Growth characteristics of SHIV without the vpu gene

  • Authors:
    • Akio Adachi
    • Maki Miyaura
    • Akiko Sakurai
    • Akiko Yoshida
    • A. Hajime Koyama
    • Mikako Fujita
  • View Affiliations

  • Published online on: December 1, 2001     https://doi.org/10.3892/ijmm.8.6.641
  • Pages: 641-644
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Abstract

NM-3 is a prototype of chimeric virus between simian and human immunodeficiency viruses (SHIV). It grows in monkey lymphocytic cells in vitro and in vivo as well as in human cells. A mutant designated NM3-E65, which lacks expression of the entire vpu gene, was constructed from NM-3, and monitored for its replication property. Examination of growth properties in simian and human cells of SHIV, HIV, and their vpu mutants revealed that the vpu gene in the genome of the chimeric virus is functional, but non-essential for virus replication.

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December 2001
Volume 8 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Adachi, A., Miyaura, M., Sakurai, A., Yoshida, A., Koyama, A.H., & Fujita, M. (2001). Growth characteristics of SHIV without the vpu gene. International Journal of Molecular Medicine, 8, 641-644. https://doi.org/10.3892/ijmm.8.6.641
MLA
Adachi, A., Miyaura, M., Sakurai, A., Yoshida, A., Koyama, A. H., Fujita, M."Growth characteristics of SHIV without the vpu gene". International Journal of Molecular Medicine 8.6 (2001): 641-644.
Chicago
Adachi, A., Miyaura, M., Sakurai, A., Yoshida, A., Koyama, A. H., Fujita, M."Growth characteristics of SHIV without the vpu gene". International Journal of Molecular Medicine 8, no. 6 (2001): 641-644. https://doi.org/10.3892/ijmm.8.6.641