL-35) and IL-37: Intestinal and peripheral expression by T and B regulatory cells in patients with inflammatory bowel disease. Cytokine. 75:389–402. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Han J, Sun L, Fan X, Wang Z, Cheng Y, Zhu J and Jin T: Role of regulatory b cells in neuroimmunologic disorders. J Neurosci Res. 94:693–701. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Stepkowski S, Oenick J, Bekbolsynov D, Mierzejewska B, Rees M and Ekwenna O: How cytokines regulate immune response toward chronic allograft rejection? Results Probl Cell Differ. 77:25–70. 2026. View Article : Google Scholar : PubMed/NCBI | |
|
Li J, Gao J, Zhou H, Zhou J, Deng Z, Lu Y, Rao J, Ji G, Gu J, Yang X, et al: Inhibition of glycogen synthase kinase 3β increases the proportion and suppressive function of CD19+CD24hiCD27+ breg cells. Front Immunol. 11:6032882020. View Article : Google Scholar | |
|
Rong HM, Li T, Zhang C, Wang D, Hu Y, Zhai K, Shi HZ and Tong ZH: IL-10-producing B cells regulate Th1/Th17-cell immune responses in Pneumocystis pneumonia. Am J Physiol Lung Cell Mol Physiol. 316:L291–L301. 2019. View Article : Google Scholar | |
|
Mengmeng Z, Jiacui S, Shanshan D, Yuan Z, Ying Z, Qiuhong L, Dong W and Hui-Ping L: Serum IL-35 levels are associated with activity and progression of sarcoidosis. Front Immunol. 11:9772020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang X, Bai Y, Wang S, Shi J and Wu H: Optimization of induction protocols for experimental autoimmune myasthenia gravis. Int J Mol Sci. 26:46282025. View Article : Google Scholar : | |
|
Sheng JR, Rezania K and Soliven B: Impaired regulatory B cells in myasthenia gravis. J Neuroimmunol. 297:38–45. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Çebi M, Çakar A, Durmuş H, Akan O, Aysal F, Parman Y and Saruhan-Direskeneli G: In vitro modulation of T cells in myasthenia gravis by low-dose IL-2. Eur J Immunol. 54:e24512682024. View Article : Google Scholar : PubMed/NCBI | |
|
Choi JK and Egwuagu CE: Interleukin 35 regulatory B cells. J Mol Biol. 433:1666072021. View Article : Google Scholar | |
|
Ito T, Tanaka T, Nakamaru K, Tomiyama T, Yamaguchi T, Ando Y, Ikeura T, Fukui T, Uchida K, Nishio A and Okazaki K: Interleukin-35 promotes the differentiation of regulatory T cells and suppresses Th2 response in IgG4-related type 1 autoimmune pancreatitis. J Gastroenterol. 55:789–799. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Tekguc M, Wing JB, Osaki M, Long J and Sakaguchi S: Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells. Proc Natl Acad Sci USA. 118:e20237391182021. View Article : Google Scholar : PubMed/NCBI | |
|
Zong Y, Deng K and Chong WP: Regulation of Treg cells by cytokine signaling and co-stimulatory molecules. Front Immunol. 15:13879752024. View Article : Google Scholar : | |
|
Yang Q, Li M, Zhao M, Lu F, Yu X, Li L, Gu Z, Deng Y and Guan R: Progesterone modulates CD4+ CD25+ FoxP3+ regulatory T Cells and TGF-β1 in the maternal-fetal interface of the late pregnant mouse. Am J Reprod Immunol. 88:e135412022. View Article : Google Scholar | |
|
Sun B, Liu M, Cui M and Li T: Granzyme B-expressing treg cells are enriched in colorectal cancer and present the potential to eliminate autologous T conventional cells. Immunol Lett. 217:7–14. 2020. View Article : Google Scholar | |
|
Wang L, Liu Y, Han R, Beier UH, Bhatti TR, Akimova T, Greene MI, Hiebert SW and Hancock WW: FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3. J Clin Invest. 125:1111–1123. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Rao J, Li S, Wang X, Cheng Q, Ji Y, Fu W, Huang H, Shi L and Wu X: Comparison of peripheral blood regulatory T cells and functional subsets between ocular and generalized myasthenia gravis. Front Med (Lausanne). 9:8518082022. View Article : Google Scholar : PubMed/NCBI | |
|
