|
1
|
Lin X, Chen Y, Zhang P, Chen G, Zhou Y and
Yu X: The potential mechanism of postoperative cognitive
dysfunction in older people. Exp Gerontol. 130:1107912020.
View Article : Google Scholar
|
|
2
|
Lopez MG, Hughes CG, DeMatteo A, O'Neal
JB, McNeil JB, Shotwell MS, Morse J, Petracek MR, Shah AS, Brown NJ
and Billings FT IV: Intraoperative oxidative damage and delirium
after cardiac surgery. Anesthesiology. 132:551–561. 2020.
View Article : Google Scholar
|
|
3
|
Wang P, Velagapudi R, Kong C, Rodriguiz
RM, Wetsel WC, Yang T, Berger M, Gelbard HA, Colton CA and Terrando
N: Neurovascular and immune mechanisms that regulate postoperative
delirium superimposed on dementia. Alzheimers Dement. 16:734–749.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Gu M, Mei XL and Zhao YN: Sepsis and
Cerebral Dysfunction: BBB damage, neuroinflammation, oxidative
stress, apoptosis and autophagy as key mediators and the potential
therapeutic approaches. Neurotox Res. 39:489–503. 2021. View Article : Google Scholar
|
|
5
|
Xu X, Hu Y, Yan E, Zhan G, Liu C and Yang
C: Perioperative neurocognitive dysfunction: Thinking from the gut?
Aging (Albany NY). 12:15797–15817. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Liu L, Shang L, Jin D, Wu X and Long B:
General anesthesia bullies the gut: A toxic relationship with
dysbiosis and cognitive dysfunction. Psychopharmacology (Berl).
239:709–728. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Giridharan VV, Generoso JS, Lence L,
Candiotto G, Streck E, Petronilho F, Pillai A, Sharshar T,
Dal-Pizzol F and Barichello T: A crosstalk between gut and brain in
sepsis-induced cognitive decline. J Neuroinflammation. 19:1142022.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Liu F and Liu J, Xiang H, Sun Z, Li Y, Li
X, Liu Y and Liu J: Dihydroartemisinin protects blood-brain barrier
permeability during sepsis by inhibiting the transcription factor
SNAI1. Clin Exp Pharmacol Physiol. 49:979–987. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Terrando N and Akassoglou K: Breaking
barriers in postoperative delirium. Br J Anaesth. 129:147–150.
2022. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Yang K, Chen J, Wang T and Zhang Y:
Pathogenesis of sepsis-associated encephalopathy: More than
blood-brain barrier dysfunction. Mol Biol Rep. 49:10091–10099.
2022. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Barichello T, Giridharan VV, Catalão CHR,
Ritter C and Dal-Pizzol F: Neurochemical effects of sepsis on the
brain. Clin Sci (Lond). 137:401–414. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Gao S, Jiang Y, Chen Z, Zhao X, Gu J, Wu
H, Liao Y, Sun H, Wang J and Chen W: Metabolic Reprogramming of
Microglia in Sepsis-Associated Encephalopathy: Insights from
Neuroinflammation. Curr Neuropharmacol. 21:1992–2005. 2023.
View Article : Google Scholar
|
|
13
|
Ji MH, Gao YZ, Shi CN, Wu XM and Yang JJ:
Acute and long-term cognitive impairment following sepsis:
Mechanism and prevention. Expert Rev Neurother. 23:931–943. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Krzyzaniak K, Krion R, Szymczyk A,
Stepniewska E and Sieminski M: Exploring neuroprotective agents for
sepsis-associated encephalopathy: A comprehensive review. Int J Mol
Sci. 24:107802023. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Zhang Q, Lu C, Fan W, Zhang J and Yin Y:
Application background and mechanism of short-chain fatty acids in
sepsis-associated encephalopathy. Front Cell Infect Microbiol.
13:11371612023. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Zhang S-h, Jia X-y, Wu Q, Jin J, Xu L-s,
Yang L, Han J-g and Zhou Q-h: The involvement of the gut microbiota
in postoperative cognitive dysfunction based on integrated
metagenomic and metabolomics analysis. Microbiol Spectr.
11:e03104232023. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Zhang Y, Baldyga K, Dong Y, Song W,
Villanueva M, Deng H, Mueller A, Houle TT, Marcantonio ER and Xie
Z: The association between gut microbiota and postoperative
delirium in patients. Transl Psychiatry. 13:1562023. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Zhou X, Wu X, Wu Y, Yang L, Shi E, Ding W,
Chen L, Shi X, Feng X, Su C, et al: Indole-3-propionic acid, a gut
microbiota metabolite, protects against the development of
postoperative delirium. Ann Surg. 278:e1164–e1174. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Wang X, Wen X, Yuan S and Zhang J:
Gut-brain axis in the pathogenesis of sepsis-associated
encephalopathy. Neurobiol Dis. 195:1064992024. View Article : Google Scholar
|
|
20
|
Xu Y, Shen B, Pan X, Liu C, Wang Y, Chen
X, Wang T, Chen G and Chen J: Palmatine ameliorated
lipopolysaccharide-induced sepsis-associated encephalopathy mice by
regulating the microbiota-gut-brain axis. Phytomedicine.
