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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2010 Volume 26 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2010 Volume 26 Issue 4

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Article

The effects of atorvastatin on pulmonary arterial hypertension and expression of p38, p27, and Jab1 in rats

  • Authors:
    • Yu-Fei Gao
    • Xiao-Duo Zhu
    • Dong-Mei Shi
    • Zhi-Cheng Jing
    • Li Li
    • Dan Ma
    • Zhi-Xin Fan
    • Jian Li
    • Yi-Wei Wang
    • Bing-Xiang Wu

  • View Affiliations / Copyright

    Affiliations: Cardiovascular Department, First Affiliated Hospital of Harbin Medical University, Heilongjiang Province, P.R. China
  • Pages: 541-547
    |
    Published online on: October 1, 2010
       https://doi.org/10.3892/ijmm_00000497
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Abstract

Statins have recently come under evaluation for the treatment of pulmonary arterial hypertension (PAH). The aim of this study was to examine the effects of atorvastatin on the clinical manifestations and expression of p38, p27 and Jab1 using a rat PAH model. Ninety-six male Wistar rats were divided into control (receiving no surgical treatment), vehicle and treatment groups, among which the last two groups underwent left pneumonectomy and were then treated with monocrotaline (MCT, 60 mg/kg). Both control and vehicle groups subsequently received saline, and the treatment group received atorvastatin (20 mg/kg) by stomach catheter. Rats were sacrificed, and mean pulmonary arterial pressure (mPAP) and right ventricle hypertrophy index (RVHI) were measured. The expression of p38, p27, and Jab1 was evaluated by immunohistochemistry and Western blotting. At 28 days, mPAP and RVHI and expression levels of Jab1 and p38 in the vehicle group were significantly higher than those in the treatment and control groups. However, the expression of p27 was lowest in the vehicle group among the three groups. Atorvastatin reduced PAP and RVHI in the rat PAH model, decreased expression of p38 and Jab1 but increased expression of p27.

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Copy and paste a formatted citation
Spandidos Publications style
Gao Y, Zhu X, Shi D, Jing Z, Li L, Ma D, Fan Z, Li J, Wang Y, Wu B, Wu B, et al: The effects of atorvastatin on pulmonary arterial hypertension and expression of p38, p27, and Jab1 in rats . Int J Mol Med 26: 541-547, 2010.
APA
Gao, Y., Zhu, X., Shi, D., Jing, Z., Li, L., Ma, D. ... Wu, B. (2010). The effects of atorvastatin on pulmonary arterial hypertension and expression of p38, p27, and Jab1 in rats . International Journal of Molecular Medicine, 26, 541-547. https://doi.org/10.3892/ijmm_00000497
MLA
Gao, Y., Zhu, X., Shi, D., Jing, Z., Li, L., Ma, D., Fan, Z., Li, J., Wang, Y., Wu, B."The effects of atorvastatin on pulmonary arterial hypertension and expression of p38, p27, and Jab1 in rats ". International Journal of Molecular Medicine 26.4 (2010): 541-547.
Chicago
Gao, Y., Zhu, X., Shi, D., Jing, Z., Li, L., Ma, D., Fan, Z., Li, J., Wang, Y., Wu, B."The effects of atorvastatin on pulmonary arterial hypertension and expression of p38, p27, and Jab1 in rats ". International Journal of Molecular Medicine 26, no. 4 (2010): 541-547. https://doi.org/10.3892/ijmm_00000497
Copy and paste a formatted citation
x
Spandidos Publications style
Gao Y, Zhu X, Shi D, Jing Z, Li L, Ma D, Fan Z, Li J, Wang Y, Wu B, Wu B, et al: The effects of atorvastatin on pulmonary arterial hypertension and expression of p38, p27, and Jab1 in rats . Int J Mol Med 26: 541-547, 2010.
APA
Gao, Y., Zhu, X., Shi, D., Jing, Z., Li, L., Ma, D. ... Wu, B. (2010). The effects of atorvastatin on pulmonary arterial hypertension and expression of p38, p27, and Jab1 in rats . International Journal of Molecular Medicine, 26, 541-547. https://doi.org/10.3892/ijmm_00000497
MLA
Gao, Y., Zhu, X., Shi, D., Jing, Z., Li, L., Ma, D., Fan, Z., Li, J., Wang, Y., Wu, B."The effects of atorvastatin on pulmonary arterial hypertension and expression of p38, p27, and Jab1 in rats ". International Journal of Molecular Medicine 26.4 (2010): 541-547.
Chicago
Gao, Y., Zhu, X., Shi, D., Jing, Z., Li, L., Ma, D., Fan, Z., Li, J., Wang, Y., Wu, B."The effects of atorvastatin on pulmonary arterial hypertension and expression of p38, p27, and Jab1 in rats ". International Journal of Molecular Medicine 26, no. 4 (2010): 541-547. https://doi.org/10.3892/ijmm_00000497
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