Connexin 26 expression correlates with less aggressive phenotype of intestinal type-gastric carcinomas

  • Authors:
    • XiaoLi Liu
    • Tomoko Furuya
    • DongYan Li
    • JingDa Xu
    • XiXi Cao
    • QingQuan Li
    • JiaWen Xu
    • ZuDe Xu
    • Kohsuke Sasaki
    • XiuPing Liu
  • View Affiliations

  • Published online on: May 1, 2010     https://doi.org/10.3892/ijmm_00000395
  • Pages: 709-716
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Abstract

Connexin 26 (Cx26), one of the gap junction-forming family members, is more controversial than other members, as a tumor suppressor. Here, we assessed Cx26 expression in gastric carcinoma, which has not been investigated before, and its clinical significance including survival analyses. Cx26 expression was assessed in 205 tissue samples from gastric carcinoma by immunohistochemistry. Of 205 gastric carcinoma cases, 79 (38.5%) were positive for Cx26 with mainly cytoplasmic localization compared to sporadic membranous staining in normal epithelium, and the expression levels were confirmed by Western blotting and real-time PCR. Negative associations were revealed between Cx26 expression and most clinicopathologic features (all P<0.05). Notably, high Cx26 expression was associated with histological intestinal-type (P=0.017) and early stage of gastric carcinoma. The multivariate regression analysis revealed that positive Cx26 expression was an independent prognostic predictor of intestinal-type GC (P=0.023, HR=2.019). Our findings suggest that aberrant expression of Cx26 in cytoplasm plays a tumor-suppressor role in gastric carcinoma and is an independent biomarker for favorable prognosis in intestinal-type gastric carcinoma.

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May 2010
Volume 25 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Liu X, Furuya T, Li D, Xu J, Cao X, Li Q, Xu J, Xu Z, Sasaki K, Liu X, Liu X, et al: Connexin 26 expression correlates with less aggressive phenotype of intestinal type-gastric carcinomas. Int J Mol Med 25: 709-716, 2010
APA
Liu, X., Furuya, T., Li, D., Xu, J., Cao, X., Li, Q. ... Liu, X. (2010). Connexin 26 expression correlates with less aggressive phenotype of intestinal type-gastric carcinomas. International Journal of Molecular Medicine, 25, 709-716. https://doi.org/10.3892/ijmm_00000395
MLA
Liu, X., Furuya, T., Li, D., Xu, J., Cao, X., Li, Q., Xu, J., Xu, Z., Sasaki, K., Liu, X."Connexin 26 expression correlates with less aggressive phenotype of intestinal type-gastric carcinomas". International Journal of Molecular Medicine 25.5 (2010): 709-716.
Chicago
Liu, X., Furuya, T., Li, D., Xu, J., Cao, X., Li, Q., Xu, J., Xu, Z., Sasaki, K., Liu, X."Connexin 26 expression correlates with less aggressive phenotype of intestinal type-gastric carcinomas". International Journal of Molecular Medicine 25, no. 5 (2010): 709-716. https://doi.org/10.3892/ijmm_00000395