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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2010 Volume 26 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2010 Volume 26 Issue 4

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Article

Expression and localization of prominin-1 in isoproterenol-treated rat parotid gland

  • Authors:
    • Fabio D'Amico
    • Evangelia Skarmoutsou
    • Katia Mangano
    • Grazia Malaponte
    • Franca Stivala
    • Maria Clorinda Mazzarino

  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Sciences, University of Catania, 95124 Catania, Italy. f.damico@unict.it
  • Pages: 505-510
    |
    Published online on: October 1, 2010
       https://doi.org/10.3892/ijmm_00000492
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Abstract

Prominin-1 (CD133) is a pentaspan cholesterol-binding membrane glycoprotein. Chronic treatment with isoproterenol, a β-receptor agonist, induces several dramatic effects on salivary glands, such as enhanced DNA synthesis and proliferation of salivary acinar cells. In addition, the biosynthetic pathways of membrane lipids may be altered by the isoproterenol stimulation. The purpose of this study was to investigate the effect of isoproterenol administration on prominin-1 expression profiles in rat parotid gland by means of PCR and immunohistochemistry. Rats were chronically treated with the β-adrenergic agonist for 1, 3, and 7 days. Our results showed that isoproterenol-treatment caused a down-regulation of prominin-1 on day 3 and 7 of treatment, as well as a differential immunostaining distribution pattern. This study suggests that isoproterenol-treatment may represent a useful tool to explore the molecular mechanisms involved in the synthesis and release of prominin-1. Such efforts could contribute to the development of diagnostic tools based on the detection of prominin-1 in biological fluids, such as saliva.

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Copy and paste a formatted citation
Spandidos Publications style
D'Amico F, Skarmoutsou E, Mangano K, Malaponte G, Stivala F and Mazzarino MC: Expression and localization of prominin-1 in isoproterenol-treated rat parotid gland . Int J Mol Med 26: 505-510, 2010.
APA
D'Amico, F., Skarmoutsou, E., Mangano, K., Malaponte, G., Stivala, F., & Mazzarino, M.C. (2010). Expression and localization of prominin-1 in isoproterenol-treated rat parotid gland . International Journal of Molecular Medicine, 26, 505-510. https://doi.org/10.3892/ijmm_00000492
MLA
D'Amico, F., Skarmoutsou, E., Mangano, K., Malaponte, G., Stivala, F., Mazzarino, M. C."Expression and localization of prominin-1 in isoproterenol-treated rat parotid gland ". International Journal of Molecular Medicine 26.4 (2010): 505-510.
Chicago
D'Amico, F., Skarmoutsou, E., Mangano, K., Malaponte, G., Stivala, F., Mazzarino, M. C."Expression and localization of prominin-1 in isoproterenol-treated rat parotid gland ". International Journal of Molecular Medicine 26, no. 4 (2010): 505-510. https://doi.org/10.3892/ijmm_00000492
Copy and paste a formatted citation
x
Spandidos Publications style
D'Amico F, Skarmoutsou E, Mangano K, Malaponte G, Stivala F and Mazzarino MC: Expression and localization of prominin-1 in isoproterenol-treated rat parotid gland . Int J Mol Med 26: 505-510, 2010.
APA
D'Amico, F., Skarmoutsou, E., Mangano, K., Malaponte, G., Stivala, F., & Mazzarino, M.C. (2010). Expression and localization of prominin-1 in isoproterenol-treated rat parotid gland . International Journal of Molecular Medicine, 26, 505-510. https://doi.org/10.3892/ijmm_00000492
MLA
D'Amico, F., Skarmoutsou, E., Mangano, K., Malaponte, G., Stivala, F., Mazzarino, M. C."Expression and localization of prominin-1 in isoproterenol-treated rat parotid gland ". International Journal of Molecular Medicine 26.4 (2010): 505-510.
Chicago
D'Amico, F., Skarmoutsou, E., Mangano, K., Malaponte, G., Stivala, F., Mazzarino, M. C."Expression and localization of prominin-1 in isoproterenol-treated rat parotid gland ". International Journal of Molecular Medicine 26, no. 4 (2010): 505-510. https://doi.org/10.3892/ijmm_00000492
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