Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
November-2026 Volume 58 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2026 Volume 58 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Multi‑omics integration in osteoarthritis: Unraveling cell‑type‑specific gene‑metabolite networks for precision medicine (Review)

  • Authors:
    • Ying Yang
    • Ruichen Zheng
    • Yun Zhang
    • Dongmei Ye
    • Jiale Xie
    • Changliang Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shanxi 710054, P.R. China, Department of Intensive Care Unit, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shanxi 710054, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 308
    |
    Published online on: September 3, 2026
       https://doi.org/10.3892/ijmm.2026.5979
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:


Abstract

Osteoarthritis (OA) is a heterogeneous joint disorder lacking disease‑modifying therapies. Recent advances in single‑cell transcriptomics, metabolomics, lipidomics, and spatial omics have enabled the reconstruction of cell‑type‑specific gene‑metabolite networks and revealed that metabolic reprogramming differs markedly across chondrocyte subsets, synovial fibroblasts and immune cells. Lipid metabolism disturbances, particularly those involving glycerophospholipids, sphingolipids and cholesterol, are consistently linked to OA severity and pain generation. Integrative multi‑omics approaches further facilitate molecular endotyping, informing patient stratification and endotype‑driven clinical trial design. However, a systematic synthesis of these emerging findings is still lacking. This review critically synthesizes current multi‑omics integration strategies, delineates cell‑type‑specific metabolic networks derived from transcriptomic and metabolomic data and discusses their implications for precision medicine in OA, while also considering the emerging contributions of spatial omics technologies.
View Figures

Figure 1

Evolution of omics technologies in OA
research: From bulk to single-cell and spatial resolution. Overview
of key technological platforms, their main contributions to the
understanding of OA and current methodological limitations.
Limitations for bulk omics include 'Masks cellular heterogeneity:
Heterogeneity cannot be resolved; molecular signals cannot be
assigned to distinct cell subsets' and 'pre-analytical
variability'. The figure was generated with Figdraw (www.figdraw.com; copyright code: AOAIIbbbda). OA,
osteoarthritis; ECM, extracellular matrix; scRNA-seq, single-cell
RNA sequencing; MALDI, matrix-assisted laser desorption ionization;
MSI, mass spectrometry imaging; SPP1, secreted phosphoprotein
1.

Figure 2

Cell-type-specific gene-metabolite
networks in OA. Chondrocyte subsets (left), synovial fibroblasts
(middle) and immune cells (right) exhibit distinct metabolic
signatures. Shared hubs (bottom) include glycerophospholipid,
sphingolipid and arachidonic acid metabolism. Arrows indicate
pathway activation or crosstalk. The figure was generated with
Figdraw (www.figdraw.com; copyright code:
ORRUT47e0e). ANGPTL4, angiopoietin-like 4; ER, endoplasmic
reticulum; LY96, lymphocyte antigen 96; SPP1, secreted
phosphoprotein 1; S1P, sphingosine-1-phosphate; SESN2, sestrin 2;
SREBP1, sterol regulatory element binding transcription factor 1;
TLR, Toll-like receptor; TSPO, translocator protein 18 kDa; YAP1,
Yes1 associated transcriptional regulator.

Figure 3

Multi-cellular crosstalk and
inter-tissue communication in the OA joint. The figure was
generated using Figdraw (www.figdraw.com; copyright code: WYWSUb4bf1). OA,
osteoarthritis; FB, fibroblast; Mac, macrophage; Chon, chondrocyte;
EV, extracellular vesicle; IPFP, infrapatellar fat pad; S1P,
sphingosine-1-phosphate; LPC, lysophosphatidylcholine; ASIC3,
acid-sensing ion channel 3; ANGPTL4, angiopoietin-like 4;
miR/miRNA, microRNA; G3BP2, G3BP stress granule assembly factor 2;
ROS, reactive oxygen species; mtDNA, mitochondrial DNA; TNF, tumor
necrosis factor; IL, interleukin.
View References

1 

Vicenti G, Bizzoca D, Carrozzo M, Solarino G and Moretti B: Multi-omics analysis of synovial fluid: A promising approach in the study of osteoarthritis. J Biol Regul Homeost Agents. 32(Suppl 1): S9–S13. 2018.

2 

Iijima H, Gilmer G, Wang K, Sivakumar S, Evans C, Matsui Y and Ambrosio F: Meta-analysis integrated with multi-omics data analysis to elucidate pathogenic mechanisms of age-related knee osteoarthritis in mice. J Gerontol A Biol Sci Med Sci. 77:1321–1334. 2022. View Article : Google Scholar : PubMed/NCBI

3 

Bensa A, Salerno M, Boffa A, de Girolamo L, Laver L, Magalon J, Sánchez M, Tischer T and Filardo G: Corticosteroid injections for the treatment of osteoarthritis present a wide spectrum of effects ranging from detrimental to disease-modifying: A systematic review of preclinical evidence by the ESSKA orthobiologic initiative. Knee Surg Sports Traumatol Arthrosc. 32:2725–2745. 2024. View Article : Google Scholar : PubMed/NCBI

4 

Bajpai P and Chandra P: Emerging anti-inflammatory attributes of curcumin: A novel paradigm and ameliorative attributes for the treatment of osteoarthritis. Curr Rheumatol Rev. 21:228–238. 2025. View Article : Google Scholar

5 

Liu Y, Molchanov V, Brass D and Yang T: Recent advances in omics and the integration of multi-omics in osteoarthritis research. Arthritis Res Ther. 27:1002025. View Article : Google Scholar : PubMed/NCBI

6 

Wei Y, Qian H, Zhang X, Wang J, Yan H, Xiao N, Zeng S, Chen B, Yang Q, Lu H, et al: Progress in multi-omics studies of osteoarthritis. Biomark Res. 13:262025. View Article : Google Scholar : PubMed/NCBI

7 

Gu Y, Hu Y, Zhang H, Wang S, Xu K and Su J: Single-cell RNA sequencing in osteoarthritis. Cell Prolif. 56:e135172023. View Article : Google Scholar : PubMed/NCBI

