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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Feb 1998 Volume 12 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Feb 1998 Volume 12 Issue 2

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Article

Differential expression and activity of P-glycoprotein and multidrug resistance-associated protein in CD34-positive KG1a leukemic cells.

  • Authors:
    • O Fardel
    • L Payen
    • A Courtois
    • B Drenou
    • R Fauchet
    • B Rault

  • View Affiliations / Copyright

    Affiliations: Laboratoire de Physiologie et Hematologie et INSERM U456, Faculte des Sciences Pharmaceutiques et Biologiques, 2 Avenue du Pr. L on Bernard, Rennes Cedex, 35043, France.
  • Pages: 315-324
    |
    Published online on: February 1, 1998
       https://doi.org/10.3892/ijo.12.2.315
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Abstract

CD34+ acute myeloid leukemias generally respond poorly to chemotherapy when compared to CD34- myeloid leukemias. In order to contribute to the analysis of the mechanisms involved in this drug resistance, expression and activity of P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP), two drug efflux pumps conferring multidrug resistance, have been investigated in the CD34+ KG1a leukemic myeloid cell line and in two CD34- K562 and HL60 leukemic myeloid cell lines. Reverse transcription-polymerase chain reaction and dye efflux assays revealed that KG1a cells express P-gp but not MRP whereas neither P-gp nor MRP were detected in K562 and HL60 cells. In addition, KG1a cells were demonstrated to display resistance to anticancer drug substrates for P-gp such as vincristine and daunorubicin and to poorly accumulate vincristine. These results indicated that P-gp, in contrast to MRP, is expressed and functional in the drug-resistant CD34+ KG1a cell line, that may constitute a useful cellular model to analyze the constitutive chemoresistance of CD34+ acute myeloid leukemias.

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Copy and paste a formatted citation
Spandidos Publications style
Fardel O, Payen L, Courtois A, Drenou B, Fauchet R and Rault B: Differential expression and activity of P-glycoprotein and multidrug resistance-associated protein in CD34-positive KG1a leukemic cells.. Int J Oncol 12: 315-324, 1998.
APA
Fardel, O., Payen, L., Courtois, A., Drenou, B., Fauchet, R., & Rault, B. (1998). Differential expression and activity of P-glycoprotein and multidrug resistance-associated protein in CD34-positive KG1a leukemic cells.. International Journal of Oncology, 12, 315-324. https://doi.org/10.3892/ijo.12.2.315
MLA
Fardel, O., Payen, L., Courtois, A., Drenou, B., Fauchet, R., Rault, B."Differential expression and activity of P-glycoprotein and multidrug resistance-associated protein in CD34-positive KG1a leukemic cells.". International Journal of Oncology 12.2 (1998): 315-324.
Chicago
Fardel, O., Payen, L., Courtois, A., Drenou, B., Fauchet, R., Rault, B."Differential expression and activity of P-glycoprotein and multidrug resistance-associated protein in CD34-positive KG1a leukemic cells.". International Journal of Oncology 12, no. 2 (1998): 315-324. https://doi.org/10.3892/ijo.12.2.315
Copy and paste a formatted citation
x
Spandidos Publications style
Fardel O, Payen L, Courtois A, Drenou B, Fauchet R and Rault B: Differential expression and activity of P-glycoprotein and multidrug resistance-associated protein in CD34-positive KG1a leukemic cells.. Int J Oncol 12: 315-324, 1998.
APA
Fardel, O., Payen, L., Courtois, A., Drenou, B., Fauchet, R., & Rault, B. (1998). Differential expression and activity of P-glycoprotein and multidrug resistance-associated protein in CD34-positive KG1a leukemic cells.. International Journal of Oncology, 12, 315-324. https://doi.org/10.3892/ijo.12.2.315
MLA
Fardel, O., Payen, L., Courtois, A., Drenou, B., Fauchet, R., Rault, B."Differential expression and activity of P-glycoprotein and multidrug resistance-associated protein in CD34-positive KG1a leukemic cells.". International Journal of Oncology 12.2 (1998): 315-324.
Chicago
Fardel, O., Payen, L., Courtois, A., Drenou, B., Fauchet, R., Rault, B."Differential expression and activity of P-glycoprotein and multidrug resistance-associated protein in CD34-positive KG1a leukemic cells.". International Journal of Oncology 12, no. 2 (1998): 315-324. https://doi.org/10.3892/ijo.12.2.315
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