|
1
|
Nakamura K, Kageyama S, Kaldas FM, Hirao
H, Ito T, Kadono K, Dery KJ, Kojima H, Gjertson DW, Sosa RA, et al:
Hepatic CEACAM1 expression indicates donor liver quality and
prevents early transplantation injury. J Clin Invest.
130:2689–2704. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Hudcova J, Scopa C, Rashid J, Waqas A,
Ruthazer R and Schumann R: Effect of early allograft dysfunction on
outcomes following liver transplantation. Clin Transplant. Dec
22–2016.Epub ahead of print. PubMed/NCBI
|
|
3
|
Rampes S and Ma D: Hepatic
ischemia-reperfusion injury in liver transplant setting: Mechanisms
and protective strategies. J Biomed Res. 33:221–234. 2019.
View Article : Google Scholar :
|
|
4
|
Nakamura K, Kageyama S and
Kupiec-Weglinski JW: The evolving role of neutrophils in liver
transplant Ischemia-reperfusion injury. Curr Transplant Rep.
6:78–89. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Oliveira THC, Marques PE, Proost P and
Teixeira MMM: Neutrophils: A cornerstone of liver ischemia and
reperfusion injury. Lab Invest. 98:51–62. 2018. View Article : Google Scholar
|
|
6
|
McDonald B, Pittman K, Menezes GB, Hirota
SA, Slaba I, Waterhouse CC, Beck PL, Muruve DA and Kubes P:
Intravascular danger signals guide neutrophils to sites of sterile
inflammation. Science. 330:362–366. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Wang J, Hossain M, Thanabalasuriar A,
Gunzer M, Meininger C and Kubes P: Visualizing the function and
fate of neutrophils in sterile injury and repair. Science.
358:111–116. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Deng Y, Zhao Z, Sheldon M, Zhao Y, Teng H,
Martinez C, Zhang J, Lin C, Sun Y, Yao F, et al: LIFR regulates
cholesterol-driven bidirectional hepatocyte-neutrophil cross-talk
to promote liver regeneration. Nat Metab. 6:1756–1774. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Lin RZ, Lee CN, Moreno-Luna R, Neumeyer J,
Piekarski B, Zhou P, Moses MA, Sachdev M, Pu WT, Emani S, et al:
Host non-inflammatory neutrophils mediate the engraftment of
bioengineered vascular networks. Nat Biomed Eng. 1:00812017.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Marques PE, Amaral SS, Pires DA, Nogueira
LL, Soriani FM, Lima BH, Lopes GA, Russo RC, Avila TV, Melgaço JG,
et al: Chemokines and mitochondrial products activate neutrophils
to amplify organ injury during mouse acute liver failure.
Hepatology. 56:1971–1982. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Ma Y, Yabluchanskiy A, Iyer RP, Cannon PL,
Flynn ER, Jung M, Henry J, Cates CA, Deleon-Pennell KY and Lindsey
ML: Temporal neutrophil polarization following myocardial
infarction. Cardiovasc Res. 110:51–61. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Cai W, Liu S, Hu M, Huang F, Zhu Q, Qiu W,
Hu X, Colello J, Zheng SG and Lu Z: Functional dynamics of
neutrophils after ischemic stroke. Transl Stroke Res. 11:108–121.
2020. View Article : Google Scholar
|
|
13
|
Fan Y, Yang J, Xie Y, Yang X, Zhu H, Liu
Y, Xia Z, Ji S and Yang R: Inflammatory memory-activated biomimetic
nanovesicles regulate neutrophil plasticity and metabolic
reprogramming for rapid diabetic wound healing via targeting
miR-193a-5p/TLR4/JNK/P38 MAPK pathways. J Nanobiotechnology.
23:1152025. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Jiang Y, Wang N, Liu J, Ren H, Jiang W,
Lei Y, Fu X, Hao M, Lang X, Liu Y, et al: Intranasal delivery of
hMSC-derived supernatant for treatment of ischemic stroke by
inhibiting the pro-inflammatory polarization of neutrophils. Stem
Cell Res Ther. 16:432025. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Eltzschig HK and Eckle T: Ischemia and
reperfusion-from mechanism to translation. Nat Med. 17:1391–1401.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Zhai Y, Petrowsky H, Hong JC, Busuttil RW
and Kupiec-Weglinski JW: Ischaemia-reperfusion injury in liver
transplantation-from bench to bedside. Nat Rev Gastroenterol
Hepatol. 10:79–89. 2013. View Article : Google Scholar :
|
|
17
|
Feng S, Roll GR, Rouhani FJ and Sanchez
Fueyo A: The future of liver transplantation. Hepatology.
80:674–697. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Liu X, Cao H, Li J, Wang B, Zhang P, Dong
Zhang X, Liu Z, Yuan H and Zhan Z: Autophagy induced by DAMPs
facilitates the inflammation response in lungs undergoing
ischemia-reperfusion injury through promoting TRAF6 ubiquitination.
