Expression of human endogenous retrovirus ERV3 (HERV-R) mRNA in normal and neoplastic tissues.
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- Published online on: February 1, 1998 https://doi.org/10.3892/ijo.12.2.309
- Pages: 309-322
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Abstract
We investigated the mRNA expression of the human endogenous retrovirus ERV3 (HERV-R) in several normal and corresponding tumor tissues. The env gene of ERV3 is expressed as mRNA in several tissues. Comparison of ERV3 mRNA expression by Northern analyses, revealed a non-systematic variation. Expression was shown to be particularly high in the adrenal gland and some cases of lung cancer. This tissue-tropism should be seen in relation to the high expression previously found in syncytiotrophoblasts in placenta and sebaceous glands of the skin, suggesting profound influences by steroid hormonal regulation.
