Journal Articles

Open Access

Polysaccharide-K augments docetaxel-induced tumor suppression and antitumor immune response in an immunocompetent murine model of human prostate cancer

Cynthia A. Wenner, Mark R. Martzen, Hailing Lu, Michael R. Verneris, Hongbo Wang, Joel W. Slaton

Pages: 905-913 Published online on: 12 December 2011
Open Access

2-Triazenoazaindoles: Α novel class of triazenes inducing transcriptional down-regulation of EGFR and HER-2 in human pancreatic cancer cells

Jan N. Kreutzer, Alessia Salvador, Patrizia Diana, Girolamo Cirrincione, Daniela Vedaldi, David W. Litchfield, Olaf-Georg Issinger, Barbara Guerra

Pages: 914-922 Published online on: 29 November 2011
Open Access

High levels of cellular proliferation predict pseudoprogression in glioblastoma patients

Henri-Benjamin Pouleau, Niloufar Sadeghi, Danielle Balériaux, Christian Mélot, Olivier De Witte, Florence Lefranc

Pages: 923-928 Published online on: 11 November 2011
Open Access

Indoleamine-2,3-dioxygenase, an immunosuppressive enzyme that inhibits natural killer cell function, as a useful target for ovarian cancer therapy

Dongdong Wang, Yasushi Saga, Hiroaki Mizukami, Naoto Sato, Hiroaki Nonaka, Hiroyuki Fujiwara, Yuji Takei, Shizuo Machida, Osamu Takikawa, Keiya Ozawa, Mitsuaki Suzuki

Pages: 929-934 Published online on: 13 December 2011
Open Access

Simvastatin inhibits cancer cell growth by inducing apoptosis correlated to activation of Bax and down-regulation of BCL-2 gene expression

Carmine Spampanato, Salvatore De Maria, Maddalena Sarnataro, Elisabetta Giordano, Mario Zanfardino, Salvatore Baiano, Maridela Cartenì, Franco Morelli

Pages: 935-941 Published online on: 29 November 2011
Open Access

Aberrant methylation of PSD disturbs Rac1-mediated immune responses governing neutrophil chemotaxis and apoptosis in ulcerative colitis-associated carcinogenesis

Takaharu Kato, Koichi Suzuki, Shinichiro Okada, Hidenori Kamiyama, Takafumi Maeda, Masaaki Saito, Kei Koizumi, Yuichiro Miyaki, Fumio Konishi

Pages: 942-950 Published online on: 15 December 2011
Open Access

Novel oncogenic function of mesoderm development candidate 1 and its regulation by MiR-574-3p in bladder cancer cell lines

Shuichi Tatarano, Takeshi Chiyomaru, Kazumori Kawakami, Hideki Enokida, Hirofumi Yoshino, Hideo Hidaka, Nijiro Nohata, Takeshi Yamasaki, Takenari Gotanda, Tokushi Tachiwada, Naohiko Seki, Masayuki Nakagawa

Pages: 951-959 Published online on: 13 December 2011

MUC2 protein expression status is useful in assessing the effects of hyperthermic intraperitoneal chemotherapy for peritoneal dissemination of colon cancer

Yuka Fujishima, Takanori Goi, Youhei Kimura, Yasuo Hirono, Kanji Katayama, Akio Yamaguchi

Pages: 960-964 Published online on: 16 January 2012

Down-regulation of Human Leukocyte Antigen class I heavy chain in tumors is associated with a poor prognosis in advanced esophageal cancer patients

Kimitaka Tanaka, Takahiro Tsuchikawa, Masaki Miyamoto, Takehiro  Maki, Masaomi  Ichinokawa, Kanako C. Kubota, Toshiaki Shichinohe, Satoshi  Hirano, Soldano  Ferrone, Hirotoshi Dosaka-Akita, Yoshihiro Matsuno, Satoshi Kondo

Pages: 965-974 Published online on: 30 November 2011

Antitumor effect of cetuximab in combination with S-1 in EGFR-amplified gastric cancer cells

Kazumasa Fukuda, Yoshiro Saikawa, Masashi Takahashi, Tsunehiro Takahashi, Norihito Wada, Hirohumi Kawakubo, Hiroya Takeuchi, Yuko Kitagawa

Pages: 975-982 Published online on: 01 December 2011

Array-based identification of common DNA methylation alterations in ulcerative colitis

Kei Koizumi, Sergio Alonso, Yuichiro Miyaki, Shinichiro Okada, Hiroyuki Ogura, Norihiko Shiiya, Fumio Konishi, Toshiki Taya, Manuel Perucho, Koichi Suzuki

