|
1
|
Tan TE and Wong TY: Diabetic retinopathy:
Looking forward to 2030. Front Endocrinol (Lausanne).
13:10776692022. View Article : Google Scholar
|
|
2
|
Teo ZL, Tham YC, Yu M, Chee M, Rim TH,
Cheung N, Bikbov MM, Wang YX, Tang Y, Lu Y, et al: Global
prevalence of diabetic retinopathy and projection of burden through
2045: Systematic review and meta-analysis. Ophthalmology.
128:1580–1591. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Himasa FI, Singhal M, Ojha A and Kumar B:
Prospective for diagnosis and treatment of diabetic retinopathy.
Curr Pharm Des. 28:560–569. 2022. View Article : Google Scholar
|
|
4
|
Ren J, Zhang S, Pan Y, Jin M, Li J, Luo Y,
Sun X and Li G: Diabetic retinopathy: Involved cells, biomarkers,
and treatments. Front Pharmacol. 13:9536912022. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Kaushik V, Gessa L, Kumar N and Fernandes
H: Towards a new biomarker for diabetic retinopathy: Exploring RBP3
structure and retinoids binding for functional imaging of eyes in
vivo. Int J Mol Sci. 24:44082023. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Lam TI, Anderson SE, Glaser N and
O'donnell ME: Bumetanide reduces cerebral edema formation in rats
with diabetic ketoacidosis. Diabetes. 54:510–516. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Guzel S, Cai CL, Ahmad T, Quan M, Valencia
GB, Aranda JV and Beharry KD: Bumetanide suppression of
angiogenesis in a rat model of Oxygen-induced retinopathy. Int J
Mol Sci. 21:9872020. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Chen C, Fan P, Zhang L, Xue K, Hu J, Huang
J, Lu W, Xu J, Xu S, Qiu G, et al: Bumetanide rescues Aquaporin-4
depolarization via suppressing β-dystroglycan cleavage and provides
neuroprotection in rat retinal ischemia-reperfusion injury.
Neuroscience. 510:95–108. 2022. View Article : Google Scholar
|
|
9
|
Navas A, Jannus F, Fernández B, Cepeda J,
Medina O'Donnell M, Díaz-Ruiz L, Sánchez-González C, Llopis J, Seco
JM, Rufino-Palomares E, et al: Designing Single-molecule magnets as
drugs with dual Anti-inflammatory and anti-diabetic effects. Int J
Mol Sci. 21:31462020. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Hampel P, Römermann K, Gailus B, Johne M,
Gericke B, Kaczmarek E and Löscher W: Effects of the NKCC1
inhibitors bumetanide, azosemide, and torasemide alone or in
combination with phenobarbital on seizure threshold in epileptic
and nonepileptic mice. Neuropharmacology. 185:1084492021.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Rivera A, Nasburg JA, Shim H, Shmukler BE,
Kitten J, Wohlgemuth JG, Dlott JS, Snyder LM, Brugnara C, Wulff H
and Alper SL: The erythroid K-Cl cotransport inhibitor
[(dihydroindenyl)oxy]acetic acid blocks erythroid Ca2+-activated K+
channel KCNN4. Am J Physiol Cell Physiol. 323:C694–C705. 2022.
View Article : Google Scholar
|
|
12
|
Tang F, Barbacioru C, Wang Y, Nordman E,
Lee C, Xu N, Wang X, Bodeau J, Tuch BB, Siddiqui A, et al: mRNA-Seq
whole-transcriptome analysis of a single cell. Nat Methods.
6:377–382. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Van Hove I, De Groef L, Boeckx B, Modave
E, Hu TT, Beets K, Etienne I, Van Bergen T, Lambrechts D, Moons L,
et al: Single-cell transcriptome analysis of the Akimba mouse
retina reveals cell-type-specific insights into the pathobiology of
diabetic retinopathy. Diabetologia. 63:2235–2248. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Zhang X, Zhang F and Xu X: Single-cell RNA
sequencing in exploring the pathogenesis of diabetic retinopathy.
Clin Transl Med. 14:e17512024. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Sun L, Wang R, Hu G, Liu H, Lv K, Duan Y,
Shen N, Wu J, Hu J, Liu Y, et al: Single cell RNA sequencing
(scRNA-Seq) deciphering pathological alterations in
streptozotocin-induced diabetic retinas. Exp Eye Res.