124:1553072024. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Yu Z, Shi H, Zhang J, Ma C, He C, Yang F
and Zhao L: Role of microglia in sepsis-associated encephalopathy
pathogenesis: An update. Shock. 61:498–508. 2024. View Article : Google Scholar
|
|
22
|
Abdullah IA, Khan S and Hassan FE:
Gut-Brain axis and perioperative gut microbiome in postoperative
cognitive dysfunction: Implications for neurosurgical patients. Med
Sci (Basel). 13:2362025.PubMed/NCBI
|
|
23
|
Chen P, Lin WL, Liu XY, Li SJ, Chen RF, Hu
ZH, Lin PT, Lin MH, Shi MY, Wu W, et al: D30 Alleviates
β2-Microglobulin-facilitated neurotoxic microglial responses in
isoflurane/surgery-induced cognitive dysfunction in aged mice. Lab
Invest. 105:1021902025. View Article : Google Scholar
|
|
24
|
Cheng J, Gao J, Li J and Tian H:
Neutrophils: A new target for postoperative cognitive dysfunction.
Apoptosis. 30:1117–1132. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Dai WB, Zhang X, Jiang XL, Zhang YZ, Chen
LK, Tian WT, Zhou XX, Sun XY, Huang LL, Gu XY, et al: The
kynurenine pathway regulated by intestinal innate lymphoid cells
mediates postoperative cognitive dysfunction. Mucosal Immunol.
18:53–65. 2025. View Article : Google Scholar
|
|
26
|
Gao S, Dai H, Hao Q, Song J, Ji K, Xu H,
Chen G and Lu J: Effect of perioperative probiotic intervention on
postoperative cognitive dysfunction in elderly patients: A
randomized double-blinded and placebo-controlled trial. J Transl
Med. 23:6372025. View Article : Google Scholar
|
|
27
|
He C, Shi H, Yu Z, Ma C, Jiao Z, Li J and
Yang F: The progress of the microbe-gut-brain axis in
sepsis-associated encephalopathy. Front Cell Infect Microbiol.
15:15874632025. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Horill S, Zhou XK and Jin W: Probiotics as
a possible novel therapeutic option to mitigate perioperative
neurocognitive disorders: A review exploring the latest research
findings. J Clin Anesth. 103:1118012025. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Huang ZB, Zhang GP, Lu CX, Gong C, Gao X,
Lin Y, Su P, Xu W, Lin Y, Lin N, et al: Gut microbiota-derived
3-indoleacetic acid confers a protection against sepsis-associated
encephalopathy through microglial aryl hydrocarbon receptors. Exp
Neurol. 384:1150552025. View Article : Google Scholar
|
|
30
|
Li W, Shi Q, Bai R, Zeng J, Lin L, Dai X,
Huang Q and Gong G: Advances in research on the pathogenesis and
signaling pathways associated with postoperative delirium (Review).
Mol Med Rep. 32:2202025. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Liu MW, Zhang Y, Xiong GF, Zhang BR, Zhang
QJ, Gao SJ, Zhu YL and Zhang LM: Dexmedetomidine for the treatment
of sepsis-associated encephalopathy: Mechanism and prospects.
Biomed Pharmacother. 188:1182092025. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Mao L, Wang L, Huang Z, Switzer JA, Hess
DC and Zhang Q: Perioperative neurocognitive disorders: Advances in
molecular mechanisms and bioactive molecules. Ageing Res Rev.
112:1028852025. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Li H, Huang D, Qiao K, Wang Z and Xu S:
Feasibility of non-intubated anesthesia and regional block for
thoracoscopic surgery under spontaneous respiration: A prospective
cohort study. Braz J Med Biol Res. 53:e86452020. View Article : Google Scholar
|
|
34
|
Liu HY, Chiang XH, Hung MH, Wang ML, Lin
MW, Cheng YJ, Hsu HH and Chen JS: Nonintubated uniportal
thoracoscopic segmentectomy for lung cancer. J Formos Med Assoc.
119:1396–1404. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Mogahed MM and Elkahwagy MS: Paravertebral
block versus intercostal nerve block in non-intubated uniportal
video-assisted thoracoscopic surgery: A randomised controlled
trial. Heart Lung Circ. 29:800–807. 2020. View Article : Google Scholar
|
|
36
|
Jiman AA, Ratze DC, Welle EJ, Patel PR,
Richie JM, Bottorff EC, Seymour JP, Chestek CA and Bruns TM:
Multi-channel intraneural vagus nerve recordings with a novel
high-density carbon fiber microelectrode array. Sci Rep.
10:155012020. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Nguyen M, Tavernier A, Gautier T, Aho S,
Morgant MC, Bouhemad B, Guinot PG and Grober J: Glucagon-like
peptide-1 is associated with poor clinical outcome,
lipopolysaccharide translocation and inflammation in patients
undergoing cardiac surgery with cardiopulmonary bypass. Cytokine.
133:1551822020. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Hu Q, Ren H, Hong Z, Wang C, Zheng T, Ren
Y, Chen K, Liu S, Wang G, Gu G, et al: Early enteral nutrition
preserves intestinal barrier function through reducing the
formation of neutrophil extracellular traps (NETs) in critically
Ill surgical patients. Oxid Med Cell Longev. 2020:88156552020.
View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Havel E: Danger of bacterial translocation
for a surgical patient. Rozhl Chir. 100:4–9. 2021.In English.
PubMed/NCBI
|
|
40
|
Magnan C, Lancry T, Salipante F, Trusson
R, Dunyach-Remy C, Roger C, Lefrant JY, Massanet P and Lavigne JP:
Role of gut microbiota and bacterial translocation in acute
intestinal injury and mortality in patients admitted in ICU for
septic shock. Front Cell Infect Microbiol. 13:13309002023.