Pages: 983-994 Published online on: 06 December 2011

Drug resistance to paclitaxel is not only associated with ABCB1 mRNA expression but also with drug accumulation in intracellular compartments in human lung cancer cell lines

Masanori Shimomura, Takeshi Yaoi, Kyoko Itoh, Daishiro Kato, Kunihiko  Terauchi, Junichi Shimada, Shinji Fushiki

Pages: 995-1004 Published online on: 13 December 2011

Establishment and characterization of two 5-fluorouracil-resistant hepatocellular carcinoma cell lines

Kazuya Uchibori, Atsushi Kasamatsu, Masahiko Sunaga, Satoshi  Yokota, Tomoya Sakurada, Eriko Kobayashi, Masaharu Yoshikawa, Katsuhiro  Uzawa, Shiro Ueda, Hideki Tanzawa, Nobunori Sato

Pages: 1005-1010 Published online on: 15 December 2011

Role of endothelin receptor signalling in squamous cell carcinoma

Shunsuke Ishimoto, Koichiro Wada, Noriaki Tanaka, Tadashi Yamanishi, Kohji Ishihama, Tomonao Aikawa, Masaya Okura, Atsushi Nakajima, Mikihiko Kogo, Yoshinori Kamisaki

Pages: 1011-1019 Published online on: 10 November 2011

Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells

Hisanori Miki, Norihisa Uehara, Ayako Kimura, Tomo Sasaki, Takashi Yuri, Katsuhiko Yoshizawa, Airo Tsubura

Pages: 1020-1028 Published online on: 03 January 2012

Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells

Seiichiro Komatsu, Keisuke Miyazawa, Shota Moriya, Akiko Takase, Munekazu Naito, Masato Inazu, Norio Kohno, Masahiro Itoh, Akio Tomoda

Pages: 1029-1039 Published online on: 23 December 2011

Keratinocyte growth factor induces matrix metalloproteinase-9 expression and correlates with venous invasion in pancreatic cancer

Kazumitsu Cho, Yoko Matsuda, Junji Ueda, Eiji  Uchida, Zenya Naito, Toshiyuki Ishiwata

Pages: 1040-1048 Published online on: 06 December 2011

Emodin reverses gemcitabine resistance in pancreatic cancer cells via the mitochondrial apoptosis pathway in vitro

Dian-Lei Liu, Heqi Bu, Hong Li, Hui Chen, Hong-Chun Guo, Zhao-Hong Wang, Hong-Fei Tong, Zhong-Lin Ni, Hai-Bin Liu, Sheng-Zhang Lin

Pages: 1049-1057 Published online on: 07 December 2011

Gomisin N enhances TRAIL-induced apoptosis via reactive oxygen species-mediated up-regulation of death receptors 4 and 5

Hiroki Inoue, Pornthip Waiwut, Ikuo Saiki, Yutaka Shimada, Hiroaki Sakurai

Pages: 1058-1065 Published online on: 15 December 2011

Tripchlorolide induces cell death in lung cancer cells by autophagy

Limin Chen, Qing Liu, Zhenghui Huang, Feng Wu, Zhiying Li, Xiangqi Chen, Tingyan Lin

Pages: 1066-1070 Published online on: 01 December 2011

Diethyldithiocarbamate induces apoptosis in HHV-8-infected primary effusion lymphoma cells via inhibition of the NF-κB pathway

Takashi Matsuno, Ryusho Kariya, Shuichiro Yano, Saori Morino-Koga, Manabu Taura, Mary Ann Suico, Yuichiro Shimauchi, Shingo Matsuyama, Yuka Okamoto, Tsuyoshi Shuto, Hirofumi Kai, Seiji Okada

Pages: 1071-1078 Published online on: 20 December 2011

Microtubule associated tumor suppressor 1 deficient mice develop spontaneous heart hypertrophy and SLE-like lymphoproliferative disease

Christina Zuern, Laszlo Krenacs, Stephanie Starke, Jutta Heimrich, Alois Palmetshofer, Bettina Holtmann, Michael Sendtner, Tobias Fischer, Jan Galle, Christoph Wanner, Stefan Seibold

Pages: 1079-1088 Published online on: 20 December 2011

Realgar-induced apoptosis and differentiation in all-trans retinoic acid (ATRA)-sensitive NB4 and ATRA-resistant MR2 cells

Siyu Chen, Yi Fang, Liheng Ma, Shanxi Liu, Xinmin Li

Pages: 1089-1096 Published online on: 30 November 2011

Stem cells with fused gene expression of cytosine deaminase and interferon-β migrate to human gastric cancer cells and result in synergistic growth inhibition for potential therapeutic use

Kyoung-Yoon Kim, Bo-Rim Yi, Hye-Rim Lee, Nam-Hee Kang, Eui-Bae Jeung, Seung U. Kim, Kyung-Chul Choi