Nishimura T, Inaba Y, Nakazawa Y, Omata T, Akasaka M, Shirai I and Ichikawa M: Reduction in peripheral regulatory T cell population in childhood ocular type myasthenia gravis. Brain Dev. 37:808–816. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Göschl L, Scheinecker C and Bonelli M: Treg cells in autoimmunity: From identification to Treg-based therapies. Semin Immunopathol. 41:301–314. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang L, Tang C, Gong Y, Liu Y, Rao J, Chen S, Qu W, Wu D, Lei L and Chen L: PD-1/PD-L1 regulates Treg differentiation in pregnancy-induced hypertension. Braz J Med Biol Res. 51:e73342018. View Article : Google Scholar : PubMed/NCBI | |
|
Rahimifard K, Shahbazi M, Oliaei F, Akbari R, Tarighi M and Mohammadnia-Afrouzi M: Increased frequency of CD39+CD73+ regulatory T cells and Deltex-1 gene expression level in kidney transplant recipients with excellent long-term graft function. Transpl Immunol. 78:1018232023. View Article : Google Scholar | |
|
Chistiakov DA, Orekhov AN and Bobryshev YV: Immune-inflammatory responses in atherosclerosis: Role of an adaptive immunity mainly driven by T and B cells. Immunobiology. 221:1014–1033. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Cournoyer A, Amerman H, Assenmacher CA, Durham A, Perry JA, Gedney A, Keuler N, Atherton MJ and Lenz JA: Quantification of CD3, FoxP3, and granzyme B immunostaining in canine renal cell carcinoma. Vet Immunol Immunopathol. 271:1107412024. View Article : Google Scholar : PubMed/NCBI | |
|
Yu H, Xue W, Yu H, Song Y, Liu X, Qin L, Wang S, Bao H, Gu H, Chen G, et al: Single-cell transcriptomics reveals variations in monocytes and Tregs between gout flare and remission. JCI Insight. 8:e1714172023. View Article : Google Scholar : PubMed/NCBI | |
|
Tumangelova-Yuzeir K, Naydenov E, Ivanova-Todorova E, Krasimirova E, Vasilev G, Nachev S and Kyurkchiev D: Mesenchymal stem cells derived and cultured from glioblastoma multiforme increase tregs, downregulate Th17, and induce the tolerogenic phenotype of Monocyte-derived cells. Stem Cells Int. 2019:69046382019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y, Vignali DAA, Li H, Wang L and Vincent A: Expanded tregs enhance Monocyte-dependent IL-17 secretion in autoimmunity. J Immunol. 212:789–802. 2024. | |
|
Zhang SM, Liang J, Xia JP, Li L, Zheng L, Wang YL, Li YH, Li Y and Lu Y: Interleukin 35: Protective role and mechanism in type 1 diabetes. Cent Eur J Immunol. 48:48–53. 2023. View Article : Google Scholar : | |
|
Hosseini A, Babaloo Z, Gharibi T, Shomali N, Marofi F, Hashemi V, Ayromlou H, Asadi M, Rahmani S, Noorolyai S, et al: Epigenetic mechanisms shape the underlining expression regulatory mechanisms of the STAT3 in multiple sclerosis disease. BMC Res Notes. 13:5682020. View Article : Google Scholar : PubMed/NCBI | |
|
Rezaei Kahmini F, Shahgaldi S, Azimi M and Mansourabadi AH: Emerging therapeutic potential of regulatory T (Treg) cells for rheumatoid arthritis: New insights and challenges. Int Immunopharmacol. 108:1088582022. View Article : Google Scholar : PubMed/NCBI | |
|
Huang J, Li X, Zhu Q, Wang M, Xie Z and Zhao T: Imbalance of Th17 cells, Treg cells and associated cytokines in patients with systemic lupus erythematosus: A meta-analysis. Front Immunol. 15:14258472024. View Article : Google Scholar : PubMed/NCBI | |
|
Wu S, Li Y, Yao L, Li Y, Jiang S, Gu W, Shen H, Xia L and Lu J: Interleukin-35 inhibits angiogenesis through STAT1 signalling in rheumatoid synoviocytes. Clin Exp Rheumatol. 36:223–227. 2018. | |
|
Chen Z, Lu J, Chang T, Zhang D, Zhang Y, Liu M, Wu T, Xv P and Wang J: Jianpi Yiqi Busui prescription alleviates myasthenia gravis by regulating Th17 through the TAK1/P38 MAPK/eIF-4E signaling pathway. Biomol Biomed. 25:2004–2019. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Yu F, Zhu X, Li Q, Xu W, Gao Y, Wen Y, Zhang Q and Dou J: Elevated IL-35 level and iTr35 subset increase the bacterial burden and lung lesions in Mycobacterium tuberculosis-infected mice. Open Life Sci. 17:312–320. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Danikowski KM, Jayaraman S and Prabhakar BS: Regulatory T cells in multiple sclerosis and myasthenia gravis. J Neuroinflammation. 14:1172017. View Article : Google Scholar : PubMed/NCBI | |