210:1087182021. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Liu K, Gao X, Hu C, Gui Y, Gui S, Ni Q,
Tao L and Jiang Z: Capsaicin ameliorates diabetic retinopathy by
inhibiting poldip2-induced oxidative stress. Redox Biol.
56:1024602022. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Theocharidis G, Thomas BE, Sarkar D, Mumme
HL, Pilcher WJR, Dwivedi B, Sandoval-Schaefer T, Sîrbulescu RF,
Kafanas A, Mezghani I, et al: Single cell transcriptomic landscape
of diabetic foot ulcers. Nat Commun. 13:1812022. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Liao D, Fan W, Li N, Li R, Wang X, Liu J,
Wang H and Hou S: A single cell atlas of circulating immune cells
involved in diabetic retinopathy. iScience. 27:1090032024.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Hu Z, Mao X, Chen M, Wu X, Zhu T, Liu Y,
Zhang Z, Fan W, Xie P, Yuan S and Liu Q: Single-cell
transcriptomics reveals novel role of microglia in fibrovascular
membrane of proliferative diabetic retinopathy. Diabetes.
71:762–773. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Xiang ZY, Chen SL, Qin XR, Lin SL, Xu Y,
Lu LN and Zou HD: Changes and related factors of blood CCN1 levels
in diabetic patients. Front Endocrinol (Lausanne). 14:11319932023.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Hui Z, Chen YM, Gong WK, Lai JB, Yao BB,
Zhao ZJ, Lu QK, Ye K, Ji LD and Xu J: Shared and specific
biological signalling pathways for diabetic retinopathy, peripheral
neuropathy and nephropathy by high-throughput sequencing analysis.
Diab Vasc Dis Res. 19:147916412211229182022. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Gui F, You Z, Fu S, Wu H and Zhang Y:
Endothelial dysfunction in diabetic retinopathy. Front Endocrinol
(Lausanne). 11:5912020. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Kaur G, Song Y, Xia K, Mccarthy K, Zhang
F, Linhardt RJ and Harris NR: Effect of high glucose on
glycosaminoglycans in cultured retinal endothelial cells and rat
retina. Glycobiology. 32:720–734. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Shi J, Lv H, Tang C, Li Y, Huang J and
Zhang H: Mangiferin inhibits cell migration and angiogenesis via
PI3K/AKT/mTOR signaling in high glucose- and hypoxia-induced
RRCECs. Mol Med Rep. 23:4732021. View Article : Google Scholar
|
|
25
|
Justus CR, Marie MA, Sanderlin EJ and Yang
LV: Transwell in vitro cell migration and invasion assays. Methods
Mol Biol. 2644:349–359. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Lin Y, Luo G, Liu Q, Yang R, Sol Reinach P
and Yan D: METTL3-mediated RNA m6A modification regulates the
angiogenic behaviors of retinal endothelial cells by methylating
MMP2 and TIE2. Invest Ophthalmol Vis Sci. 64:182023. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Li J, Lu X, Wei L, Ye D, Lin J, Tang X,
Cui K, Yu S, Xu Y and Liang X: PHD2 attenuates high-glucose-induced
blood retinal barrier breakdown in human retinal microvascular
endothelial cells by regulating the Hif-1α/VEGF pathway. Inflamm
Res. 71:69–79. 2021. View Article : Google Scholar
|
|
28
|
Giebel SJ, Menicucci G, Mcguire PG and Das
A: Matrix metalloproteinases in early diabetic retinopathy and
their role in alteration of the blood-retinal barrier. Lab Invest.
85:597–607. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Huang Y, Wang Z, Ye B, Ma JH, Ji S, Sheng
W, Ye S, Ou Y, Peng Y, Yang X, et al: Sodium butyrate ameliorates
diabetic retinopathy in mice via the regulation of gut microbiota
and related short-chain fatty acids. J Transl Med. 21:4512023.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Zhang L, Zhou X, Chen H, You L, Zhang T,
Cheng M, Yao Y, Pan X and Yang X: Mulberry extract ameliorates
T2DM-related symptoms via AMPK pathway in STZ-HFD-induced C57BL/6J
mice. J Ethnopharmacol. 313:1164752023. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Wu L, Li J, Zhao F and Xiang Y: MiR-340-5p
inhibits Müller cell activation and pro-inflammatory cytokine
production by targeting BMP4 in experimental diabetic retinopathy.
