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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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December 2010 Volume 26 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2010 Volume 26 Issue 6

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Article

T lymphocyte responses against hepatitis B virus-related hepatocellular carcinoma induced by adenovirus vaccine encoding HBx

  • Authors:
    • Yuhua Li
    • Ping Cheng
    • Yanjun Wen
    • Ping Chen
    • Li Yang
    • Xia Zhao
    • Huimin Lv
    • Qingli Quan
    • Yonglin Wu
    • Huiqiang Yang
    • Jie Liu
    • Xueru Wen
    • Nina Liu
    • Zhuang Kang
    • Shan Luo
    • Lian Wang
    • Yuquan Wei
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Biotherapy, West China Hospital and College of Life Science, Sichuan University, Chengdu 610041, P.R. China
  • Pages: 869-876
    |
    Published online on: December 1, 2010
       https://doi.org/10.3892/ijmm_00000536
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Abstract

HBx is an oncogenic tumor-associated antigen and is dominantly expressed in hepatitis and hepatoma tissues, the induction of active cellular responses against HBx should be a promising approach for the treatment of hepatitis B virus-related hepatocellular carcinoma. The present study was designed to test whether a replication-defective adenovirus vaccine expressing HBx antigen could be effectively used in the immunotherapy of hepatocellular carcinoma. To validate the possibility, we developed a novel HBx-positive hepatocellular carcinoma in mice by inoculated the pcDNA-HBx transfected Hepa1-6 cells subcutaneously into the right flank of mice. We found that immunotherapy with Ad-HBx was effective at both protective and therapeutic antitumor immunity in the hepatoma models in immune-competent mice. Histological examination revealed that Ad-HBx treatment led to significantly increased induction of apoptosis, tumor necrosis, and elevated CD8+ lymphocyte infiltration. In addition, the induction efficacy of the CTL response is dramatically enhanced by immunotherapy. Cytokine analysis comfirmed that the antitumor efficacy of Ad-HBx may mostly result from cellular immunity. Our findings may prove useful in development of adenovirus vaccine based on HBx antigen to the treatment of HBV-associated hepatocellular carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Cheng P, Wen Y, Chen P, Yang L, Zhao X, Lv H, Quan Q, Wu Y, Yang H, Yang H, et al: T lymphocyte responses against hepatitis B virus-related hepatocellular carcinoma induced by adenovirus vaccine encoding HBx . Int J Mol Med 26: 869-876, 2010.
APA
Li, Y., Cheng, P., Wen, Y., Chen, P., Yang, L., Zhao, X. ... Wei, Y. (2010). T lymphocyte responses against hepatitis B virus-related hepatocellular carcinoma induced by adenovirus vaccine encoding HBx . International Journal of Molecular Medicine, 26, 869-876. https://doi.org/10.3892/ijmm_00000536
MLA
Li, Y., Cheng, P., Wen, Y., Chen, P., Yang, L., Zhao, X., Lv, H., Quan, Q., Wu, Y., Yang, H., Liu, J., Wen, X., Liu, N., Kang, Z., Luo, S., Wang, L., Wei, Y." T lymphocyte responses against hepatitis B virus-related hepatocellular carcinoma induced by adenovirus vaccine encoding HBx ". International Journal of Molecular Medicine 26.6 (2010): 869-876.
Chicago
Li, Y., Cheng, P., Wen, Y., Chen, P., Yang, L., Zhao, X., Lv, H., Quan, Q., Wu, Y., Yang, H., Liu, J., Wen, X., Liu, N., Kang, Z., Luo, S., Wang, L., Wei, Y." T lymphocyte responses against hepatitis B virus-related hepatocellular carcinoma induced by adenovirus vaccine encoding HBx ". International Journal of Molecular Medicine 26, no. 6 (2010): 869-876. https://doi.org/10.3892/ijmm_00000536
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Cheng P, Wen Y, Chen P, Yang L, Zhao X, Lv H, Quan Q, Wu Y, Yang H, Yang H, et al: T lymphocyte responses against hepatitis B virus-related hepatocellular carcinoma induced by adenovirus vaccine encoding HBx . Int J Mol Med 26: 869-876, 2010.
APA
Li, Y., Cheng, P., Wen, Y., Chen, P., Yang, L., Zhao, X. ... Wei, Y. (2010). T lymphocyte responses against hepatitis B virus-related hepatocellular carcinoma induced by adenovirus vaccine encoding HBx . International Journal of Molecular Medicine, 26, 869-876. https://doi.org/10.3892/ijmm_00000536
MLA
Li, Y., Cheng, P., Wen, Y., Chen, P., Yang, L., Zhao, X., Lv, H., Quan, Q., Wu, Y., Yang, H., Liu, J., Wen, X., Liu, N., Kang, Z., Luo, S., Wang, L., Wei, Y." T lymphocyte responses against hepatitis B virus-related hepatocellular carcinoma induced by adenovirus vaccine encoding HBx ". International Journal of Molecular Medicine 26.6 (2010): 869-876.
Chicago
Li, Y., Cheng, P., Wen, Y., Chen, P., Yang, L., Zhao, X., Lv, H., Quan, Q., Wu, Y., Yang, H., Liu, J., Wen, X., Liu, N., Kang, Z., Luo, S., Wang, L., Wei, Y." T lymphocyte responses against hepatitis B virus-related hepatocellular carcinoma induced by adenovirus vaccine encoding HBx ". International Journal of Molecular Medicine 26, no. 6 (2010): 869-876. https://doi.org/10.3892/ijmm_00000536
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