View Article : Google Scholar
|
|
41
|
Huang Q, Wu Z, Chi C, Wu C, Su L, Zhang Y,
Zhu J and Liu Y: Angiopoietin-2 is an early predictor for acute
gastrointestinal injury and intestinal barrier dysfunction in
patients with acute pancreatitis. Dig Dis Sci. 66:114–120. 2021.
View Article : Google Scholar
|
|
42
|
Erikson K, Tuominen H, Vakkala M,
Liisanantti JH, Karttunen T, Syrjälä H and Ala-Kokko TI: Brain
tight junction protein expression in sepsis in an autopsy series.
Crit Care. 24:3852020. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Bigagli E, D'Ambrosio M, Cinci L, Fiorindi
C, Agostiniani S, Bruscoli E, Nannoni A, Lodovici M, Scaringi S,
Giudici F and Luceri C: Impact of preoperative immunonutrition on
oxidative stress and gut barrier function in surgical patients with
Crohn's disease. Nutrients. 15:8822023. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Hu Y, Hu XD, He ZQ, Liu Y, Gui YK, Zhu SH,
Da X, Liu YN, Liu LX, Shen QY and Xu GH: Anesthesia/surgery
activate MMP9 leading to blood-brain barrier disruption, triggering
neuroinflammation and POD-like behavior in aged mice. Int
Immunopharmacol. 135:1122902024. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Hu X, Liu L, Da X, Zhu S, Wang J, Shan M,
Liu Y, He Z and Xu G: Anesthesia/surgery leads to blood-brain
barrier disruption via the transcellular and paracellular pathways,
and postoperative delirium-like behavior: A comparative study in
mice of different ages. Exp Neurol. 383:1150442025. View Article : Google Scholar
|
|
46
|
Rodrigues AJ, Marmerstein JT, Kotamraju
BP, McCallum GA and Durand DM: Effect of anesthesia and diurnal
variation on chronic vagus nerve activity in rats. J Neurosci Res.
103:e700452025. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Baek MS, Kim S, Kim WY, Kweon MN and Huh
JW: Gut microbiota alterations in critically Ill patients with
carbapenem-resistant Enterobacteriaceae colonization: A clinical
analysis. Front Microbiol. 14:11404022023. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Hajjar R, Oliero M, Cuisiniere T, Fragoso
G, Calvé A, Djediai S, Annabi B, Richard CS and Santos MM:
Improvement of colonic healing and surgical recovery with
perioperative supplementation of inulin and
galacto-oligosaccharides. Clin Nutr. 40:3842–3851. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Xu X, Wang K, Cao X, Li Z, Zhou Y, Ren J
and Liu F: Gut microbial metabolite short-chain fatt acids
partially reverse surgery and anesthesia-induced behavior deficits
in C57BL/6J mice. Front Neurosci. 15:6646412021. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Luo A, Li S, Wang X, Xie Z, Li S and Hua
D: Cefazolin improves anesthesia and surgery-induced cognitive
impairments by modulating blood-brain barrier function, gut
bacteria and short chain fatty acids. Front Aging Neurosci.
13:7486372021. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Liu T, Wang C, Wang YY, Wang LL, Ojo O,
Feng QQ, Jiang XS and Wang XH: Effect of dietary fiber on gut
barrier function, gut microbiota, short-chain fatty acids,
inflammation, and clinical outcomes in critically ill patients: A
systematic review and meta-analysis. JPEN J Parenter Enteral Nutr.
46:997–1010. 2022. View Article : Google Scholar
|
|
52
|
Liu X, Cui J, Tan X, Yu Y, Niu J and Wang
Q: Short-chain fatty acids alleviate perioperative neurocognitive
disorders through BDNF/PI3K/Akt pathway in middle-aged rats. Mol
Neurobiol. 62:11544–11559. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Huang ZB, Hu Z, Lu CX, Luo SD, Chen Y,
Zhou ZP, Hu JJ, Zhang FL, Deng F and Liu KX: Gut microbiota-derived
indole 3-propionic acid partially activates aryl hydrocarbon
receptor to promote macrophage phagocytosis and attenuate septic
injury. Front Cell Infect Microbiol. 12:10153862022. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Kuo SZ, Dettmer K, Annavajhala MK, Chong
DH, Uhlemann AC, Abrams JA, Oefner PJ and Freedberg DE:
Associations between urinary 3-indoxyl sulfate, a gut
microbiome-derived biomarker, and patient outcomes after intensive
care unit admission. J Crit Care. 63:15–21. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Hu L, Bai Y, Lai C, Mo L, Li Y, Jiang X,
Xu W, He Y, Zhou X and Chen C: Plasma indole-3-aldehyde as a novel
biomarker of acute kidney injury after cardiac surgery: A
reanalysis using prospective metabolomic data. BMC Anesthesiol.