Cytokine. 149:1557452021. View Article : Google Scholar
|
|
32
|
Ai X, Yu P, Luo L, Sun J, Tao H, Wang X
and Meng X: Berberis Dictyophylla F. inhibits angiogenesis and
apoptosis of diabetic retinopathy via suppressing
HIF-1α/VEGF/DLL-4/Notch-1 pathway. J Ethnopharmacol.
296:1154532022. View Article : Google Scholar
|
|
33
|
Kyrylkova K, Kyryachenko S, Leid M and
Kioussi C: Detection of apoptosis by TUNEL assay. Methods Mol Biol.
887:41–47. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Hu L, Lv X, Li D, Zhang W, Ran G, Li Q and
Hu J: The anti-angiogenesis role of FBXW7 in diabetic retinopathy
by facilitating the ubiquitination degradation of c-Myc to
orchestrate the HDAC2. J Cell Mol Med. 25:2190–2202. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Shao J, Bai Z, Zhang L and Zhang F:
Ferrostatin-1 alleviates tissue and cell damage in diabetic
retinopathy by improving the antioxidant capacity of the Xc-GPX4
system. Cell Death Discov. 8:4262022. View Article : Google Scholar
|
|
36
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
37
|
Simó R, Simó-Servat O, Bogdanov P and
Hernández C: Diabetic retinopathy: Role of neurodegeneration and
therapeutic perspectives. Asia Pac J Ophthalmol (Phila).
11:160–167. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Kaštelan S, Orešković I, Bišćan F,
Kaštelan H and Gverović Antunica A: Inflammatory and angiogenic
biomarkers in diabetic retinopathy. Biochem Med (Zagreb).
30:0305022020. View Article : Google Scholar
|
|
39
|
Gardner TW: Histamine, ZO-1 and increased
blood-retinal barrier permeability in diabetic retinopathy. Trans
Am Ophthalmol Soc. 93:583–621. 1995.PubMed/NCBI
|
|
40
|
Blum A, Pastukh N, Socea D and Jabaly H:
Levels of adhesion molecules in peripheral blood correlat with
stages of diabetic retinopathy and may serve as bio markers for
microvascular complications. Cytokine. 106:76–79. 2018. View Article : Google Scholar
|
|
41
|
Uludag G, Hassan M, Matsumiya W, Pham BH,
Chea S, Trong Tuong Than N, Doan HL, Akhavanrezayat A, Halim MS, Do
DV and Nguyen QD: Efficacy and safety of intravitreal anti-VEGF
therapy in diabetic retinopathy: What we have learned and what
should we learn further? Expert Opin Biol Ther. 22:1275–1291. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Crewther SG, Murphy MJ and Crewther DP:
Potassium channel and NKCC cotransporter involvement in ocular
refractive control mechanisms. PLoS One. 3:e28392008. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Russell JM: Sodium-potassium-chloride
cotransport. Physiol Rev. 80:211–276. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Betts-Obregon BS, Vellanki S, Buikema J,
Tsin AT and Wright K: Effect of glucose on retinal endothelial cell
viability and VEGF secretion. HSOA J Cell Biol Cell Metabol.
3:0082016.PubMed/NCBI
|
|
45
|
Uemura A, Fruttiger M, D'amore PA, De
Falco S, Joussen AM, Sennlaub F, Brunck LR, Johnson KT, Lambrou GN,
Rittenhouse KD and Langmann T: VEGFR1 signaling in retinal
angiogenesis and microinflammation. Prog Retin Eye Res.
84:1009542021. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Tang L, Xu GT and Zhang JF: Inflammation
in diabetic retinopathy: Possible roles in pathogenesis and
potential implications for therapy. Neural Regen Res. 18:976–982.
2023. View Article : Google Scholar :
|
|
47
|
Panda SP, Reddy PH, Gorla US and Prasanth
D: Neuroinflammation and neovascularization in diabetic eye
diseases (DEDs): Identification of potential pharmacotherapeutic
targets. Mol Biol Rep. 50:1857–1869. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Guzel S, Cai CL, Aranda JV and Beharry KD:
Dose response of bumetanide on aquaporins and angiogenesis
biomarkers in human retinal endothelial cells exposed to
intermittent hypoxia. Pharmaceuticals (Basel). 14:9672021.
View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Yang S, Zhang J and Chen L: The cells
involved in the pathological process of diabetic retinopathy.