8 

Danzeng L, Sun Y, He Z, Hou X and Li L: Single-cell sequencing reveals the immune microenvironment in osteoarthritis: From heterogeneity to therapeutic targets. Int Immunopharmacol. 165:1155212025. View Article : Google Scholar : PubMed/NCBI

9 

Boffa A, Perucca Orfei C, Sourugeon Y, Laver L, Magalon J, Sánchez M, Tischer T, de Girolamo L and Filardo G: Cell-based therapies have disease-modifying effects on osteoarthritis in animal models. A systematic review by the ESSKA orthobiologic initiative. Part 2: Bone marrow-derived cell-based injectable therapies. Knee Surg Sports Traumatol Arthrosc. 31:3230–3242. 2023. View Article : Google Scholar : PubMed/NCBI

10 

Sourugeon Y, Boffa A, Perucca Orfei C, de Girolamo L, Magalon J, Sánchez M, Tischer T, Filardo G and Laver L: Cell-based therapies have disease-modifying effects on osteoarthritis in animal models: A systematic review by the ESSKA orthobiologic initiative. Part 3: Umbilical cord, placenta, and other sources for cell-based injectable therapies. Knee Surg Sports Traumatol Arthrosc. 33:1695–1708. 2025. View Article : Google Scholar :

11 

D'Arrigo D, Salerno M, De Marziani L, Boffa A and Filardo G: A call for standardization for secretome and extracellular vesicles in osteoarthritis: Results show disease-modifying potential, but protocols are too heterogeneous-a systematic review. Hum Cell. 37:1243–1275. 2024. View Article : Google Scholar : PubMed/NCBI

12 

Tan D, Huang Z, Zhao Z, Chen X, Liu J, Wang D, Deng Z and Li W: Single-cell sequencing, genetics, and epigenetics reveal mesenchymal stem cell senescence in osteoarthritis (review). Int J Mol Med. 53:22024. View Article : Google Scholar

13 

Wang T, Ng CY, Ng BZJ, Toh WS and Hui JHP: Multi-omics analysis of small extracellular vesicles in osteoarthritis: Bridging the gap between molecular insights and clinical applications. Burns Trauma. 13:tkaf0232025. View Article : Google Scholar : PubMed/NCBI

14 

Rai MF, Collins KH, Lang A, Maerz T, Geurts J, Ruiz-Romero C, June RK, Ramos Y, Rice SJ, Ali SA, et al: Three decades of advancements in osteoarthritis research: Insights from transcriptomic, proteomic, and metabolomic studies. Osteoarthritis Cartilage. 32:385–397. 2024. View Article : Google Scholar

15 

Van Pevenage PM, Birchmier JT and June RK: Utilizing metabolomics to identify potential biomarkers and perturbed metabolic pathways in osteoarthritis: A systematic review. Semin Arthritis Rheum. 59:1521632023. View Article : Google Scholar : PubMed/NCBI

16 

Ji Q, Zheng Y, Zhang G, Hu Y, Fan X, Hou Y, Wen L, Li L, Xu Y, Wang Y and Tang F: Single-cell RNA-seq analysis reveals the progression of human osteoarthritis. Ann Rheum Dis. 78:100–110. 2019. View Article : Google Scholar :

17 

Fan Y, Bian X, Meng X, Li L, Fu L, Zhang Y, Wang L, Zhang Y, Gao D, Guo X, et al: Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integration. Ann Rheum Dis. 83:926–944. 2024. View Article : Google Scholar : PubMed/NCBI

18 

Liao S, Yang M, Li D, Wu Y, Sun H, Lu J, Liu X, Deng T, Wang Y, Xie N, et al: Comprehensive bulk and single-cell transcriptome profiling give useful insights into the characteristics of osteoarthritis associated synovial macrophages. Front Immunol. 13:10784142022. View Article : Google Scholar

19 

Sebastian A, Hum NR, McCool JL, Wilson SP, Murugesh DK, Martin KA, Rios-Arce ND, Amiri B, Christiansen BA and Loots GG: Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis. Front Immunol. 13:9380752022. View Article : Google Scholar : PubMed/NCBI

20 

Huang ZY, Luo ZY, Cai YR, Chou CH, Yao ML, Pei FX, Kraus VB and Zhou ZK: Single cell transcriptomics in human osteoarthritis synovium and in silico deconvoluted bulk RNA sequencing. Osteoarthritis Cartilage. 30:475–480. 2022. View Article : Google Scholar : PubMed/NCBI

21 

Wang Q, Huang M and Guo JJ: From cells to clinic: Single-cell transcriptomics shaping the future of orthopedics. J Orthop Translat. 53:1–11. 2025. View Article : Google Scholar : PubMed/NCBI

22 

Fan X, Sun AR, Young RSE, Afara IO, Hamilton BR, Ong LJY, Crawford R and Prasadam I: Spatial analysis of the osteoarthritis microenvironment: Techniques, insights, and applications. Bone Res. 12:72024. View Article : Google Scholar : PubMed/NCBI

23 

Fan X, Young RSE, Sun AR, Hamilton BR, Nedunchezhiyan U, Crawford R, Blanksby SJ and Prasadam I: Functional mass spectrometry imaging maps phospholipase-A2 enzyme activity during osteoarthritis progression. Theranostics. 13:4636–4649. 2023. View Article : Google Scholar : PubMed/NCBI

24 

Lee YR, Briggs MT, Kuliwaba JS, Jagiello J, Anderson PH and Hoffmann P: High-resolution N-glycan MALDI mass spectrometry imaging of subchondral bone tissue microarrays in patients with knee osteoarthritis. Anal Chem. 95:12640–12647. 2023. View Article : Google Scholar : PubMed/NCBI

25 

Rocha B, Cillero-Pastor B, Ruiz-Romero C, Paine MRL, Cañete JD, Heeren RMA and Blanco FJ: Identification of a distinct lipidomic profile in the osteoarthritic synovial membrane by mass spectrometry imaging. Osteoarthritis Cartilage. 29:750–761. 2021. View Article : Google Scholar : PubMed/NCBI