23:3642023. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Han S, Zheng H, Han F, Zhang X, Zhang G,
Ma S, Liu K, Qin W and Wu G: Lactobacillus johnsonii 6084
alleviated sepsis-induced organ injury by modulating gut
microbiota. Food Sci Nutr. 10:3931–3941. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Fang H, Fang M, Wang Y, Zhang H, Li J,
Chen J, Wu Q, He L, Xu J, Deng J, et al: Indole-3-propionic acid as
a potential therapeutic agent for sepsis-induced gut microbiota
disturbance. Microbiol Spectr. 10:e00125222022. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Fang H, Wang Y, Deng J, Zhang H, Wu Q, He
L, Xu J, Shao X, Ouyang X, He Z, et al: Sepsis-induced gut
dysbiosis mediates the susceptibility to sepsis-associated
encephalopathy in mice. mSystems. 7:e01399212022. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Kean IRL, Wagner J, Wijeyesekera A, De
Goffau M, Thurston S, Clark JA, White DK, Ridout J, Agrawal S,
Kayani R, et al: Profiling gut microbiota and bile acid metabolism
in critically ill children. Sci Rep. 12:104322022. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Hou L, Wang H, Yan M, Cai Y, Zheng R, Ma
Y, Tang W and Jiang W: Obeticholic acid attenuates the intestinal
barrier disruption in a rat model of short bowel syndrome. Biochim
Biophys Acta Mol Basis Dis. 1870:1672212024. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Du L and Jiang W, Zhu X, Zhu L, Fan Y and
Jiang W: Rifaximin alleviates intestinal barrier disruption and
systemic inflammation via the PXR/NFκB/MLCK pathway and modulates
intestinal Lachnospiraceae abundance in heat-stroke mice. Int
Immunopharmacol. 143(Pt 2): 1134622024. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Gong S, Yan Z, Liu Z, Niu M, Fang H, Li N,
Huang C, Li L, Chen G, Luo H, et al: Intestinal microbiota mediates
the susceptibility to polymicrobial sepsis-induced liver injury by
granisetron generation in mice. Hepatology. 69:1751–1767. 2019.
View Article : Google Scholar
|
|
63
|
Zhang H, Xu J, Wu Q, Fang H, Shao X,
Ouyang X, He Z, Deng Y and Chen C: Gut microbiota mediates the
susceptibility of mice to sepsis-associated encephalopathy by
butyric acid. J Inflamm Res. 15:2103–2119. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Kim SM, DeFazio JR, Hyoju SK, Sangani K,
Keskey R, Krezalek MA, Khodarev NN, Sangwan N, Christley S, Harris
KG, et al: Fecal microbiota transplant rescues mice from human
pathogen mediated sepsis by restoring systemic immunity. Nat
Commun. 11:23542020. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Zhang Y, Xie B, Chen X, Zhang J and Yuan
S: A key role of gut microbiota-vagus nerve/spleen axis in sleep
deprivation-mediated aggravation of systemic inflammation after LPS
administration. Life Sci. 265:1187362021. View Article : Google Scholar
|
|
66
|
Jiang XL, Gu XY, Zhou XX, Chen XM, Zhang
X, Yang YT, Qin Y, Shen L, Yu WF and Su DS: Intestinal
dysbacteriosis mediates the reference memory deficit induced by
anaesthesia/surgery in aged mice. Brain Behav Immun. 80:605–615.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Wang LK, Yang XD, Zhou D, Cheng T, Zhang X
and Wu HY: Prenatal isoflurane exposure induces developmental
neurotoxicity in rats: the role of gut microbiota. Neurotox Res.
40:485–497. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Serbanescu M, Lee S, Li F, Boppana SH,
Elebasy M, White JR and Mintz CD: Effects of perioperative exposure
on the microbiome and outcomes from an immune challenge in C57Bl/6
adult mice. Anesth Analg. 142:171–180. 2026. View Article : Google Scholar
|
|
69
|
Zhou X, Xu X, Lu D, Chen K, Wu Y, Yang X,
Xiong W, Chen X, Lan L, Li W, et al: Repeated early-life exposure
to anaesthesia and surgery causes subsequent anxiety-like behaviour
and gut microbiota dysbiosis in juvenile rats. Br J Anaesth.
130:191–201. 2023. View Article : Google Scholar
|
|
70
|
Alberda C, Marcushamer S, Hewer T,
Journault N and Kutsogiannis D: Feasibility of a lactobacillus
casei drink in the intensive care unit for prevention of antibiotic
associated diarrhea and clostridium difficile. Nutrients.
10:5392018. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Johani K, Abualsaud D, Costa DM, Hu H,
Whiteley G, Deva A and Vickery K: Characterization of microbial
community composition, antimicrobial resistance and biofilm on
intensive care surfaces. J Infect Public Health. 11:418–424. 2018.
View Article : Google Scholar
|
|
72
|
Kang M, Mischel RA, Bhave S, Komla E, Cho
A, Huang C, Dewey WL and Akbarali HI: The effect of gut microbiome
on tolerance to morphine mediated antinociception in mice. Sci Rep.
7:426582017. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Zhang L, Meng J, Ban Y, Jalodia R,
Chupikova I, Fernandez I, Brito N, Sharma U, Abreu MT, Ramakrishnan
S and Roy S: Morphine tolerance is attenuated in germfree mice and
reversed by probiotics, implicating the role of gut microbiome.
Proc Natl Acad Sci USA. 116:13523–13532. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Thomas KR, Watt J, Wu CMJ, Akinrinoye A,
Amjad S, Colvin L, Cowe R, Duncan SH, Russell WR and Forget P: Pain
and opioid-induced gut microbial dysbiosis. Biomedicines.
10:18152022. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Hofford RS, Meckel KR, Wiser EJ, Wang W,
Sens JP, Kim M, Godino A, Lam TT and Kiraly DD: Microbiome
depletion increases fentanyl self-administration and alters the
striatal proteome through short-chain fatty acids. eNeuro.
