|
1
|
Rudd KE, Johnson SC, Agesa KM, Shackelford
KA, Tsoi D, Kievlan DR, Colombara DV, Ikuta KS, Kissoon N, Finfer
S, et al: Global, regional, and national sepsis incidence and
mortality, 1990-2017: Analysis for the Global Burden of Disease
Study. Lancet. 395:200–211. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Deutschman CS and Tracey KJ: Sepsis:
Current dogma and new perspectives. Immunity. 40:463–475. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Willmann K and Moita LF: Physiologic
disruption and metabolic reprogramming in infection and sepsis.
Cell Metab. 36:927–946. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
GBD 2021 Global Sepsis Collaborators:
Global, regional, and national sepsis incidence and mortality,
1990-2021: A systematic analysis. Lancet Glob Health.
13:e2013–e2026. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Alhazzani W, Møller MH, Arabi YM, Loeb M,
Gong MN, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A, et al:
Surviving sepsis campaign: Guidelines on the management of
critically ill adults with coronavirus disease 2019 (COVID-19).
Intensive Care Med. 46:854–887. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Crunkhorn S: New route to sepsis therapy.
Nat Rev Drug Discov. 18:251. 2019.
|
|
7
|
Weis S, Carlos AR, Moita MR, Singh S,
Blankenhaus B, Cardoso S, Larsen R, Rebelo S, Schäuble S, Del
Barrio L, et al: Metabolic adaptation establishes disease tolerance
to sepsis. Cell. 169:1263–1275.e14. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Wiersinga WJ, Leopold SJ, Cranendonk DR
and van der Poll T: Host innate immune responses to sepsis.
Virulence. 5:36–44. 2014. View Article : Google Scholar :
|
|
9
|
Darden DB, Kelly LS, Fenner BP, Moldawer
LL, Mohr AM and Efron PA: Dysregulated Immunity and Immunotherapy
after Sepsis. J Clin Med. 10:17422021. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Chen XS, Liu YC, Gao YL, Shou ST and Chai
YF: The roles of macrophage polarization in the host immune
response to sepsis. Int Immunopharmacol. 96:1077912021. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Chinetti-Gbaguidi G and Staels B:
Macrophage polarization in metabolic disorders: Functions and
regulation. Curr Opin Lipidol. 22:365–372. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Dominski A, Krawczyk M, Konieczny T,
Kasprów M, Foryś A, Pastuch-Gawołek G and Kurcok P: Biodegradable
pH-responsive micelles loaded with 8-hydroxyquinoline
glycoconjugates for Warburg effect based tumor targeting. Eur J
Pharm Biopharm. 154:317–329. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
O'Neill LA, Kishton RJ and Rathmell J: A
guide to immunometabolism for immunologists. Nat Rev Immunol.
16:553–565. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Jha AK, Huang SC, Sergushichev A,
Lampropoulou V, Ivanova Y, Loginicheva E, Chmielewski K, Stewart
KM, Ashall J, Everts B, et al: Network integration of parallel
metabolic and transcriptional data reveals metabolic modules that
regulate macrophage polarization. Immunity. 42:419–430. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Arts RJ, Gresnigt MS, Joosten LA and Netea
MG: Cellular metabolism of myeloid cells in sepsis. J Leukoc Biol.
101:151–164. 2017. View Article : Google Scholar
|
|
16
|
Saxton RA and Sabatini DM: mTOR signaling
in growth, metabolism, and disease. Cell. 169:361–371. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Hotchkiss RS, Monneret G and Payen D:
Sepsis-induced immunosuppression: From cellular dysfunctions to
immunotherapy. Nat Rev Immunol. 13:862–874. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
King EG, Bauzá GJ, Mella JR and Remick DG:
Pathophysiologic mechanisms in septic shock. Lab Invest. 94:4–12.
2014. View Article : Google Scholar
|
|
19
|
Dang B, Gao Q, Zhang L, Zhang J, Cai H,
Zhu Y, Zhong Q, Liu J, Niu Y, Mao K, et al: The glycolysis/HIF-1α
axis defines the inflammatory role of IL-4-primed macrophages. Cell
Rep. 42:1124712023. View Article : Google Scholar
|
|
20
|
Giamarellos-Bourboulis EJ, Kotsaki A,
Kotsamidi I, Efthymiou A, Koutsoukou V, Ehler J, Paridou A,
Frantzeskaki F, Müller MCA, Pickkers P, et al: Precision
immunotherapy to improve sepsis outcomes: The ImmunoSep randomized
clinical trial. JAMA. 335:775–786. 2026. View Article : Google Scholar
|
|
21
|
Chen XS, Wang SH, Liu CY, Gao YL, Meng XL,
Wei W, Shou ST, Liu YC and Chai YF: Losartan attenuates
sepsis-induced cardiomyopathy by regulating macrophage polarization
via TLR4-mediated NF-κB and MAPK signaling. Pharmacol Res.
185:1064732022. View Article : Google Scholar
|
|
22
|
Jaitin DA, Adlung L, Thaiss CA, Weiner A,
Li B, Descamps H, Lundgren P, Bleriot C, Liu Z, Deczkowska A, et
al: Lipid-associated macrophages control metabolic homeostasis in a
Trem2-dependent manner. Cell. 178:686–698.e14. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Hou J, Zhang J, Cui P, Zhou Y, Liu C, Wu
X, Ji Y, Wang S, Cheng B, Ye H, et al: TREM2 sustains
macrophage-hepatocyte metabolic coordination in nonalcoholic fatty
liver disease and sepsis. J Clin Invest. 131:e1351972021.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Zhang K, Wang Y, Chen S, Mao J, Jin Y, Ye
H, Zhang Y, Liu X, Gong C, Cheng X, et al: TREM2hi resident
macrophages protect the septic heart by maintaining cardiomyocyte
homeostasis. Nat Metab. 5:129–146. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Ming S, Li X, Xiao Q, Qu S, Wang Q, Fang
Q, Liang P, Xu Y, Yang J, Yang Y, et al: TREM2 aggravates sepsis by
inhibiting fatty acid oxidation via the SHP1/BTK axis. J Clin
Invest. 135:e1594002024. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Liu X, Zhang J, Zeigler AC, Nelson AR,
Lindsey ML and Saucerman JJ: Network analysis reveals a distinct
axis of macrophage activation in response to conflicting
inflammatory cues. J Immunol. 206:883–891. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Murray PJ, Allen JE, Biswas SK, Fisher EA,
Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence
T, et al: Macrophage activation and polarization: Nomenclature and
experimental guidelines. Immunity. 41:14–20. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Ye Q, Lai X, Liu Y, Zhang Z, Fu Y, Luo J,
Liu C, Duan J, Ding H, Liu Y, et al: Single-cell multi-omic
landscape reveals anatomical-specific immune features in adult and
pediatric sepsis. Nat Immunol. 27:150–165. 2026. View Article : Google Scholar
|
|
29
|
Murao A, Jha A, Aziz M and Wang P:
Transcriptomic profiling of immune cells in murine polymicrobial
sepsis. Front Immunol. 15:13474532024. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Mo Q, Mo Q and Mo F: Single-cell RNA
sequencing and transcriptomic analysis reveal key genes and
regulatory mechanisms in sepsis. Biotechnol Genet Eng Rev.
