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Article

Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model

  • Authors:
    • Susan J. Zunino
    • David H. Storms
    • John W. Newman
    • Theresa L. Pedersen
    • Carl L. Keen
    • Jonathan M. Ducore
  • View Affiliations / Copyright

    Affiliations: Western Human Nutrition Research Center, 430 West Health Sciences Drive, University of California, Davis, CA 95616, USA
  • Pages: 1277-1284
    |
    Published online on: December 22, 2011
       https://doi.org/10.3892/ijo.2011.1316
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Abstract

The efficacy of resveratrol as a preventive agent against the growth of t(4;11) acute lymphoblastic leukemia (ALL) was evaluated in NOD.CB17-Prkdcscid/J mice engrafted with the human t(4;11) ALL SEM cell line. SEM cells were injected into the tail vein and engraftment was monitored by flow cytometry. Once engraftment was observed, mice were injected intraperitoneally with resveratrol (10 mg/kg body weight) dissolved in dimethylsulfoxide (DMSO) or DMSO alone (control) every other day, or vincristine (0.5 mg/kg body weight) 3 times per week for 4 weeks (n=16 per group). Comparisons of the percent of human leukemia cells in blood and survival curves showed resveratrol did not inhibit progression of the disease. Liquid chromatography-tandem mass spectrometry analyses of mouse sera showed resveratrol was rapidly metabolized to glucuronidated and sulfated forms 1 h post-injection, with low to no resveratrol or metabolites observed in sera by 24-48 h. These data indicate that in contrast to findings in in vitro models, parenterally administered resveratrol does not have potential as a preventive agent against high risk t(4;11) ALL.
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Copy and paste a formatted citation
Spandidos Publications style
Zunino SJ, Storms DH, Newman JW, Pedersen TL, Keen CL and Ducore JM: Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model. Int J Oncol 40: 1277-1284, 2012.
APA
Zunino, S.J., Storms, D.H., Newman, J.W., Pedersen, T.L., Keen, C.L., & Ducore, J.M. (2012). Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model. International Journal of Oncology, 40, 1277-1284. https://doi.org/10.3892/ijo.2011.1316
MLA
Zunino, S. J., Storms, D. H., Newman, J. W., Pedersen, T. L., Keen, C. L., Ducore, J. M."Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model". International Journal of Oncology 40.4 (2012): 1277-1284.
Chicago
Zunino, S. J., Storms, D. H., Newman, J. W., Pedersen, T. L., Keen, C. L., Ducore, J. M."Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model". International Journal of Oncology 40, no. 4 (2012): 1277-1284. https://doi.org/10.3892/ijo.2011.1316
Copy and paste a formatted citation
x
Spandidos Publications style
Zunino SJ, Storms DH, Newman JW, Pedersen TL, Keen CL and Ducore JM: Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model. Int J Oncol 40: 1277-1284, 2012.
APA
Zunino, S.J., Storms, D.H., Newman, J.W., Pedersen, T.L., Keen, C.L., & Ducore, J.M. (2012). Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model. International Journal of Oncology, 40, 1277-1284. https://doi.org/10.3892/ijo.2011.1316
MLA
Zunino, S. J., Storms, D. H., Newman, J. W., Pedersen, T. L., Keen, C. L., Ducore, J. M."Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model". International Journal of Oncology 40.4 (2012): 1277-1284.
Chicago
Zunino, S. J., Storms, D. H., Newman, J. W., Pedersen, T. L., Keen, C. L., Ducore, J. M."Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model". International Journal of Oncology 40, no. 4 (2012): 1277-1284. https://doi.org/10.3892/ijo.2011.1316
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