Pages: 1097-1104 Published online on: 08 December 2011

MicroRNA miR-451 downregulates the PI3K/AKT pathway through CAB39 in human glioma

Yuan Tian, Yang Nan, Lei Han, Anling Zhang, Guangxiu Wang, Zhifan Jia, Jianwei Hao, Peiyu Pu, Yue Zhong, Chunsheng Kang

Pages: 1105-1112 Published online on: 15 December 2011

Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment

Tamaro S. Hudson, Susan N. Perkins, Stephen D. Hursting, Heather A. Young, Young S. Kim, Tien-Chung Wang, Thomas T.Y. Wang

Pages: 1113-1121 Published online on: 17 January 2012

Identification of prognostic biomarkers for glioblastomas using protein expression profiling

Yong Jung, Kyeung Min Joo, Dong Ho Seong, Yoon-La Choi, Doo-Sik Kong, Yonghyun Kim, Mi Hyun Kim, Juyoun Jin, Yeon-Lim Suh, Ho Jun Seol, Chul Soo Shin, Jung-Il Lee, Jong-Hyun Kim, Sang Yong Song, Do-Hyun Nam

Pages: 1122-1132 Published online on: 15 December 2011

Targeting lysophosphatidic acid receptor type 1 with Debio 0719 inhibits spontaneous metastasis dissemination of breast cancer cells independently of cell proliferation and angiogenesis

Marion David, Johnny Ribeiro, Françoise Descotes, Claire-Marie Serre, Maryse Barbier, Maximilien Murone, Philippe Clézardin, Olivier Peyruchaud

Pages: 1133-1141 Published online on: 20 December 2011

Adult diffuse gliomas produce mRNA transcripts encoding EGFR isoforms lacking a tyrosine kinase domain

Angélique Guillaudeau, Karine Durand, Hélène Rabinovitch-Chable, Isabelle Pommepuy, Laura Mesturoux, Sandrine Robert, Alain Chaunavel, Jean-Jacques Moreau, François Labrousse

Pages: 1142-1152 Published online on: 08 December 2011

Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways

Azhar Rasul, Bo Yu, Muhammad Khan, Kun Zhang, Furhan Iqbal, Tonghui Ma, Hong Yang

Pages: 1153-1161 Published online on: 30 November 2011

MicroRNA-200a suppresses the Wnt/β-catenin signaling pathway by interacting with β-catenin

Juan Su, Anling Zhang, Zhendong Shi, Feifei Ma, Peiyu Pu, Tao Wang, Jie Zhang, Chunsheng Kang, Qingyu Zhang

Pages: 1162-1170 Published online on: 30 December 2011

IL-6-induced epithelial-mesenchymal transition promotes the generation of breast cancer stem-like cells analogous to mammosphere cultures

Guozhu Xie, Qiwei Yao, Ying Liu, Shasha Du, Aihua Liu, Zhaoze Guo, Aimin Sun, Jian Ruan, Longhua Chen, Changsheng Ye, Yawei Yuan

Pages: 1171-1179 Published online on: 30 November 2011

Homeobox gene expression profile indicates HOXA5 as a candidate prognostic marker in oral squamous cell carcinoma

Camila Oliveira Rodini, Flávia Caló Aquino Xavier, Katiúcia Batista Silva Paiva, Maria Fernanda De Souza Setúbal Destro, Raquel Ajub Moyses, Pedro Michaluarte, Marcos Brasilino Carvalho, Erica Erina Fukuyama, Head and Neck Genome Project Gencapo, Eloiza Helena Tajara, Oswaldo Keith Okamoto, Fabio Daumas Nunes

Pages: 1180-1188 Published online on: 29 December 2011

The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition

Xiaofei Wang, Yan Zhang, Xiwen Zhang, Wenxia Tian, Wenli Feng, Tingmei Chen

Pages: 1189-1195 Published online on: 14 December 2011

Lewis Y regulates signaling molecules of the transforming growth factor β pathway in ovarian carcinoma-derived RMG-I cells

Fei-Fei Li, Juan-Juan Liu, Da-Wo Liu, Bei Lin, Ying-Ying Hao, Jian-Ping Cong, Lian-Cheng Zhu, Song Gao, Shu-Lan Zhang, Masao Iwamori

Pages: 1196-1202 Published online on: 13 December 2011

The involvement of FoxO in cell survival and chemosensitivity mediated by Mirk/Dyrk1B in ovarian cancer

Jingchun Gao, Xiangjun Yang, Ping Yin, Wenfeng Hu, Hongfeng Liao, Zhihui Miao, Chao Pan, Na Li