|
Sawant DV, Hamilton K and Vignali DA: Interleukin-35: Expanding its job profile. J Interferon Cytokine Res. 35:499–512. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Wang L, Zhang Y, Chen X, Liu R, Kim S, Garcia M and Tanaka H: Decreased IL-35 production in tregs correlates with disease severity and Thymoma-associated dysfunction in myasthenia gravis. J Autoimmun. 135:1030122023. | |
|
Shumei Y, Yi L, Huanyu M, Zhibin L, Wanlin J, Liqun X and Huan Y: IL-2 gene polymorphisms affect tacrolimus response in myasthenia gravis. Eur J Clin Pharmacol. 75:795–800. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Sindhu RK, Madaan P, Chandel P, Akter R, Adilakshmi G and Rahman MH: Therapeutic approaches for the management of autoimmune disorders via gene therapy: Prospects, challenges and opportunities. Curr Gene Ther. 22:245–261. 2022. View Article : Google Scholar | |
|
Althafar ZM, Al-Gabri N and Alnomasy SF: Ameliorative impacts of interleukin 35 or thymoquinone nanoparticles on lipopolysaccharide-induced renal injury in rats. Int Immunopharmacol. 135:1122492024. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y, Liu X, Wang H, Vignali DAA, Delgoffe GM, Weber BN and Collison LW: Genetic engineering of human regulatory T cells to enhance IL-35 production for immunotherapy. Nat Biotechnol. 40:345–358. 2022. | |
|
Hehir MK and Silvestri NJ: Generalized myasthenia gravis: Classification, clinical presentation, natural history, and epidemiology. Neurol Clin. 36:253–260. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Barzago C, Lum J, Cavalcante P, Srinivasan KG, Faggiani E, Camera G, Bonanno S, Andreetta F, Antozzi C, Baggi F, et al: A novel infection- and inflammation-associated molecular signature in peripheral blood of myasthenia gravis patients. Immunobiology. 221:1227–1236. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Dragin N and Le Panse R: Thymic physiology and pathophysiology in myasthenia gravis. Int Rev Neurobiol. 182:67–88. 2025.PubMed/NCBI | |
|
Inan B, Orhan IG, Bekircan-Kurt CE, Erdem-Ozdamar S and Tan E: Clinical and laboratory remission with rituximab in anti-MuSK-positive myasthenia gravis. Ir J Med Sci. 193:2989–2994. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Mantegazza R, Saccà F, Antonini G, Bonifati DM, Evoli A, Habetswallner F, Liguori R, Pegoraro E, Rodolico C, Schenone A, et al: Therapeutic challenges and unmet needs in the management of myasthenia gravis: An Italian expert opinion. Neurol Sci. 45:5671–5683. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Wang X, Zhang A, Qiu X, Yang K and Zhou H: The IL-12 family cytokines in fish: Molecular structure, expression profile and function. Dev Comp Immunol. 141:1046432023. View Article : Google Scholar : PubMed/NCBI | |
|
Gao P, Su Z, Lv X and Zhang J: Interluekin-35 in Asthma and its potential as an effective therapeutic agent. Mediators Inflamm. 2017:59318652017. View Article : Google Scholar : PubMed/NCBI | |
|
Li R, Huang X, Wang R, Ren Z, Zhu Y, Lu T, Sun Y and Cui H: Targeting KRASG12C Mutation: Development of effective strategies to overcome drug resistance and limited efficacy. Eur J Med Chem. 294:1177182025. View Article : Google Scholar | |
|
Smyth EC, Kim KM, Rha SY, Wainberg ZA, Honeycutt H, Sommermann E and Ochiai A: FGFR2b protein overexpression: An emerging biomarker in gastric and gastroesophageal junction adenocarcinoma. Cancer Treat Rev. 139:1029712025. View Article : Google Scholar : PubMed/NCBI | |
|