11:ENEURO.0388-23.20232024. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Lankelma JM, van Vught LA, Belzer C,
Schultz MJ, van der Poll T, de Vos WM and Wiersinga WJ: Critically
ill patients demonstrate large interpersonal variation in
intestinal microbiota dysregulation: A pilot study. Intensive Care
Med. 43:59–68. 2017. View Article : Google Scholar
|
|
77
|
Tranberg A, Thorarinsdottir HR, Holmberg
A, Schött U and Klarin B: Proton pump inhibitor medication is
associated with colonisation of gut flora in the oropharynx. Acta
Anaesthesiol Scand. 62:791–800. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Chen C, Liang H, He M, Duan R, Guan Y,
Wang F and Duan L: Impact of short-term proton pump inhibitors vs.
histamine-2 receptor antagonists on gut microbiota in patients with
acute coronary syndrome: A multicenter randomized trial. Chin Med J
(Engl). 138:542–552. 2025. View Article : Google Scholar
|
|
79
|
Yao B, Liu JY, Liu Y, Song XX, Wang SB,
Liu N, Dong ZH, Yuan ZY, Han XN and Xing JY: Sequential versus
continuous feeding and its effect on the gut microbiota in
critically ill patients: A randomized controlled trial. Clin Nutr
ESPEN. 66:245–254. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Martindale RG and Warren M: Should enteral
nutrition be started in the first week of critical illness? Curr
Opin Clin Nutr Metab Care. 18:202–206. 2015.PubMed/NCBI
|
|
81
|
Patel JJ, Rice T and Heyland DK: Safety
and outcomes of early enteral nutrition in circulatory shock. JPEN
J Parenter Enteral Nutr. 44:779–784. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Green CH, Busch RA and Patel JJ: Fiber in
the ICU: Should it be a regular part of feeding? Curr Gastroenterol
Rep. 23:142021. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Xu R, Tan C, Zhu J, Zeng X, Gao X, Wu Q,
Chen Q, Wang H, Zhou H, He Y, et al: Dysbiosis of the intestinal
microbiota in neurocritically ill patients and the risk for death.
Crit Care. 23:1952019. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Trøseid M, Holter JC, Holm K, Vestad B,
Sazonova T, Granerud BK, Dyrhol-Riise AM, Holten AR, Tonby K,
Kildal AB, et al: Gut microbiota composition during hospitalization
is associated with 60-day mortality after severe COVID-19. Crit
Care. 27:692023. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Ren M and Lotfipour S: Antibiotic
knockdown of gut bacteria sex-dependently enhances intravenous
fentanyl self-administration in adult sprague dawley rats. Int J
Mol Sci. 24:4092022. View Article : Google Scholar
|
|
86
|
Bauer M: The liver-gut-axis: Initiator and
responder to sepsis. Curr Opin Crit Care. 28:216–220.
2022.PubMed/NCBI
|
|
87
|
Ferlini L, Maenhout C, Crippa IA,
Quispe-Cornejo AA, Creteur J, Taccone FS and Gaspard N: The
association between the presence and burden of periodic discharges
and outcome in septic patients: an observational prospective study.
Crit Care. 27:1792023. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Loe ME, Khanmohammadi S, Morrissey MJ,
Landre R, Tomko SR, Guerriero RM and Ching S: Resolving and
characterizing the incidence of millihertz EEG modulation in
critically ill children. Clin Neurophysiol. 137:84–91. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Ferlini L, Nonclercq A, Su F, Creteur J,
Taccone FS and Gaspard N: Sepsis modulates cortical excitability
and alters the local and systemic hemodynamic response to seizures.
Sci Rep. 12:113362022. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Fong MWK, Norris S, Percy J, Hirsch LJ and
Herlopian A: Hemisphere-dependent ictal tachycardia versus ictal
bradycardia in a critically Ill patient. J Clin Neurophysiol.
39:e15–e18. 2022. View Article : Google Scholar
|
|
91
|
Gofton TE, Norton L, Laforge G, Gibson R,
Debicki D, Althenayan E, Scales N, Beinum AV, Hornby L, Shemie S,
et al: Cerebral cortical activity after withdrawal of
life-sustaining measures in critically ill patients. Am J
Transplant. 22:3120–3129. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Lutz R, Müller C, Dragovic S, Schneider F,
Ribbe K, Anders M, Schmid S, García PS, Schneider G, Kreuzer M and
Kratzer S: The absence of dominant alpha-oscillatory EEG activity
during emergence from delta-dominant anesthesia predicts
neurocognitive impairment-results from a prospective observational
trial. J Clin Anesth. 82:1109492022. View Article : Google Scholar
|
|
93
|
Chen Q, Liang X, Wu T, Jiang J, Jiang Y,
Zhang S, Ruan Y, Zhang H, Zhang C, Chen P, et al: Integrative
analysis of metabolomics and proteomics reveals amino acid
metabolism disorder in sepsis. J Transl Med. 20:1232022. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Cooter Wright M, Bunning T, Eleswarpu SS,
Heflin MT, McDonald SR, Lagoo-Deenadalayan S, Whitson HE,
Martinez-Camblor P, Deiner SG and Berger M: A processed
electroencephalogram-based brain anesthetic resistance index is
associated with postoperative delirium in older adults: A dual
center study. Anesth Analg. 134:149–158. 2022. View Article : Google Scholar
|
|
95
|
Pu Y, Qian F, Guo J, Sha Y and Qian Y:
Selegiline protects against lipopolysaccharide (LPS)-Induced
impairment of the blood-brain barrier through regulating the
NF-κB/MLCK/p-MLC signaling pathway. Neurotox Res. 40:267–275. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
96
|
David-Bercholz J, Acker L, Caceres AI, Wu
PY, Goenka S, Franklin NO, Rodriguiz RM, Wetsel WC, Devinney M,
Wright MC, et al: Conserved YKL-40 changes in mice and humans after
postoperative delirium. Brain Behav Immun Health. 26:1005552022.