40:1636–1658. 2024. View Article : Google Scholar
|
|
31
|
Viola A, Munari F, Sánchez-Rodríguez R,
Scolaro T and Castegna A: The metabolic signature of macrophage
responses. Front Immunol. 10:14622019. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Alves-Filho JC and Pålsson-McDermott EM:
Pyruvate Kinase M2: A potential target for regulating inflammation.
Front Immunol. 7:1452016. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Van Wyngene L, Vandewalle J and Libert C:
Reprogramming of basic metabolic pathways in microbial sepsis:
Therapeutic targets at last? EMBO Mol Med. 10:e87122018. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Yu D, Huang W, Sheng M, Zhang S, Pan H,
Ren F, Luo L, Zhou J, Huang D and Tang L: Angiotensin-(1-7)
modulates the Warburg effect to alleviate inflammation in
LPS-induced macrophages and septic mice. J Inflamm Res. 17:469–485.
2024. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Hard GC: Some biochemical aspects of the
immune macrophage. Br J Exp Pathol. 51:97–105. 1970.PubMed/NCBI
|
|
36
|
Ma G, Wu X, Qi C, Yu X and Zhang F:
Development of macrophage-associated genes prognostic signature
predicts clinical outcome and immune infiltration for sepsis. Sci
Rep. 14:20262024. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Pan L, Hu L, Zhang L, Xu H, Chen Y, Bian
Q, Zhu A and Wu H: Deoxyelephantopin decreases the release of
inflammatory cytokines in macrophage associated with attenuation of
aerobic glycolysis via modulation of PKM2. Int Immunopharmacol.
79:1060482020. View Article : Google Scholar
|
|
38
|
Chen Y, Zhang P, Han F, Zhou Y, Wei J,
Wang C, Song M, Lin S, Xu Y and Chen X: MiR-106a-5p targets PFKFB3
and improves sepsis through regulating macrophage pyroptosis and
inflammatory response. J Biol Chem. 300:1073342024. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Wang F, Wang K, Xu W, Zhao S, Ye D, Wang
Y, Xu Y, Zhou L, Chu Y, Zhang C, et al: SIRT5 desuccinylates and
activates pyruvate kinase M2 to block macrophage IL-1β production
and to prevent DSS-induced colitis in mice. Cell Rep. 19:2331–2344.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Li T, Han J, Jia L, Hu X, Chen L and Wang
Y: PKM2 coordinates glycolysis with mitochondrial fusion and
oxidative phosphorylation. Protein Cell. 10:583–594. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Yang L, Xie M, Yang M, Yu Y, Zhu S, Hou W,
Kang R, Lotze MT, Billiar TR, Wang H, et al: PKM2 regulates the
Warburg effect and promotes HMGB1 release in sepsis. Nat Commun.
5:44362014. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Wang L, Tang D and Zhang P: Changes of
serum pyruvate kinase M2 level in patients with sepsis and its
clinical value. Infect Drug Resist. 16:6437–6449. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Palmer CS, Ostrowski M, Balderson B,
Christian N and Crowe SM: Glucose metabolism regulates T cell
activation, differentiation, and functions. Front Immunol. 6:12015.
View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Tannahill GM, Curtis AM, Adamik J,
Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ,
Kelly B, Foley NH, et al: Succinate is an inflammatory signal that
induces IL-1β through HIF-1α. Nature. 496:238–242. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Palsson-McDermott EM, Curtis AM, Goel G,
Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR,
Domingo-Fernandez R, Johnston DG, et al: Pyruvate kinase M2
regulates Hif-1α activity and IL-1β induction and is a critical
determinant of the warburg effect in LPS-activated macrophages.
Cell Metab. 21:65–80. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Van den Bossche J, O'Neill LA and Menon D:
Macrophage immunometabolism: Where are we (Going)? Trends Immunol.
38:395–406. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Littlewood-Evans A, Sarret S, Apfel V,
Loesle P, Dawson J, Zhang J, Muller A, Tigani B, Kneuer R, Patel S,
et al: GPR91 senses extracellular succinate released from
inflammatory macrophages and exacerbates rheumatoid arthritis. J
Exp Med. 213:1655–1662. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Cheng SC, Scicluna BP, Arts RJ, Gresnigt
MS, Lachmandas E, Giamarellos-Bourboulis EJ, Kox M, Manjeri GR,
Wagenaars JA, Cremer OL, et al: Broad defects in the energy
metabolism of leukocytes underlie immunoparalysis in sepsis. Nat
Immunol. 17:406–413. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Düvel K, Yecies JL, Menon S, Raman P,
Lipovsky AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S,
et al: Activation of a metabolic gene regulatory network downstream
of mTOR complex 1. Mol Cell. 39:171–183. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Ganeshan K and Chawla A: Metabolic
regulation of immune responses. Annu Rev Immunol. 32:609–634. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Damasceno LEA, Prado DS, Veras FP, Fonseca
MM, Toller-Kawahisa JE, Rosa MH, Públio GA, Martins TV, Ramalho FS,
Waisman A, et al: PKM2 promotes Th17 cell differentiation and
autoimmune inflammation by fine-tuning STAT3 activation. J Exp Med.
217:e201906132020. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Huang J, Liu K, Zhu S, Xie M, Kang R, Cao
L and Tang D: AMPK regulates immunometabolism in sepsis. Brain
Behav Immun. 72:89–100. 2018. View Article : Google Scholar
|
|
53
|
Yang K, Fan M, Wang X, Xu J, Wang Y, Tu F,
Gill PS, Ha T, Liu L, Williams DL and Li C: Lactate promotes
macrophage HMGB1 lactylation, acetylation, and exosomal release in
polymicrobial sepsis. Cell Death Differ. 29:133–146. 2022.
