Induction of c-Myc-dependent cell proliferation through toll-like receptor 3 in head and neck cancer

  • Authors:
    • Ralph Pries
    • Lisa Hogrefe
    • Lei Xie
    • Henning Frenzel
    • Carsten Brocks
    • Claudia Ditz
    • Barbara Wollenberg
  • View Affiliations

  • Published online on: February 1, 2008     https://doi.org/10.3892/ijmm.21.2.209
  • Pages: 209-215
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Abstract

Protein expression of human toll-like receptors (TLR) 1-10 was measured in cell lines and solid tumors of head and neck squamous cell carcinoma (HNSCC). All HNSCC cell lines and 80% of solid tumors were found to express TLR3 as a predominantly intracellular protein, while no other TLR proteins were expressed. TLR3 has previously been shown to contribute to the activation of nuclear factor-κB (NF-κB), a transcription factor which promotes several types of human cancers. Significantly, NF-κB expression was strongest in protein extracts from carcinoma tissue in which TLR3 was overexpressed. Inhibition of TLR3 expression in permanent HNSCC cell lines resulted in decreased expression of the oncoprotein c-Myc resulting in decreased cell proliferation. Correspondingly, overexpression of human TLR3 in mouse fibroblasts resulted in an upregulation of c-Myc and increased sensitivity for PolyI:C-induced cell proliferation. Our data suggest that TLR3 contributes to the malignant phenotype leading to invasive carcinoma in HNSCC.

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February 2008
Volume 21 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Pries R, Hogrefe L, Xie L, Frenzel H, Brocks C, Ditz C and Wollenberg B: Induction of c-Myc-dependent cell proliferation through toll-like receptor 3 in head and neck cancer. Int J Mol Med 21: 209-215, 2008
APA
Pries, R., Hogrefe, L., Xie, L., Frenzel, H., Brocks, C., Ditz, C., & Wollenberg, B. (2008). Induction of c-Myc-dependent cell proliferation through toll-like receptor 3 in head and neck cancer. International Journal of Molecular Medicine, 21, 209-215. https://doi.org/10.3892/ijmm.21.2.209
MLA
Pries, R., Hogrefe, L., Xie, L., Frenzel, H., Brocks, C., Ditz, C., Wollenberg, B."Induction of c-Myc-dependent cell proliferation through toll-like receptor 3 in head and neck cancer". International Journal of Molecular Medicine 21.2 (2008): 209-215.
Chicago
Pries, R., Hogrefe, L., Xie, L., Frenzel, H., Brocks, C., Ditz, C., Wollenberg, B."Induction of c-Myc-dependent cell proliferation through toll-like receptor 3 in head and neck cancer". International Journal of Molecular Medicine 21, no. 2 (2008): 209-215. https://doi.org/10.3892/ijmm.21.2.209