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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2012 Volume 40 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2012 Volume 40 Issue 3

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Article

Newcastle disease virus induces pro-inflammatory conditions and type I interferon for counter-acting Treg activity

  • Authors:
    • Philippe Fournier
    • Annette Arnold
    • Holger Wilden
    • Volker Schirrmacher

  • View Affiliations / Copyright

    Affiliations: German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
  • Pages: 840-850
    |
    Published online on: November 16, 2011
       https://doi.org/10.3892/ijo.2011.1265
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Abstract

Newcastle disease virus (NDV) is a negative sense RNA paramyxovirus of birds which in human tumor cells, in contrast to human non-tumor cells, has shown replication competence leading to tumor cell death (i.e., tumor selectivity and viral oncolysis). Our study demonstrates that this virus induces high levels of pro-inflammatory cytokines in the bronchial lavage fluid of mice after nasal application and also in vitro in human dendritic cells (DCs). NDV is known as a very efficient inductor of type I interferon (IFN). The presented data show the key role played by the cell surface receptor to type I IFN (IFNAR) but not by the interferon transcription factors IRF-3 and IRF-7 in the induction of the important pro-inflammatory cytokine IL-12 upon transcription of NDV genes in DCs. We show that NDV activates in infected cells the helicase RIG-I. In Tregs, the activation of RIG-I was shown in other studies to inhibit the suppressive function of these cells. We thus conclude that NDV in tumor therapy may help to stimulate T effector cells but also to block Treg cells, thereby alleviating a brake to antitumor activity.

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Copy and paste a formatted citation
Spandidos Publications style
Fournier P, Arnold A, Wilden H and Schirrmacher V: Newcastle disease virus induces pro-inflammatory conditions and type I interferon for counter-acting Treg activity. Int J Oncol 40: 840-850, 2012.
APA
Fournier, P., Arnold, A., Wilden, H., & Schirrmacher, V. (2012). Newcastle disease virus induces pro-inflammatory conditions and type I interferon for counter-acting Treg activity. International Journal of Oncology, 40, 840-850. https://doi.org/10.3892/ijo.2011.1265
MLA
Fournier, P., Arnold, A., Wilden, H., Schirrmacher, V."Newcastle disease virus induces pro-inflammatory conditions and type I interferon for counter-acting Treg activity". International Journal of Oncology 40.3 (2012): 840-850.
Chicago
Fournier, P., Arnold, A., Wilden, H., Schirrmacher, V."Newcastle disease virus induces pro-inflammatory conditions and type I interferon for counter-acting Treg activity". International Journal of Oncology 40, no. 3 (2012): 840-850. https://doi.org/10.3892/ijo.2011.1265
Copy and paste a formatted citation
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Spandidos Publications style
Fournier P, Arnold A, Wilden H and Schirrmacher V: Newcastle disease virus induces pro-inflammatory conditions and type I interferon for counter-acting Treg activity. Int J Oncol 40: 840-850, 2012.
APA
Fournier, P., Arnold, A., Wilden, H., & Schirrmacher, V. (2012). Newcastle disease virus induces pro-inflammatory conditions and type I interferon for counter-acting Treg activity. International Journal of Oncology, 40, 840-850. https://doi.org/10.3892/ijo.2011.1265
MLA
Fournier, P., Arnold, A., Wilden, H., Schirrmacher, V."Newcastle disease virus induces pro-inflammatory conditions and type I interferon for counter-acting Treg activity". International Journal of Oncology 40.3 (2012): 840-850.
Chicago
Fournier, P., Arnold, A., Wilden, H., Schirrmacher, V."Newcastle disease virus induces pro-inflammatory conditions and type I interferon for counter-acting Treg activity". International Journal of Oncology 40, no. 3 (2012): 840-850. https://doi.org/10.3892/ijo.2011.1265
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