26 

Zhu L, Diao X, Yuan C, Lau CML, Wang J, Wu W, Mobasheri A, Houard X, Wen C and Cai Z: Integrative spatially resolved proteomic and metabolomic imaging reveals synovitis endotypes implicated in osteoarthritis progression. Theranostics. 15:9729–9741. 2025. View Article : Google Scholar : PubMed/NCBI

27 

Xie P, Sun AR, Gao F, Li L, Crawford R and Prasadam I: Resolving microenvironment complexity and cellular heterogeneity in osteoarthritis via spatial transcriptomics. Osteoarthritis Cartilage. 34:332–342. 2026. View Article : Google Scholar

28 

Kreitmaier P, Katsoula G and Zeggini E: Insights from multi-omics integration in complex disease primary tissues. Trends Genet. 39:46–58. 2023. View Article : Google Scholar

29 

Huang Z, He Z, Kong Y, Liu Z and Gong L: Insight into osteoarthritis through integrative analysis of metabolomics and transcriptomics. Clin Chim Acta. 510:323–329. 2020. View Article : Google Scholar : PubMed/NCBI

30 

Ojha A, Chatterjee P, Kippner LE, Stevens HY, Boden SD, Drissi H, Mautner K, Yeago C, Roy K and Sinha S: Multi-omics integration at cell type resolution uncovers gene-metabolite mechanisms underlying osteoarthritis heterogeneity. bioRxiv [Preprint]: 2025.09.26.678886. 2025.

31 

Katsoula G, Kreitmaier P and Zeggini E: Insights into the molecular landscape of osteoarthritis in human tissues. Curr Opin Rheumatol. 34:79–90. 2022. View Article : Google Scholar

32 

Wang Y, Zeng T, Tang D, Cui H, Wan Y and Tang H: Integrated multi-omics analyses reveal lipid metabolic signature in osteoarthritis. J Mol Biol. 437:1688882025. View Article : Google Scholar

33 

He H, Zhao X, Zhang B, Zhao S and Wu Y: Integrated multi-omics and machine learning reveals immune-metabolic signatures in osteoarthritis: From bulk RNA-seq to single-cell resolution. Front Immunol. 16:15999302025. View Article : Google Scholar : PubMed/NCBI

34 

Wu K, Zhong Z, Chen L, Luo H, Jiang A, Tao L and Jiang Y: Integrative analysis of bulk and single-cell RNA sequencing data reveals increased arachidonic acid metabolism in osteoarthritic chondrocytes. Front Med (Lausanne). 12:15520292025. View Article : Google Scholar : PubMed/NCBI

35 

Wijesinghe SN, Badoume A, Nanus DE, Sharma-Oates A, Farah H, Certo M, Alnajjar F, Davis ET, Mauro C, Lindsay MA and Jones SW: Obesity defined molecular endotypes in the synovium of patients with osteoarthritis provides a rationale for therapeutic targeting of fibroblast subsets. Clin Transl Med. 13:e12322023. View Article : Google Scholar : PubMed/NCBI

36 

Southan J, McHugh E, Walker H and Ismail HM: Metabolic signature of articular cartilage following mechanical injury: An integrated transcriptomics and metabolomics analysis. Front Mol Biosci. 7:5929052020. View Article : Google Scholar

37 

Qu Y, Wang Y, Wang S, Yu X, He Y, Lu R, Chen S, Meng C, Xu H, Pei W, et al: A comprehensive analysis of single-cell RNA transcriptome reveals unique SPP1+ chondrocytes in human osteoarthritis. Comput Biol Med. 160:1069262023. View Article : Google Scholar : PubMed/NCBI

38 

Matta C, Takács R, Dvir-Ginzberg M, Richardson SM, Pelttari K, Pattappa G, Risbud MV and Mobasheri A: Insights into chondrocyte populations in cartilaginous tissues at the single-cell level. Nat Rev Rheumatol. 21:465–477. 2025. View Article : Google Scholar : PubMed/NCBI

39 

Chen W, Xiao J, Zhou Y, Liu W, Jian J, Yang J, Chen B, Ye Z, Liu J, Xu X, et al: Curcumenol regulates Histone H3K27me3 demethylases KDM6B affecting Succinic acid metabolism to alleviate cartilage degeneration in knee osteoarthritis. Phytomedicine. 133:1559222024. View Article : Google Scholar : PubMed/NCBI

40 

Zhang Z, Cheng D, Dang J, Wang X, Fan H and Liu D: Decoding endoplasmic reticulum stress on chondrocyte driving osteoarthritis development through integrating single-cell and transcriptomic profiling. Int J Med Sci. 22:3906–3923. 2025. View Article : Google Scholar : PubMed/NCBI

41 

Pan B, Yao P, Ma J, Lin X, Zhou L and Lin C, Zhang Y, Lin B and Lin C: Identification of key biomarkers related to fibrocartilage chondrocytes for osteoarthritis based on bulk, single-cell transcriptomic data. Front Immunol. 15:14823612024. View Article : Google Scholar : PubMed/NCBI

42 

Kang X, Zhang K, Wang Y, Zhao Y and Lu Y: Single-cell RNA sequencing analysis of human chondrocytes reveals cell-cell communication alterations mediated by interactive signaling pathways in osteoarthritis. Front Cell Dev Biol. 11:10992872023. View Article : Google Scholar : PubMed/NCBI

43 

Acharjee A, Wijesinghe SN, Russ D, Gkoutos G and Jones SW: Cross-species transcriptomics identifies obesity associated genes between human and mouse studies. J Transl Med. 22:5922024. View Article : Google Scholar : PubMed/NCBI

44 

Yang J, Li S, Li Z, Yao L, Liu M, Tong KL, Xu Q, Yu B, Peng R, Gui T, et al: Targeting YAP1-regulated glycolysis in fibroblast-like synoviocytes impairs macrophage infiltration to ameliorate diabetic osteoarthritis progression. Adv Sci (Weinh). 11:e23046172024. View Article : Google Scholar :