View Article : Google Scholar :
|
|
54
|
Yang H, Ochani M, Li J, Qiang X, Tanovic
M, Harris HE, Susarla SM, Ulloa L, Wang H, DiRaimo R, et al:
Reversing established sepsis with antagonists of endogenous
high-mobility group box 1. Proc Natl Acad Sci USA. 101:296–301.
2004. View Article : Google Scholar :
|
|
55
|
Angus DC, Yang L, Kong L, Kellum JA,
Delude RL, Tracey KJ and Weissfeld L; GenIMS Investigators:
Circulating high-mobility group box 1 (HMGB1) concentrations are
elevated in both uncomplicated pneumonia and pneumonia with severe
sepsis. Crit Care Med. 35:1061–1067. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Karlsson S, Pettilä V, Tenhunen J,
Laru-Sompa R, Hynninen M and Ruokonen E: HMGB1 as a predictor of
organ dysfunction and outcome in patients with severe sepsis.
Intensive Care Med. 34:1046–1053. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Yagmur E, Buendgens L, Herbers U, Beeretz
A, Weiskirchen R, Koek GH, Trautwein C, Tacke F and Koch A: High
mobility group box 1 as a biomarker in critically ill patients. J
Clin Lab Anal. 32:e225842018. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Chen R, Cao C, Liu H, Jiang W, Pan R, He
H, Ding K and Meng Q: Macrophage Sprouty4 deficiency diminishes
sepsis-induced acute lung injury in mice. Redox Biol.
58:1025132022. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Xie T, Xu Q, Wan H, Xing S, Shang C, Gao Y
and He Z: Lipopolysaccharide promotes lung fibroblast proliferation
through autophagy inhibition via activation of the PI3K-Akt-mTOR
pathway. Lab Invest. 99:625–633. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Li R, Ren T and Zeng J: Mitochondrial
coenzyme Q protects sepsis-induced acute lung injury by activating
PI3K/Akt/GSK-3β/mTOR pathway in rats. Biomed Res Int.
2019:52408982019. View Article : Google Scholar
|
|
61
|
Mills EL and O'Neill LA: Reprogramming
mitochondrial metabolism in macrophages as an anti-inflammatory
signal. Eur J Immunol. 46:13–21. 2016. View Article : Google Scholar
|
|
62
|
Mills E and O'Neill LA: Succinate: A
metabolic signal in inflammation. Trends Cell Biol. 24:313–320.
2014. View Article : Google Scholar
|
|
63
|
Huang SC, Everts B, Ivanova Y, O'Sullivan
D, Nascimento M, Smith AM, Beatty W, Love-Gregory L, Lam WY,
O'Neill CM, et al: Cell-intrinsic lysosomal lipolysis is essential
for alternative activation of macrophages. Nat Immunol. 15:846–855.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Williams NC and O'Neill LAJ: A role for
the Krebs cycle intermediate citrate in metabolic reprogramming in
innate immunity and inflammation. Front Immunol. 9:1412018.
View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Lauterbach MA, Hanke JE, Serefidou M,
Mangan MSJ, Kolbe CC, Hess T, Rothe M, Kaiser R, Hoss F, Gehlen J,
et al: Toll-like receptor signaling rewires macrophage metabolism
and promotes histone acetylation via ATP-citrate Lyase. Immunity.
51:997–1011.e7. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Xu Y, Zhang S, Rong J, Lin Y, Du L, Wang Y
and Zhang Z: Sirt3 is a novel target to treat sepsis induced
myocardial dysfunction by acetylated modulation of critical enzymes
within cardiac tricarboxylic acid cycle. Pharmacol Res.
159:1048872020. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Ma W, Ao S, Zhou J, Li J, Liang X, Yang X,
Zhang H, Liu B, Tang W, Liu H, et al: Methylsulfonylmethane
protects against lethal dose MRSA-induced sepsis through promoting
M2 macrophage polarization. Mol Immunol. 146:69–77. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Chu X, Di C, Chang P, Li L, Feng Z, Xiao
S, Yan X, Xu X, Li H, Qi R, et al: Lactylated histone H3K18 as a
potential biomarker for the diagnosis and predicting the severity
of septic shock. Front Immunol. 12:7866662021. View Article : Google Scholar
|
|
69
|
Pereverzeva L, van Linge CCA, Schuurman
AR, Klarenbeek AM, Ramirez Moral I, Otto NA, Peters-Sengers H,
Butler JM, Schomakers BV, van Weeghel M, et al: Human alveolar
macrophages do not rely on glucose metabolism upon activation by
lipopolysaccharide. Biochim Biophys Acta Mol Basis Dis.
1868:1664882022. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Woods PS, Kimmig LM, Sun KA, Meliton AY,
Shamaa OR, Tian Y, Cetin-Atalay R, Sharp WW, Hamanaka RB and Mutlu
GM: HIF-1α induces glycolytic reprograming in tissue-resident
alveolar macrophages to promote cell survival during acute lung
injury. Elife. 11:e774572022. View Article : Google Scholar
|
|
71
|
Svedberg FR, Brown SL, Krauss MZ, Campbell
L, Sharpe C, Clausen M, Howell GJ, Clark H, Madsen J, Evans CM, et
al: The lung environment controls alveolar macrophage metabolism
and responsiveness in type 2 inflammation. Nat Immunol. 20:571–580.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Russell DG, Huang L and VanderVen BC:
Immunometabolism at the interface between macrophages and
pathogens. Nat Rev Immunol. 19:291–304. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Haschemi A, Kosma P, Gille L, Evans CR,
Burant CF, Starkl P, Knapp B, Haas R, Schmid JA, Jandl C, et al:
The sedoheptulose kinase CARKL directs macrophage polarization
through control of glucose metabolism. Cell Metab. 15:813–826.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
de Boer JF, Kuipers F and Groen AK:
Cholesterol transport revisited: A new turbo mechanism to drive
cholesterol excretion. Trends Endocrinol Metab. 29:123–133. 2018.
View Article : Google Scholar
|
|
75
|
Chauhan P and Saha B: Metabolic regulation
of infection and inflammation. Cytokine. 112:1–11. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Colaço HG, Barros A, Neves-Costa A, Seixas
E, Pedroso D, Velho T, Willmann KL, Faisca P, Grabmann G, Yi HS, et
al: Tetracycline antibiotics induce host-dependent disease
tolerance to infection. Immunity. 54:53–67.e57. 2021. View Article : Google Scholar :
|
|
77
|
Huen SC: Metabolism as disease tolerance:
Implications for sepsis-associated acute kidney injury. Nephron.