Biomed Pharmacother. 132:1108182020. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Rajendran S, Seetharaman S, Dharmarajan A
and Kuppan K: Microvascular cells: A special focus on heterogeneity
of pericytes in diabetes associated complications. Int J Biochem
Cell Biol. 134:1059712021. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Abu El-Asrar AM, De Hertogh G, Van Den
Eynde K, Alam K, Van Raemdonck K, Opdenakker G, Van Damme J, Geboes
K and Struyf S: Myofibroblasts in proliferative diabetic
retinopathy can originate from infiltrating fibrocytes and through
endothelial-to-mesenchymal transition (EndoMT). Exp Eye Res.
132:179–189. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Tuleta I and Frangogiannis NG: Diabetic
fibrosis. Biochim Biophys Acta Mol Basis Dis. 1867:1660442020.
View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Yao X, Zhao Z, Zhang W, Liu R, Ni T, Cui
B, Lei Y, Du J, Ai D, Jiang H, et al: Specialized retinal
endothelial cells modulate Blood-Retina barrier in diabetic
retinopathy. Diabetes. 73:225–236. 2024. View Article : Google Scholar
|
|
54
|
Yamato M, Kato N, Yamada KI and Inoguchi
T: The early pathogenesis of diabetic retinopathy and its
attenuation by sodium-glucose transporter 2 inhibitors. Diabetes.
73:1153–1166. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
O'Leary F and Campbell M: The blood-retina
barrier in health and disease. FEBS J. 290:878–891. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Maurissen TL, Spielmann AJ, Schellenberg
G, Bickle M, Vieira JR, Lai SY, Pavlou G, Fauser S, Westenskow PD,
Kamm RD and Ragelle H: Modeling early pathophysiological phenotypes
of diabetic retinopathy in a human inner blood-retinal
barrier-on-a-chip. Nat Commun. 15:13722024. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Wang N, Yao F, Xu W, Feng T, Li Z, Zhang
Q, Wang W, Zhang X, Lei W, Zheng G, et al: The transcription factor
Islet-1 regulates Diabetes-induced inner blood-retinal barrier
disruption. Invest Ophthalmol Vis Sci. 66:82025. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Kowluru RA, Zhong Q and Santos JM: Matrix
metalloproteinases in diabetic retinopathy: Potential role of
MMP-9. Expert Opin Investig Drugs. 21:797–805. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Qian HY, Wei XH and Huang JO: Inflammatory
mechanisms in diabetic retinopathy: Pathogenic roles and
therapeutic perspectives. Am J Transl Res. 17:6262–6274. 2025.
View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Joys S and Siddiqui K: Molecular and
pathophysiological mechanisms of diabetic retinopathy in relation
to adhesion molecules. Curr Diabetes Rev. 15:363–371. 2019.
View Article : Google Scholar
|
|
61
|
Yue T, Shi Y, Luo S, Weng J, Wu Y and
Zheng X: The role of inflammation in immune system of diabetic
retinopathy: Molecular mechanisms, pathogenetic role and
therapeutic implications. Front Immunol. 13:10550872022. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Xu Y, Hou H and Zhao L: The role of VCAM-1
in diabetic retinopathy: A systematic review and meta-analysis. J
Diabetes Complications. 37:1083802023. View Article : Google Scholar
|
|
63
|
Jerome JR, Deliyanti D, Suphapimol V,
Kolkhof P and Wilkinson-Berka JL: Finerenone, a Non-steroidal
mineralocorticoid receptor antagonist, reduces vascular injury and
increases regulatory T-Cells: Studies in rodents with diabetic and
neovascular retinopathy. Int J Mol Sci. 24:23342023. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Borgström P, Hughes GK, Hansell P,
Wolitsky BA and Sriramarao P: Leukocyte adhesion in angiogenic
blood vessels. Role of E-selectin, P-selectin, and beta2 integrin
in lymphotoxin-mediated leukocyte recruitment in tumor
microvessels. J Clin Invest. 99:2246–2253. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Kasza M, Meleg J, Vardai J, Nagy B, Szalai
E, Damjanovich J, Csutak A, Ujhelyi B and Nagy V: Plasma E-selectin
levels can play a role in the development of diabetic retinopathy.
Graefes Arch Clin Exp Ophthalmol. 255:25–30. 2017. View Article : Google Scholar
|
|
66
|
Penman A, Hoadley S, Wilson JG, Taylor HA,
Chen CJ and Sobrin L: P-selectin plasma levels and genetic variant
associated with diabetic retinopathy in african Americans. Am J
Ophthalmol. 159:1152–1160.e2. 2015. View Article : Google Scholar : PubMed/NCBI
|
