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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2012 Volume 40 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Inhibition of migration and invasion of LNCaP human prostate carcinoma cells by cordycepin through inactivation of Akt

  • Authors:
    • Jin-Woo Jeong
    • Cheng-Yun Jin
    • Cheol Park
    • Min Ho Han
    • Gi-Young Kim
    • Sung-Kwon Moon
    • Chan Gil Kim
    • Yong Kee Jeong
    • Wun-Jae Kim
    • Jae-Dong Lee
    • Yung Hyun Choi

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Research Institute of Oriental Medicine, Dongeui University College of Oriental Medicine, Busan 614-052, Republic of Korea, Department of Microbiology, College of Natural Sciences, Pusan National University, Busan 609-735, Republic of Korea, Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614-052, Republic of Korea
  • Pages: 1697-1704
    |
    Published online on: January 13, 2012
       https://doi.org/10.3892/ijo.2012.1332
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Abstract

Cordycepin (3'-deoxyadenosine), a major bioactive compound of Cordyceps militaris, has many pharmacological actions, such as anti-inflammatory and anticancer activities. In this study, the relationship between inhibition of cell motility and anti-invasive activity by cordycepin in LNCaP human prostate carcinoma cells was investigated. Within the concentration range that was not cytotoxic, cordycepin time-dependently inhibited cell motility and invasiveness of LNCaP cells. The inhibitory effects of cordycepin on cell invasiveness were associated with tightening of tight junctions (TJs), which was demonstrated by an increase in transepithelial electrical resistance (TER). Immunoblotting indicated that cordycepin decreases levels of claudin proteins, which are major components of TJs that play a key role in control and selectivity of paracellular transport. Furthermore, cordycepin inhibited the expression and activity of matrix metalloproteinase (MMP)-2 and MMP-9, and simultaneously increased levels of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2. These effects were related to inactivation of the phosphoinositide 3-kinase (PI3K)/Akt pathway in LNCaP cells. These findings suggest that cordycepin inhibits the migration and invasion of LNCaP cells by downregulating the activity of TJs and MMPs, possibly in association with suppression of Akt activation.

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Copy and paste a formatted citation
Spandidos Publications style
Jeong J, Jin C, Park C, Han MH, Kim G, Moon S, Kim CG, Jeong YK, Kim W, Lee J, Lee J, et al: Inhibition of migration and invasion of LNCaP human prostate carcinoma cells by cordycepin through inactivation of Akt. Int J Oncol 40: 1697-1704, 2012.
APA
Jeong, J., Jin, C., Park, C., Han, M.H., Kim, G., Moon, S. ... Choi, Y.H. (2012). Inhibition of migration and invasion of LNCaP human prostate carcinoma cells by cordycepin through inactivation of Akt. International Journal of Oncology, 40, 1697-1704. https://doi.org/10.3892/ijo.2012.1332
MLA
Jeong, J., Jin, C., Park, C., Han, M. H., Kim, G., Moon, S., Kim, C. G., Jeong, Y. K., Kim, W., Lee, J., Choi, Y. H."Inhibition of migration and invasion of LNCaP human prostate carcinoma cells by cordycepin through inactivation of Akt". International Journal of Oncology 40.5 (2012): 1697-1704.
Chicago
Jeong, J., Jin, C., Park, C., Han, M. H., Kim, G., Moon, S., Kim, C. G., Jeong, Y. K., Kim, W., Lee, J., Choi, Y. H."Inhibition of migration and invasion of LNCaP human prostate carcinoma cells by cordycepin through inactivation of Akt". International Journal of Oncology 40, no. 5 (2012): 1697-1704. https://doi.org/10.3892/ijo.2012.1332
Copy and paste a formatted citation
x
Spandidos Publications style
Jeong J, Jin C, Park C, Han MH, Kim G, Moon S, Kim CG, Jeong YK, Kim W, Lee J, Lee J, et al: Inhibition of migration and invasion of LNCaP human prostate carcinoma cells by cordycepin through inactivation of Akt. Int J Oncol 40: 1697-1704, 2012.
APA
Jeong, J., Jin, C., Park, C., Han, M.H., Kim, G., Moon, S. ... Choi, Y.H. (2012). Inhibition of migration and invasion of LNCaP human prostate carcinoma cells by cordycepin through inactivation of Akt. International Journal of Oncology, 40, 1697-1704. https://doi.org/10.3892/ijo.2012.1332
MLA
Jeong, J., Jin, C., Park, C., Han, M. H., Kim, G., Moon, S., Kim, C. G., Jeong, Y. K., Kim, W., Lee, J., Choi, Y. H."Inhibition of migration and invasion of LNCaP human prostate carcinoma cells by cordycepin through inactivation of Akt". International Journal of Oncology 40.5 (2012): 1697-1704.
Chicago
Jeong, J., Jin, C., Park, C., Han, M. H., Kim, G., Moon, S., Kim, C. G., Jeong, Y. K., Kim, W., Lee, J., Choi, Y. H."Inhibition of migration and invasion of LNCaP human prostate carcinoma cells by cordycepin through inactivation of Akt". International Journal of Oncology 40, no. 5 (2012): 1697-1704. https://doi.org/10.3892/ijo.2012.1332
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