146:291–294. 2022. View Article : Google Scholar
|
|
78
|
Li R, Li X, Zhao J, Meng F, Yao C, Bao E,
Sun N, Chen X, Cheng W, Hua H, et al: Mitochondrial STAT3
exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid
oxidation. Theranostics. 12:976–998. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Korbecki J and Bajdak-Rusinek K: The
effect of palmitic acid on inflammatory response in macrophages: An
overview of molecular mechanisms. Inflamm Res. 68:915–932. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Tian H, Liu C, Zou X, Wu W, Zhang C and
Yuan D: MiRNA-194 regulates Palmitic acid-induced toll-like
receptor 4 inflammatory responses in THP-1 cells. Nutrients.
7:3483–3496. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Wen Y, Gu J, Chakrabarti SK, Aylor K,
Marshall J, Takahashi Y, Yoshimoto T and Nadler JL: The role of
12/15-lipoxygenase in the expression of interleukin-6 and tumor
necrosis factor-alpha in macrophages. Endocrinology. 148:1313–1322.
2007. View Article : Google Scholar
|
|
82
|
Yang Y, Zhong ZT, Xiao YG and Chen HB: The
activation of AMPK/NRF2 pathway in lung epithelial cells is
involved in the protective effects of kinsenoside on
lipopolysaccharide-induced acute lung injury. Oxid Med Cell Longev.
2022:35892772022. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Ma L, Li W, Zhang Y, Qi L, Zhao Q, Li N,
Lu Y, Zhang L, Zhou F, Wu Y, et al: FLT4/VEGFR3 activates AMPK to
coordinate glycometabolic reprogramming with autophagy and
inflammasome activation for bacterial elimination. Autophagy.
18:1385–1400. 2022. View Article : Google Scholar :
|
|
84
|
Russo S, Kwiatkowski M, Govorukhina N,
Bischoff R and Melgert BN: Meta-inflammation and metabolic
reprogramming of macrophages in diabetes and obesity: The
importance of metabolites. Front Immunol. 12:7461512021. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Vandewalle J and Libert C: Sepsis: A
failing starvation response. Trends Endocrinol Metab. 33:292–304.
2022. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Vandewalle J, Timmermans S, Paakinaho V,
Vancraeynest L, Dewyse L, Vanderhaeghen T, Wallaeys C, Van Wyngene
L, Van Looveren K, Nuyttens L, et al: Combined glucocorticoid
resistance and hyperlactatemia contributes to lethal shock in
sepsis. Cell Metab. 33:1763–1776.e5. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Van Wyngene L, Vanderhaeghen T, Timmermans
S, Vandewalle J, Van Looveren K, Souffriau J, Wallaeys C, Eggermont
M, Ernst S, Van Hamme E, et al: Hepatic PPARα function and lipid
metabolic pathways are dysregulated in polymicrobial sepsis. EMBO
Mol Med. 12:e113192020. View Article : Google Scholar
|
|
88
|
Singh N, Gurav A, Sivaprakasam S, Brady E,
Padia R, Shi H, Thangaraju M, Prasad PD, Manicassamy S, Munn DH, et
al: Activation of Gpr109a, receptor for niacin and the commensal
metabolite butyrate, suppresses colonic inflammation and
carcinogenesis. Immunity. 40:128–139. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Youm YH, Nguyen KY, Grant RW, Goldberg EL,
Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti
TD, et al: The ketone metabolite β-hydroxybutyrate blocks NLRP3
inflammasome-mediated inflammatory disease. Nat Med. 21:263–269.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Das UN: Essential fatty acids and their
metabolites in the pathobiology of inflammation and its resolution.
Biomolecules. 11:18732021. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Vats D, Mukundan L, Odegaard JI, Zhang L,
Smith KL, Morel CR, Wagner RA, Greaves DR, Murray PJ and Chawla A:
Oxidative metabolism and PGC-1beta attenuate macrophage-mediated
inflammation. Cell Metab. 4:13–24. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Chen YL, Xie YJ, Liu ZM, Chen WB, Zhang R,
Ye HX, Wang W, Liu XY and Chen HS: Omega-3 fatty acids impair
miR-1-3p-dependent Notch3 down-regulation and alleviate
sepsis-induced intestinal injury. Mol Med. 28:92022. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Fu Y, Gong T, Loughran PA, Li Y, Billiar
TR, Liu Y, Wen Z and Fan J: Roles of TLR4 in macrophage immunity
and macrophage-pulmonary vascular/lymphatic endothelial cell
interactions in sepsis. Commun Biol. 8:4692025. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Liu L, Lu Y, Martinez J, Bi Y, Lian G,
Wang T, Milasta S, Wang J, Yang M, Liu G, et al: Proinflammatory
signal suppresses proliferation and shifts macrophage metabolism
from Myc-dependent to HIF1α-dependent. Proc Natl Acad Sci USA.
113:1564–1569. 2016. View Article : Google Scholar
|
|
95
|
Wellhoener P, Vietheer A, Sayk F, Schaaf
B, Lehnert H and Dodt C: Metabolic alterations in adipose tissue
during the early phase of experimental endotoxemia in humans. Horm
Metab Res. 43:754–759. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Das UN: The dysregulation of essential
fatty acid (EFA) metabolism may be a factor in the pathogenesis of
sepsis. Medicina (Kaunas). 60:9342024. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Chang X, Guo Y, Wang J, Liu J, Ma Y, Lu Q
and Han Y: Heart-type fatty acid binding protein (H-FABP) as an
early biomarker in sepsis-induced cardiomyopathy: A prospective
observational study. Lipids Health Dis. 23:2832024. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Wang Z, Li Y, Yang X, Zhang L, Shen H, Xu
W and Yuan C: Protective effects of rapamycin induced autophagy on
CLP septic mice. Comp Immunol Microbiol Infect Dis. 64:47–52. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Chawla A: Control of macrophage activation
and function by PPARs. Circ Res. 106:1559–1569. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Crossland H, Constantin-Teodosiu D and
Greenhaff PL: The regulatory roles of PPARs in skeletal muscle fuel
metabolism and inflammation: Impact of PPAR Agonism on muscle in
chronic disease, contraction and sepsis. Int J Mol Sci.
22:97752021. View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Marin JJ, Macias RI, Briz O, Banales JM
and Monte MJ: Bile acids in physiology, pathology and pharmacology.
