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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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February 2009 Volume 23 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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February 2009 Volume 23 Issue 2

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Article

Tacrolimus but not cyclosporine A enhances FGF-2-induced VEGF release in osteoblasts

  • Authors:
    • Junichi Yamauchi
    • Shinji Takai
    • Rie Matsushima-Nishiwaki
    • Seiji Adachi
    • Chiho Minamitani
    • Hideo Natsume
    • Jun Mizutani
    • Takanobu Otsuka
    • Jun Takeda
    • Atsushi Harada
    • Osamu Kozawa
    • Haruhiko Tokuda

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
  • Pages: 267-272
    |
    Published online on: February 1, 2009
       https://doi.org/10.3892/ijmm_00000126
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Abstract

We previously reported that basic fibroblast growth factor (FGF-2) stimulates the release of vascular endothelial growth factor (VEGF) via p44/p42 mitogen-activated protein (MAP) kinase and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in osteoblast-like MC3T3-E1 cells and that FGF-2-activated p38 MAP kinase negatively regulates VEGF release. In addition, p70 S6 kinase activated by FGF-2 negatively regulates VEGF release via SAPK/JNK. In the present study, we investigated the effects of tacrolimus (FK506) and cyclosporine A, well-known immunosuppressants, on the FGF-2-induced VEGF release in these cells. Tacrolimus, but not cyclosporine A which alone had no effect on VEGF basal levels, significantly enhanced FGF-2-stimulated VEGF release. Tacrolimus markedly enhanced FGF-2-induced phosphorylation of SAPK/JNK without affecting the phosphorylation of p44/p42 MAP or p38 MAP kinases. SP600125, a specific inhibitor of SAPK/JNK, reduced the amplification by tacrolimus of the FGF-2-induced VEGF release. The FGF-2-induced phosphorylation of p70 S6 kinase was suppressed by tacrolimus. These results strongly suggest that tacrolimus enhances FGF-2-stimulated VEGF release via up-regulation of SAPK/JNK through modulating p70 S6 kinase in osteoblasts.

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Copy and paste a formatted citation
Spandidos Publications style
Yamauchi J, Takai S, Matsushima-Nishiwaki R, Adachi S, Minamitani C, Natsume H, Mizutani J, Otsuka T, Takeda J, Harada A, Harada A, et al: Tacrolimus but not cyclosporine A enhances FGF-2-induced VEGF release in osteoblasts. Int J Mol Med 23: 267-272, 2009.
APA
Yamauchi, J., Takai, S., Matsushima-Nishiwaki, R., Adachi, S., Minamitani, C., Natsume, H. ... Tokuda, H. (2009). Tacrolimus but not cyclosporine A enhances FGF-2-induced VEGF release in osteoblasts. International Journal of Molecular Medicine, 23, 267-272. https://doi.org/10.3892/ijmm_00000126
MLA
Yamauchi, J., Takai, S., Matsushima-Nishiwaki, R., Adachi, S., Minamitani, C., Natsume, H., Mizutani, J., Otsuka, T., Takeda, J., Harada, A., Kozawa, O., Tokuda, H."Tacrolimus but not cyclosporine A enhances FGF-2-induced VEGF release in osteoblasts". International Journal of Molecular Medicine 23.2 (2009): 267-272.
Chicago
Yamauchi, J., Takai, S., Matsushima-Nishiwaki, R., Adachi, S., Minamitani, C., Natsume, H., Mizutani, J., Otsuka, T., Takeda, J., Harada, A., Kozawa, O., Tokuda, H."Tacrolimus but not cyclosporine A enhances FGF-2-induced VEGF release in osteoblasts". International Journal of Molecular Medicine 23, no. 2 (2009): 267-272. https://doi.org/10.3892/ijmm_00000126
Copy and paste a formatted citation
x
Spandidos Publications style
Yamauchi J, Takai S, Matsushima-Nishiwaki R, Adachi S, Minamitani C, Natsume H, Mizutani J, Otsuka T, Takeda J, Harada A, Harada A, et al: Tacrolimus but not cyclosporine A enhances FGF-2-induced VEGF release in osteoblasts. Int J Mol Med 23: 267-272, 2009.
APA
Yamauchi, J., Takai, S., Matsushima-Nishiwaki, R., Adachi, S., Minamitani, C., Natsume, H. ... Tokuda, H. (2009). Tacrolimus but not cyclosporine A enhances FGF-2-induced VEGF release in osteoblasts. International Journal of Molecular Medicine, 23, 267-272. https://doi.org/10.3892/ijmm_00000126
MLA
Yamauchi, J., Takai, S., Matsushima-Nishiwaki, R., Adachi, S., Minamitani, C., Natsume, H., Mizutani, J., Otsuka, T., Takeda, J., Harada, A., Kozawa, O., Tokuda, H."Tacrolimus but not cyclosporine A enhances FGF-2-induced VEGF release in osteoblasts". International Journal of Molecular Medicine 23.2 (2009): 267-272.
Chicago
Yamauchi, J., Takai, S., Matsushima-Nishiwaki, R., Adachi, S., Minamitani, C., Natsume, H., Mizutani, J., Otsuka, T., Takeda, J., Harada, A., Kozawa, O., Tokuda, H."Tacrolimus but not cyclosporine A enhances FGF-2-induced VEGF release in osteoblasts". International Journal of Molecular Medicine 23, no. 2 (2009): 267-272. https://doi.org/10.3892/ijmm_00000126
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