45 

Wu Y, Liu J, Yu W, Wang X, Li J and Zeng W: Single-cell transcriptome and multi-omics integration reveal ferroptosis-driven immune microenvironment remodeling in knee osteoarthritis. Front Immunol. 16:16083782025. View Article : Google Scholar : PubMed/NCBI

46 

Wei M, Shi X, Tang W, Lv Q, Wu Y and Xu Y: Shared M0 macrophage infiltration-related gene signatures in osteoarthritis and osteomyelitis by integrating bulk and single-cell RNA transcriptome. Eur J Med Res. 30:11112025. View Article : Google Scholar : PubMed/NCBI

47 

Deng M, Jiang Y, Chen Z, Chen K, Cao N, Huang Y, Quan Z and Chen C: Senescent synovial intimal fibroblasts aggravate osteoarthritis by regulating macrophage polarization and chondrocyte phenotype through ANGPTL4-α5β1 axis. Adv Sci (Weinh). 13:e180562026. View Article : Google Scholar

48 

Komaravolu RK, Mehta-D'souza P, Conner T, Allen M, Lumry J, Batushansky A, Pezant NP, Montgomery CG and Griffin TM: Sex-specific effects of injury and beta-adrenergic activation on metabolic and inflammatory mediators in a murine model of post-traumatic osteoarthritis. Osteoarthritis Cartilage. 32:1097–1112. 2024. View Article : Google Scholar : PubMed/NCBI

49 

Huang J, Liu M, Zhang H, Sun G, Furey A, Rahman P and Zhai G: Multi-omics integrative analyses identified two endotypes of hip osteoarthritis. Metabolites. 14:4802024. View Article : Google Scholar : PubMed/NCBI

50 

Tang S, Yao L, Ruan J, Kang J, Cao Y, Nie X, Lan W, Zhu Z, Han W, Liu Y, et al: Single-cell atlas of human infrapatellar fat pad and synovium implicates APOE signaling in osteoarthritis pathology. Sci Transl Med. 16:eadf45902024. View Article : Google Scholar : PubMed/NCBI

51 

Lu Y, Liu J, Wang S, Gan J, Cao W and Wu B: Identification and validation of a glutamine metabolism-related gene signature as a diagnostic and therapeutic target in osteoarthritis through integrated multi-omics analysis. PeerJ. 14:e207012026. View Article : Google Scholar : PubMed/NCBI

52 

Welsing PMJ, El Bouhaddani S, Zhu L, Nijhof NC, Mastbergen SC, Wen C, Bacardit J, Ruiz-Romero C, Blanco FJ and Mobasheri A: Omics-driven insights into the molecular pathways driving osteoarthritis pathogenesis. Connect Tissue Res. 66:323–330. 2025. View Article : Google Scholar : PubMed/NCBI

53 

Choi WS, Lee G, Song WH, Koh JT, Yang J, Kwak JS, Kim HE, Kim SK, Son YO, Nam H, et al: The CH25H-CYP7B1-RORα axis of cholesterol metabolism regulates osteoarthritis. Nature. 566:254–258. 2019. View Article : Google Scholar : PubMed/NCBI

54 

Lee G, Yang J, Kim SJ, Tran TT, Lee SY, Park KH, Kwon SH, Chung KH, Koh JT, Huh YH, et al: Enhancement of intracellular cholesterol efflux in chondrocytes leading to alleviation of osteoarthritis progression. Arthritis Rheumatol. 77:151–162. 2025. View Article : Google Scholar :

55 

Kosinska MK, Mastbergen SC, Liebisch G, Wilhelm J, Dettmeyer RB, Ishaque B, Rickert M, Schmitz G, Lafeber FP and Steinmeyer J: Comparative lipidomic analysis of synovial fluid in human and canine osteoarthritis. Osteoarthritis Cartilage. 24:1470–1478. 2016. View Article : Google Scholar : PubMed/NCBI

56 

Steinmeyer J: Phospholipids and sphingolipids in osteoarthritis. Biomolecules. 15:2502025. View Article : Google Scholar : PubMed/NCBI

57 

Ma H, Liu CM, Shao SQ, Song YY, Zhou J, Cao LN, Yin HQ and Yin SL: Myriocin alleviates Oleic/Palmitate induced chondrocyte degeneration via the suppression of ceramide. Eur Rev Med Pharmacol Sci. 24:12938–12947. 2020.PubMed/NCBI

58 

Cherifi C, Latourte A, Vettorazzi S, Tuckermann J, Provot S, Ea HK, Ledoux A, Casas J, Cuvillier O, Richette P, et al: Inhibition of sphingosine 1-phosphate protects mice against chondrocyte catabolism and osteoarthritis. Osteoarthritis Cartilage. 29:1335–1345. 2021. View Article : Google Scholar : PubMed/NCBI

59 

Jacquot F, Khoury S, Labrum B, Delanoe K, Pidoux L, Barbier J, Delay L, Bayle A, Aissouni Y, Barriere DA, et al: Lysophosphatidylcholine 16:0 mediates chronic joint pain associated to rheumatic diseases through acid-sensing ion channel 3. Pain. 163:1999–2013. 2022. View Article : Google Scholar : PubMed/NCBI

60 

Pousinis P, Gowler PRW, Burston JJ, Ortori CA, Chapman V and Barrett DA: Lipidomic identification of plasma lipids associated with pain behaviour and pathology in a mouse model of osteoarthritis. Metabolomics. 16:322020. View Article : Google Scholar : PubMed/NCBI

61 

Cao C, Shi Y, Zhang X, Li Q, Zhang J, Zhao F, Meng Q, Dai W, Liu Z, Yan W, et al: Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4. Nat Commun. 13:71392022. View Article : Google Scholar : PubMed/NCBI

62 

Zhao Y, Hasse S, Vaillancourt M, Zhao C, Davis L, Boilard E, Fortin P, Di Battista J, Poubelle PE and Bourgoin SG: Phospholipase A1 member A activates fibroblast-like synoviocytes through the autotaxin-lysophosphatidic acid receptor axis. Int J Mol Sci. 22:126852021. View Article : Google Scholar : PubMed/NCBI