View Article : Google Scholar : PubMed/NCBI
|
|
97
|
de Araújo BES, da Silva Fontana R, de
Magalhães-Barbosa MC, Lima-Setta F, Paravidino VB, Riveiro PM,
Pulcheri LB, Dos Santos Salú M, Genuíno-Oliveira MB, Robaina JR, et
al: Clinical features, electroencephalogram, and biomarkers in
pediatric sepsis-associated encephalopathy. Sci Rep. 12:106732022.
View Article : Google Scholar : PubMed/NCBI
|
|
98
|
de Montmollin E, Dupuis C, Jaquet P,
Sarton B, Sazio C, Susset V, Conrad M, Argaud L, Demeret S, Tadié
JM, et al: Herpes simplex virus encephalitis with initial negative
polymerase chain reaction in the cerebrospinal fluid: Prevalence,
associated factors, and clinical impact. Crit Care Med.
50:e643–e648. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Dhawan R: EEG in cardiac surgery-moving
past the obvious. J Cardiothorac Vasc Anesth. 36:3526–3528. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Ding H, Li Y, Chen S, Wen Y, Zhang S, Luo
E, Li X, Zhong W and Zeng H: Fisetin ameliorates cognitive
impairment by activating mitophagy and suppressing
neuroinflammation in rats with sepsis-associated encephalopathy.
CNS Neurosci Ther. 28:247–258. 2022. View Article : Google Scholar
|
|
101
|
Ditzel FL, Hut SC, Dijkstra-Kersten SM,
Numan T, Leijten FS, van den Boogaard M and Slooter AJ: An
automated electroencephalography algorithm to detect polymorphic
delta activity in acute encephalopathy presenting as postoperative
delirium. Psychiatry Clin Neurosci. 76:676–678. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Orobtsova M, Gorelik S, Belousova O,
Avdeeva I and Krupenkina L: Prevention of cognitive frailty in
patients of older age groups after open-heart surgery under
cardiopulmonary bypass. Arch Razi Inst. 77:1113–1123. 2022.
|
|
103
|
Pan S, Lv Z, Wang R, Shu H, Yuan S, Yu Y
and Shang Y: Sepsis-induced brain dysfunction: Pathogenesis,
diagnosis, and treatment. Oxid Med Cell Longev. 2022:13287292022.
View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Persson NDA, Uusalo P, Nedergaard M,
Lohela TJ and Lilius TO: Could dexmedetomidine be repurposed as a
glymphatic enhancer? Trends Pharmacol Sci. 43:1030–1040. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Corriero A, Gadaleta RM, Puntillo F,
Inchingolo F, Moschetta A and Brienza N: The central role of the
gut in intensive care. Crit Care. 26:3792022. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Mullish BH, Innes AJ, Roberts LA,
Anim-Burton S, Webber L, Johnson NA, Ghani R, Farshi P, Khan AB,
Kinsella F, et al: Intestinal microbiota transplant prior to
allogeneic stem cell transplant (MAST) trial: Study protocol for a
multicentre, double-blinded, placebo-controlled, phase IIa trial.
BMJ Open. 14:e0931202024. View Article : Google Scholar
|
|
107
|
Ma Y, Zhao M, Zhang C, Hao X, Yu S, Kong
Q, Liu S, Fu Y and Liu Y: A bifunctional inhibitor CYT-1
synergistically suppresses pyroptosis to improve cognitive
dysfunction in diabetic encephalopathy. Int Immunopharmacol.
162:1151272025. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Zhang LM, Xin Y, Wu ZY, Song RX, Miao HT,
Zheng WC, Li Y, Zhang DX and Zhao XC: STING mediates
neuroinflammatory response by activating NLRP3-related pyroptosis
in severe traumatic brain injury. J Neurochem. 162:444–462. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Zanza C, Romenskaya T, Thangathurai D,
Ojetti V, Saviano A, Abenavoli L, Robba C, Cammarota G, Franceschi
F, Piccioni A and Longhitano Y: Microbiome in critical care: An
unconventional and unknown ally. Curr Med Chem. 29:3179–3188. 2022.
View Article : Google Scholar
|
|
110
|
Li C, Liu L, Gao Z, Zhang J, Chen H, Ma S,
Liu A, Mo M, Wu C, Chen D, et al: Synbiotic therapy prevents
nosocomial infection in critically Ill adult patients: A systematic
review and network meta-analysis of randomized controlled trials
based on a bayesian framework. Front Med (Lausanne). 8:6931882021.
View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Sharif S, Greer A, Skorupski C, Hao Q,
Johnstone J, Dionne JC, Lau V, Manzanares W, Eltorki M, Duan E, et
al: Probiotics in critical Illness: A systematic review and
meta-analysis of randomized controlled trials. Crit Care Med.
50:1175–1186. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Lee ZY, Lew CCH, Ortiz-Reyes A, Patel JJ,
Wong YJ, Loh CTI, Martindale RG and Heyland DK: Benefits and harm
of probiotics and synbiotics in adult critically ill patients. A
systematic review and meta-analysis of randomized controlled trials
with trial sequential analysis. Clin Nutr. 42:519–531. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Innes AJ, Mullish BH, Ghani R, Szydlo RM,
Apperley JF, Olavarria E, Palanicawandar R, Kanfer EJ, Milojkovic
D, McDonald JAK, et al: Fecal microbiota transplant mitigates
adverse outcomes seen in patients colonized with
multidrug-resistant organisms undergoing allogeneic hematopoietic
cell transplantation. Front Cell Infect Microbiol. 11:6846592021.