Curr Drug Metab. 17:4–29. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Mutemberezi V, Guillemot-Legris O and
Muccioli GG: Oxysterols: From cholesterol metabolites to key
mediators. Prog Lipid Res. 64:152–169. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Duan Y, Gong K, Xu S, Zhang F, Meng X and
Han J: Regulation of cholesterol homeostasis in health and
diseases: From mechanisms to targeted therapeutics. Signal
Transduct Target Ther. 7:2652022. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Varshney P, Yadav V and Saini N: Lipid
rafts in immune signalling: Current progress and future
perspective. Immunology. 149:13–24. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Golucci A, Marson FAL, Ribeiro AF and
Nogueira RJN: Lipid profile associated with the systemic
inflammatory response syndrome and sepsis in critically ill
patients. Nutrition. 55-56:7–14. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Walley KR, Boyd JH, Kong HJ and Russell
JA: Low low-density lipoprotein levels are associated with, but do
not causally contribute to, increased mortality in sepsis. Crit
Care Med. 47:463–466. 2019. View Article : Google Scholar
|
|
107
|
van Leeuwen HJ, Heezius EC, Dallinga GM,
van Strijp JA, Verhoef J and van Kessel KP: Lipoprotein metabolism
in patients with severe sepsis. Crit Care Med. 31:1359–1366. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Trinder M, Genga KR, Kong HJ, Blauw LL, Lo
C, Li X, Cirstea M, Wang Y, Rensen PCN, Russell JA, et al:
Cholesteryl ester transfer protein influences high-density
lipoprotein levels and survival in sepsis. Am J Respir Crit Care
Med. 199:854–862. 2019. View Article : Google Scholar
|
|
109
|
Chang L, Chen X and Lian C: The
association between the non-HDL-cholesterol to HDL-cholesterol
ratio and 28-day mortality in sepsis patients: A cohort study. Sci
Rep. 12:34762022. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Hardy JP, Streeter EM and DeCook RR:
Retrospective evaluation of plasma cholesterol concentration in
septic dogs and its association with morbidity and mortality: 51
cases (2005-2015). J Vet Emerg Crit Care (San Antonio). 28:149–156.
2018. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Morel J, Hargreaves I, Brealey D,
Neergheen V, Backman JT, Lindig S, Bläss M, Bauer M, McAuley DF and
Singer M: Simvastatin pre-treatment improves survival and
mitochondrial function in a 3-day fluid-resuscitated rat model of
sepsis. Clin Sci (Lond). 131:747–758. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Vavrova L, Rychlikova J, Mrackova M,
Novakova O, Zak A and Novak F: Increased inflammatory markers with
altered antioxidant status persist after clinical recovery from
severe sepsis: A correlation with low HDL cholesterol and albumin.
Clin Exp Med. 16:557–569. 2016. View Article : Google Scholar
|
|
113
|
Fessler MB and Parks JS: Intracellular
lipid flux and membrane microdomains as organizing principles in
inflammatory cell signaling. J Immunol. 187:1529–1535. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Luo J, Yang H and Song BL: Mechanisms and
regulation of cholesterol homeostasis. Nat Rev Mol Cell Biol.
21:225–245. 2020. View Article : Google Scholar
|
|
115
|
Tabas I and Lichtman AH:
Monocyte-macrophages and T cells in atherosclerosis. Immunity.
47:621–634. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Pownall HJ, Rosales C, Gillard BK and
Gotto AM Jr: High-density lipoproteins, reverse cholesterol
transport and atherogenesis. Nat Rev Cardiol. 18:712–723. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Hofmaenner DA, Kleyman A, Press A, Bauer M
and Singer M: The many roles of cholesterol in sepsis: A review. Am
J Respir Crit Care Med. 205:388–396. 2022. View Article : Google Scholar :
|
|
118
|
Van Dender C, Timmermans S, Paakinaho V,
Vanderhaeghen T, Vandewalle J, Claes M, Garcia B, Roman B, De Waele
J, Croubels S, et al: A critical role for HNF4α in polymicrobial
sepsis-associated metabolic reprogramming and death. EMBO Mol Med.
16:2485–2515. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Yang L, Chu Z, Liu M, Zou Q, Li J, Liu Q,
Wang Y, Wang T, Xiang J and Wang B: Amino acid metabolism in immune
cells: Essential regulators of the effector functions, and
promising opportunities to enhance cancer immunotherapy. J Hematol
Oncol. 16:592023. View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Chen Q, Liang X, Wu T, Jiang J, Jiang Y,
Zhang S, Ruan Y, Zhang H, Zhang C, Chen P, et al: Integrative
analysis of metabolomics and proteomics reveals amino acid
metabolism disorder in sepsis. J Transl Med. 20:1232022. View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Hezaveh K, Shinde RS, Klötgen A, Halaby
MJ, Lamorte S, Ciudad MT, Quevedo R, Neufeld L, Liu ZQ, Jin R, et
al: Tryptophan-derived microbial metabolites activate the aryl
hydrocarbon receptor in tumor-associated macrophages to suppress
anti-tumor immunity. Immunity. 55:324–340.e328. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
122
|
Roager HM and Licht TR: Microbial
tryptophan catabolites in health and disease. Nat Commun.
9:32942018. View Article : Google Scholar : PubMed/NCBI
|
|
123
|
Mulder K, Patel AA, Kong WT, Piot C,
Halitzki E, Dunsmore G, Khalilnezhad S, Irac SE, Dubuisson A,
Chevrier M, et al: Cross-tissue single-cell landscape of human
monocytes and macrophages in health and disease. Immunity.
54:1883–1900.e5. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
124
|
Wang F, Zhang M, Yin L, Zhou Z, Peng Z, Li
W, Chen H, Yu G and Tang J: The tryptophan metabolite kynurenic
acid ameliorates septic colonic injury through activation of the
PPARγ signaling pathway. Int Immunopharmacol. 147:1136512025.
View Article : Google Scholar
|
|
125
|
Zangerle R, Kurz K, Neurauter G, Kitchen
M, Sarcletti M and Fuchs D: Increased blood phenylalanine to
tyrosine ratio in HIV-1 infection and correction following
effective antiretroviral therapy. Brain Behav Immun. 24:403–408.
2010. View Article : Google Scholar
|
|
126
|
Shang M, Cappellesso F, Amorim R, Serneels
J, Virga F, Eelen G, Carobbio S, Rincon MY, Maechler P, De Bock K,
et al: Macrophage-derived glutamine boosts satellite cells and
muscle regeneration. Nature. 587:626–631. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
127
|
Wang B, Pei J, Xu S, Liu J and Yu J: A
glutamine tug-of-war between cancer and immune cells: Recent
advances in unraveling the ongoing battle. J Exp Clin Cancer Res.