63 

Zhou Q, Ghorasaini M, Cornelis FMF, Hayer S, Giera M, Monteagudo S and Lories RJ: Temporal profiling of lipid mediators in synovium and tibial plateau during joint inflammation in a collagenase-induced mouse model of osteoarthritis. Osteoarthritis Cartilage. 33:1307–1315. 2025. View Article : Google Scholar : PubMed/NCBI

64 

Lee JC: Microarray analysis after adipose derived mesenchymal stem cells injection in monosodium iodoacetate-induced osteoarthritis rats. Genes Genomics. 40:25–37. 2018. View Article : Google Scholar : PubMed/NCBI

65 

Huang G, Jiang W, Xie W, Lu W, Zhu W and Deng Z: Role of peroxisome proliferator-activated receptors in osteoarthritis (review). Mol Med Rep. 23:1592021. View Article : Google Scholar

66 

Liu Z, Jiang H, Zhang Z, Jiang R, Wang R, Li J, Li W, Tan G, Fei Y, Lv Z, et al: SESN2 maintains cartilage homeostasis by SREBP1-mediated lipid metabolism during osteoarthritis progression. iScience. 28:1130972025. View Article : Google Scholar : PubMed/NCBI

67 

Sun MM and Beier F: Liver X receptor activation regulates genes involved in lipid homeostasis in developing chondrocytes. Osteoarthr Cartil Open. 2:1000302020. View Article : Google Scholar : PubMed/NCBI

68 

Park S, Oh J, Kim YI, Choe SK, Chun CH and Jin EJ: Suppression of ABCD2 dysregulates lipid metabolism via dysregulation of miR-141:ACSL4 in human osteoarthritis. Cell Biochem Funct. 36:366–376. 2018. View Article : Google Scholar : PubMed/NCBI

69 

Kondreddy V, Magisetty J, Kathirvel M, Helal M, Kumar P, Jala R and Das K: LPCAT3-ABCA1 axis regulates the dose-sparing effects of steroid drugs in osteoarthritis in mice. Int J Biol Macromol. 330:1481402025. View Article : Google Scholar : PubMed/NCBI

70 

Pandey A and Bhutani N: Profiling joint tissues at single-cell resolution: Advances and insights. Nat Rev Rheumatol. 20:7–20. 2024. View Article : Google Scholar

71 

Raut RD, Chakraborty AK, Neogi T, Albro M, Snyder B, Schaer TP, Zhang C, Grinstaff MW and Bais MV: A multi-tissue human knee single-cell atlas identifies that osteoarthritis reduces regenerative tissue stem cells while increasing inflammatory pain macrophages. Commun Biol. 8:11462025. View Article : Google Scholar : PubMed/NCBI

72 

Hu YJ, Yu YE, Cooper HJ, Shah RP, Geller JA, Lu XL, Shane E, Bathon J, Lane NE and Guo XE: Mechanical and structural properties of articular cartilage and subchondral bone in human osteoarthritic knees. J Bone Miner Res. 39:1120–1131. 2024. View Article : Google Scholar : PubMed/NCBI

73 

Wang H, Li M, Wang X, Han J and Zhang XA: The Notch signaling pathway in regulating bone and cartilage homeostasis: Novel insights into the pathogenesis and therapeutics of osteoarthritis. Cell Commun Signal. 24:352025. View Article : Google Scholar : PubMed/NCBI

74 

Semenistaja S, Skuja S, Kadisa A and Groma V: Healthy and osteoarthritis-affected joints facing the cellular crosstalk. Int J Mol Sci. 24:41202023. View Article : Google Scholar : PubMed/NCBI

75 

Wang J, Liu C, Wang T, Li S, Bai Y, Pan F, Wang J, Han J, Luo R, Wan X, et al: Single-cell communication patterns and their intracellular information flow in synovial fibroblastic osteoarthritis and rheumatoid arthritis. Immunol Lett. 263:1–13. 2023. View Article : Google Scholar : PubMed/NCBI

76 

Chen B, Sun Y, Xu G, Jiang J, Zhang W, Wu C, Xue P and Cui Z: Role of crosstalk between synovial cells and chondrocytes in osteoarthritis (review). Exp Ther Med. 27:2012024. View Article : Google Scholar : PubMed/NCBI

77 

Laouteouet D, Bortolotti O, Marineche L, Hannemann N, Chambon M, Glasson Y, Dumé AS, De Lima J, Fournial M, Touchet D, et al: Monocyte-derived macrophages-synovial fibroblasts crosstalk unravels oncostatin signaling network as a driver of synovitis in osteoarthritis. Arthritis Rheumatol. 78:105–118. 2026. View Article : Google Scholar :

78 

Chen P, Zeng L, Wang T, He J, Xiong S, Chen G, Wang Q, Chen H and Xie J: The communication role of extracellular vesicles in the osteoarthritis microenvironment. Front Immunol. 16:15498332025. View Article : Google Scholar : PubMed/NCBI

79 

Kong H, Zheng J, Han J, Meng X, Li X, Wang X and Zhang XA: The crosstalk among macrophages, chondrocytes and mesenchymal stem cells in osteoarthritis: The role of extracellular vesicles. Stem Cell Res Ther. 16:5532025. View Article : Google Scholar : PubMed/NCBI

80 

Liu N, Ma Y, Gong W, Shao X, Shi T, Li L, Wu W, Chen X, Shi Y, Zhang P, et al: Osteocyte-derived extracellular vesicles mediate the bone-to-cartilage crosstalk and promote osteoarthritis progression. Nat Commun. 16:47462025. View Article : Google Scholar : PubMed/NCBI

81 

Li S, Yan Z, Zhi X, Zheng W, Zhang Z, Dai Z, Chen W, Lu H, Feng Z, Cheng T, et al: Extracellular vesicles from IPFP-MSCs trigger osteoarthritis by transferring mtDNA. Bioact Mater. 58:252–273. 2026.PubMed/NCBI