View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Cibulková I, Řehořová V, Hajer J and Duška
F: Fecal microbial transplantation in critically Ill
patients-structured review and perspectives. Biomolecules.
11:14592021. View Article : Google Scholar : PubMed/NCBI
|
|
115
|
He W, Jiang M, Mao P and Yan F: TLR4
inhibition ameliorates mesencephalic substantia nigra injury in
neonatal rats exposed to lipopolysaccharide via regulation of
neuro-immunity. Brain Res Bull. 165:90–96. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Ren Y, Wang Q, Yang Z, Feng L and Zhang Y:
MCC950 ameliorates the dementia symptom at the early age of line
M83 mouse and reduces hippocampal α-synuclein accumulation. Biochem
Biophys Res Commun. 611:23–30. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Cao Y, Wang Y, Li X, Yang X, Zeng B and
Guo Z: MCC950 ameliorates cognitive function by reducing white
matter microstructure damage in rats after SAH. Brain Res Bull.
202:1107432023. View Article : Google Scholar : PubMed/NCBI
|
|
118
|
Darbandi A, Banar M, Koupaei M, Afifirad
R, Asadollahi P, Bafandeh E, Rasooli I, Emamie A, Navidifar T and
Owlia P: Clinical efficacy of probiotics in prevention of
infectious diseases among hospitalized patients in ICU and non-ICU
wards in clinical randomized trials: A systematic review. Health
Sci Rep. 6:e14692023. View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Ward JA, Yerke J, Lumpkin M, Kapoor A,
Lindenmeyer CC and Bass S: Evaluation of a protocol for rifaximin
discontinuation in critically ill patients with liver disease
receiving broad-spectrum antibiotic therapy. World J Hepatol.
15:1226–1236. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Sohail A, Cheema HA, Mithani MS, Shahid A,
Nawaz A, Hermis AH, Chinnam S, Nashwan AJ, Cherrez-Ojeda I, Awan RU
and Ahmad S: Probiotics for the prevention and treatment of
COVID-19: A rapid systematic review and meta-analysis. Front Nutr.
10:12741222023. View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Chamani A, Mashhadi F, Khademi G, Nematy
M, Emadzadeh M, Sezavar M and Roudi F: Investigating the effect of
synbiotic supplementation on inflammatory indices in critically ill
septic children: A protocol study for randomized control trial.
Trials. 25:7122024. View Article : Google Scholar : PubMed/NCBI
|
|
122
|
McClave SA, Omer E, Eisa M, Klosterbauer
A, Lowen CC and Martindale RG: The importance of providing dietary
fiber in medical and surgical critical care. Nutr Clin Pract.
39:546–556. 2024. View Article : Google Scholar
|
|
123
|
Ren Y, Wu K, He Y, Zhang H, Ma J, Li C,
Ruan Y, Zhang J, Wen Y, Wu X, et al: The role of NLRP3
inflammasome-mediated neuroinflammation in chronic noise-induced
impairment of learning and memory ability. Ecotoxicol Environ Saf.
286:1171832024. View Article : Google Scholar : PubMed/NCBI
|
|
124
|
Naves PVF and Caboclo LO: Independent risk
factors for seizures in critically ill patients on continuous EEG.
Epileptic Disord. 24:287–294. 2022. View Article : Google Scholar
|
|
125
|
van Sleuwen M, Sun H, Eckhardt C,
Neelagiri A, Tesh RA, Westmeijer M, Paixao L, Rajan S, Velpula
Krishnamurthy P, Sikka P, et al: Physiological assessment of
delirium severity: The electroencephalographic confusion assessment
method severity score (E-CAM-S). Crit Care Med. 50:e11–e19. 2022.
View Article : Google Scholar
|
|
126
|
Williams Roberson S, Azeez NA, Fulton JN,
Zhang KC, Lee AXT, Ye F, Pandharipande P, Brummel NE, Patel NB and
Ely EW: Quantitative EEG signatures of delirium and coma in
mechanically ventilated ICU patients. Clin Neurophysiol. 146:40–48.
2023. View Article : Google Scholar
|
|
127
|
Acker L, Wong MK, Wright MC, Reese M,
Giattino CM, Roberts KC, Au S, Colon-Emeric C, Lipsitz LA, Devinney
MJ, et al: Preoperative electroencephalographic alpha-power changes
with eyes opening are associated with postoperative attention
impairment and inattention-related delirium severity. Br J Anaesth.
