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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2011 Volume 38 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2011 Volume 38 Issue 3

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Article Open Access

Anti-proliferative potential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway

  • Authors:
    • Marie-Hélène Teiten
    • François Gaascht
    • Marcus Cronauer
    • Estelle Henry
    • Mario Dicato
    • Marc Diederich

  • View Affiliations / Copyright

    Affiliations: Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg, 9 rue Edward Steichen, L-2540 Luxembourg, Luxembourg
  • Pages: 603-611
    |
    Published online on: January 14, 2011
       https://doi.org/10.3892/ijo.2011.905
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Abstract

Activation of the Wingless (Wnt)/ß-catenin signaling pathway contributes to prostate tumorigenesis and metastasis. Depending of the stage of prostate cancer development, current drug therapies are of limited efficiency, so that prevention with natural compounds appears as an attractive strategy especially due to the slow progressive development of prostate cancer. We report here that the chemopreventive agent curcumin from the rhizome of Curcuma longa was able to affect cell proliferation of androgen-dependent prostate cancer through the induction of cell cycle arrest in G2 and modulation of Wnt signaling. Curcumin decreases the level of Tcf-4, CBP and p300 proteins implicated in the Wnt transcriptional complex that leads to the decrease of ß-catenin/Tcf-4 transcriptional activity and of the expression of ß-catenin target genes (cyclin D1 and c-myc). Subsequent cell death induction is linked to autophagy. Interestingly, in androgen-independent prostate cancer cells, curcumin does not affect Wnt/ß-catenin transcriptional activity. Altogether our results suggest that curcumin is an interesting chemopreventive agent for early stage prostate cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Teiten M, Gaascht F, Cronauer M, Henry E, Dicato M and Diederich M: Anti-proliferative potential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway. Int J Oncol 38: 603-611, 2011.
APA
Teiten, M., Gaascht, F., Cronauer, M., Henry, E., Dicato, M., & Diederich, M. (2011). Anti-proliferative potential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway. International Journal of Oncology, 38, 603-611. https://doi.org/10.3892/ijo.2011.905
MLA
Teiten, M., Gaascht, F., Cronauer, M., Henry, E., Dicato, M., Diederich, M."Anti-proliferative potential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway". International Journal of Oncology 38.3 (2011): 603-611.
Chicago
Teiten, M., Gaascht, F., Cronauer, M., Henry, E., Dicato, M., Diederich, M."Anti-proliferative potential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway". International Journal of Oncology 38, no. 3 (2011): 603-611. https://doi.org/10.3892/ijo.2011.905
Copy and paste a formatted citation
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Spandidos Publications style
Teiten M, Gaascht F, Cronauer M, Henry E, Dicato M and Diederich M: Anti-proliferative potential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway. Int J Oncol 38: 603-611, 2011.
APA
Teiten, M., Gaascht, F., Cronauer, M., Henry, E., Dicato, M., & Diederich, M. (2011). Anti-proliferative potential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway. International Journal of Oncology, 38, 603-611. https://doi.org/10.3892/ijo.2011.905
MLA
Teiten, M., Gaascht, F., Cronauer, M., Henry, E., Dicato, M., Diederich, M."Anti-proliferative potential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway". International Journal of Oncology 38.3 (2011): 603-611.
Chicago
Teiten, M., Gaascht, F., Cronauer, M., Henry, E., Dicato, M., Diederich, M."Anti-proliferative potential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway". International Journal of Oncology 38, no. 3 (2011): 603-611. https://doi.org/10.3892/ijo.2011.905
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