|
1
|
Wang L, Yu W, Yin X, Cui L, Tang S, Jiang
N, Cui L, Zhao N, Lin Q, Chen L, et al: Prevalence of osteoporosis
and fracture in China: The China osteoporosis prevalence study.
JAMA Netw Open. 4:e21211062021. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Curtis EM, Moon RJ, Dennison EM, Harvey NC
and Cooper C: Recent advances in the pathogenesis and treatment of
osteoporosis. Clin Med (Lond). 16:360–364. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Rachner TD, Khosla S and Hofbauer LC:
Osteoporosis: Now and the future. Lancet. 377:1276–1287. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Ayers C, Kansagara D, Lazur B, Fu R, Kwon
A and Harrod C: Effectiveness and safety of treatments to prevent
fractures in people with low bone mass or primary osteoporosis: A
living systematic review and network meta-analysis for the american
college of physicians. Ann Intern Med. 176:182–195. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Stegen S and Carmeliet G: Metabolic
regulation of skeletal cell fate and function. Nat Rev Endocrinol.
20:399–413. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Zhang J, Hu W, Zou Z, Li Y, Kang F, Li J
and Dong S: The role of lipid metabolism in osteoporosis: Clinical
implication and cellular mechanism. Genes Dis. 11:1011222024.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Zou J, Chen H, Fan X, Qiu Z, Zhang J and
Sun J: Garcinol prevents oxidative stress-induced bone loss and
dysfunction of BMSCs through NRF2-antioxidant signaling. Cell Death
Discov. 10:822024. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Alves CH, Farrell E, Vis M, Colin EM and
Lubberts E: Animal models of bone loss in inflammatory arthritis:
From cytokines in the bench to novel treatments for bone loss in
the Bedside-a comprehensive review. Clin Rev Allergy Immunol.
51:27–47. 2016. View Article : Google Scholar :
|
|
9
|
Zhang W, Wu X, Li W, Zhang H, Wang Y, Xu
J, Li W, Qin Y, Wu Z, Ge G, et al: Pinosylvin inhibits inflammatory
and osteoclastogenesis via NLRP3 inflammasome. Adv Sci (Weinh).
12:e015322025. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Costa AG, Cusano NE, Silva BC, Cremers S
and Bilezikian JP: Cathepsin K: Its skeletal actions and role as a
therapeutic target in osteoporosis. Nat Rev Rheumatol. 7:447–456.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Veis DJ and O'Brien CA: Osteoclasts,
master sculptors of bone. Annu Rev Pathol. 18:257–281. 2023.
View Article : Google Scholar
|
|
12
|
Riegger J, Schoppa A, Ruths L,
Haffner-Luntzer M and Ignatius A: Oxidative stress as a key
modulator of cell fate decision in osteoarthritis and osteoporosis:
A narrative review. Cell Mol Biol Lett. 28:762023. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Iantomasi T, Romagnoli C, Palmini G,
Donati S, Falsetti I, Miglietta F, Aurilia C, Marini F, Giusti F
and Brandi M: Oxidative stress and inflammation in osteoporosis:
Molecular mechanisms involved and the relationship with microRNAs.
Int J Mol Sci. 24:37722023. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Akune T, Ohba S, Kamekura S, Yamaguchi M,
Chung UI, Kubota N, Terauchi Y, Harada Y, Azuma Y, Nakamura K, et
al: PPARgamma insufficiency enhances osteogenesis through
osteoblast formation from bone marrow progenitors. J Clin Invest.
113:846–855. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Ahmadian M, Suh JM, Hah N, Liddle C,
Atkins AR, Downes M and Evans RM: PPARgamma signaling and
metabolism: The good, the bad and the future. Nat Med. 19:557–566.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Tsai YS and Maeda N: PPARgamma: A critical
determinant of body fat distribution in humans and mice. Trends
Cardiovasc Med. 15:81–85. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Tontonoz P and Spiegelman BM: Fat and
beyond: The diverse biology of PPARgamma. Annu Rev Biochem.
77:289–312. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Liu C, Xiong Q, Li Q, Lin W, Jiang S,
Zhang D, Wang Y, Duan X, Gong P and Kang N: CHD7 regulates bone-fat
balance by suppressing PPAR-gamma signaling. Nat Commun.