Cell Death Differ. 24:683–693. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Zhou J, Chen J, Wei Q, Saeb-Parsy K and Xu
X: The Role of Ischemia/reperfusion injury in early hepatic
allograft dysfunction. Liver Transpl. 26:1034–1048. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Teoh NC and Farrell GC: Hepatic ischemia
reperfusion injury: Pathogenic mechanisms and basis for
hepatoprotection. J Gastroenterol Hepatol. 18:891–902. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Gores GJ, Nieminen AL, Wray BE, Herman B
and Lemasters JJ: Intracellular pH during 'chemical hypoxia' in
cultured rat hepatocytes. Protection by intracellular acidosis
against the onset of cell death. J Clin Invest. 83:386–396. 1989.
View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Semenza GL: Cellular and molecular
dissection of reperfusion injury: ROS within and without. Circ Res.
86:117–118. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Fujii Y, Johnson ME and Gores GJ:
Mitochondrial dysfunction during anoxia/reoxygenation injury of
liver sinusoidal endothelial cells. Hepatology. 20:177–185.
1994.PubMed/NCBI
|
|
24
|
Nishimura Y, Romer LH and Lemasters JJ:
Mitochondrial dysfunction and cytoskeletal disruption during
chemical hypoxia to cultured rat hepatic sinusoidal endothelial
cells: The pH paradox and cytoprotection by glucose, acidotic pH,
and glycine. Hepatology. 27:1039–1049. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Kaltenmeier C, Yazdani HO, Handu S, Popp
B, Geller D and Tohme S: The role of neutrophils as a driver in
hepatic ischemia-reperfusion injury and cancer growth. Front
Immunol. 13:8875652022. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Kalogeris T, Baines CP, Krenz M and
Korthuis RJ: Cell biology of ischemia/reperfusion injury. Int Rev
Cell Mol Biol. 298:229–317. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Saleh H and El-Shorbagy HM: Chitosan
protects liver against ischemia-reperfusion injury via regulating
Bcl-2/Bax, TNF-α and TGF-β expression. Int J Biol Macromol.
164:1565–1574. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Bektas S, Karakaya K, Can M, Bahadir B,
Guven B, Erdogan N and Ozdamar SO: The effects of tadalafil and
pentoxifylline on apoptosis and nitric oxide synthase in liver
ischemia/reperfusion injury. Kaohsiung J Med Sci. 32:339–347. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Kageyama S, Nakamura K, Fujii T, Ke B,
Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW and
Kupiec-Weglinski JW: Recombinant relaxin protects liver transplants
from ischemia damage by hepatocyte glucocorticoid receptor: From
bench-to-bedside. Hepatology. 68:258–273. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Adams DH, Ju C, Ramaiah SK, Uetrecht J and
Jaeschke H: Mechanisms of immune-mediated liver injury. Toxicol
Sci. 115:307–321. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Okajima K, Harada N, Uchiba M and Mori M:
Neutrophil elastase contributes to the development of
ischemia-reperfusion-induced liver injury by decreasing endothelial
production of prostacyclin in rats. Am J Physiol Gastrointest Liver
Physiol. 287:G1116–G1123. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Kawai M, Harada N, Takeyama H and Okajima
K: Neutrophil elastase contributes to the development of
ischemia/reperfusion-induced liver injury by decreasing the
production of insulin-like growth factor-I in rats. Transl Res.
155:294–304. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Wang L, Li J, He S, Liu Y, Chen H, He S,
Yin M, Zou D, Chen S, Luo T, et al: Resolving the graft
ischemia-reperfusion injury during liver transplantation at the
single cell resolution. Cell Death Dis. 12:5892021. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Fahrner R, Trochsler M, Corazza N,
Graubardt N, Keogh A, Candinas D, Brunner T, Stroka D and Beldi G:
Tumor necrosis factor-related apoptosis-inducing ligand on NK cells
protects from hepatic ischemia-reperfusion injury. Transplantation.
97:1102–1109. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Zhai Y, Busuttil RW and Kupiec-Weglinski
JW: Liver ischemia and reperfusion injury: New insights into
mechanisms of innate-adaptive immune-mediated tissue inflammation.
Am J Transplant. 11:1563–1569. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Heo MJ, Suh JH, Poulsen KL, Ju C and Kim
KH: Updates on the immune cell basis of hepatic
ischemia-reperfusion injury. Mol Cells. 46:527–534. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Arrenberg P, Maricic I and Kumar V:
Sulfatide-mediated activation of type II natural killer T cells
prevents hepatic ischemic reperfusion injury in mice.
Gastroenterology. 140:646–655. 2011. View Article : Google Scholar
|
|
38
|
Yang SH, Lee JP, Jang HR, Cha RH, Han SS,
Jeon US, Kim DK, Song J, Lee DS and Kim YS: Sulfatide-reactive
natural killer T cells abrogate ischemia-reperfusion injury. J Am
Soc Nephrol. 22:1305–1314. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Huang HF, Zeng Z, Wang KH, Zhang HY, Wang
S, Zhou WX, Wang ZB, Xu WG and Duan J: Heme oxygenase-1 protects
rat liver against warm ischemia/reperfusion injury via
TLR2/TLR4-triggered signaling pathways. World J Gastroenterol.
21:2937–2948. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Huang H, Tohme S, Al-Khafaji AB, Tai S,
Loughran P, Chen L, Wang S, Kim J, Billiar T, Wang Y, et al:
Damage-associated molecular pattern-activated neutrophil
extracellular trap exacerbates sterile inflammatory liver injury.