43:742024. View Article : Google Scholar : PubMed/NCBI
|
|
128
|
Hou YC, Wu JM, Chen KY, Wu MH, Yang PJ,
Lee PC, Chen PD, Yeh SL and Lin MT: Glutamine and leucine
administration attenuates muscle atrophy in sepsis. Life Sci.
314:1213272023. View Article : Google Scholar
|
|
129
|
Wu D, Su S, Zha X, Wei Y, Yang G, Huang Q,
Yang Y, Xia L, Fan S and Peng X: Glutamine promotes O-GlcNAcylation
of G6PD and inhibits AGR2 S-glutathionylation to maintain the
intestinal mucus barrier in burned septic mice. Redox Biol.
59:1025812023. View Article : Google Scholar
|
|
130
|
Chen K, Rao Z, Dong S, Chen Y, Wang X, Luo
Y, Gong F and Li X: Roles of the fibroblast growth factor signal
transduction system in tissue injury repair. Burns Trauma.
10:tkac0052022. View Article : Google Scholar : PubMed/NCBI
|
|
131
|
Yang Y, Chen Q, Fan S, Lu Y, Huang Q, Liu
X and Peng X: Glutamine sustains energy metabolism and alleviates
liver injury in burn sepsis by promoting the assembly of
mitochondrial HSP60-HSP10 complex via SIRT4 dependent protein
deacetylation. Redox Rep. 29:23123202024. View Article : Google Scholar : PubMed/NCBI
|
|
132
|
Li W, Tao S, Wu Q, Wu T, Tao R and Fan J:
Glutamine reduces myocardial cell apoptosis in a rat model of
sepsis by promoting expression of heat shock protein 90. J Surg
Res. 220:247–254. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
133
|
Briassouli E, Tzanoudaki M, Goukos D,
Vardas K, Briassoulis P, Ilia S, Kanariou M, Routsi C, Nanas S,
Daikos GL and Briassoulis G: Ex vivo evaluation of glutamine
treatment in sepsis and trauma in a human peripheral blood
mononuclear cells model. Nutrients. 15:2522023. View Article : Google Scholar : PubMed/NCBI
|
|
134
|
Jennaro TS, Viglianti EM, Ingraham NE,
Jones AE, Stringer KA and Puskarich MA: Serum levels of
acylcarnitines and amino acids are associated with liberation from
organ support in patients with septic shock. J Clin Med.
11:6272022. View Article : Google Scholar : PubMed/NCBI
|
|
135
|
van Zanten AR, Dhaliwal R, Garrel D and
Heyland DK: Enteral glutamine supplementation in critically ill
patients: A systematic review and meta-analysis. Crit Care.
19:2942015. View Article : Google Scholar : PubMed/NCBI
|
|
136
|
Heyland D, Muscedere J, Wischmeyer PE,
Cook D, Jones G, Albert M, Elke G, Berger MM and Day AG; Canadian
Critical Care Trials Group: A randomized trial of glutamine and
antioxidants in critically ill patients. N Engl J Med.
368:1489–1497. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
137
|
Mulherin DW and Sacks GS: Uncertainty
about the safety of supplemental glutamine: An editorial on 'A
randomized trial of glutamine and antioxidants in critically ill
patients'. Hepatobiliary Surg Nutr. 4:76–79. 2015.PubMed/NCBI
|
|
138
|
Briassouli E and Briassoulis G: Glutamine
randomized studies in early life: The unsolved riddle of
experimental and clinical studies. Clin Dev Immunol.
2012:7491892012. View Article : Google Scholar : PubMed/NCBI
|
|
139
|
Van den Bossche J, Baardman J, Otto NA,
van der Velden S, Neele AE, van den Berg SM, Luque-Martin R, Chen
HJ, Boshuizen MC, Ahmed M, et al: Mitochondrial dysfunction
prevents repolarization of inflammatory macrophages. Cell Rep.
17:684–696. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
140
|
Schairer DO, Chouake JS, Nosanchuk JD and
Friedman AJ: The potential of nitric oxide releasing therapies as
antimicrobial agents. Virulence. 3:271–279. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
141
|
Bogdan C: Nitric oxide and the immune
response. Nat Immunol. 2:907–916. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
142
|
Mills CD: Anatomy of a discovery: M1 and
m2 macrophages. Front Immunol. 6:2122015. View Article : Google Scholar : PubMed/NCBI
|
|
143
|
Wijnands KA, Castermans TM, Hommen MP,
Meesters DM and Poeze M: Arginine and citrulline and the immune
response in sepsis. Nutrients. 7:1426–1463. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
144
|
Chantranupong L, Scaria SM, Saxton RA,
Gygi MP, Shen K, Wyant GA, Wang T, Harper JW, Gygi SP, Sabatini DM,
et al: The CASTOR proteins are arginine sensors for the mTORC1
pathway. Cell. 165:153–164. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
145
|
Wijnands KA, Vink H, Briedé JJ, van
Faassen EE, Lamers WH, Buurman WA and Poeze M: Citrulline a more
suitable substrate than arginine to restore NO production and the
microcirculation during endotoxemia. PLoS One. 7:e374392012.
View Article : Google Scholar : PubMed/NCBI
|
|
146
|
Yeh CL, Pai MH, Shih YM, Shih JM and Yeh
SL: Intravenous arginine administration promotes proangiogenic
cells mobilization and attenuates lung injury in mice with
polymicrobial sepsis. Nutrients. 9:5072017. View Article : Google Scholar : PubMed/NCBI
|
|
147
|
Yeh CL, Tanuseputero SA, Wu JM, Tseng YR,
Yang PJ, Lee PC, Yeh SL and Lin MT: Intravenous arginine
administration benefits CD4+ T-cell homeostasis and attenuates
liver inflammation in mice with polymicrobial sepsis. Nutrients.
12:10472020. View Article : Google Scholar
|
|
148
|
Martí ILAA and Reith W: Arginine-dependent
immune responses. Cell Mol Life Sci. 78:5303–5324. 2021. View Article : Google Scholar
|
|
149
|
Karadima E, Chavakis T and Alexaki VI:
Arginine metabolism in myeloid cells in health and disease. Semin
Immunopathol. 47:112025. View Article : Google Scholar : PubMed/NCBI
|
|
150
|
Qualls JE, Neale G, Smith AM, Koo MS,
DeFreitas AA, Zhang H, Kaplan G, Watowich SS and Murray PJ:
Arginine usage in mycobacteria-infected macrophages depends on
autocrine-paracrine cytokine signaling. Sci Signal. 3:ra622010.