13:19892022. View Article : Google Scholar
|
|
19
|
Zhang YW, Song PR, Wang SC, Liu H, Shi ZM
and Su JC: Diets intervene osteoporosis via gut-bone axis. Gut
Microbes. 16:22954322024. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Zhang YW, Wu Y, Liu XF, Chen X and Su JC:
Targeting the gut microbiota-related metabolites for osteoporosis:
The inextricable connection of gut-bone axis. Ageing Res Rev.
94:1021962024. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Al Saedi A, Sharma S, Summers MA, Nurgali
K and Duque G: The multiple faces of tryptophan in bone biology.
Exp Gerontol. 129:1107782020. View Article : Google Scholar
|
|
22
|
Xiang T, Yang C, Xie L, Xiao S, Tang Y,
Huang G, Sun D, Chen Y and Luo F: Aberrant tryptophan metabolism
manipulates osteochondral homeostasis. Research (Wash D C).
8:07282025.PubMed/NCBI
|
|
23
|
Miao H, Zhang SJ, Wu X, Li P and Zhao YY:
Tryptophan metabolism as a target in gut microbiota, ageing and
kidney disease. Int J Biol Sci. 21:4374–4387. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Chen Y, Yang C, Deng Z, Xiang T, Ni Q, Xu
J, Sun D and Luo F: Gut microbially produced tryptophan metabolite
melatonin ameliorates osteoporosis via modulating SCFA and TMAO
metabolism. J Pineal Res. 76:e129542024. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Su S and Tian L: Association between
dietary tryptophan intake and bone health: A cross-sectional study.
Calcif Tissue Int. 116:62024. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Xu H, Luo Y, An Y and Wu X: The mechanism
of action of indole-3-propionic acid on bone metabolism. Food
Funct. 16:406–421. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Kim CS, Jung S, Hwang GS and Shin DM: Gut
microbiota indole-3-propionic acid mediates neuroprotective effect
of probiotic consumption in healthy elderly: A randomized,
double-blind, placebo-controlled, multicenter trial and in vitro
study. Clin Nutr. 42:1025–1033. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Anaya JM, Bollag WB, Hamrick MW and Isales
CM: The role of tryptophan metabolites in musculoskeletal stem cell
aging. Int J Mol Sci. 21:66702020. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Li J, Zhang L, Wu T, Li Y, Zhou X and Ruan
Z: Indole-3-propionic acid improved the intestinal barrier by
enhancing epithelial barrier and mucus barrier. J Agric Food Chem.
69:1487–1495. 2021. View Article : Google Scholar
|
|
30
|
Zeng Y, Guo M, Wu Q, Tan X, Jiang C, Teng
F, Chen J, Zhang F, Ma X, Li X, et al: Gut microbiota-derived
indole-3-propionic acid alleviates diabetic kidney disease through
its mitochondrial protective effect via reducing ubiquitination
mediated-degradation of SIRT1. J Adv Res. 73:607–630. 2025.
View Article : Google Scholar :
|
|
31
|
Zhao ZH, Xin FZ, Xue Y, Hu Z, Han Y, Ma F,
Zhou D, Liu XL, Cui A, Liu Z, et al: Indole-3-propionic acid
inhibits gut dysbiosis and endotoxin leakage to attenuate
steatohepatitis in rats. Exp Mol Med. 51:1–14. 2019.
|
|
32
|
Wu R, Kong Y, Li J, Chen H, Jiao Y, Sun C
and Ju Y: Indole-3 propionate inhibits NF-kappaB/NLRP3-mediated
osteoclastogenesis and improves bone quality in high-fat-diet
induced obese mice. Biochim Biophys Acta Mol Basis Dis.
1871:1679522025. View Article : Google Scholar
|
|
33
|
Bai J, Si G, Wang R, Su S, Fan J, He X, Lv
Y, Gao S and Zhou F: Gut metabolite indoleacrylic acid suppresses
osteoclast formation by AHR mediated NF-κB signaling pathway. Int J
Biol Sci. 22:951–969. 2026. View Article : Google Scholar
|
|
34
|
Bai J, Han G, Fan J, Wang R, Su S, Sun A,
Hu D, Lv Y, Gao S and Zhou F: Gut microbial metabolite alleviates
osteoporosis by attenuating AKT-NFATc1 signaling pathway and ROS
production. Free Radic Biol Med. 243:351–366. 2026. View Article : Google Scholar
|
|
35
|
Peng R, Song C, Gou S, Liu H, Kang H, Dong
Y, Xu Y, Hu P, Cai K, Feng Q, et al: Gut Clostridium
sporogenes-derived indole propionic acid suppresses osteoclast
formation by activating pregnane X receptor. Pharmacol Res.
