|
1
|
Fischer V and Haffner-Luntzer M:
Interaction between bone and immune cells: Implications for
postmenopausal osteoporosis. Semin Cell Dev Biol. 123:14–21. 2022.
View Article : Google Scholar
|
|
2
|
Ott SM: Osteoporosis treatment: Not easy.
Ann Intern Med. 176:278–279. 2023. View
Article : Google Scholar : PubMed/NCBI
|
|
3
|
Adler RA: Osteoporosis treatment:
Decreased mortality too? J Clin Endocrinol Metab. 108:e48–e49.
2023. View Article : Google Scholar
|
|
4
|
Song S, Guo Y, Yang Y and Fu D: Advances
in pathogenesis and therapeutic strategies for osteoporosis.
Pharmacol Ther. 237:1081682022. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Adami G, Fassio A, Rossini M, Caimmi C,
Giollo A, Orsolini G, Viapiana O and Gatti D: Osteoporosis in
rheumatic diseases. Int J Mol Sci. 20:58672019. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Valero C and González Macías J:
Atherosclerosis, vascular calcification and osteoporosis. Med Clin
(Barc). 164:e13–e20. 2025.In English, Spanish. View Article : Google Scholar
|
|
7
|
Weaver CM: Nutrition and bone health. Oral
Dis. 23:412–415. 2017. View Article : Google Scholar
|
|
8
|
Kimball JS, Johnson JP and Carlson DA:
Oxidative stress and osteoporosis. J Bone Joint Surg Am.
103:1451–1461. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Yao Y, Cai X, Chen Y, Zhang M and Zheng C:
Estrogen deficiency-mediated osteoimmunity in postmenopausal
osteoporosis. Med Res Rev. 45:561–575. 2025. View Article : Google Scholar
|
|
10
|
Zhang YW, Cao MM, Li YJ, Lu PP, Dai GC,
Zhang M, Wang H and Rui YF: Fecal microbiota transplantation
ameliorates bone loss in mice with ovariectomy-induced osteoporosis
via modulating gut microbiota and metabolic function. J Orthop
Translat. 37:46–60. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Wang G, Tan J, Huang C, Xu Y, Yang Z and
Huo L: Based on NF-κB and Notch1/Hes1 signaling pathways, the
mechanism of artesunate on inflammation in osteoporosis in
ovariectomized rats was investigated. Front Biosci (Landmark Ed).
29:2662024. View Article : Google Scholar
|
|
12
|
Sun D, Peng Y, Ge S and Fu Q: USP1
inhibits NF-κB/NLRP3 induced pyroptosis through TRAF6 in
osteoblastic MC3T3-E1 cells. J Musculoskelet Neuronal Interact.
22:536–545. 2022.PubMed/NCBI
|
|
13
|
Xu L, Zhang L, Wang Z, Li C, Li S, Li L,
Fan Q and Zheng L: Melatonin suppresses estrogen deficiency-induced
osteoporosis and promotes osteoblastogenesis by inactivating the
NLRP3 inflammasome. Calcif Tissue Int. 103:400–410. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
An T, Zha W and Zi J: Biotechnological
production of betulinic acid and derivatives and their
applications. Appl Microbiol Biotechnol. 104:3339–3348. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Lou H, Li H, Zhang S, Lu H and Chen Q: A
review on preparation of betulinic acid and its biological
activities. Molecules. 26:55832021. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Zheng X, Cao Z, Wang M, Yuan R, Han Y, Li
A and Wang X: Betulinic acid reduces intestinal inflammation and
enhances intestinal tight junctions by modulating the PPAR-γ/NF-κB
signaling pathway in intestinal cells and organoids. Nutrients.
17:20522025. View Article : Google Scholar
|
|
17
|
Xia G, Shen C, Xiao Y, Wang X, Qiu L, Lei
S and Jiang R: Shenling Baizhu Powder and Betulin attenuate
sepsis-induced intestinal injury by targeting GADD45B/TAOK1/p38
MAPK pathway. J Ethnopharmacol. 353:1202822025. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Zheng LY, Zou X, Wang YL, Zou M, Ma F,
Wang N, Li JW, Wang MS, Hung HY and Wang Q: Betulinic
acid-nucleoside hybrid prevents acute alcohol-induced liver damage
by promoting anti-oxidative stress and autophagy. Eur J Pharmacol.
