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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Feb 1998 Volume 12 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Feb 1998 Volume 12 Issue 2

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Article

DNA synthesis, mismatch repair and cancer.

  • Authors:
    • J S Hoffmann
    • C Cazaux
  • View Affiliations / Copyright

    Affiliations: Institut de Pharmacologie et de Biologie Structurale, CNRS UPR 9062, 205 route de Narbonne, 31077 Toulouse cedex, France.
  • Pages: 377-459
    |
    Published online on: February 1, 1998
       https://doi.org/10.3892/ijo.12.2.377
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Abstract

The entire nucleotide sequence of the genome must be transmitted from one generation to the next with no or few errors. Preservation of this integrity requires multiple genes whose alteration can lead to an early event in tumorigenesis by increasing the mutation rate. This mutator phenotype would provide a continuing pool of mutants upon which selection could act to promote a tumor. Recent evidence consistant with this hypothesis is the mutator phenotype of tumor cells of patients with a hereditary form of colon cancer (HNPCC) which exhibit a several hundred-fold increase in spontaneous mutations in addition to a high degree of microsatellite instability. The multiple genomic alterations increasingly reported as associated with most cancers may therefore be linked to a variety of DNA metabolic processes guardians of the genome, including fidelity of the DNA synthesis and mismatch repair. The connection between cancer and deregulation of nucleotide synthesis, imbalance of the pools of nucleotides, deficiency of DNA polymerases, and mismatch repair is the subject of this review. We consider how perturbation in these DNA transactions results in instability of the genome and cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Hoffmann J and Cazaux C: DNA synthesis, mismatch repair and cancer.. Int J Oncol 12: 377-459, 1998.
APA
Hoffmann, J., & Cazaux, C. (1998). DNA synthesis, mismatch repair and cancer.. International Journal of Oncology, 12, 377-459. https://doi.org/10.3892/ijo.12.2.377
MLA
Hoffmann, J., Cazaux, C."DNA synthesis, mismatch repair and cancer.". International Journal of Oncology 12.2 (1998): 377-459.
Chicago
Hoffmann, J., Cazaux, C."DNA synthesis, mismatch repair and cancer.". International Journal of Oncology 12, no. 2 (1998): 377-459. https://doi.org/10.3892/ijo.12.2.377
Copy and paste a formatted citation
x
Spandidos Publications style
Hoffmann J and Cazaux C: DNA synthesis, mismatch repair and cancer.. Int J Oncol 12: 377-459, 1998.
APA
Hoffmann, J., & Cazaux, C. (1998). DNA synthesis, mismatch repair and cancer.. International Journal of Oncology, 12, 377-459. https://doi.org/10.3892/ijo.12.2.377
MLA
Hoffmann, J., Cazaux, C."DNA synthesis, mismatch repair and cancer.". International Journal of Oncology 12.2 (1998): 377-459.
Chicago
Hoffmann, J., Cazaux, C."DNA synthesis, mismatch repair and cancer.". International Journal of Oncology 12, no. 2 (1998): 377-459. https://doi.org/10.3892/ijo.12.2.377
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