Multidrug resistance mediated by overexpression of P-glycoprotein in human osteosarcoma in vivo.

  • Authors:
    • R Suto
    • Y Abe
    • M Nakamura
    • Y Ohnishi
    • M Yoshimura
    • Y H Lee
    • T Imanishi
    • H Yamazaki
    • H Kijima
    • T Tokunaga
    • Y Oshika
    • N Hiraoka
    • N Tamaoki
    • H Fukuda
    • Y Ueyama
  • View Affiliations

  • Published online on: February 1, 1998     https://doi.org/10.3892/ijo.12.2.287
  • Pages: 287-378
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Abstract

We examined the expression levels of P-glycoprotein (P-Gp)/the human multidrug resistance gene (MDR1) and in vivo chemosensitivity in the 7 osteosarcoma xenografts. Three of seven (43%) osteosarcoma xenografts expressed MDR1 by reverse transcriptase-polymerase chain reaction (RT-PCR). The OSS-516R xenograft selected with vincristine (VCR) from the MDR1-negative xenograft OSS-516, which was sensitive to VCR and doxorubicin (DOX), acquired cross-resistance to DOX. In the OSS-516R, RT-PCR assay showed definite MDR1 expression and immunohistochemical analysis demonstrated P-Gp-positive tumor cells. These results suggest that P-Gp/MDR1 overexpression is related to multidrug resistance in human osteosarcoma in vivo.

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Feb 1998
Volume 12 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Suto R, Abe Y, Nakamura M, Ohnishi Y, Yoshimura M, Lee Y, Imanishi T, Yamazaki H, Kijima H, Tokunaga T, Tokunaga T, et al: Multidrug resistance mediated by overexpression of P-glycoprotein in human osteosarcoma in vivo.. Int J Oncol 12: 287-378, 1998
APA
Suto, R., Abe, Y., Nakamura, M., Ohnishi, Y., Yoshimura, M., Lee, Y. ... Ueyama, Y. (1998). Multidrug resistance mediated by overexpression of P-glycoprotein in human osteosarcoma in vivo.. International Journal of Oncology, 12, 287-378. https://doi.org/10.3892/ijo.12.2.287
MLA
Suto, R., Abe, Y., Nakamura, M., Ohnishi, Y., Yoshimura, M., Lee, Y., Imanishi, T., Yamazaki, H., Kijima, H., Tokunaga, T., Oshika, Y., Hiraoka, N., Tamaoki, N., Fukuda, H., Ueyama, Y."Multidrug resistance mediated by overexpression of P-glycoprotein in human osteosarcoma in vivo.". International Journal of Oncology 12.2 (1998): 287-378.
Chicago
Suto, R., Abe, Y., Nakamura, M., Ohnishi, Y., Yoshimura, M., Lee, Y., Imanishi, T., Yamazaki, H., Kijima, H., Tokunaga, T., Oshika, Y., Hiraoka, N., Tamaoki, N., Fukuda, H., Ueyama, Y."Multidrug resistance mediated by overexpression of P-glycoprotein in human osteosarcoma in vivo.". International Journal of Oncology 12, no. 2 (1998): 287-378. https://doi.org/10.3892/ijo.12.2.287