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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2001 Volume 18 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2001 Volume 18 Issue 3

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Article

Association of Epstein-Barr virus with tumor cell proliferation: Clinical implication in nasopharyngeal carcinoma

  • Authors:
    • Taro Kijima
    • Noriko Kinukawa
    • William E. Gooding
    • Masatsune Uno

  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Nihon University Hospital, Chiyoda-ku, Tokyo 101-8309, Japan
  • Pages: 479-485
    |
    Published online on: March 1, 2001
       https://doi.org/10.3892/ijo.18.3.479
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Abstract

Nasopharyngeal carcinoma (NPC) is characterized by its association with Epstein-Barr virus (EBV) infection. Unlike other upper aerodigestive tract squamous cell carcinomas, clinical and pathologic features are unable to predict outcome in NPC. EBV has been demonstrated to have transforming potential in B-cell systems so that its infection can rapidly and efficiently induce sustained lymphocyte proliferation in vitro. However, the relationship between cell proliferation and EBV infection in NPC has not been previously reported. This study was designed to determine the association of EBV infection and NPC tumor cell proliferation. Cell proliferation index, as measured by two markers, PCNA and Ki-67, were moderately correlated (r=0.534, p=0.033). Quantitative analysis of EBV positivity was highly correlated with both cell proliferation indices (r=0.802, p=0.0039 and r=0.720, p=0.0174 for PCNA and Ki-67, respectively). TNM staging did not demonstrate prognostic significance. NPC patients whose tumors were EBV positive demonstrated increased survival compared with patients whose tumors were EBV negative (p=0.043). These results indicate that EBV infection may regulate cell proliferation in NPC and the presence of EBV can be used as a positive prognostic factor.

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Copy and paste a formatted citation
Spandidos Publications style
Kijima T, Kinukawa N, Gooding WE and Uno M: Association of Epstein-Barr virus with tumor cell proliferation: Clinical implication in nasopharyngeal carcinoma. Int J Oncol 18: 479-485, 2001.
APA
Kijima, T., Kinukawa, N., Gooding, W.E., & Uno, M. (2001). Association of Epstein-Barr virus with tumor cell proliferation: Clinical implication in nasopharyngeal carcinoma. International Journal of Oncology, 18, 479-485. https://doi.org/10.3892/ijo.18.3.479
MLA
Kijima, T., Kinukawa, N., Gooding, W. E., Uno, M."Association of Epstein-Barr virus with tumor cell proliferation: Clinical implication in nasopharyngeal carcinoma". International Journal of Oncology 18.3 (2001): 479-485.
Chicago
Kijima, T., Kinukawa, N., Gooding, W. E., Uno, M."Association of Epstein-Barr virus with tumor cell proliferation: Clinical implication in nasopharyngeal carcinoma". International Journal of Oncology 18, no. 3 (2001): 479-485. https://doi.org/10.3892/ijo.18.3.479
Copy and paste a formatted citation
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Spandidos Publications style
Kijima T, Kinukawa N, Gooding WE and Uno M: Association of Epstein-Barr virus with tumor cell proliferation: Clinical implication in nasopharyngeal carcinoma. Int J Oncol 18: 479-485, 2001.
APA
Kijima, T., Kinukawa, N., Gooding, W.E., & Uno, M. (2001). Association of Epstein-Barr virus with tumor cell proliferation: Clinical implication in nasopharyngeal carcinoma. International Journal of Oncology, 18, 479-485. https://doi.org/10.3892/ijo.18.3.479
MLA
Kijima, T., Kinukawa, N., Gooding, W. E., Uno, M."Association of Epstein-Barr virus with tumor cell proliferation: Clinical implication in nasopharyngeal carcinoma". International Journal of Oncology 18.3 (2001): 479-485.
Chicago
Kijima, T., Kinukawa, N., Gooding, W. E., Uno, M."Association of Epstein-Barr virus with tumor cell proliferation: Clinical implication in nasopharyngeal carcinoma". International Journal of Oncology 18, no. 3 (2001): 479-485. https://doi.org/10.3892/ijo.18.3.479
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