914:1746862022. View Article : Google Scholar
|
|
19
|
Ou Z, Zhu L, Huang C, Ma C, Kong L, Lin X,
Gao X, Huang L, Wen L, Liang Z, et al: Betulinic acid attenuates
cyclophosphamide-induced intestinal mucosa injury by inhibiting the
NF-κB/MAPK signalling pathways and activating the Nrf2 signalling
pathway. Ecotoxicol Environ Saf. 225:1127462021. View Article : Google Scholar
|
|
20
|
Li J, Bao G, ALyafeai E, Ding J, Li S,
Sheng S, Shen Z, Jia Z, Lin C, Zhang C, et al: Betulinic acid
enhances the viability of random-pattern skin flaps by activating
autophagy. Front Pharmacol. 10:10172019. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Liu Y, Bi Y, Mo C, Zeng T, Huang S, Gao L,
Sun X and Lv Z: Betulinic acid attenuates liver fibrosis by
inducing autophagy via the mitogen-activated protein
kinase/extracellular signal-regulated kinase pathway. J Nat Med.
73:179–189. 2019. View Article : Google Scholar
|
|
22
|
Liu B, Wu Y, Liang T, Zhou Y, Chen G, He
J, Ji C, Liu P, Zhang C, Lin J, et al: Betulinic acid attenuates
osteoarthritis via limiting NLRP3 inflammasome activation to
decrease interleukin-1β maturation and secretion. Mediators
Inflamm. 2023:37064212023. View Article : Google Scholar
|
|
23
|
Wu C, Chen H, Zhuang R, Zhang H, Wang Y,
Hu X, Xu Y, Li J, Li Y, Wang X, et al: Betulinic acid inhibits
pyroptosis in spinal cord injury by augmenting autophagy via the
AMPK-mTOR-TFEB signaling pathway. Int J Biol Sci. 17:1138–1152.
2021. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Liu T, Wang L, Liang P, Wang X, Liu Y, Cai
J, She Y, Wang D, Wang Z, Guo Z, et al: USP19 suppresses
inflammation and promotes M2-like macrophage polarization by
manipulating NLRP3 function via autophagy. Cell Mol Immunol.
18:2431–2442. 2021. View Article : Google Scholar
|
|
25
|
Behera J, Ison J, Tyagi A, Mbalaviele G
and Tyagi N: Mechanisms of autophagy and mitophagy in skeletal
development, diseases and therapeutics. Life Sci. 301:1205952022.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Wang J, Zhang Y, Cao J, Wang Y, Anwar N,
Zhang Z, Zhang D, Ma Y, Xiao Y, Xiao L and Wang X: The role of
autophagy in bone metabolism and clinical significance. Autophagy.
19:2409–2427. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Lin Z, Gu Y, Liu Y, Chen Z, Fang S, Wang
Z, Liu Z, Lin Q, Hu Y, Jiang N, et al: Melatonin attenuates
inflammatory bone loss by alleviating mitophagy and lactate
production. Apoptosis. 30:1351–1371. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Tang N, Zhao H, Zhang H and Dong Y: Effect
of autophagy gene DRAM on proliferation, cell cycle, apoptosis, and
autophagy of osteoblast in osteoporosis rats. J Cell Physiol.
234:5023–5032. 2019. View Article : Google Scholar
|
|
29
|
Qiao J, Liu A, Sun C and Liu Q: HIF1A
overexpression promotes osteoblast differentiation through
activation of autophagy to alleviate osteoporosis. Sci Rep.
15:303702025. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
31
|
Choi H, Jeong BC, Kook MS and Koh JT:
Betulinic acid synergically enhances BMP2-induced bone formation
via stimulating Smad 1/5/8 and p38 pathways. J Biomed Sci.
23:452016. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Zhang Y, He N, Zhou X, Wang F, Cai H,
Huang SH, Chen X, Hu Z and Jin X: Betulinic acid induces
autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in
human bladder cancer cells. Aging (Albany NY). 13:21251–21267.
2021. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Wang S, Deng Z, Ma Y, Jin J, Qi F, Li S,
Liu C, Lyu FJ and Zheng Q: The role of autophagy and mitophagy in
bone metabolic disorders. Int J Biol Sci. 16:2675–2691. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Du J, Wang Y, Wu C, Zhang X, Zhang X and
Xu X: Targeting bone homeostasis regulation: Potential of
traditional Chinese medicine flavonoids in the treatment of
osteoporosis. Front Pharmacol. 15:13618642024. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Kim JM, Lin C, Stavre Z, Greenblatt MB and
Shim JH: Osteoblast-osteoclast communication and bone homeostasis.
Cells. 9:20732020. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Li J, Chen X, Lu L and Yu X: The
relationship between bone marrow adipose tissue and bone metabolism
in postmenopausal osteoporosis. Cytokine Growth Factor Rev.
52:88–98. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Zhang C, Li H, Li J, Hu J, Yang K and Tao
L: Oxidative stress: A common pathological state in a high-risk
population for osteoporosis. Biomed Pharmacother. 163:1148342023.
View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Weitzmann MN and Pacifici R: Estrogen
deficiency and bone loss: An inflammatory tale. J Clin Invest.
