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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2011 Volume 39 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2011 Volume 39 Issue 6

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Article

Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system

  • Authors:
    • Khalil Abou-El-Ardat
    • Hanane Derradji
    • Winnok de Vos
    • Tim de Meyer
    • Sofie Bekaert
    • Wim van Criekinge
    • Sarah Baatout
  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular and Cellular Biology, Radiobiology Unit, Belgian Nuclear Research Center (SCK-CEN), 2400 Mol, Belgium, Department of Molecular Biotechnology, FBW, Ghent University, 9000 Ghent, Belgium
  • Pages: 1429-1441
    |
    Published online on: August 29, 2011
       https://doi.org/10.3892/ijo.2011.1175
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Abstract

The link between high doses of radiation and thyroid cancer has been well established in various studies, as opposed to the effects of low doses. In this study, we investi­gated the effects of low-dose X-ray irradiation in a papillary thyroid carcinoma model with wild-type and mutated p53. A low dose of 62.5 mGy was enough to cause an upregulation of p16 and a decrease in the number of TPC-1 cells in the S phase, but not in the number of BCPAP p53-mutant cells. At a dose of 0.5 Gy, visible signs of senescence appeared only in the TPC-1 cells. We conclude that low doses of X-rays are enough to cause a change in cell cycle distribution, possibly p53-dependent p16 activation, but no significant apoptosis. Senescence requires higher doses of X-irradiation via a mechanism involving both p16 and p21.

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Copy and paste a formatted citation
Spandidos Publications style
Abou-El-Ardat K, Derradji H, de Vos W, de Meyer T, Bekaert S, van Criekinge W and Baatout S: Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system. Int J Oncol 39: 1429-1441, 2011.
APA
Abou-El-Ardat, K., Derradji, H., de Vos, W., de Meyer, T., Bekaert, S., van Criekinge, W., & Baatout, S. (2011). Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system. International Journal of Oncology, 39, 1429-1441. https://doi.org/10.3892/ijo.2011.1175
MLA
Abou-El-Ardat, K., Derradji, H., de Vos, W., de Meyer, T., Bekaert, S., van Criekinge, W., Baatout, S."Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system". International Journal of Oncology 39.6 (2011): 1429-1441.
Chicago
Abou-El-Ardat, K., Derradji, H., de Vos, W., de Meyer, T., Bekaert, S., van Criekinge, W., Baatout, S."Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system". International Journal of Oncology 39, no. 6 (2011): 1429-1441. https://doi.org/10.3892/ijo.2011.1175
Copy and paste a formatted citation
x
Spandidos Publications style
Abou-El-Ardat K, Derradji H, de Vos W, de Meyer T, Bekaert S, van Criekinge W and Baatout S: Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system. Int J Oncol 39: 1429-1441, 2011.
APA
Abou-El-Ardat, K., Derradji, H., de Vos, W., de Meyer, T., Bekaert, S., van Criekinge, W., & Baatout, S. (2011). Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system. International Journal of Oncology, 39, 1429-1441. https://doi.org/10.3892/ijo.2011.1175
MLA
Abou-El-Ardat, K., Derradji, H., de Vos, W., de Meyer, T., Bekaert, S., van Criekinge, W., Baatout, S."Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system". International Journal of Oncology 39.6 (2011): 1429-1441.
Chicago
Abou-El-Ardat, K., Derradji, H., de Vos, W., de Meyer, T., Bekaert, S., van Criekinge, W., Baatout, S."Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system". International Journal of Oncology 39, no. 6 (2011): 1429-1441. https://doi.org/10.3892/ijo.2011.1175
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