82 

Wu J, Wu J, Xiang W, Gong Y, Feng D, Fang S, Wu Y, Liu Z, Li Y, Chen R, et al: Engineering exosomes derived from TNF-α preconditioned IPFP-MSCs enhance both yield and therapeutic efficacy for osteoarthritis. J Nanobiotechnology. 22:5552024. View Article : Google Scholar

83 

Clarke EJ, Chabronova A and Peffers MJ: Extracellular vesicles in cartilage homeostasis, osteoarthritis, and biomarker discovery. Connect Tissue Res. 66:428–434. 2025. View Article : Google Scholar : PubMed/NCBI

84 

Yin X, Wang Q, Tang Y, Wang T, Zhang Y and Yu T: Research progress on macrophage polarization during osteoarthritis disease progression: A review. J Orthop Surg Res. 19:5842024. View Article : Google Scholar : PubMed/NCBI

85 

Zou X, Xu H and Qian W: Macrophage polarization in the osteoarthritis pathogenesis and treatment. Orthop Surg. 17:22–35. 2025. View Article : Google Scholar :

86 

He XX, Huang YJ, Hu CL, Xu QQ and Wei QJ: Songorine modulates macrophage polarization and metabolic reprogramming to alleviate inflammation in osteoarthritis. Front Immunol. 15:13449492024. View Article : Google Scholar : PubMed/NCBI

87 

Yin J, Huang J, Wu J, Gao L, Xu H, Zhu J, Mai H, Luo J, Yao Z, Li Y, et al: Emapunil relieves osteoarthritis by regulating the CD14/TLR4/LY96 pathway in synovial macrophages through translocator protein 18 kDa. Osteoarthritis Cartilage. 33:1107–1120. 2025. View Article : Google Scholar : PubMed/NCBI

88 

Henry ÓC and O'Neill LAJ: Metabolic reprogramming in stromal and immune cells in rheumatoid arthritis and osteoarthritis: Therapeutic possibilities. Eur J Immunol. 55:e2024513812025. View Article : Google Scholar : PubMed/NCBI

89 

Wang C, Zeng Z, Wang T, Xie Z, Zhang J, Dong W, Zhang F and Peng W: Unraveling the spatial and signaling dynamics and splicing kinetics of immune infiltration in osteoarthritis synovium. Front Immunol. 16:15210382025. View Article : Google Scholar : PubMed/NCBI

90 

Mobasheri A, Saarakkala S, Finnilä M, Karsdal MA, Bay-Jensen AC and van Spil WE: Recent advances in understanding the phenotypes of osteoarthritis. F1000Res. 8:F1000 Faculty Rev-20912019. View Article : Google Scholar : PubMed/NCBI

91 

Mobasheri A and Loeser R: Clinical phenotypes, molecular endotypes and theratypes in OA therapeutic development. Nat Rev Rheumatol. 20:525–526. 2024. View Article : Google Scholar : PubMed/NCBI

92 

Mobasheri A, van Spil WE, Budd E, Uzieliene I, Bernotiene E, Bay-Jensen AC, Larkin J, Levesque MC, Gualillo O and Henrotin Y: Molecular taxonomy of osteoarthritis for patient stratification, disease management and drug development: Biochemical markers associated with emerging clinical phenotypes and molecular endotypes. Curr Opin Rheumatol. 31:80–89. 2019. View Article : Google Scholar

93 

Henrotin Y: Osteoarthritis in year 2021: Biochemical markers. Osteoarthritis Cartilage. 30:237–248. 2022. View Article : Google Scholar

94 

Hannani MT, Thudium CS, Karsdal MA, Ladel C, Mobasheri A, Uebelhoer M, Larkin J, Bacardit J, Struglics A and Bay-Jensen AC: From biochemical markers to molecular endotypes of osteoarthritis: A review on validated biomarkers. Expert Rev Mol Diagn. 24:23–38. 2024. View Article : Google Scholar : PubMed/NCBI

95 

Pattappa G, Karlsson NG, Steinecker-Frohnwieser B, Mobasheri A, Bernotiene E, Zaucke F, Roesch G, Uzieliene I, Meulenbelt I, Rios JL, et al: Towards stratification in osteoarthritis: A review of the scientific terminology used in published basic research. BMC Rheumatol. 9:1092025. View Article : Google Scholar : PubMed/NCBI

96 

Karalilova R, Popova V, Batalov K, Kolev D, Kodzhaahmed L, Petrova-Stoyankova D, Tepeliev N, Kostova T, Mekenyan L and Batalov Z: Ultrasound phenotype-based approach to treatment choice in osteoarthritis. Life (Basel). 15:11402025.PubMed/NCBI

97 

Rockel JS, Sharma D, Espin-Garcia O, Hueniken K, Sandhu A, Pastrello C, Sundararajan K, Potla P, Fine N, Lively SS, et al: Deep learning-based clustering for endotyping and post-arthroplasty response classification using knee osteoarthritis multiomic data. Ann Rheum Dis. 84:844–855. 2025. View Article : Google Scholar : PubMed/NCBI

98 

Karsdal MA, Rovati LC, Tambiah J, Kubassova O, Ladel C, Berenbaum F, Bay-Jensen AC, Mclean L, Loeser R, Mobasheri A and Kraus VB: The inflammatory endotype in osteoarthritis: Reflections from the 2024 OARSI clinical trials symposium (CTS) with a special emphasis on feasibility for clinical development. Osteoarthr Cartil Open. 7:1005722025. View Article : Google Scholar : PubMed/NCBI

99 

Thudium CS, Hannani MT, Collins JE, Roemer FW, Kraus VB, Bihlet AR, Karsdal MA and Bay-Jensen AC: Diagnosing, treating and monitoring the inflammatory endotype in osteoarthritis clinical trials. Expert Rev Mol Diagn. 25:709–722. 2025. View Article : Google Scholar : PubMed/NCBI