Hepatology. 62:600–614. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Xiahou Z, Wang X, Shen J, Zhu X, Xu F, Hu
R, Guo D, Li H, Tian Y, Liu Y and Liang H: NMI and IFP35 serve as
proinflammatory DAMPs during cellular infection and injury. Nat
Commun. 8:9502017. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Chen R, Du J, Zhu H and Ling Q: The role
of cGAS-STING signalling in liver diseases. JHEP Rep. 3:1003242021.
View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Liu J, Zhou J, Luan Y, Li X, Meng X, Liao
W, Tang J and Wang Z: cGAS-STING, inflammasomes and pyroptosis: An
overview of crosstalk mechanism of activation and regulation. Cell
Commun Signal. 22:222024. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Chen R, Yang T, Jiang Z, Long Y, Qian B
and Fu W: Novel perspectives in hepatic ischemia-reperfusion
injury: The cGAS-STING pathway. J Inflamm Res. 18:16427–16448.
2025. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
de Carvalho Ribeiro M and Szabo G: Role of
the inflammasome in liver disease. Annu Rev Pathol. 17:345–365.
2022. View Article : Google Scholar
|
|
46
|
Nemeth N, Peto K, Magyar Z, Klarik Z,
Varga G, Oltean M, Mantas A, Czigany Z and Tolba RH:
Hemorheological and microcirculatory factors in liver
Ischemia-Reperfusion Injury-an update on pathophysiology, molecular
mechanisms and protective strategies. Int J Mol Sci. 22:18642021.
View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Vollmar B, Glasz J, Leiderer R, Post S and
Menger MD: Hepatic microcirculatory perfusion failure is a
determinant of liver dysfunction in warm ischemia-reperfusion. Am J
Pathol. 145:1421–1431. 1994.PubMed/NCBI
|
|
48
|
Vollmar B, Richter S and Menger MD:
Leukocyte stasis in hepatic sinusoids. Am J Physiol. 270:G798–G803.
1996.PubMed/NCBI
|
|
49
|
Zhang JX, Jones DV and Clemens MG: Effect
of activation on neutrophil-induced hepatic microvascular injury in
isolated rat liver. Shock. 1:273–278. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Yamanaka K, Houben P, Bruns H, Schultze D,
Hatano E and Schemmer P: A systematic review of pharmacological
treatment options used to reduce ischemia reperfusion injury in rat
liver transplantation. PLoS One. 10:e01222142014. View Article : Google Scholar
|
|
51
|
Dery KJ, Chiu R, Kasargod A and
Kupiec-Weglinski JW: Feedback loops shape oxidative and immune
interactions in hepatic Ischemia-reperfusion injury. Antioxidants
(Basel). 14:9442025. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Elsayed Abouzed DE, Bafail DA, Refaie SM,
Aboelez MO, Elsayed AA, Mallasiy LO, Bayoumy NMK and Hagar H:
Protective effect of valsartan alone and in combination with
neprilysin inhibitor (valsartan + sacubitril) against hepatic
ischemia-reperfusion injury: Targeting angiotensin II
receptor-neprilysin and modulating SMAD-4/NF-κβ/JNK pathways in
rats. Naunyn Schmiedebergs Arch Pharmacol. 398:8797–8811. 2025.
View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Schwabe RF and Brenner DA: Mechanisms of
liver injury. I. TNF-alpha-induced liver injury: Role of IKK, JNK,
and ROS pathways. Am J Physiol Gastrointest Liver Physiol.
290:G583–G589. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Oe S, Hiros T, Fujii H, Yasuchika K,
Nishio T, Iimuro Y, Morimoto T, Nagao M and Yamaoka Y: Continuous
intravenous infusion of deleted form of hepatocyte growth factor
attenuates hepatic ischemia-reperfusion injury in rats. J Hepatol.
34:832–839. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Csak T, Ganz M, Pespisa J, Kodys K,
Dolganiuc A and Szabo G: Fatty acid and endotoxin activate
inflammasomes in mouse hepatocytes that release danger signals to
stimulate immune cells. Hepatology. 54:133–144. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Teoh N, Field J and Farrell G:
Interleukin-6 is a key mediator of the hepatoprotective and
pro-proliferative effects of ischaemic preconditioning in mice. J
Hepatol. 45:20–27. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Tsurui Y, Sho M, Kuzumoto Y, Hamada K,
Akashi S, Kashizuka H, Ikeda N, Nomi T, Mizuno T, Kanehiro H and
Nakajima Y: Dual role of vascular endothelial growth factor in
hepatic ischemia-reperfusion injury. Transplantation. 79:1110–1115.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Xiao X, Liu D, Chen S, Li X, Ge M and
Huang W: Sevoflurane preconditioning activates HGF/Met-mediated
autophagy to attenuate hepatic ischemia-reperfusion injury in mice.
Cell Signal. 82:1099662021. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
McDonald B, Urrutia R, Yipp BG, Jenne CN
and Kubes P: Intravascular neutrophil extracellular traps capture
bacteria from the bloodstream during sepsis. Cell Host Microbe.
