[Expression of Concern] DTX3L is upregulated in glioma and is associated with glioma progression

Xu,Peng; Tao,Xuelei; Zhao,Chengjin; Huang,Qingfeng; Chang,Hao; Ban,Na; Bei,Yuanqi; Xia,Xiaojie; Shen,Chaoyan; Wang,Kun; Xu,Li; Wu,Peizhang; Ren,Jianbing; Wang,Donglin

doi:10.3892/ijmm.2026.5816

June-2026 Volume 57 Issue 6

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June-2026 Volume 57 Issue 6

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Expression of Concern Open Access

[Expression of Concern] DTX3L is upregulated in glioma and is associated with glioma progression

Authors:
- Peng Xu
- Xuelei Tao
- Chengjin Zhao
- Qingfeng Huang
- Hao Chang
- Na Ban
- Yuanqi Bei
- Xiaojie Xia
- Chaoyan Shen
- Kun Wang
- Li Xu
- Peizhang Wu
- Jianbing Ren
- Donglin Wang
View Affiliations / Copyright

Affiliations: Department of Pathology, Nantong University, Nantong, Jiangsu 226001, P.R. China, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Targets, Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Neurosurgery, The Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Neurosurgery, The Second People's Hospital of Nantong; 4Department of Neurosurgery, The Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China

Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 145
|
Published online on: March 30, 2026

https://doi.org/10.3892/ijmm.2026.5816
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Abstract

Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that, regarding the paraffin‑embedded glioma tissue sections shown in Fig. 2A on p. 494, the Ki‑67/Grade III and DTX3L/Grade IV data panels contained an overlapping section, suggesting that these data panels were derived from the same original source where different experimental groups were reported. In addition, GAPDH control western blots featured in Figs. 1C and 4E were found to be strikingly similar, even though the experimental conditions reported for these figure parts were different. The authors have been contacted by the Editorial Office to offer an explanation for these apparent anomalies in the presentation of the data in their paper, and we are awaiting their response. Due to the fact that we have been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of these potential problems while the Editorial Office continues to investigate this matter further. [International Journal of Molecular Medicine 40: 491‑498, 2017; DOI: 10.3892/ijmm.2017.3023]

Int J Mol Med 40: [Related article:] 491-498, 2017; DOI: 10.3892/ijmm.2017.3023

Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that, regarding the paraffin-embedded glioma tissue sections shown in Fig. 2A on p. 494, the Ki-67/Grade III and DTX3L/Grade IV data panels contained an overlapping section, suggesting that these data panels were derived from the same original source where different experimental groups were reported. In addition, GAPDH control western blots featured in Figs. 1C and 4E were found to be strikingly similar, even though the experimental conditions reported for these figure parts were different.

The authors have been contacted by the Editorial Office to offer an explanation for these apparent anomalies in the presentation of the data in their paper, and we are awaiting their response. Due to the fact that we have been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of these potential problems while the Editorial Office continues to investigate this matter further.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

[Expression of Concern] DTX3L is upregulated in glioma and is associated with glioma progression

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Abstract

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