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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2012 Volume 40 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2012 Volume 40 Issue 3

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Article

Identification and validation of a gene expression signature that predicts outcome in malignant glioma patients

  • Authors:
    • Atsushi Kawaguchi
    • Naoki Yajima
    • Yoshihiro Komohara
    • Hiroshi Aoki
    • Naoto Tsuchiya
    • Jumpei Homma
    • Masakazu Sano
    • Manabu Natsumeda
    • Takeo Uzuka
    • Akihiko Saitoh
    • Hideaki Takahashi
    • Yuko Sakai
    • Hitoshi Takahashi
    • Yukihiko Fujii
    • Tatsuyuki Kakuma
    • Ryuya Yamanaka
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Niigata University, Kyoto 602-8566, Japan, Kyoto Prefectural University of Medicine, Graduate School for Health Care Science, 465 Kajii-cho, Kamigyoku, Kyoto 602-8566, Japan
  • Pages: 721-730
    |
    Published online on: October 21, 2011
       https://doi.org/10.3892/ijo.2011.1240
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Abstract

Better understanding of the underlying biology of malignant gliomas is critical for the development of early detection strategies and new therapeutics. This study aimed to define genes associated with survival. We investigated whether genes selected using random survival forests model could be used to define subgroups of gliomas objectively. RNAs from 50 non-treated gliomas were analyzed using the GeneChip Human Genome U133 Plus 2.0 Expression array. We identified 82 genes whose expression was strongly and consistently related to patient survival. For practical purposes, a 15-gene set was also selected. Both the complete 82 gene signature and the 15 gene set subgroup indicated their significant predictivity in the 3 out of 4 independent external dataset. Our method was effective for objectively classifying gliomas, and provided a more accurate predictor of prognosis. We assessed the relationship between gene expressions and survival time by using the random survival forests model and this performance was a better classifier compared to significance analysis of microarrays.

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Copy and paste a formatted citation
Spandidos Publications style
Kawaguchi A, Yajima N, Komohara Y, Aoki H, Tsuchiya N, Homma J, Sano M, Natsumeda M, Uzuka T, Saitoh A, Saitoh A, et al: Identification and validation of a gene expression signature that predicts outcome in malignant glioma patients. Int J Oncol 40: 721-730, 2012.
APA
Kawaguchi, A., Yajima, N., Komohara, Y., Aoki, H., Tsuchiya, N., Homma, J. ... Yamanaka, R. (2012). Identification and validation of a gene expression signature that predicts outcome in malignant glioma patients. International Journal of Oncology, 40, 721-730. https://doi.org/10.3892/ijo.2011.1240
MLA
Kawaguchi, A., Yajima, N., Komohara, Y., Aoki, H., Tsuchiya, N., Homma, J., Sano, M., Natsumeda, M., Uzuka, T., Saitoh, A., Takahashi, H., Sakai, Y., Takahashi, H., Fujii, Y., Kakuma, T., Yamanaka, R."Identification and validation of a gene expression signature that predicts outcome in malignant glioma patients". International Journal of Oncology 40.3 (2012): 721-730.
Chicago
Kawaguchi, A., Yajima, N., Komohara, Y., Aoki, H., Tsuchiya, N., Homma, J., Sano, M., Natsumeda, M., Uzuka, T., Saitoh, A., Takahashi, H., Sakai, Y., Takahashi, H., Fujii, Y., Kakuma, T., Yamanaka, R."Identification and validation of a gene expression signature that predicts outcome in malignant glioma patients". International Journal of Oncology 40, no. 3 (2012): 721-730. https://doi.org/10.3892/ijo.2011.1240
Copy and paste a formatted citation
x
Spandidos Publications style
Kawaguchi A, Yajima N, Komohara Y, Aoki H, Tsuchiya N, Homma J, Sano M, Natsumeda M, Uzuka T, Saitoh A, Saitoh A, et al: Identification and validation of a gene expression signature that predicts outcome in malignant glioma patients. Int J Oncol 40: 721-730, 2012.
APA
Kawaguchi, A., Yajima, N., Komohara, Y., Aoki, H., Tsuchiya, N., Homma, J. ... Yamanaka, R. (2012). Identification and validation of a gene expression signature that predicts outcome in malignant glioma patients. International Journal of Oncology, 40, 721-730. https://doi.org/10.3892/ijo.2011.1240
MLA
Kawaguchi, A., Yajima, N., Komohara, Y., Aoki, H., Tsuchiya, N., Homma, J., Sano, M., Natsumeda, M., Uzuka, T., Saitoh, A., Takahashi, H., Sakai, Y., Takahashi, H., Fujii, Y., Kakuma, T., Yamanaka, R."Identification and validation of a gene expression signature that predicts outcome in malignant glioma patients". International Journal of Oncology 40.3 (2012): 721-730.
Chicago
Kawaguchi, A., Yajima, N., Komohara, Y., Aoki, H., Tsuchiya, N., Homma, J., Sano, M., Natsumeda, M., Uzuka, T., Saitoh, A., Takahashi, H., Sakai, Y., Takahashi, H., Fujii, Y., Kakuma, T., Yamanaka, R."Identification and validation of a gene expression signature that predicts outcome in malignant glioma patients". International Journal of Oncology 40, no. 3 (2012): 721-730. https://doi.org/10.3892/ijo.2011.1240
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