116:1186–1194. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Cheng CH, Chen LR and Chen KH:
Osteoporosis due to hormone imbalance: An overview of the effects
of estrogen deficiency and glucocorticoid overuse on bone turnover.
Int J Mol Sci. 23:13762022. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Wu M, Chen G and Li YP: TGF-β and BMP
signaling in osteoblast, skeletal development, and bone formation,
homeostasis and disease. Bone Res. 4:160092016. View Article : Google Scholar
|
|
41
|
Zanotti S and Canalis E: Notch signaling
and the skeleton. Endocr Rev. 37:223–253. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Uluçkan Ö, Jimenez M, Karbach S, Jeschke
A, Graña O, Keller J, Busse B, Croxford AL, Finzel S, Koenders M,
et al: Chronic skin inflammation leads to bone loss by
IL-17-mediated inhibition of Wnt signaling in osteoblasts. Sci
Transl Med. 8:330ra3372016. View Article : Google Scholar
|
|
43
|
Zhang H, Hilton MJ, Anolik JH, Welle SL,
Zhao C, Yao Z, Li X, Wang Z, Boyce BF and Xing L: NOTCH inhibits
osteoblast formation in inflammatory arthritis via noncanonical
NF-κB. J Clin Invest. 124:3200–3214. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Livshits G and Kalinkovich A: Targeting
chronic inflammation as a potential adjuvant therapy for
osteoporosis. Life Sci. 306:1208472022. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Iantomasi T, Romagnoli C, Palmini G,
Donati S, Falsetti I, Miglietta F, Aurilia C, Marini F, Giusti F
and Brandi ML: Oxidative stress and inflammation in osteoporosis:
Molecular mechanisms involved and the relationship with microRNAs.
Int J Mol Sci. 24:37722023. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Abais JM, Xia M, Zhang Y, Boini KM and Li
PL: Redox regulation of NLRP3 inflammasomes: ROS as trigger or
effector? Antioxid Redox Signal. 22:1111–1129. 2015. View Article : Google Scholar
|
|
47
|
Que X, Zheng S, Song Q, Pei H and Zhang P:
Fantastic voyage: The journey of NLRP3 inflammasome activation.
Genes Dis. 11:819–829. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Fu J and Wu H: Structural mechanisms of
NLRP3 inflammasome assembly and activation. Annu Rev Immunol.
41:301–316. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Jiang W, Li X, Dong S and Zhou W:
Betulinic acid in the treatment of tumour diseases: Application and
research progress. Biomed Pharmacother. 142:1119902021. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Feng R, Wang Q, Yu T, Hu H, Wu G, Duan X,
Jiang R, Xu Y and Huang Y: Quercetin ameliorates bone loss in OVX
rats by modulating the intestinal flora-SCFAs-inflammatory
signaling axis. Int Immunopharmacol. 136:1123412024. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Liu S, Yao S, Yang H, Liu S and Wang Y:
Autophagy: Regulator of cell death. Cell Death Dis. 14:6482023.
View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Di Q, Zhao X, Tang H, Li X, Xiao Y, Wu H,
Wu Z, Quan J and Chen W: USP22 suppresses the NLRP3 inflammasome by
degrading NLRP3 via ATG5-dependent autophagy. Autophagy.
19:873–885. 2023. View Article : Google Scholar
|
|
53
|
Lin Q, Li S, Jiang N, Jin H, Shao X, Zhu
X, Wu J, Zhang M, Zhang Z, Shen J, et al: Inhibiting NLRP3
inflammasome attenuates apoptosis in contrast-induced acute kidney
injury through the upregulation of HIF1A and BNIP3-mediated
mitophagy. Autophagy. 17:2975–2990. 2021. View Article : Google Scholar
|
|
54
|
Chen H, Cheng Y, Du H, Zhang C, Zhou Y,
Zhao Z, Li Y, Friedemann T, Mei J, Schröder S, et al: Shufeng Jiedu
capsule ameliorates olfactory dysfunction via the AMPK/mTOR
autophagy pathway in a mouse model of allergic rhinitis.
Phytomedicine. 107:1544262022. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Wei J, Li Y, Liu Q, Lan Y, Wei C, Tian K,
Wu L, Lin C, Xu J, Zhao J and Yang Y: Betulinic acid protects from
bone loss in ovariectomized mice and suppresses RANKL-associated
osteoclastogenesis by inhibiting the MAPK and NFATc1 pathways.
Front Pharmacol. 11:10252020. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Jeong DH, Kwak SC, Lee MS, Yoon KH, Kim JY
and Lee CH: Betulinic acid inhibits RANKL-induced
osteoclastogenesis via attenuating Akt, NF-κB, and
PLCγ2-Ca2+ signaling and prevents inflammatory bone
loss. J Nat Prod. 83:1174–1182. 2020. View Article : Google Scholar : PubMed/NCBI
|