12:324–333. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Silvestre-Roig C, Fridlender ZG, Glogauer
M and Scapini P: Neutrophil diversity in health and disease. Trends
Immunol. 40:565–583. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Tsuda Y, Takahashi H, Kobayashi M,
Hanafusa T, Herndon DN and Suzuki F: Three different neutrophil
subsets exhibited in mice with different susceptibilities to
infection by methicillin-resistant Staphylococcus aureus. Immunity.
21:215–226. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
de Oliveira THC and Gonçalves GKN: Liver
ischemia reperfusion injury: Mechanisms, cellular pathways, and
therapeutic approaches. Int Immunopharmacol. 150:1142992025.
View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Nourshargh S, Renshaw SA and Imhof BA:
Reverse migration of neutrophils: Where, When, How, and Why? Trends
Immunol. 37:273–286. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Wilson GC, Kuboki S, Freeman CM, Nojima H,
Schuster RM, Edwards MJ and Lentsch AB: CXC chemokines function as
a rheostat for hepatocyte proliferation and liver regeneration.
PLoS One. 10:e01200922015. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Petri B and Sanz MJ: Neutrophil
chemotaxis. Cell Tissue Res. 371:425–436. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Kusakabe J, Hata K, Tamaki I, Tajima T,
Miyauchi H, Wang Y, Nigmet Y, Okamura Y, Kubota T, Tanaka H, et al:
Complement 5 inhibition ameliorates hepatic Ischemia/reperfusion
injury in mice, dominantly via the C5a-mediated cascade.
Transplantation. 104:2065–2077. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Zhang X, Hu J, Becker KV, Engle JW, Ni D,
Cai W, Wu D and Qu S: Antioxidant and C5a-blocking strategy for
hepatic ischemia-reperfusion injury repair. J Nanobiotechnology.
19:1072021. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Hilscher MB, Sehrawat T, Arab JP, Zeng Z,
Gao J, Liu M, Kostallari E, Gao Y, Simonetto DA, Yaqoob U, et al:
Mechanical stretch increases expression of CXCL1 in liver
sinusoidal endothelial cells to recruit neutrophils, generate
sinusoidal microthombi, and promote portal hypertension.
Gastroenterology. 157:193–209.e9. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Verkaar F, van Offenbeek J, van der Lee
MMC, van Lith LHCJ, Watts AO, Rops ALWMM, Aguilar DC, Ziarek JJ,
van der Vlag J, Handel TM, et al: Chemokine cooperativity is caused
by competitive glycosaminoglycan binding. J Immunol. 192:3908–3914.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Rajarathnam K and Desai UR: Structural
insights into how proteoglycans determine chemokine-CXCR1/CXCR2
interactions: Progress and challenges. Front Immunol. 11:6602020.
View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Sepuru KM and Rajarathnam K: Structural
basis of chemokine interactions with heparan sulfate, chondroitin
sulfate, and dermatan sulfate. J Biol Chem. 294:15650–15661. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Bao X, Moseman EA, Saito H, Petryniak B,
Thiriot A, Hatakeyama S, Ito Y, Kawashima H, Yamaguchi Y, Lowe JB,
et al: Endothelial heparan sulfate controls chemokine presentation
in recruitment of lymphocytes and dendritic cells to lymph nodes.
Immunity. 33:817–829. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Vanheule V, Janssens R, Boff D, Kitic N,
Berghmans N, Ronsse I, Kungl AJ, Amaral FA, Teixeira MM, Van Damme
J, et al: The positively charged COOH-terminal
Glycosaminoglycan-binding CXCL9(74-103) peptide inhibits
CXCL8-induced neutrophil extravasation and monosodium Urate
Crystal-induced gout in mice. J Biol Chem. 290:21292–21304. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Song J, He Z, Yang M, Yu T, Wang X, Liu B
and Li J: HepaticIschemia/Reperfusion Injuryinvolves functional
tryptase/PAR-2 signaling in liver sinusoidal endothelial cell
population. Int Immunopharmacol. 100:1080522021. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Rossaint J and Zarbock A: Tissue-specific
neutrophil recruitment into the lung, liver, and kidney. J Innate
Immun. 5:348–357. 2013. View Article : Google Scholar
|
|
76
|
Wang Y and Liu Y: Neutrophil-induced liver
injury and interactions between neutrophils and liver sinusoidal
endothelial cells. Inflammation. 44:1246–1262. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Wong J, Johnston B, Lee SS, Bullard DC,
Smith CW, Beaudet AL and Kubes P: A minimal role for selectins in
the recruitment of leukocytes into the inflamed liver
microvasculature. J Clin Invest. 99:2782–2790. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Khan AI, Kerfoot SM, Heit B, Liu L,
Andonegui G, Ruffell B, Johnson P and Kubes P: Role of CD44 and
hyaluronan in neutrophil recruitment. J Immunol. 173:7594–7601.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
McDonald B, Jenne CN, Zhuo L, Kimata K and
Kubes P: Kupffer cells and activation of endothelial TLR4
coordinate neutrophil adhesion within liver sinusoids during
endotoxemia. Am J Physiol Gastrointest Liver Physiol.