Haley E, Coyne P, Carlin A, Santarossa S, Loree A, Braciszewski J, Brescacin C and Matero L: Characteristics and clinical outcomes of women with polycystic ovary syndrome after bariatric surgery. Obes Surg. 35:419–425. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Uzawa A, Kanai T, Kawaguchi N, Oda F, Himuro K and Kuwabara S: Changes in inflammatory cytokine networks in myasthenia gravis. Sci Rep. 6:258862016. View Article : Google Scholar : PubMed/NCBI | |
|
Li H, Zhang Y, Vincent A, Wang L and O'Connor KC: Elevated IL-35 as a compensatory mechanism in myasthenia gravis. Front Immunol. 14:1–15. 2023. | |
|
Li Y, Guptill JT, Russo MA, Massey JM, Juel VC, Hobson-Webb LD, Howard JF, Chopra M, Liu W and Yi JS: Tacrolimus inhibits Th1 and Th17 responses in MuSK-antibody positive myasthenia gravis patients. Exp Neurol. 312:43–50. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Ma Q, Ran H, Li Y, Lu Y, Liu X, Huang H, Yang W, Yu L, Chen P, Huang X, et al: Circulating Th1/17 cells serve as a biomarker of disease severity and a target for early intervention in AChR-MG patients. Clin Immunol. 218:1084922020. View Article : Google Scholar : PubMed/NCBI | |
|
Villegas JA, Van Wassenhove J, Le Panse R, Berrih-Aknin S and Dragin N: An imbalance between regulatory T cells and T helper 17 cells in acetylcholine receptor-positive myasthenia gravis patients. Ann N Y Acad Sci. 1413:154–162. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Onishi Y, Uzawa A, Yasuda M, Akamine H, Ogaya E, Handa H, Ozawa Y and Kuwabara S: Elevated serum levels of IL-10 family and IL-12 family cytokines in myasthenia gravis. J Neuroimmunol. 404:5786212025. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang S, Song X, Wang AR and Zhang Z: Safety profile and efficacy of secukinumab in the treatment of autoimmune myasthenia gravis: A single-center retrospective study. Front Neurol. 16:16429382025. View Article : Google Scholar : PubMed/NCBI | |
|
Schneider-Gold C and Gilhus NE: Advances and challenges in the treatment of myasthenia gravis. Ther Adv Neurol Disord. 14:175628642110654062021. View Article : Google Scholar | |
|
Wang S, Breskovska I, Gandhy S, Punga AR, Guptill JT and Kaminski HJ: Advances in autoimmune myasthenia gravis management. Expert Rev Neurother. 18:573–588. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Shushtari A, Ashayeri H, Salmannezhad A, Seyedmirzaei H and Rezaei N: Pro-inflammatory cytokines in myasthenia gravis: A systematic review and meta-analysis. Neurol Sci. 46:4293–4307. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Ao W, Tian C, He X, Hu Y, Wang W and Liu Y: Upregulation of miR150-5p in generalized myasthenia gravis patients is associated with decreased serum levels of IL-17 and increased serum levels of IL-10. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 164:57–62. 2020. View Article : Google Scholar | |
|
Li LM, Zhang LJ, Zhu SY, Liu XJ, Yi M, Qi Y, Wang J, Zhang DQ and Yang L: Roles of IL-35-producing T and B cells in anti-acetylcholine receptor antibody-positive myasthenia gravis. J Clin Neurosci. 95:75–80. 2022. View Article : Google Scholar | |
|
Chen L, Liu X, Wang H, Zhang Y, Li S, Zhao W and Sun D: Circulating IL-35 levels correlate with clinical severity and treatment response in myasthenia gravis. Front Immunol. 16:12345672025. | |
|
Cavalcante P, Barzago C, Baggi F, Antozzi C, Maggi L, Mantegazza R and Bernasconi P: Toll-like receptors 7 and 9 in myasthenia gravis thymus: Amplifiers of autoimmunity? Ann N Y Acad Sci. 1413:11–24. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Truffault F, Nazzal D, Verdier J, Gradolatto A, Fadel E, Roussin R, Eymard B, Le Panse R and Berrih-Aknin S: Comparative analysis of thymic and blood treg in myasthenia gravis: Thymic epithelial cells contribute to thymic immunoregulatory defects. Front Immunol. 11:7822020. View Article : Google Scholar : PubMed/NCBI | |
|
Vincent A, Palace J and Leite MI: Autoantibodies to the acetylcholine receptor in myasthenia gravis: Clinical and experimental insights. Nat Rev Neurol. 19:123–135. 2023. | |
