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Review Open Access

Advances in sirtuin research in lung diseases (Review)

  • Authors:
    • Shuangyun Xi
    • Weijun Chen
    • Xiuli Li
    • Yudan Wang
    • Yong Ke
  • View Affiliations / Copyright

    Affiliations: Center of Forensic Expertise, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563099, P.R. China
    Copyright: © Xi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 296
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    Published online on: August 25, 2026
       https://doi.org/10.3892/ijmm.2026.5967
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Abstract

Sirtuins, which comprise a family of NAD+-dependent deacetylases, have emerged as critical regulators in the pathogenesis of pulmonary diseases because of their pleiotropic roles in oxidative stress, metabolic homeostasis and inflammation. Growing evidence indicates that sirtuins modulate key cellular processes, including mitochondrial function, cell survival and death pathways, via protein deacetylation, thereby influencing disease progression in chronic obstructive pulmonary disease, pulmonary fibrosis and lung cancer. Notably, dysregulated sirtuin expression and activity are implicated in various lung pathologies, highlighting their dual potential as diagnostic biomarkers and therapeutic targets. The present review synthesized recent advances in sirtuin research, focusing on molecular mechanisms and translational applications, to provide a foundation for developing novel strategies for lung disease prevention and treatment. A comprehensive literature review of the relationship between sirtuins and lung‑related diseases was conducted. Literature published in PubMed and Web of Science up to May 2025 was searched using the keywords ‘sirtuin,’ ‘SIRTs,’ ‘lung disease,’ and ‘pulmonary disease.’
View Figures

Figure 1

Comprehensive regulatory network of
sirtuins in pulmonary pathophysiology. SIRT1-SIRT7, Sirtuin
1-Sirtuin 7; AMPK, AMP-activated protein kinase; NF-κB, Nuclear
factor-kappa B; HIF-1α, Hypoxia-inducible factor-1α; AP-1,
Activator protein-1; FOXO3a, Forkhead box O3a; PGC-1α, Peroxisome
proliferator-activated receptor γ coactivator-1α; NLRP3, NOD-like
receptor family pyrin domain-containing 3; GLS1, Glutaminase 1;
TGF-β, Transforming growth factor-β; Smad2/3, Mothers against
decapentaplegic homolog 2/3; p53, Tumor protein p53; PI3K,
Phosphatidylinositol 3-kinase; AKT, Protein kinase B; mTOR,
Mammalian target of rapamycin; ACE2, Angiotensin-converting enzyme
2; STAT3, Signal transducer and activator of transcription 3; PIM1,
Proviral integration site for Moloney murine leukemia virus 1;
LIRI, Lung ischemia-reperfusion injury; COPD, Chronic obstructive
pulmonary disease.
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Copy and paste a formatted citation
Spandidos Publications style
Xi S, Chen W, Li X, Wang Y and Ke Y: Advances in sirtuin research in lung diseases (Review). Int J Mol Med 58: 296, 2026.
APA
Xi, S., Chen, W., Li, X., Wang, Y., & Ke, Y. (2026). Advances in sirtuin research in lung diseases (Review). International Journal of Molecular Medicine, 58, 296. https://doi.org/10.3892/ijmm.2026.5967
MLA
Xi, S., Chen, W., Li, X., Wang, Y., Ke, Y."Advances in sirtuin research in lung diseases (Review)". International Journal of Molecular Medicine 58.5 (2026): 296.
Chicago
Xi, S., Chen, W., Li, X., Wang, Y., Ke, Y."Advances in sirtuin research in lung diseases (Review)". International Journal of Molecular Medicine 58, no. 5 (2026): 296. https://doi.org/10.3892/ijmm.2026.5967
Copy and paste a formatted citation
x
Spandidos Publications style
Xi S, Chen W, Li X, Wang Y and Ke Y: Advances in sirtuin research in lung diseases (Review). Int J Mol Med 58: 296, 2026.
APA
Xi, S., Chen, W., Li, X., Wang, Y., & Ke, Y. (2026). Advances in sirtuin research in lung diseases (Review). International Journal of Molecular Medicine, 58, 296. https://doi.org/10.3892/ijmm.2026.5967
MLA
Xi, S., Chen, W., Li, X., Wang, Y., Ke, Y."Advances in sirtuin research in lung diseases (Review)". International Journal of Molecular Medicine 58.5 (2026): 296.
Chicago
Xi, S., Chen, W., Li, X., Wang, Y., Ke, Y."Advances in sirtuin research in lung diseases (Review)". International Journal of Molecular Medicine 58, no. 5 (2026): 296. https://doi.org/10.3892/ijmm.2026.5967
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