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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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December 2008 Volume 22 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2008 Volume 22 Issue 6

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Article

Expression of PPARγ is reduced by medium supplementation with L-glutamine in human colorectal Caco-2 cells

  • Authors:
    • Cathy Fiatte
    • Cécile Huin
    • Philippe Collet
    • François Plénat
    • Michel Dauça
    • Hervé Schohn

  • View Affiliations / Copyright

    Affiliations: Laboratoire d'Ingénierie Moléculaire et Biochimie Pharmacologique, EA 3940, Université P. Verlaine, Metz, Campus Bridoux, F57070 Metz, France
  • Pages: 825-832
    |
    Published online on: December 1, 2008
       https://doi.org/10.3892/ijmm_00000091
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Abstract

Peroxisome proliferator-activated receptor-γ (PPARγ) belongs to the nuclear hormone receptor family. This receptor is implicated in colon cell differentiation and in colon cancer. Receptor activation by specific agonists has been shown to protect against colon cancer progression. PPARγ protein content within cells is modulated by several mechanisms, including proteasome degradation, activation of Wnt signalling pathways and presence of fermentation products such as butyrate. Herein, we investigated the impact of L-glutamine on PPARγ expression during the differentiation of Caco-2 cells grown in medium containing dialyzed fetal calf serum supplemented or not with L-glutamine. Using RT-PCR and Western blotting, we demonstrated that PPARγ expression was decreased when L-glutamine was added to the medium. Using immunohistochemistry, we demonstrated that PPARγ immunostaining was mainly found in cytoplasm when cells were cultured with L-glutamine while it was found in nuclei and cytoplasm when cells were grown without the addition of L-glutamine. Supershift retardation assays demonstrated a decrease of PPARγ binding onto consensus peroxisome proliferator response element. We concluded that L-glutamine modulated PPARγ expression in Caco-2 cells.

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Copy and paste a formatted citation
Spandidos Publications style
Fiatte C, Huin C, Collet P, Plénat F, Dauça M and Schohn H: Expression of PPARγ is reduced by medium supplementation with L-glutamine in human colorectal Caco-2 cells. Int J Mol Med 22: 825-832, 2008.
APA
Fiatte, C., Huin, C., Collet, P., Plénat, F., Dauça, M., & Schohn, H. (2008). Expression of PPARγ is reduced by medium supplementation with L-glutamine in human colorectal Caco-2 cells. International Journal of Molecular Medicine, 22, 825-832. https://doi.org/10.3892/ijmm_00000091
MLA
Fiatte, C., Huin, C., Collet, P., Plénat, F., Dauça, M., Schohn, H."Expression of PPARγ is reduced by medium supplementation with L-glutamine in human colorectal Caco-2 cells". International Journal of Molecular Medicine 22.6 (2008): 825-832.
Chicago
Fiatte, C., Huin, C., Collet, P., Plénat, F., Dauça, M., Schohn, H."Expression of PPARγ is reduced by medium supplementation with L-glutamine in human colorectal Caco-2 cells". International Journal of Molecular Medicine 22, no. 6 (2008): 825-832. https://doi.org/10.3892/ijmm_00000091
Copy and paste a formatted citation
x
Spandidos Publications style
Fiatte C, Huin C, Collet P, Plénat F, Dauça M and Schohn H: Expression of PPARγ is reduced by medium supplementation with L-glutamine in human colorectal Caco-2 cells. Int J Mol Med 22: 825-832, 2008.
APA
Fiatte, C., Huin, C., Collet, P., Plénat, F., Dauça, M., & Schohn, H. (2008). Expression of PPARγ is reduced by medium supplementation with L-glutamine in human colorectal Caco-2 cells. International Journal of Molecular Medicine, 22, 825-832. https://doi.org/10.3892/ijmm_00000091
MLA
Fiatte, C., Huin, C., Collet, P., Plénat, F., Dauça, M., Schohn, H."Expression of PPARγ is reduced by medium supplementation with L-glutamine in human colorectal Caco-2 cells". International Journal of Molecular Medicine 22.6 (2008): 825-832.
Chicago
Fiatte, C., Huin, C., Collet, P., Plénat, F., Dauça, M., Schohn, H."Expression of PPARγ is reduced by medium supplementation with L-glutamine in human colorectal Caco-2 cells". International Journal of Molecular Medicine 22, no. 6 (2008): 825-832. https://doi.org/10.3892/ijmm_00000091
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