305:G797–G806. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Benedicto A, Herrero A, Romayor I, Marquez
J, Smedsrød B, Olaso E and Arteta B: Liver sinusoidal endothelial
cell ICAM-1 mediated tumor/endothelial crosstalk drives the
development of liver metastasis by initiating inflammatory and
angiogenic responses. Sci Rep. 9:131112019. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Woodfin A, Voisin MB, Beyrau M, Colom B,
Caille D, Diapouli FM, Nash GB, Chavakis T, Albelda SM, Rainger GE,
et al: The junctional adhesion molecule JAM-C regulates polarized
transendothelial migration of neutrophils in vivo. Nat Immunol.
12:761–769. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Ley K, Laudanna C, Cybulsky MI and
Nourshargh S: Getting to the site of inflammation: The leukocyte
adhesion cascade updated. Nat Rev Immunol. 7:678–689. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Zhang P, Yue K, Liu X, Yan X, Yang Z, Duan
J, Xia C, Xu X, Zhang M, Liang L, et al: Endothelial Notch
activation promotes neutrophil transmigration via downregulating
endomucin to aggravate hepatic ischemia/reperfusion injury. Sci
China Life Sci. 63:375–387. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Yazdani HO, Chen HW, Tohme S, Tai S, van
der Windt DJ, Loughran P, Rosborough BR, Sud V, Beer-Stolz D,
Turnquist HR, et al: IL-33 exacerbates liver sterile inflammation
by amplifying neutrophil extracellular trap formation. J Hepatol.
Sep 21–2017.Epub ahead of print. PubMed/NCBI
|
|
85
|
Kato H, Duarte S, Liu D, Busuttil RW and
Coito AJ: Matrix Metalloproteinase-2 (MMP-2) gene deletion enhances
MMP-9 activity, impairs PARP-1 degradation, and exacerbates hepatic
ischemia and reperfusion injury in mice. PLoS One. 10:e01376422015.
View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Duarte S, Matian P, Ma S, Busuttil RW and
Coito AJ: Adeno-associated Virus-mediated gene transfer of tissue
inhibitor of Metalloproteinases-1 impairs neutrophil extracellular
trap formation and ameliorates hepatic ischemia and reperfusion
injury. Am J Pathol. 188:1820–1832. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Tharp WG, Yadav R, Irimia D, Upadhyaya A,
Samadani A, Hurtado O, Liu SY, Munisamy S, Brainard DM, Mahon MJ,
et al: Neutrophil chemorepulsion in defined interleukin-8 gradients
in vitro and in vivo. J Leukoc Biol. 79:539–554. 2006. View Article : Google Scholar
|
|
88
|
Buckley CD, Ross EA, McGettrick HM,
Osborne CE, Haworth O, Schmutz C, Stone PC, Salmon M, Matharu NM,
Vohra RK, et al: Identification of a phenotypically and
functionally distinct population of long-lived neutrophils in a
model of reverse endothelial migration. J Leukoc Biol. 79:303–311.
2006. View Article : Google Scholar
|
|
89
|
Colom B, Bodkin JV, Beyrau M, Woodfin A,
Ody C, Rourke C, Chavakis T, Brohi K, Imhof BA and Nourshargh S:
Leukotriene B4-Neutrophil elastase axis drives neutrophil reverse
transendothelial cell migration in vivo. Immunity. 42:1075–1086.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Burn T and Alvarez JI: Reverse
transendothelial cell migration in inflammation: To help or to
hinder? Cell Mol Life Sci. 74:1871–1881. 2017. View Article : Google Scholar
|
|
91
|
de Oliveira S, Rosowski EE and
Huttenlocher A: Neutrophil migration in infection and wound repair:
Going forward in reverse. Nat Rev Immunol. 16:378–391. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Brinkmann V and Zychlinsky A: Neutrophil
extracellular traps: Is immunity the second function of chromatin?
J Cell Biol. 198:773–783. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
von Meijenfeldt FA, Stravitz RT, Zhang J,
Adelmeijer J, Zen Y, Durkalski V, Lee WM and Lisman TJ: Generation
of neutrophil extracellular traps in patients with acute liver
failure is associated with poor outcome. Hepatology. 75:623–633.
2022. View Article : Google Scholar :
|
|
94
|
Middleton EA, He XY, Denorme F, Campbell
RA, Ng D, Salvatore SP, Mostyka M, Baxter-Stoltzfus A, Borczuk AC,
Loda M, et al: Neutrophil extracellular traps contribute to
immunothrombosis in COVID-19 acute respiratory distress syndrome.
Blood. 136:1169–1179. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Shapouri-Moghaddam A, Mohammadian S,
Vazini H, Taghadosi M, Esmaeili SA, Mardani F, Seifi B, Mohammadi
A, Afshari JT and Sahebkar A: Macrophage plasticity, polarization,
and function in health and disease. J Cell Physiol. 233:6425–6440.