View Article : Google Scholar : PubMed/NCBI
|
|
151
|
Dowling JK, Afzal R, Gearing LJ,
Cervantes-Silva MP, Annett S, Davis GM, De Santi C, Assmann N,
Dettmer K, Gough DJ, et al: Mitochondrial arginase-2 is essential
for IL-10 metabolic reprogramming of inflammatory macrophages. Nat
Commun. 12:14602021. View Article : Google Scholar : PubMed/NCBI
|
|
152
|
Hannemann N, Cao S, Eriksson D, Schnelzer
A, Jordan J, Eberhardt M, Schleicher U, Rech J, Ramming A, Uebe S,
et al: Transcription factor Fra-1 targets arginase-1 to enhance
macrophage-mediated inflammation in arthritis. J Clin Invest.
129:2669–2684. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
153
|
Yang Z and Ming XF: Functions of arginase
isoforms in macrophage inflammatory responses: Impact on
cardiovascular diseases and metabolic disorders. Front Immunol.
5:5332014. View Article : Google Scholar : PubMed/NCBI
|
|
154
|
Zhang Y, Higgins CB, Tica S, Adams JA, Sun
J, Kelly SC, Zong X, Dietzen DJ, Pietka T, Ballentine SJ, et al:
Hierarchical tricarboxylic acid cycle regulation by hepatocyte
arginase 2 links the urea cycle to oxidative metabolism. Cell
Metab. 36:2069–2085.e8. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
155
|
Canè S, Geiger R and Bronte V: The roles
of arginases and arginine in immunity. Nat Rev Immunol. 25:266–284.
2025. View Article : Google Scholar
|
|
156
|
De Santi C, Nally FK, Afzal R, Duffy CP,
Fitzsimons S, Annett SL, Robson T, Dowling JK, Cryan SA and McCoy
CE: Enhancing arginase 2 expression using target site blockers as a
strategy to modulate macrophage phenotype. Mol Ther Nucleic Acids.
29:643–655. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
157
|
Fitzsimons S, Muñoz-San Martín M, Nally F,
Dillon E, Fashina IA, Strowitzki MJ, Ramió-Torrentà L, Dowling JK,
De Santi C, McCoy CE, et al: Inhibition of pro-inflammatory
signaling in human primary macrophages by enhancing arginase-2 via
target site blockers. Mol Ther Nucleic Acids. 33:941–959. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
158
|
Ming XF, Rajapakse AG, Yepuri G, Xiong Y,
Carvas JM, Ruffieux J, Scerri I, Wu Z, Popp K, Li J, et al:
Arginase II promotes macrophage inflammatory responses through
mitochondrial reactive oxygen species, contributing to insulin
resistance and atherogenesis. J Am Heart Assoc. 1:e0009922012.
View Article : Google Scholar : PubMed/NCBI
|
|
159
|
Li R, Li Y, Jiang K, Zhang L, Li T, Zhao
A, Zhang Z, Xia Y, Ge K, Chen Y, et al: Lighting up arginine
metabolism reveals its functional diversity in physiology and
pathology. Cell Metab. 37:291–304.e9. 2025. View Article : Google Scholar
|
|
160
|
Velho TR, Santos I, Póvoa P and Moita LF:
Sepsis: The need for tolerance not complacency. Swiss Med Wkly.
146:W142762016. View Article : Google Scholar : PubMed/NCBI
|
|
161
|
Cecconi M, Evans L, Levy M and Rhodes A:
Sepsis and septic shock. Lancet. 392:75–87. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
162
|
Evans L, Rhodes A, Alhazzani W, Antonelli
M, Coopersmith CM, French C, Machado FR, Mcintyre L, Ostermann M,
Prescott HC, et al: Surviving sepsis campaign: International
guidelines for management of sepsis and septic shock 2021.
Intensive Care Med. 47:1181–1247. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
163
|
Soni M, Handa M, Singh KK and Shukla R:
Recent nanoengineered diagnostic and therapeutic advancements in
management of Sepsis. J Control Release. 352:931–945. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
164
|
Qiu P, Liu Y and Zhang J: Review: The role
and mechanisms of macrophage autophagy in sepsis. Inflammation.
42:6–19. 2019. View Article : Google Scholar
|
|
165
|
Zhong H, Tang R, Feng JH, Peng YW, Xu QY,
Zhou Y, He ZY, Mei SY and Xing SP: Metformin mitigates
sepsis-associated pulmonary fibrosis by promoting AMPK activation
and inhibiting HIF-1α-induced aerobic glycolysis. Shock.
61:283–293. 2024. View Article : Google Scholar
|
|
166
|
Liang H, Song H, Zhang X, Song G, Wang Y,
Ding X, Duan X, Li L, Sun T and Kan Q: Metformin attenuated
sepsis-related liver injury by modulating gut microbiota. Emerg
Microbes Infect. 11:815–828. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
167
|
Saraiva IE, Hamahata N, Huang DT,
Kane-Gill SL, Rivosecchi RM, Shiva S, Nolin TD, Chen X, Minturn J,
Chang CH, et al: Metformin for sepsis-associated AKI: A protocol
for the randomized clinical trial of the safety and FeasibiLity of
metformin as a treatment for sepsis-associated AKI (LiMiT AKI). BMJ
Open. 14:e0811202024. View Article : Google Scholar : PubMed/NCBI
|
|
168
|
Fan SY, Zhao ZC, Liu XL, Peng YG, Zhu HM,
Yan SF, Liu YJ, Xie Q, Jiang Y and Zeng SZ: Metformin mitigates
sepsis-induced acute lung injury and inflam-mation in young mice by
suppressing the S100A8/A9-NLRP3-IL-1β signaling pathway. J Inflamm
Res. 17:3785–3799. 2024. View Article : Google Scholar
|
|
169
|
Quan H, Yin M, Kim J, Jang EA, Yang SH,
Bae HB and Jeong S: Resveratrol suppresses the reprogramming of
macrophages into an endotoxin-tolerant state through the activation
of AMP-activated protein kinase. Eur J Pharmacol. 899:1739932021.