132:154–163. 2024. View Article : Google Scholar
|
|
128
|
Reese M, Wright MC, Roberts KC, Browndyke
JN, Bennett M, Acker L, Devinney MJ, Reekes TH, Waligorska T, Shaw
LM, et al: Associations between anaesthetic dose-adjusted
intraoperative EEG alpha power, processing speed, and postoperative
delirium: analysis of data from three prospective studies. Br J
Anaesth. 135:109–120. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
129
|
Park SK, Han DW, Chang CH, Jung H, Kang H
and Song Y: Association between intraoperative electroencephalogram
burst suppression and postoperative delirium: A systematic review
and meta-analysis. Anesthesiology. 142:107–120. 2025. View Article : Google Scholar
|
|
130
|
Fang PP, Shang ZX, Xu J, Hu J, Zhang SC,
Fan YG, Lu Y, Liu XS and Maze M: Contribution of intraoperative
electroencephalogram suppression to frailty-associated
postoperative delirium: Mediation analysis of a prospective
surgical cohort. Br J Anaesth. 130:e263–e271. 2023. View Article : Google Scholar
|
|
131
|
Baron Shahaf D and Shahaf G:
Intraoperative EEG-based monitors: Are we looking under the
lamppost? Curr Opin Anaesthesiol. 37:177–183. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
132
|
Gao X, Lin C, Feng Y, You Y, Jin Z, Li M,
Zhou Y and Chen K: Akkermansia muciniphila-derived small
extracellular vesicles attenuate intestinal
ischemia-reperfusion-induced postoperative cognitive dysfunction by
suppressing microglia activation via the TLR2/4 signaling. Biochim
Biophys Acta Mol Cell Res. 1871:1196302024. View Article : Google Scholar
|
|
133
|
Battaglini D, Premraj L, Huth S, Fanning
J, Whitman G, Arora RC, Bellapart J, Bastos Porto J, Taccone FS,
Suen JY, et al: The use of noninvasive multimodal neuromonitoring
in adult critically Ill patients with COVID-19 infection. J
Neurosurg Anesthesiol. 35:423–428. 2023. View Article : Google Scholar
|
|
134
|
Eshraghi R, Yazdani MS, Bahrami A,
Amani-Beni R, Darouei B, Mokhtari M and Hashemian SM: Advanced
neuromonitoring techniques for medical and neurological ICU
patients. Brain Res Bull. 230:1115132025. View Article : Google Scholar : PubMed/NCBI
|
|
135
|
Liu LF, Hu Y, Liu YN, Shi DW, Liu C, Da X,
Zhu SH, Zhu QY, Zhang JQ and Xu GH: Reactive oxygen species
contribute to delirium-like behavior by activating CypA/MMP9
signaling and inducing blood-brain barrier impairment in aged mice
following anesthesia and surgery. Front Aging Neurosci.
14:10211292022. View Article : Google Scholar : PubMed/NCBI
|
|
136
|
Zhong L, Ren X, Ai Y and Liu Z: SS-31
improves cognitive function in sepsis-associated encephalopathy by
inhibiting the Drp1-NLRP3 inflammasome activation. Neuromolecular
Med. 25:230–241. 2023. View Article : Google Scholar
|
|
137
|
Watne LO, Pollmann CT, Neerland BE,
Quist-Paulsen E, Halaas NB, Idland AV, Hassel B, Henjum K, Knapskog
AB, Frihagen F, et al: Cerebrospinal fluid quinolinic acid is
strongly associated with delirium and mortality in hip-fracture
patients. J Clin Invest. 133:e1634722023. View Article : Google Scholar
|
|
138
|
Deschamps A, Ben Abdallah A, Jacobsohn E,
Saha T, Djaiani G, El-Gabalawy R, Overbeek C, Palermo J, Courbe A,
Cloutier I, et al: Electroencephalography-guided anesthesia and
delirium in older adults after cardiac surgery: The ENGAGES-Canada
Randomized clinical trial. JAMA. 332:112–123. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
139
|
Silva BM, Alves E, Gomes AD, Marcolin
Miranda L, Albuquerque LG, Defante MLR, Miranda NCD, De Lima PEC
and Damião VP: Impact of electroencephalography-guided anesthesia
in cardiothoracic surgery: A systematic review and updated
meta-analysis of randomized controlled trials. J Cardiothorac Vasc
Anesth. 39:3154–3162. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
140
|
Filipiak W, Włodarski R, Żuchowska K,
Tracewska A, Winiarek M, Daszkiewicz D, Marszałek M, Depka D and
Bogiel T: Analysis of bacterial metabolites in breath gas of
critically Ill patients for diagnosis of ventilator-associated
pneumonia-A proof of concept study. Biomolecules. 14:14802024.
View Article : Google Scholar
|
|
141
|
Li F, Jiang L, Pan S, Jiang S, Fan Y,
Jiang C, Gao C and Leng Y: Multi-omic profiling reveals that
intra-abdominal-hypertension-induced intestinal damage can be
prevented by microbiome and metabolic modulations with
5-hydroxyindoleacetic acid as a diagnostic marker. mSystems.
7:e01204212022. View Article : Google Scholar : PubMed/NCBI
|
|
142
|
Wu X, He T, He F and Liu L: Is
postoperative cognitive dysfunction a disease of microglial
inflammatory memory? A state-transition model from metabolic stress
to epigenetic lock-in. Front Mol Neurosci. 18:16481612025.
View Article : Google Scholar : PubMed/NCBI
|
|
143
|
Lin QC, Wang J, Wang XL, Pan C, Jin SW,
Char S, Tao YX, Cao X and Li J: Hippocampal HDAC6 promotes POCD by
regulating NLRP3-induced microglia pyroptosis via HSP90/HSP70 in
aged mice. Biochim Biophys Acta Mol Basis Dis. 1870:1671372024.
View Article : Google Scholar : PubMed/NCBI
|
|
144
|
Ditzel FL, Hut SCA, van den Boogaard M,
Boonstra M, Leijten FSS, Wils EJ, van Nesselrooij T, Kromkamp M,
Rood PJT, Röder C, et al: DeltaScan for the assessment of acute
encephalopathy and delirium in ICU and non-ICU patients, a
prospective cross-sectional multicenter validation study. Am J
Geriatr Psychiatry. 32:1093–1104. 2024. View Article : Google Scholar : PubMed/NCBI
|