An aqueous extract of green tea Camellia sinensis increases expression of Th1 cell-specific anti-asthmatic markers

  • Authors:
    • Jin-Chul Heo
    • Jae Rang Rho
    • Tae-Ho Kim
    • Shin-Yoon Kim
    • Sang-Han Lee
  • View Affiliations

  • Published online on: December 1, 2008     https://doi.org/10.3892/ijmm_00000083
  • Pages: 763-767
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study provides evidence of the anti-asthmatic signaling activity of an aqueous fraction of green tea using specific in vitro and in vivo assays in an ovalbumin-induced asthmatic model. Mice sensitized to ovalbumin were orally administered an aqueous extract of Camellia sinensis. The lungs of these mice were then examined by hematoxylin and eosin staining and ELISA analysis to measure cytokine expression. The aqueous extract of Camellia sinensis exhibited potent anti-asthmatic activity by increasing the expression level of tumor necrosis factor-β and interferon-γ and decreasing the expression of anti-asthmatic cytokines in the lung. Together, these results indicate that the aqueous fraction of Camellia sinensis is effective in alleviating asthmatic symptoms by increasing the expression of Th1 cell-specific anti-asthmatic biomarkers.

Related Articles

Journal Cover

December 2008
Volume 22 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Heo J, Rho JR, Kim T, Kim S and Lee S: An aqueous extract of green tea Camellia sinensis increases expression of Th1 cell-specific anti-asthmatic markers. Int J Mol Med 22: 763-767, 2008
APA
Heo, J., Rho, J.R., Kim, T., Kim, S., & Lee, S. (2008). An aqueous extract of green tea Camellia sinensis increases expression of Th1 cell-specific anti-asthmatic markers. International Journal of Molecular Medicine, 22, 763-767. https://doi.org/10.3892/ijmm_00000083
MLA
Heo, J., Rho, J. R., Kim, T., Kim, S., Lee, S."An aqueous extract of green tea Camellia sinensis increases expression of Th1 cell-specific anti-asthmatic markers". International Journal of Molecular Medicine 22.6 (2008): 763-767.
Chicago
Heo, J., Rho, J. R., Kim, T., Kim, S., Lee, S."An aqueous extract of green tea Camellia sinensis increases expression of Th1 cell-specific anti-asthmatic markers". International Journal of Molecular Medicine 22, no. 6 (2008): 763-767. https://doi.org/10.3892/ijmm_00000083