100 

Kim H, Seo J, Lee Y, Park K, Perry TA, Arden NK, Mobasheri A and Choi H: The current state of the osteoarthritis drug development pipeline: A comprehensive narrative review of the present challenges and future opportunities. Ther Adv Musculoskelet Dis. 14:1759720X2210859522022. View Article : Google Scholar : PubMed/NCBI

101 

Jenei-Lanzl Z, Maurer S, Brenner RE, Zaucke F, Fuchs M and Riegger J: Emerging concepts and challenges in the development of disease-modifying osteoarthritis drugs-a more refined perspective. Arch Pharm Res. 48:467–494. 2025. View Article : Google Scholar : PubMed/NCBI

102 

Hannani MT, Thudium CS, Gellhorn AC, Larkin J, Karsdal MA, Lisowska-Petersen Z, Frederiksen P, Bager CL, Ladel C, Struglics A, et al: Longitudinal stability of molecular endotypes of knee osteoarthritis patients. Osteoarthritis Cartilage. 33:166–175. 2025. View Article : Google Scholar

103 

Oo WM: Prospects of disease-modifying osteoarthritis drugs. Rheum Dis Clin North Am. 50:483–518. 2024. View Article : Google Scholar : PubMed/NCBI

104 

Ghirardi GM, Delrosso CA, Nerviani A and Boutet MA: Molecular portrait of chronic joint diseases: Defining endotypes toward personalized medicine. Joint Bone Spine. 91:1056922024. View Article : Google Scholar : PubMed/NCBI

105 

Wang T, Li Z, Zhao S, Liu Y, Guo W, Alarcòn Rodrìguez R, Wu Y and Wei R: Characterizing hedgehog pathway features in senescence associated osteoarthritis through Integrative multi-omics and machine learning analysis. Front Genet. 15:12554552024. View Article : Google Scholar : PubMed/NCBI

106 

Wu Y, Hu H, Wang T, Guo W, Zhao S and Wei R: Characterizing mitochondrial features in osteoarthritis through integrative multi-omics and machine learning analysis. Front Immunol. 15:14143012024. View Article : Google Scholar : PubMed/NCBI

107 

Hao T, Pei Z, Hu S, Zhao Z, He W, Wang J, Jiang L, Ariben J, Wu L, Yang X, et al: Identification of osteoarthritis-associated chondrocyte subpopulations and key gene-regulating drugs based on multi-omics analysis. Sci Rep. 15:124482025. View Article : Google Scholar : PubMed/NCBI

108 

Winthrop KL, Mease P, Kerschbaumer A, Voll RE, Breedveld FC, Smolen JS, Gottenberg JE, Baraliakos X, Kiener HP, Aletaha D, et al: Unmet need in rheumatology: Reports from the Advances in Targeted Therapies meeting, 2023. Ann Rheum Dis. 83:409–416. 2024. View Article : Google Scholar

109 

Jamshidi A, Zhai G, Liu M, Zhang W, Jones G, Cicuttini FM, Pelletier JP and Martel-Pelletier J: An interpretable metabolomic-driven machine learning model for early prediction of knee structural OA progression. Rheumatology (Oxford). 65:keaf6862026. View Article : Google Scholar

110 

Rafiei M, Das S, Bakhtiari M, Roos EM, Skou ST, Grønne DT, Baumbach J and Baumbach L: Personalized predictions for changes in knee pain among patients with osteoarthritis participating in supervised exercise and education: Prognostic model study. JMIR Rehabil Assist Technol. 12:e601622025. View Article : Google Scholar : PubMed/NCBI

111 

Sharma D: Artificial intelligence, machine learning and omic data integration in osteoarthritis. Osteoarthritis Cartilage. 34:311–320. 2026. View Article : Google Scholar

112 

Russell J, Rosen J and Vella-Baldacchino M: Artificial intelligence fails to outperform orthopaedic surgeons: A systematic review. J Exp Orthop. 12:e705482025. View Article : Google Scholar : PubMed/NCBI

113 

Yan Y, Wang C, Zhang M, Jiang X and Cheng W: Multi-omics integration identifies FGF1 as a diagnostic biomarker and RAS-MAPK-driven pathogenic factor in osteoarthritis. J Inflamm Res. 18:17803–17824. 2025. View Article : Google Scholar : PubMed/NCBI

114 

Kang Z, Zhang J, Liu W, Zhu C, Zhu Y, Li P, Li K, Tong Q and Dai SM: Plasma proteomic profiles predict individual future osteoarthritis risk. Arthritis Rheumatol. 77:981–995. 2025. View Article : Google Scholar : PubMed/NCBI

115 

Pang WW, Cai YS, Cao C, Zhang FR, Zeng Q, Liu DY, Wang N, Qu XC, Chen XD, Deng HW and Tan LJ: Mendelian randomization and transcriptome analysis identified immune-related biomarkers for osteoarthritis. Front Immunol. 15:13344792024. View Article : Google Scholar : PubMed/NCBI

116 

Liao B, Mu Y, Luo M, Liu Y, Yang Q, Yang H, Ye J, Wu Y, Cheng F, Sun X and Nie M: Unraveling the shared genetic architecture of osteoarthritis and metabolic traits through multi-omics insights. Osteoarthritis Cartilage. 34:460–474. 2026. View Article : Google Scholar

117 

Tu B, Fang R, Lu P, Liu M, Yang S, Hu D, Ruan R and Ning R: Multi-omic profiling reveals age-specific blood biomarkers and aging-driven B cell remodeling in osteoarthritis. Int J Surg. 111:7814–7828. 2025. View Article : Google Scholar : PubMed/NCBI

118 

Glinkowski WM, Spalińska A, Wołk A and Wołk K: Artificial intelligence in orthopaedics: Clinical performance, limitations, and translational readiness-a review. J Clin Med. 15:17512026. View Article : Google Scholar : PubMed/NCBI

119 

Luo G, Tan S, Luo L and Hu K: Artificial intelligence and multimodal imaging in orthopaedics: From technological advances to clinical translation. Front Med (Lausanne). 12:17282482026. View Article : Google Scholar : PubMed/NCBI