Pages: 1203-1209 Published online on: 12 December 2011

Apoptotic and anti-metastatic effects of the whole skin of Venenum bufonis in A549 human lung cancer cells

Jeong-Seok Park, Dong Yeok Shin, Yeon-Weol Lee, Chong-Kwan Cho, Gi Young Kim, Wun-Jae Kim, Hwa-Seung Yoo, Yung Hyun Choi

Pages: 1210-1219 Published online on: 20 December 2011

In vitro expansion of human glioblastoma cells at non-physiological oxygen tension irreversibly alters subsequent in vivo aggressiveness and AC133 expression

Erika Bourseau-Guilmain, Laurent Lemaire, Audrey Griveau, Eric Hervouet, François Vallette, François Berger, Philippe Menei, Jean-Pierre Benoit, Didier Wion, Emmanuel Garcion

Pages: 1220-1229 Published online on: 23 November 2011

Erythropoietin promotes the growth of pituitary adenomas by enhancing angiogenesis

Jinsheng Yang, Zheng Xiao, Tao Li, Xuanmin Gu, Bo Fan

Pages: 1230-1237 Published online on: 11 November 2011

Pinus densiflora leaf essential oil induces apoptosis via ROS generation and activation of caspases in YD-8 human oral cancer cells

Jeong-Rang Jo, Ju Sung Park, Yu-Kyοung Park, Young Zoo Chae, Gyu-Hee Lee, Gy-Young Park, Byeong-Churl Jang

Pages: 1238-1245 Published online on: 11 November 2011

Low circulating serum levels of second mitochondria-derived activator of caspase (Smac/DIABLO) in patients with bladder cancer

Yoichi Mizutani, Yoji Katsuoka, Benjamin Bonavida

Pages: 1246-1250 Published online on: 03 January 2012

Multiple antitumor effects of picropodophyllin in colon carcinoma cell lines: Clinical implications

Xiaoying Feng, Eiman Aleem, Yingbo Lin, Magnus Axelson, Olle Larsson, Thomas Strömberg

Pages: 1251-1258 Published online on: 06 December 2011

NVP-BKM120, a novel PI3K inhibitor, shows synergism with a STAT3 inhibitor in human gastric cancer cells harboring KRAS mutations

Eunju Park, Jinah Park, Sae-Won Han, Seock-Ah Im, Tae-You Kim, Do-Youn Oh, Yung-Jue Bang

Pages: 1259-1266 Published online on: 08 December 2011

Blockade of irradiation-induced autophagosome formation impairs proliferation but does not enhance cell death in HCT-116 human colorectal carcinoma cells

Ana Cristina de Albuquerque-Xavier, Lilian Gonçalves R. Bastos, Julio Cesar Madureira de Freitas, Fernanda Leve, Waldemir Fernández de Souza, Wallace  Martins de Araujo, João Luiz Mendes Wanderley, Marcelo  Neves Tanaka, Wanderley de Souza, José Andrés Morgado-Díaz

Pages: 1267-1276 Published online on: 10 January 2012

Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model

Susan J. Zunino, David H. Storms, John W. Newman, Theresa L. Pedersen, Carl L. Keen, Jonathan M. Ducore

Pages: 1277-1284 Published online on: 22 December 2011

Possible association of decreased NKG2D expression levels and suppression of the activity of natural killer cells in patients with colorectal cancer

Yajuan Shen, Chao Lu, Wenjun Tian, Laicheng Wang, Bin Cui, Yulian Jiao, Chunyan Ma, Ying Ju, Ling Zhu, Chunhong Shao, Xinqi Liu, Jian Wang, Bingchang Zhang, Zhiming Lu

Pages: 1285-1290 Published online on: 22 December 2011

RNAi-mediated knockdown of ERK1/2 inhibits cell proliferation and invasion and increases chemosensitivity to cisplatin in human osteosarcoma U2-OS cells in vitro

Haipeng Si, Changliang Peng, Jingjing Li, Xiqian Wang, Lianwen Zhai, Xiaofeng Li, Jianmin Li

Pages: 1291-1297 Published online on: 15 December 2011

Aspirin induces apoptosis in vitro and inhibits tumor growth of human hepatocellular carcinoma cells in a nude mouse xenograft model

Mohammad Akbar Hossain, Dong Hwan Kim, Jung Yoon Jang, Yong Jung Kang, Jeong-Hyun Yoon, Jeon-Ok Moon, Hae Young Chung, Gi-Young Kim, Yung Hyun Choi, Bryan L. Copple, Nam Deuk Kim

Pages: 1298-1304 Published online on: 15 December 2011
Journal Cover

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April 2012
Volume 40 Issue 4

Print ISSN: 1019-6439
Online ISSN: 1791-2423

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