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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
February 2008 Volume 21 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2008 Volume 21 Issue 2

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Article

Induction of c-Myc-dependent cell proliferation through toll-like receptor 3 in head and neck cancer

  • Authors:
    • Ralph Pries
    • Lisa Hogrefe
    • Lei Xie
    • Henning Frenzel
    • Carsten Brocks
    • Claudia Ditz
    • Barbara Wollenberg

  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, University of Schleswig-Holstein, Campus Lübeck, D-23538 Lübeck, Germany
  • Pages: 209-215
    |
    Published online on: February 1, 2008
       https://doi.org/10.3892/ijmm.21.2.209
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Abstract

Protein expression of human toll-like receptors (TLR) 1-10 was measured in cell lines and solid tumors of head and neck squamous cell carcinoma (HNSCC). All HNSCC cell lines and 80% of solid tumors were found to express TLR3 as a predominantly intracellular protein, while no other TLR proteins were expressed. TLR3 has previously been shown to contribute to the activation of nuclear factor-κB (NF-κB), a transcription factor which promotes several types of human cancers. Significantly, NF-κB expression was strongest in protein extracts from carcinoma tissue in which TLR3 was overexpressed. Inhibition of TLR3 expression in permanent HNSCC cell lines resulted in decreased expression of the oncoprotein c-Myc resulting in decreased cell proliferation. Correspondingly, overexpression of human TLR3 in mouse fibroblasts resulted in an upregulation of c-Myc and increased sensitivity for PolyI:C-induced cell proliferation. Our data suggest that TLR3 contributes to the malignant phenotype leading to invasive carcinoma in HNSCC.

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Copy and paste a formatted citation
Spandidos Publications style
Pries R, Hogrefe L, Xie L, Frenzel H, Brocks C, Ditz C and Wollenberg B: Induction of c-Myc-dependent cell proliferation through toll-like receptor 3 in head and neck cancer. Int J Mol Med 21: 209-215, 2008.
APA
Pries, R., Hogrefe, L., Xie, L., Frenzel, H., Brocks, C., Ditz, C., & Wollenberg, B. (2008). Induction of c-Myc-dependent cell proliferation through toll-like receptor 3 in head and neck cancer. International Journal of Molecular Medicine, 21, 209-215. https://doi.org/10.3892/ijmm.21.2.209
MLA
Pries, R., Hogrefe, L., Xie, L., Frenzel, H., Brocks, C., Ditz, C., Wollenberg, B."Induction of c-Myc-dependent cell proliferation through toll-like receptor 3 in head and neck cancer". International Journal of Molecular Medicine 21.2 (2008): 209-215.
Chicago
Pries, R., Hogrefe, L., Xie, L., Frenzel, H., Brocks, C., Ditz, C., Wollenberg, B."Induction of c-Myc-dependent cell proliferation through toll-like receptor 3 in head and neck cancer". International Journal of Molecular Medicine 21, no. 2 (2008): 209-215. https://doi.org/10.3892/ijmm.21.2.209
Copy and paste a formatted citation
x
Spandidos Publications style
Pries R, Hogrefe L, Xie L, Frenzel H, Brocks C, Ditz C and Wollenberg B: Induction of c-Myc-dependent cell proliferation through toll-like receptor 3 in head and neck cancer. Int J Mol Med 21: 209-215, 2008.
APA
Pries, R., Hogrefe, L., Xie, L., Frenzel, H., Brocks, C., Ditz, C., & Wollenberg, B. (2008). Induction of c-Myc-dependent cell proliferation through toll-like receptor 3 in head and neck cancer. International Journal of Molecular Medicine, 21, 209-215. https://doi.org/10.3892/ijmm.21.2.209
MLA
Pries, R., Hogrefe, L., Xie, L., Frenzel, H., Brocks, C., Ditz, C., Wollenberg, B."Induction of c-Myc-dependent cell proliferation through toll-like receptor 3 in head and neck cancer". International Journal of Molecular Medicine 21.2 (2008): 209-215.
Chicago
Pries, R., Hogrefe, L., Xie, L., Frenzel, H., Brocks, C., Ditz, C., Wollenberg, B."Induction of c-Myc-dependent cell proliferation through toll-like receptor 3 in head and neck cancer". International Journal of Molecular Medicine 21, no. 2 (2008): 209-215. https://doi.org/10.3892/ijmm.21.2.209
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