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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2011 Volume 39 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2011 Volume 39 Issue 5

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Article

Tumor-derived vascular endothelial growth factor (VEGF)-A facilitates tumor metastasis through the VEGF-VEGFR1 signaling pathway

  • Authors:
    • Wenbo Liu
    • Jiying Xu
    • Mingming Wang
    • Qiangxiu Wang
    • Yuli Bi
    • Mingyong Han

  • View Affiliations / Copyright

    Affiliations: Department of Immunology, Shandong Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan 250014, P.R. China, Cancer Therapy Center, Shandong Provincial Hospital, Shandong University, 324 Jingwuweiqi Road, 250021 Jinan, P.R. China
  • Pages: 1213-1220
    |
    Published online on: July 22, 2011
       https://doi.org/10.3892/ijo.2011.1138
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Abstract

Vascular endothelial growth factor (VEGF) and its receptors are involved in carcinogenesis, invasion and tumor angiogenesis, but the underlying mechanism by which VEGF promotes tumor metastasis is poorly understood. In this study, we show that in cancer patients high expression of VEGF is correlated with metastasis, and anti-VEGF treatment (bevacizumab) has clinical effects on tumor metastasis. Two human lung carcinoma cell lines (A549 and SPCA1 cells) with distinct VEGF expression were injected intravenously through the lateral tail vein of SCID mice and a murine model was developed. We investigated the association between the expression of VEGF and tumor metastasis by microvessel density, immunohistochemistry and whole mount staining. At sacrifice, in the high VEGF expression A549 cell line group, the induced tumor was distinctively larger in size and multiple metastatic lesions were found in lung tissues. Two specific neutralizing anti-mouse VEGFR1 and VEGFR2 antibodies were administered to the tumor-bearing mice; anti-VEGFR1, but not anti-VEGFR2 treatment produced inhibitive effects on VEGF-induced tumor metastasis. These findings demonstrate that the VEGF-VEGFR1 signaling pathway is crucial for tumor metastasis and the blockade of VEGF-VEGFR1-induced metastasis may provide a novel approach for the prevention and treatment of tumor metastasis.

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Copy and paste a formatted citation
Spandidos Publications style
Liu W, Xu J, Wang M, Wang Q, Bi Y and Han M: Tumor-derived vascular endothelial growth factor (VEGF)-A facilitates tumor metastasis through the VEGF-VEGFR1 signaling pathway. Int J Oncol 39: 1213-1220, 2011.
APA
Liu, W., Xu, J., Wang, M., Wang, Q., Bi, Y., & Han, M. (2011). Tumor-derived vascular endothelial growth factor (VEGF)-A facilitates tumor metastasis through the VEGF-VEGFR1 signaling pathway. International Journal of Oncology, 39, 1213-1220. https://doi.org/10.3892/ijo.2011.1138
MLA
Liu, W., Xu, J., Wang, M., Wang, Q., Bi, Y., Han, M."Tumor-derived vascular endothelial growth factor (VEGF)-A facilitates tumor metastasis through the VEGF-VEGFR1 signaling pathway". International Journal of Oncology 39.5 (2011): 1213-1220.
Chicago
Liu, W., Xu, J., Wang, M., Wang, Q., Bi, Y., Han, M."Tumor-derived vascular endothelial growth factor (VEGF)-A facilitates tumor metastasis through the VEGF-VEGFR1 signaling pathway". International Journal of Oncology 39, no. 5 (2011): 1213-1220. https://doi.org/10.3892/ijo.2011.1138
Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Xu J, Wang M, Wang Q, Bi Y and Han M: Tumor-derived vascular endothelial growth factor (VEGF)-A facilitates tumor metastasis through the VEGF-VEGFR1 signaling pathway. Int J Oncol 39: 1213-1220, 2011.
APA
Liu, W., Xu, J., Wang, M., Wang, Q., Bi, Y., & Han, M. (2011). Tumor-derived vascular endothelial growth factor (VEGF)-A facilitates tumor metastasis through the VEGF-VEGFR1 signaling pathway. International Journal of Oncology, 39, 1213-1220. https://doi.org/10.3892/ijo.2011.1138
MLA
Liu, W., Xu, J., Wang, M., Wang, Q., Bi, Y., Han, M."Tumor-derived vascular endothelial growth factor (VEGF)-A facilitates tumor metastasis through the VEGF-VEGFR1 signaling pathway". International Journal of Oncology 39.5 (2011): 1213-1220.
Chicago
Liu, W., Xu, J., Wang, M., Wang, Q., Bi, Y., Han, M."Tumor-derived vascular endothelial growth factor (VEGF)-A facilitates tumor metastasis through the VEGF-VEGFR1 signaling pathway". International Journal of Oncology 39, no. 5 (2011): 1213-1220. https://doi.org/10.3892/ijo.2011.1138
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