A small interfering ABCE1-targeting RNA inhibits the proliferation and invasiveness of small cell lung cancer

  • Authors:
    • Bo Huang
    • Ying Gao
    • Dali Tian
    • Maogen Zheng
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  • Published online on: May 1, 2010     https://doi.org/10.3892/ijmm_00000392
  • Pages: 687-693
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Abstract

Small cell lung cancer (SCLC) is a highly aggressive lung neoplasm. To study the pathogenesis of SCLC, we investigated roles of ABCE1, a member of the ATP-binding cassette (ABC) superfamily, in the development of small cell lung cancer. RNA interference was used to knock down ABCE1 expression in human small cell lung cancer cell lines (NCI-H446). Then we examined the effects of ABCE1 knockdown in cancer cells, including proliferation, invasiveness, apoptosis, and gene expression. We found that ABCE1 could be efficiently knocked down by siRNA, and the ABCE1 silence inhibited the proliferation, invasiveness of small cell lung cancer cell lines NCI-H446. In conclusion, our results suggest that ABCE1 play an important role in the pathogenesis of human small cell lung cancer cell. ABCE1 may be used as a potential target of gene therapy for small cell lung cancer in future.

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May 2010
Volume 25 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Huang B, Gao Y, Tian D and Zheng M: A small interfering ABCE1-targeting RNA inhibits the proliferation and invasiveness of small cell lung cancer. Int J Mol Med 25: 687-693, 2010.
APA
Huang, B., Gao, Y., Tian, D., & Zheng, M. (2010). A small interfering ABCE1-targeting RNA inhibits the proliferation and invasiveness of small cell lung cancer. International Journal of Molecular Medicine, 25, 687-693. https://doi.org/10.3892/ijmm_00000392
MLA
Huang, B., Gao, Y., Tian, D., Zheng, M."A small interfering ABCE1-targeting RNA inhibits the proliferation and invasiveness of small cell lung cancer". International Journal of Molecular Medicine 25.5 (2010): 687-693.
Chicago
Huang, B., Gao, Y., Tian, D., Zheng, M."A small interfering ABCE1-targeting RNA inhibits the proliferation and invasiveness of small cell lung cancer". International Journal of Molecular Medicine 25, no. 5 (2010): 687-693. https://doi.org/10.3892/ijmm_00000392