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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2011 Volume 39 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Increased ΔNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma

  • Authors:
    • Ryota Matsubara
    • Shintaro Kawano
    • Takahiro Kiyosue
    • Yuichi Goto
    • Mitsuhiro Hirano
    • Teppei Jinno
    • Takeshi Toyoshima
    • Ryoji Kitamura
    • Kazunari Oobu
    • Seiji Nakamura

  • View Affiliations / Copyright

    Affiliations: Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
  • Pages: 1391-1399
    |
    Published online on: August 9, 2011
       https://doi.org/10.3892/ijo.2011.1151
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Abstract

This study examined immunohistochemical expression of ΔNp63, a keratinocyte stem cell marker, in oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC) and then to elucidate usefulness of ΔNp63 as a marker for diagnosis and prognosis. One-hundred and twelve cases of OL and 81 cases of OSCC were analyzed by immunohistochemical staining for ΔNp63, Ki-67, and cytokeratin 14. These labeling indices (LIs) were calculated, and the association of these LIs with clinicopathologic characteristics in the OL and OSCC was evaluated. In the OL, these LIs increased significantly according to the severity of epithelial dysplasia (p<0.0001). ΔNp63-LI in the OL with malignant transformation was significantly higher than that in the OL without (49.3 vs. 34.2%; p<0.01). In the OSCC, the LIs increased significantly in association with the histologic grade (p<0.0001). A significant difference between the high and low ΔNp63-LI groups was found in the incidence of cervical lymph node and distant metastasis (p<0.05). The prognosis of the high ΔNp63-LI (mean value >73.8%) group is poorer than that of the low ΔNp63-LI (mean value ≤73.8%) group (p<0.05). These results suggested that increased ΔNp63 expression is involved in malignant transformation in epithelial dysplasia and poor prognosis in OSCC.

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Copy and paste a formatted citation
Spandidos Publications style
Matsubara R, Kawano S, Kiyosue T, Goto Y, Hirano M, Jinno T, Toyoshima T, Kitamura R, Oobu K, Nakamura S, Nakamura S, et al: Increased ΔNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma. Int J Oncol 39: 1391-1399, 2011.
APA
Matsubara, R., Kawano, S., Kiyosue, T., Goto, Y., Hirano, M., Jinno, T. ... Nakamura, S. (2011). Increased ΔNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma. International Journal of Oncology, 39, 1391-1399. https://doi.org/10.3892/ijo.2011.1151
MLA
Matsubara, R., Kawano, S., Kiyosue, T., Goto, Y., Hirano, M., Jinno, T., Toyoshima, T., Kitamura, R., Oobu, K., Nakamura, S."Increased ΔNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma". International Journal of Oncology 39.6 (2011): 1391-1399.
Chicago
Matsubara, R., Kawano, S., Kiyosue, T., Goto, Y., Hirano, M., Jinno, T., Toyoshima, T., Kitamura, R., Oobu, K., Nakamura, S."Increased ΔNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma". International Journal of Oncology 39, no. 6 (2011): 1391-1399. https://doi.org/10.3892/ijo.2011.1151
Copy and paste a formatted citation
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Spandidos Publications style
Matsubara R, Kawano S, Kiyosue T, Goto Y, Hirano M, Jinno T, Toyoshima T, Kitamura R, Oobu K, Nakamura S, Nakamura S, et al: Increased ΔNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma. Int J Oncol 39: 1391-1399, 2011.
APA
Matsubara, R., Kawano, S., Kiyosue, T., Goto, Y., Hirano, M., Jinno, T. ... Nakamura, S. (2011). Increased ΔNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma. International Journal of Oncology, 39, 1391-1399. https://doi.org/10.3892/ijo.2011.1151
MLA
Matsubara, R., Kawano, S., Kiyosue, T., Goto, Y., Hirano, M., Jinno, T., Toyoshima, T., Kitamura, R., Oobu, K., Nakamura, S."Increased ΔNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma". International Journal of Oncology 39.6 (2011): 1391-1399.
Chicago
Matsubara, R., Kawano, S., Kiyosue, T., Goto, Y., Hirano, M., Jinno, T., Toyoshima, T., Kitamura, R., Oobu, K., Nakamura, S."Increased ΔNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma". International Journal of Oncology 39, no. 6 (2011): 1391-1399. https://doi.org/10.3892/ijo.2011.1151
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