120 

Awasthi S, Tiwari PC, Awasthi S, Dwivedi A and Srivastava S: Artificial intelligence in osteoarthritis diagnosis and treatment: Advancements, challenges, and future prospects. Hand Surg Rehabil. Jan 31–2026.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

121 

Kim SY, Choi BS, Han HS and Ro DH: Artificial intelligence in orthopedics: Current applications, challenges, and future directions. Knee Surg Relat Res. 38:142026. View Article : Google Scholar : PubMed/NCBI

122 

Fairley JL, Kapoor M and Sharma D: Generative artificial intelligence in osteoarthritis: A systematic scoping review of current applications and future directions. Osteoarthritis Cartilage. 34:784–793. 2026. View Article : Google Scholar : PubMed/NCBI

123 

Ou J, Zhang J, Alswadeh M, Zhu Z, Tang J, Sang H and Lu K: Advancing osteoarthritis research: The role of AI in clinical, imaging and omics fields. Bone Res. 13:482025. View Article : Google Scholar : PubMed/NCBI

124 

Kuswanto W and Baker MC: Repurposing drugs for the treatment of osteoarthritis. Osteoarthritis Cartilage. 32:886–895. 2024. View Article : Google Scholar : PubMed/NCBI

125 

Maroun G, Fissoun C, Villaverde M, Brondello JM and Pers YM: Senescence-regulatory factors as novel circulating biomarkers and therapeutic targets in regenerative medicine for osteoarthritis. Joint Bone Spine. 91:1056402024. View Article : Google Scholar

126 

Han M, Lin W, Cao Y, Murray P, Wilm B, McWilliam SJ, Curran J and Xie R: Microphysiological systems for comorbidity studies: Chronic kidney disease and osteoarthritis. Adv Healthc Mater. 14:e25005502025. View Article : Google Scholar : PubMed/NCBI

127 

Del Río E: A multidimensional definition of pre-osteoarthritis: Toward 21st-century subclinical detection and targeted intervention. Int J Mol Sci. 26:114472025. View Article : Google Scholar : PubMed/NCBI

128 

Eichner G, Liebisch G, Hild C, Rickert M and Steinmeyer J: Serum phospholipids and sphingolipids are linked to early-stage osteoarthritis by lipidomic profiling. Arthritis Res Ther. 27:692025. View Article : Google Scholar : PubMed/NCBI

129 

Saha P, Defernez M, Gall GL, Cardenas-Canto P, Dainty J, Wortley GM, Yates M, Davidson R, Clark IM, Traka M, et al: OA04 Metabolomic predictors of osteoarthritis onset in the UK Biobank. Rheumatology. 65(Suppl 2): keag121.0042026. View Article : Google Scholar

130 

Xu S, Driban JB, Prakash PS, McAlindon TE, Eaton CB and Lu B: Metabolomic signatures of dietary patterns and incident radiographic knee osteoarthritis: A case-cohort study from the osteoarthritis initiative. J Rheumatol. 53:443–449. 2026. View Article : Google Scholar

131 

Tay MRJ, Kim JM, Ong PL, Khin LW, Wong CJ, Kong KH, Tan BY, Lee ES, Sim SZ, Lim WS, et al: Targeting osteosarcopenia and multimorbidity for frailty prevention through identification and deep phenotyping methods in healthy ageing and high-burden disease cohorts (OPTIMA-C): A longitudinal observational cohort study protocol for neuromusculoskeletal muscle health. BMJ Open. 15:e0942792025. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang Y, Zheng R, Zhang Y, Ye D, Xie J and Zhu C: Multi‑omics integration in osteoarthritis: Unraveling cell‑type‑specific gene‑metabolite networks for precision medicine (Review). Int J Mol Med 58: 308, 2026.
APA
Yang, Y., Zheng, R., Zhang, Y., Ye, D., Xie, J., & Zhu, C. (2026). Multi‑omics integration in osteoarthritis: Unraveling cell‑type‑specific gene‑metabolite networks for precision medicine (Review). International Journal of Molecular Medicine, 58, 308. https://doi.org/10.3892/ijmm.2026.5979
MLA
Yang, Y., Zheng, R., Zhang, Y., Ye, D., Xie, J., Zhu, C."Multi‑omics integration in osteoarthritis: Unraveling cell‑type‑specific gene‑metabolite networks for precision medicine (Review)". International Journal of Molecular Medicine 58.5 (2026): 308.
Chicago
Yang, Y., Zheng, R., Zhang, Y., Ye, D., Xie, J., Zhu, C."Multi‑omics integration in osteoarthritis: Unraveling cell‑type‑specific gene‑metabolite networks for precision medicine (Review)". International Journal of Molecular Medicine 58, no. 5 (2026): 308. https://doi.org/10.3892/ijmm.2026.5979
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y, Zheng R, Zhang Y, Ye D, Xie J and Zhu C: Multi‑omics integration in osteoarthritis: Unraveling cell‑type‑specific gene‑metabolite networks for precision medicine (Review). Int J Mol Med 58: 308, 2026.
APA
Yang, Y., Zheng, R., Zhang, Y., Ye, D., Xie, J., & Zhu, C. (2026). Multi‑omics integration in osteoarthritis: Unraveling cell‑type‑specific gene‑metabolite networks for precision medicine (Review). International Journal of Molecular Medicine, 58, 308. https://doi.org/10.3892/ijmm.2026.5979
MLA
Yang, Y., Zheng, R., Zhang, Y., Ye, D., Xie, J., Zhu, C."Multi‑omics integration in osteoarthritis: Unraveling cell‑type‑specific gene‑metabolite networks for precision medicine (Review)". International Journal of Molecular Medicine 58.5 (2026): 308.
Chicago
Yang, Y., Zheng, R., Zhang, Y., Ye, D., Xie, J., Zhu, C."Multi‑omics integration in osteoarthritis: Unraveling cell‑type‑specific gene‑metabolite networks for precision medicine (Review)". International Journal of Molecular Medicine 58, no. 5 (2026): 308. https://doi.org/10.3892/ijmm.2026.5979
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team