2018. View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Shaul ME, Levy L, Sun J, Mishalian I,
Singhal S, Kapoor V, Horng W, Fridlender G, Albelda SM and
Fridlender ZG: Tumor-associated neutrophils display a distinct N1
profile following TGFβ modulation: A transcriptomics analysis of
pro-vs. antitumor TANs. Oncoimmunology. 5:e12322212016. View Article : Google Scholar
|
|
97
|
Zou JM, Qin J, Li YC, Wang Y, Li D, Shu Y,
Luo C, Wang SS, Chi G, Guo F, et al: IL-35 induces N2 phenotype of
neutrophils to promote tumor growth. Oncotarget. 8:33501–33514.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Mihaila AC, Ciortan L, Macarie RD, Vadana
M, Cecoltan S, Preda MB, Hudita A, Gan AM, Jakobsson G, Tucureanu
MM, et al: Transcriptional profiling and functional analysis of
N1/N2 neutrophils reveal an immunomodulatory effect of
S100A9-blockade on the pro-inflammatory N1 subpopulation. Front
Immunol. 12:7087702021. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
García-Culebras A, Durán-Laforet V,
Peña-Martínez C, Moraga A, Ballesteros I, Cuartero MI, de la Parra
J, Palma-Tortosa S, Hidalgo A, Corbí AL, et al: Role of TLR4
(Toll-Like Receptor 4) in N1/N2 neutrophil programming after
stroke. Stroke. 50:2922–2932. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Giese MA, Hind LE and Huttenlocher A:
Neutrophil plasticity in the tumor microenvironment. Blood.
133:2159–2167. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Cuartero MI, Ballesteros I, Moraga A,
Nombela F, Vivancos J, Hamilton JA, Corbí ÁL, Lizasoain I and Moro
MA: N2 neutrophils, novel players in brain inflammation after
stroke: Modulation by the PPARγ agonist rosiglitazone. Stroke.
44:3498–3508. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Napoli M, Sitaru S, Budke A, Kammerl A,
Querner G, Immler R, Rohwedder I, Seifert S, Ferraro B, Weckbach L,
et al: The dual non-competitive CXCR1/2 inhibitor ladarixin impairs
neutrophil extravasation without altering intravascular adhesion.
Haematologica. Aug 28–2025.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Chapman RW, Phillips JE, Hipkin RW, Curran
AK, Lundell D and Fine JS: CXCR2 antagonists for the treatment of
pulmonary disease. Pharmacol Ther. 121:55–68. 2009. View Article : Google Scholar
|
|
104
|
Rennard SI, Dale DC, Donohue JF, Kanniess
F, Magnussen H, Sutherland ER, Watz H, Lu S, Stryszak P, Rosenberg
E and Staudinger H: CXCR2 antagonist MK-7123. A phase 2
Proof-of-Concept trial for chronic obstructive pulmonary disease.
Am J Respir Crit Care Med. 191:1001–1011. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Madan A, Chen S, Yates P, Washburn ML,
Roberts G, Peat AJ, Tao Y, Parry MF, Barnum O, McClain MT, et al:
Efficacy and safety of danirixin (GSK1325756) Co-administered with
Standard-of-Care antiviral (Oseltamivir): A Phase 2b, global,
randomized study of adults hospitalized with influenza. Open Forum
Infect Dis. 6:ofz1632019. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Howard JF Jr, Utsugisawa K, Benatar M,
Murai H, Barohn RJ, Illa I, Jacob S, Vissing J, Burns TM, Kissel
JT, et al: Safety and efficacy of eculizumab in anti-acetylcholine
receptor antibody-positive refractory generalised myasthenia gravis
(REGAIN): A phase 3, randomised, double-blind, placebo-controlled,
multi-centre study. Lancet Neurol. 16:976–986. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
107
|
Mastellos DC, Ricklin D and Lambris JD:
Clinical promise of next-generation complement therapeutics. Nat
Rev Drug Discov. 18:707–729. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Melgaço JG, Veloso CE, Pacheco-Moreira LF,
Vitral CL and Pinto MA: Complement system as a target for therapies
to control liver Regeneration/damage in acute liver failure induced
by viral hepatitis. J Immunol Res. 2018:39170322018. View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Di Bona D, Montalto G, Clemenza L, Bascone
F, Accardo P, Bellavia D, Craxì A and Brai M: Soluble complement
receptor type 1 (sCR1) in chronic liver diseases: Serum levels at
different stages of liver diseases. Clin Exp Immunol. 114:102–105.
1998. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Stahl GL, Shernan SK, Smith PK and Levy
JH: Complement activation and cardiac surgery: A novel target for
improving outcomes. Anesth Analg. 115:759–771. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Preissler G, Eichhorn M, Waldner H, Winter
H, Kleespies A and Massberg S: Intercellular adhesion molecule-1
blockade attenuates inflammatory response and improves
microvascular perfusion in rat pancreas grafts. Pancreas.
41:1112–1118. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Sakai S, Tajima H, Miyashita T, Nakanuma
S, Makino I, Hayashi H, Nakagawara H, Kitagawa H, Fushida S,
Fujimura T, et al: Sivelestat sodium hydrate inhibits neutrophil
migration to the vessel wall and suppresses hepatic
ischemia-reperfusion injury. Dig Dis Sci. 59:787–794. 2014.
View Article : Google Scholar
|
|
113
|
Xia F, Xiang S, Qiu Y, Lou H, Wang S, Liu
Y, Yu F and Li S: Macrophage Membrane-camouflaged nanozymes for
combating the oxidative Stress-microvascular perfusion negative
feedback in Ischemia-reperfusion induced acute kidney injury. Adv
Healthc Mater. 14:e24050902025. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Luan H, Wang C, Sun J, Zhao L, Li L, Zhou
B, Shao S, Shen X and Xu Y: Resolvin D1 protects against
Ischemia/Reperfusion-Induced acute kidney injury by increasing treg
percentages via the ALX/FPR2 pathway. Front Physiol. 11:2852020.