202:1071212024. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Chen C, Cao Z, Lei H, Zhang C, Wu M, Huang
S, Li X, Xie D, Liu M, Zhang L and Chen G: Microbial tryptophan
metabolites ameliorate Ovariectomy-induced bone loss by repairing
intestinal AhR-mediated gut-bone signaling pathway. Adv Sci
(Weinh). 11:e24045452024. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Bai J, Zhang W, Zhou C, Zhao G, Zhong H,
Hang K, Xu J, Zhang W, Chen E, Wu J, et al: MFG-E8 promotes
osteogenic differentiation of human bone marrow mesenchymal stem
cells through GSK3β/β-catenin signaling pathway. FASEB J.
37:e229502023. View Article : Google Scholar
|
|
38
|
Wu X, Wang K, Chen H, Cao B, Wang Y, Wang
Z, Dai C, Yao M, Ji X, Jiang X, et al: Hypoxia-induced
mitochondrial fission regulates the fate of bone marrow mesenchymal
stem cells by maintaining HIF1α stabilization. Free Radic Biol Med.
225:127–144. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Jurisic V, Srdic-Rajic T, Konjevic G,
Bogdanovic G and Colic M: TNF-α induced apoptosis is accompanied
with rapid CD30 and slower CD45 shedding from K-562 cells. J Membr
Biol. 239:115–122. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Liu Y, Yang X, Gan J, Chen S, Xiao ZX and
Cao Y: CB-Dock2: Improved protein-ligand blind docking by
integrating cavity detection, docking and homologous template
fitting. Nucleic Acids Res. 50:W159–W164. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Li D, Zhao Z, Zhu L, Feng H, Song J, Fu J,
Li J, Chen Z and Fu H: 7,8-DHF inhibits BMSC oxidative stress via
the TRKB/PI3K/AKT/NRF2 pathway to improve symptoms of
postmenopausal osteoporosis. Free Radic Biol Med. 223:413–429.
2024. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Chen M, Liang H, Wu M, Ge H, Ma Y, Shen Y,
Lu S, Shen C, Zhang H, Wang Z and Tang L: Fgf9 regulates bone
marrow mesenchymal stem cell fate and bone-fat balance in
osteoporosis by PI3K/AKT/Hippo and MEK/ERK signaling. Int J Biol
Sci. 20:3461–3479. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Yang L, Liu X, Chen S, Sun J, Tao Y, Ma L,
Zeng Y, Luo K, Tian R and Meng X: Scutellarin ameliorates
mitochondrial dysfunction and apoptosis in OGD/R-insulted HT22
cells through mitophagy induction. Biomed Pharmacother.
179:1173402024. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Zhao J, Bai X, Du J, Chen Y, Guo X, Zhang
J, Gan J, Wu P, Chen S, Zhang X, et al: Tryptophan metabolism: From
physiological functions to key roles and therapeutic targets in
cancer (Review). Oncol Rep. 54:862025. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Li Y, Jin D, Xie W, Wen L, Chen W, Xu J,
Ding J and Ren D: PPAR-γ and wnt regulate the differentiation of
MSCs into adipocytes and osteoblasts respectively. Curr Stem Cell
Res Ther. 13:185–192. 2018. View Article : Google Scholar
|
|
46
|
Kim K, Kim JH, Kim I, Seong S, Koh JT and
Kim N: Sestrin2 inhibits RANKL-induced osteoclastogenesis through
AMPK activation and ROS inhibition. Free Radic Biol Med. 211:77–88.
2024. View Article : Google Scholar
|
|
47
|
Ye W, Liao Y, Liu X, Wang Y, Li T, Zhao Y,
He Z, Chen J, Yin M, Sheng Y, et al: Dectin-2 depletion alleviates
osteoclast-induced bone loss in periodontitis via Syk/NOX2/ROS
signaling. Free Radic Biol Med. 229:13–29. 2025. View Article : Google Scholar : PubMed/NCBI
|