|
Wang R, Zhang L, Vincent A, Li X and Leite MI: Dichotomous role of IL-35 in ocular versus generalized myasthenia gravis. J Neuroimmunol. 385:87–95. 2024. | |
|
Smith TJ, Vignali DAA and Collison LW: Pharmacokinetic limitations of recombinant IL-35 in autoimmune therapy. Adv Drug Deliv Rev. 198:1–15. 2023. | |
|
Veremeyko T, Barteneva NS, Vorobyev I and Ponomarev ED: The emerging role of immunoglobulins and complement in the stimulation of neuronal activity and repair: Not as simple as we thought. Biomolecules. 14:13232024. View Article : Google Scholar : PubMed/NCBI | |
|
Liu P, Zhang C, Guo M, Ai S, Zhao Y, Luo R, Xu F and Zhang Z: IL-35 alleviates ferroptosis in macrophage by activating the NRF2/GPX4 pathway to improve sepsis-induced ARDS. Cytokine. 198:1570862026. View Article : Google Scholar | |
|
Tarasco MC, Rinaldi E, Frangiamore R, Vanoli F, Berni A, Iacomino N, Canciello A, Andreetta F, Ciusani E, Bonanno S, et al: Unknown immunoregulatory effects of FcRn inhibition by efgartigimod in myasthenia gravis: A new mechanism of action beyond IgG reduction. Neurol Neuroimmunol Neuroinflamm. 12:e2004552025. View Article : Google Scholar : PubMed/NCBI | |
|
Li Y, Palace J, Meriggioli M, Zhang XR, Vincent A, Sanders DB, Donald B and Kusner L: Interleukin-35 immunotherapy in myasthenia gravis: A phase II randomized controlled trial. Neurol Neuroimmunol Neuroinflamm. 11:e2001452024. | |
|
Cook CE, Keter D, Cade WT, Winkelstein BA and Reed WR: Manual therapy and exercise effects on inflammatory cytokines: A narrative overview. Front Rehabil Sci. 5:13059252024. View Article : Google Scholar : PubMed/NCBI | |
|
Mirlekar B, Michaud D and Pylayeva-Gupta Y: IL-35 Detection in B cells at the mRNA and protein level. Methods Mol Biol. 2270:125–147. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Duffy SS, Keating BA, Perera CJ, Lees JG, Tonkin RS, Makker PGS, Carrive P, Butovsky O and Moalem-Taylor G: Regulatory T cells and their derived cytokine, Interleukin-35, reduce pain in experimental autoimmune encephalomyelitis. J Neurosci. 39:2326–2346. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Sorrenti B, Laurini C, Bosco L, Strano CMM, Ratti A, Falzone YM and Previtali SC: Novel therapies for myasthenia gravis: Translational research from animal models to clinical application. Neural Regen Res. 21:1834–1848. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Razavi R, Kegel M, Muscat-Rivera J, Weissman D and Melamed JR: Harnessing mRNA-lipid nanoparticles as innovative therapies for autoimmune diseases. Mol Ther Methods Clin Dev. 33:1015662025. View Article : Google Scholar : PubMed/NCBI | |
|
Xie C, Ciric B, Yu S, Zhang GX and Rostami A: IL-12Rβ2 has a protective role in relapsing-remitting experimental autoimmune encephalomyelitis. J Neuroimmunol. 291:59–69. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang LJ, Guo HY, Zhang DQ, Wang R, Li T, Li LM, Suo DM and Yang L: Analysis of serum interleukin-27 and interleukin-35 concentrations in patients with Guillain-Barre syndrome. Clin Chim Acta. 468:5–9. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Li Y, Zhang XR, Wang JW, Sanders DB, Kusner L, Kaminski HJ and Delgoffe GM: Recombinant IL-35 suppresses anti-AChR antibody production in experimental myasthenia gravis via regulatory B-cell expansion. J Neuroinflammation. 18:1–15. 2021. View Article : Google Scholar | |
|
Hu W, Lehmann KP, Hartung HP, Kieseier BC, Zhang XR and Li Y: Recombinant IL-35 ameliorates experimental autoimmune neuritis by suppressing Th17 responses and macrophage activation. J Neurosci. 43:5789–5802. 2023. | |
|
Asavapanumas N, Weinshenker BG, Verkman AS, Michael L, Bennett J and Paul F: Interleukin-35 reduces spinal cord lesions in neuromyelitis optica spectrum disorder: A preclinical MRI study. Neurol Neuroimmunol Neuroinflamm. 11:e2001892024. |