View Article : Google Scholar : PubMed/NCBI
|
|
115
|
Oda H, Tanaka S, Shinohara M, Morimura Y,
Yokoyama Y, Kayawake H, Yamada Y, Yutaka Y, Ohsumi A, Nakajima D,
et al: Specialized proresolving lipid meditators agonistic to
formyl peptide receptor type 2 attenuate Ischemia-reperfusion
injury in rat lung. Transplantation. 106:1159–1169. 2022.
View Article : Google Scholar
|
|
116
|
Kollareth DJM, Leroy V, Tu Z,
Woolet-Stockton MJ, Kamat M, Garrett TJ, Atkinson C, Cai G,
Upchurch GR Jr, Sharma AK, et al: Lipoxin A4/FPR2 signaling
mitigates ferroptosis of alveolar epithelial cells via
NRF2-Dependent pathway during lung Ischemia-reperfusion injury.
FASEB J. 39:e705452025. View Article : Google Scholar
|
|
117
|
Sener G, Tosun O, Sehirli AO, Kaçmaz A,
Arbak S, Ersoy Y and Ayanoğlu-Dülger G: Melatonin and
N-acetylcysteine have beneficial effects during hepatic ischemia
and reperfusion. Life Sci. 72:2707–2718. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
118
|
Tohme S, Yazdani HO, Sud V, Loughran P,
Huang H, Zamora R, Simmons RL, Vodovotz Y and Tsung A:
Computational analysis supports IL-17A as a central driver of
neutrophil extracellular Trap-mediated injury in liver ischemia
reperfusion. J Immunol. 202:268–277. 2019. View Article : Google Scholar
|
|
119
|
Li L, Huang L, Vergis AL, Ye H, Bajwa A,
Narayan V, Strieter RM, Rosin DL and Okusa MD: IL-17 produced by
neutrophils regulates IFN-gamma-mediated neutrophil migration in
mouse kidney ischemia-reperfusion injury. J Clin Invest.
120:331–342. 2010. View Article : Google Scholar :
|
|
120
|
Lin AM, Rubin CJ, Khandpur R, Wang JY,
Riblett M, Yalavarthi S, Villanueva EC, Shah P, Kaplan MJ and Bruce
AT: Mast cells and neutrophils release IL-17 through extracellular
trap formation in psoriasis. J Immunol. 187:490–500. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Yazdani HO, Roy E, Comerci AJ, van der
Windt DJ, Zhang H, Huang H, Loughran P, Shiva S, Geller DA,
Bartlett DL, et al: Neutrophil extracellular traps drive
mitochondrial homeostasis in tumors to augment growth. Cancer Res.
79:5626–5639. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
122
|
Yang K, Gao R, Chen H, Hu J, Zhang P, Wei
X, Shi J, Chen Y, Zhang L, Chen J, et al: Myocardial reperfusion
injury exacerbation due to ALDH2 deficiency is mediated by
neutrophil extracellular traps and prevented by leukotriene C4
inhibition. Eur Heart J. 45:1662–1680. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
123
|
Arumugam S, Girish Subbiah K, Kemparaju K
and Thirunavukkarasu C: Neutrophil extracellular traps in acrolein
promoted hepatic ischemia reperfusion injury: Therapeutic potential
of NOX2 and p38MAPK inhibitors. J Cell Physiol. 233:3244–3261.
2018. View Article : Google Scholar
|
|
124
|
Belvončíková P, Feješ A, Gromová B,
Janovičová Ľ, Farkašová A, Babál P and Gardlík R: Therapeutic
effects of DNase I on peripheral and local markers of liver injury
and neutrophil extracellular traps in a model of Alcohol-related
liver disease. Int J Mol Sci. 26:18932025. View Article : Google Scholar
|
|
125
|
Zeng FL, Zhang Y, Wang ZH, Zhang H, Meng
XT, Wu YQ, Qian ZZ, Ding YH, Li J, Ma TT and Huang C: Neutrophil
extracellular traps promote acetaminophen-induced acute liver
injury in mice via AIM2. Acta Pharmacol Sin. 45:1660–1672. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
126
|
Liu T, Lv X, Xu Q, Qi X, Qiu S, Luan Y,
Shen N, Cheng J, Jin L, Tian T, et al: Stroke-homing Peptide-DNase1
alleviates intestinal ischemia reperfusion injury by selectively
degrading neutrophil extracellular traps. Cell Prolif.
58:e700102025. View Article : Google Scholar : PubMed/NCBI
|
|
127
|
George J, Lu Y, Tsuchishima M and Tsutsumi
M: Cellular and molecular mechanisms of hepatic
ischemia-reperfusion injury: The role of oxidative stress and
therapeutic approaches. Redox Biol. 75:1032582024. View Article : Google Scholar : PubMed/NCBI
|
|
128
|
Rhee JE, Jung SE, Shin SD, Suh GJ, Noh DY,
Youn YK, Oh SK and Choe KJ: The effects of antioxidants and nitric
oxide modulators on hepatic ischemic-reperfusion injury in rats. J
Korean Med Sci. 17:502–506. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
129
|
Loeschner K, Hadrup N, Hansen M, Pereira
SA, Gammelgaard B, Møller LH, Mortensen A, Lam HR and Larsen EH:
Absorption, distribution, metabolism and excretion of selenium
following oral administration of elemental selenium nanoparticles
or selenite in rats. Metallomics. 6:330–337. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
130
|
Huang B, Zhang J, Hou J and Chen C: Free
radical scavenging efficiency of Nano-Se in vitro. Free Radic Biol
Med. 35:805–813. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
131
|
Deng X, Ouyang P, Xu W, Yang E, Bao Z, Wu
Y, Gong J and Pan J: Research progress of nano selenium in the
treatment of oxidative stress injury during hepatic
ischemia-reperfusion injury. Front Pharmacol. 13:11034832022.