View Article : Google Scholar : PubMed/NCBI
|
|
170
|
Li J, Zeng X, Yang F, Wang L, Luo X, Liu
R, Zeng F, Lu S, Huang X, Lei Y and Lan Y: Resveratrol: Potential
application in sepsis. Front Pharmacol. 13:8213582022. View Article : Google Scholar : PubMed/NCBI
|
|
171
|
Pandey S, Anang V, Singh S, Seth S, Bhatt
AN, Kalra N, Manda K, Soni R, Roy BG, Natarajan K and Dwarakanath
BS: Dietary administration of the glycolytic inhibitor
2-deoxy-D-glucose reduces endotoxemia-induced inflammation and
oxidative stress: Implications in PAMP-associated acute and chronic
pathology. Front Pharmacol. 14:9401292023. View Article : Google Scholar : PubMed/NCBI
|
|
172
|
Tan C, Gu J, Li T, Chen H, Liu K, Liu M,
Zhang H and Xiao X: Inhibition of aerobic glycolysis alleviates
sepsis-induced acute kidney injury by promoting lactate/Sirtuin
3/AMPK-regulated autophagy. Int J Mol Med. 47:192021. View Article : Google Scholar
|
|
173
|
Orsini EM, Roychowdhury S, Gangadhariah M,
Cross E, Abraham S, Reinhardt A, Grund ME, Zhou JY, Stuehr O, Pant
B, et al: TRPV4 regulates the macrophage metabolic response to
limit Sepsis-induced lung injury. Am J Respir Cell Mol Biol.
70:457–467. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
174
|
Shao C, Lin S, Liu S, Jin P, Lu W, Li N,
Zhang Y, Bo L and Bian J: HIF1α-Induced glycolysis in macrophage is
essential for the protective effect of ouabain during endotoxemia.
Oxid Med Cell Longev. 2019:71365852019. View Article : Google Scholar
|
|
175
|
Zhang Z, Deng W, Kang R, Xie M, Billiar T,
Wang H, Cao L and Tang D: Plumbagin protects mice from lethal
sepsis by modulating immunometabolism upstream of PKM2. Mol Med.
22:162–172. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
176
|
Virga F, Cappellesso F, Stijlemans B,
Henze AT, Trotta R, Van Audenaerde J, Mirchandani AS,
Sanchez-Garcia MA and Vandewalle J: Macrophage miR-210 induction
and metabolic reprogramming in response to pathogen interaction
boost life-threatening inflammation. Sci Adv. 7:eabf04662021.
View Article : Google Scholar : PubMed/NCBI
|
|
177
|
Xu J, Gao C, He Y, Fang X, Sun D, Peng Z,
Xiao H, Sun M, Zhang P, Zhou T, et al: NLRC3 expression in
macrophage impairs glycolysis and host immune defense by modulating
the NF-κB-NFAT5 complex during septic immunosuppression. Mol Ther.
31:154–173. 2023. View Article : Google Scholar
|
|
178
|
Wang D, Li Y, Yang H, Shen X, Shi X, Li C,
Zhang Y, Liu X, Jiang B, Zhu X, et al: Disruption of TIGAR-TAK1
alleviates immunopathology in a murine model of sepsis. Nat Commun.
15:43402024. View Article : Google Scholar : PubMed/NCBI
|
|
179
|
Sfogliarini C, Pepe G, Dolce A, Della
Torre S, Cesta MC, Allegretti M, Locati M and Vegeto E: Tamoxifen
twists again: On and off-targets in macrophages and infections.
Front Pharmacol. 13:8790202022. View Article : Google Scholar : PubMed/NCBI
|
|
180
|
Pepe G, Sfogliarini C, Rizzello L,
Battaglia G, Pinna C, Rovati G, Ciana P, Brunialti E, Mornata F,
Maggi A, et al: ERα-independent NRF2-mediated immunoregulatory
activity of tamoxifen. Biomed Pharmacother. 144:1122742021.
View Article : Google Scholar
|
|
181
|
Xu Y, An X, Liu L, Cao X, Wu Z, Jia W, Sun
J, Wang H, Huo J, Sun Z, et al: Self-cascade redox modulator
trilogically renovates intestinal microenvironment for mitigating
endotoxemia. ACS Nano. 18:2131–2148. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
182
|
Yeung ST, Ovando LJ, Russo AJ, Rathinam VA
and Khanna KM: CD169+ macrophage intrinsic IL-10 production
regulates immune homeostasis during sepsis. Cell Rep.
42:1121712023. View Article : Google Scholar : PubMed/NCBI
|
|
183
|
Saxton RA, Tsutsumi N, Su LL, Abhiraman
GC, Mohan K, Henneberg LT, Aduri NG, Gati C and Garcia KC:
Structure-based decoupling of the pro- and anti-inflammatory
functions of interleukin-10. Science. 371:eabc84332021. View Article : Google Scholar : PubMed/NCBI
|
|
184
|
Wu Y, Wang Q, Li M, Lao J, Tang H, Ming S,
Wu M, Gong S, Li L, Liu L and Huang X: SLAMF7 regulates the
inflammatory response in macrophages during polymicrobial sepsis. J
Clin Invest. 133:1502242023. View Article : Google Scholar
|
|
185
|
Zhu S, Chen Y, Lao J, Wu C, Zhan X, Wu Y,
Shang Y, Zou Z, Zhou J, Ji X, et al: Signaling lymphocytic
activation molecule Family-7 alleviates corneal inflammation by
promoting M2 polarization. J Infect Dis. 223:854–865. 2021.
View Article : Google Scholar
|
|
186
|
Shi Y, Zhu ML, Wu Q, Huang Y, Xu XL and
Chen W: The potential of drug delivery nanosystems for sepsis
treatment. J Inflamm Res. 14:7065–7077. 2021. View Article : Google Scholar
|
|
187
|
Hou X, Zhang X, Zhao W, Zeng C, Deng B,
McComb DW, Du S, Zhang C, Li W and Dong Y: Vitamin lipid
nanoparticles enable adoptive macrophage transfer for the treatment
of multi-drug-resistant bacterial sepsis. Nat Nanotechnol.
15:41–46. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
188
|
Qu H, Wu J, Pan Y, Abdulla A, Duan Z,
Cheng W, Wang N, Chen H, Wang C, Yang J, et al: Biomimetic
nanomodulator regulates oxidative and inflammatory stresses to
treat Sepsis-associated encephalopathy. ACS Nano. 18:28228–28245.
2024. View Article : Google Scholar : PubMed/NCBI
|
|
189
|
Zhang D, Tang Z, Huang H, Zhou G, Cui C,
Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, et al: Metabolic
regulation of gene expression by histone lactylation. Nature.
574:575–580. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
190
|
Mills EL, Ryan DG, Prag HA, Dikovskaya D,
Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E,
et al: Itaconate is an anti-inflammatory metabolite that activates
Nrf2 via alkylation of KEAP1. Nature. 556:113–117. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
191
|
Lindell RB and Meyer NJ: Charting a course
for precision therapy trials in sepsis. Lancet Respir Med.
12:265–267. 2024. View Article : Google Scholar : PubMed/NCBI
|
