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Article

Down-regulation of Human Leukocyte Antigen class I heavy chain in tumors is associated with a poor prognosis in advanced esophageal cancer patients

  • Authors:
    • Kimitaka Tanaka
    • Takahiro Tsuchikawa
    • Masaki Miyamoto
    • Takehiro  Maki
    • Masaomi  Ichinokawa
    • Kanako C. Kubota
    • Toshiaki Shichinohe
    • Satoshi  Hirano
    • Soldano  Ferrone
    • Hirotoshi Dosaka-Akita
    • Yoshihiro Matsuno
    • Satoshi Kondo
  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo, Hokkaido 060-8648, Japan
  • Pages: 965-974
    |
    Published online on: November 30, 2011
       https://doi.org/10.3892/ijo.2011.1274
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Abstract

The HLA class I antigen processing machinery (APM) plays a crucial role in the anticancer immune response. The aim of this study was to assess the clinical significance of APM components in esophageal cancer. A total of 11 esophageal cancer cell lines were evaluated by Western blot analysis for 13 HLA class I APM components. There was a different expression pattern among cancer cell lines for HLA class I heavy chain (HLA-HC), β2 microglobulin, Tapasin, TAP‑1, TAP-2, LMP-7 and LMP-10. Immunohistochemical staining utilizing a tissue microarray method for HLA class I APM expression showing different expression patterns among cell lines was performed for 95 surgical specimens from patients with esophageal cancer. Prognostic factors were the down-regulation of HLA-HC, and the up-regulation of β2 microglobulin and TAP-1 in the cancer tissues. Multivariate analysis using a Cox regression model indicated that the down-regulation of HLA-HC, and up-regulation of TAP-1 in cancer tissues are independent, unfavorable prognostic factors (hazard ratio, 2.361 and 2.297; P=0.0141 and 0.0145, respectively). Although there was no significant difference in survival for selected p-stage I and II patients (n=54) in all APM components, only down-regulation of HLA-HC was an unfavorable prognostic factor by a Cox regression model for selected p-stage III and IV patients (n=41). In conclusion, the current results suggest that the down-regulation of HLA-HC in tumors is especially associated with a poor prognosis among advanced esophageal cancer patients.
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Copy and paste a formatted citation
Spandidos Publications style
Tanaka K, Tsuchikawa T, Miyamoto M, Maki T, Ichinokawa M, Kubota KC, Shichinohe T, Hirano S, Ferrone S, Dosaka-Akita H, Dosaka-Akita H, et al: Down-regulation of Human Leukocyte Antigen class I heavy chain in tumors is associated with a poor prognosis in advanced esophageal cancer patients. Int J Oncol 40: 965-974, 2012.
APA
Tanaka, K., Tsuchikawa, T., Miyamoto, M., Maki, T., Ichinokawa, M., Kubota, K.C. ... Kondo, S. (2012). Down-regulation of Human Leukocyte Antigen class I heavy chain in tumors is associated with a poor prognosis in advanced esophageal cancer patients. International Journal of Oncology, 40, 965-974. https://doi.org/10.3892/ijo.2011.1274
MLA
Tanaka, K., Tsuchikawa, T., Miyamoto, M., Maki, T., Ichinokawa, M., Kubota, K. C., Shichinohe, T., Hirano, S., Ferrone, S., Dosaka-Akita, H., Matsuno, Y., Kondo, S."Down-regulation of Human Leukocyte Antigen class I heavy chain in tumors is associated with a poor prognosis in advanced esophageal cancer patients". International Journal of Oncology 40.4 (2012): 965-974.
Chicago
Tanaka, K., Tsuchikawa, T., Miyamoto, M., Maki, T., Ichinokawa, M., Kubota, K. C., Shichinohe, T., Hirano, S., Ferrone, S., Dosaka-Akita, H., Matsuno, Y., Kondo, S."Down-regulation of Human Leukocyte Antigen class I heavy chain in tumors is associated with a poor prognosis in advanced esophageal cancer patients". International Journal of Oncology 40, no. 4 (2012): 965-974. https://doi.org/10.3892/ijo.2011.1274
Copy and paste a formatted citation
x
Spandidos Publications style
Tanaka K, Tsuchikawa T, Miyamoto M, Maki T, Ichinokawa M, Kubota KC, Shichinohe T, Hirano S, Ferrone S, Dosaka-Akita H, Dosaka-Akita H, et al: Down-regulation of Human Leukocyte Antigen class I heavy chain in tumors is associated with a poor prognosis in advanced esophageal cancer patients. Int J Oncol 40: 965-974, 2012.
APA
Tanaka, K., Tsuchikawa, T., Miyamoto, M., Maki, T., Ichinokawa, M., Kubota, K.C. ... Kondo, S. (2012). Down-regulation of Human Leukocyte Antigen class I heavy chain in tumors is associated with a poor prognosis in advanced esophageal cancer patients. International Journal of Oncology, 40, 965-974. https://doi.org/10.3892/ijo.2011.1274
MLA
Tanaka, K., Tsuchikawa, T., Miyamoto, M., Maki, T., Ichinokawa, M., Kubota, K. C., Shichinohe, T., Hirano, S., Ferrone, S., Dosaka-Akita, H., Matsuno, Y., Kondo, S."Down-regulation of Human Leukocyte Antigen class I heavy chain in tumors is associated with a poor prognosis in advanced esophageal cancer patients". International Journal of Oncology 40.4 (2012): 965-974.
Chicago
Tanaka, K., Tsuchikawa, T., Miyamoto, M., Maki, T., Ichinokawa, M., Kubota, K. C., Shichinohe, T., Hirano, S., Ferrone, S., Dosaka-Akita, H., Matsuno, Y., Kondo, S."Down-regulation of Human Leukocyte Antigen class I heavy chain in tumors is associated with a poor prognosis in advanced esophageal cancer patients". International Journal of Oncology 40, no. 4 (2012): 965-974. https://doi.org/10.3892/ijo.2011.1274
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