View Article : Google Scholar
|
|
132
|
Mohamed RA, Ghoneim ME, Tawfiq RA and El
Sayed NF: Amygdalin synergizes with the TNF-α monoclonal antibody
infliximab to modulate HSP90 and related
necro-inflammatory/oxidative stress pathways in a rat model of
hepatic I/R. Naunyn Schmiedebergs Arch Pharmacol. Dec 17–2025.Epub
ahead of print. View Article : Google Scholar
|
|
133
|
Chaabani R, Bejaoui M, Ben Jeddou I,
Zaouali MA, Haouas Z, Belgacem S, Peralta C and Ben Abdennebi H:
Effect of the Non-steroidal Anti-inflammatory drug diclofenac on
Ischemia-reperfusion injury in rat liver: A Nitric Oxide-dependent
mechanism. Inflammation. 46:1221–1235. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
134
|
Montalvo-Javé EE, Ortega-Salgado JA,
Castell A, Carrasco-Daza D, Jay D, Gleason R, Muñoz E,
Montalvo-Arenas C, Hernández-Muñoz R and Piña E: Piroxicam and
meloxicam ameliorate hepatic oxidative stress and protein
carbonylation in Kupffer and sinusoidal endothelial cells promoted
by ischemia-reperfusion injury. Transpl Int. 24:489–500. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
135
|
Huang Y, Xu Q, Zhang J, Yin Y, Pan Y,
Zheng Y, Cai X, Xia Q and He K: Prussian blue scavenger ameliorates
hepatic ischemia-reperfusion injury by inhibiting inflammation and
reducing oxidative stress. Front Immunol. 13:8913512022. View Article : Google Scholar : PubMed/NCBI
|
|
136
|
Shen P, Huang K, Zhang X, Qin M, Wang X
and Fan Z: Neutrophil-Mimicking Prussian blue nanozymes for
synergistic targeted immuno-metabolic therapy of hepatic
ischemia-reperfusion injury. J Nanobiotechnology. 23:7362025.
View Article : Google Scholar : PubMed/NCBI
|
|
137
|
Zhang Y, Wu D, Zhou C, Bai M, Wan Y, Zheng
Q, Fan Z, Wang X and Yang C: Engineered extracellular vesicles for
tissue repair and regeneration. Burns Trauma. 12:tkae0622024.
View Article : Google Scholar : PubMed/NCBI
|
|
138
|
Thomas BL, Montero-Melendez T, Oggero S,
Kaneva MK, Chambers D, Pinto AL, Nerviani A, Lucchesi D,
Austin-Williams S, Hussain MT, et al: Molecular determinants of
neutrophil extracellular vesicles that drive cartilage regeneration
in inflammatory arthritis. Arthritis Rheumatol. 76:1705–1718. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
139
|
Huang Z, Wang H, Long J, Lu Z, Chun C and
Li X: Neutrophil membrane-coated therapeutic liposomes for targeted
treatment in acute lung injury. Int J Pharm. 624:1219712022.
View Article : Google Scholar : PubMed/NCBI
|
|
140
|
Yuan HX, Ye YY, Shen P, Zhang J, Meng QF,
Chen Y, Xu X, Zhang XL, Rao L, Fan ZJ, et al: Engineering
neutrophil vesicles for synergistic protection against
Ischemia/Reperfusion injury after lung transplant. Adv Sci (Weinh).
12:e061272025. View Article : Google Scholar : PubMed/NCBI
|
|
141
|
Lu T, Zhang J, Cai J, Xiao J, Sui X, Yuan
X, Li R, Li Y, Yao J, Lv G, et al: Extracellular vesicles derived
from mesenchymal stromal cells as nanotherapeutics for liver
ischaemia-reperfusion injury by transferring mitochondria to
modulate the formation of neutrophil extracellular traps.
Biomaterials. 284:1214862022. View Article : Google Scholar : PubMed/NCBI
|
|
142
|
Mantovani A, Cassatella MA, Costantini C
and Jaillon S: Neutrophils in the activation and regulation of
innate and adaptive immunity. Nat Rev Immunol. 11:519–531. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
143
|
Conigliaro P, Triggianese P, Ballanti E,
Perricone C, Perricone R and Chimenti MS: Complement, infection,
and autoimmunity. Curr Opin Rheumatol. 31:532–541. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
144
|
Geller A and Yan J: The role of membrane
bound complement regulatory proteins in tumor development and
cancer immunotherapy. Front Immunol. 10:10742019. View Article : Google Scholar : PubMed/NCBI
|
