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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2012 Volume 40 Issue 4

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International Journal of Molecular Medicine

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

MUC2 protein expression status is useful in assessing the effects of hyperthermic intraperitoneal chemotherapy for peritoneal dissemination of colon cancer

  • Authors:
    • Yuka Fujishima
    • Takanori Goi
    • Youhei Kimura
    • Yasuo Hirono
    • Kanji Katayama
    • Akio Yamaguchi
  • View Affiliations / Copyright

    Affiliations: First Department of Surgery, University of Fukui, 23-3 Eiheiji-cho, Yoshida-gun, Fukui, Japan, First Department of Surgery, University of Fukui, 23-3 Eiheiji-cho, Yoshida-gun, Fukui, Japan
  • Pages: 960-964
    |
    Published online on: January 16, 2012
       https://doi.org/10.3892/ijo.2012.1334
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Abstract

We conducted a molecular biological investigation to determine the outcomes of hyperthermic intraperitoneal chemotherapy (HIPEC) treatment, and whether it is effective in all cases for patients with peritoneal dissemination of colon cancer. In the HIPEC group, the 3-year survival rate was 39.2%, whereas in the non-HIPEC group the 3-year survival rate was 15.6%. MUC2 expression was investigated in the HIPEC group, in patients positive for MUC2 expression, and the 3-year survival rate was 0.0%, while in patients negative for MUC2 expression, the 3-year survival rate was 61.1%. In addition, as a result of introducing MUC2-siRNA into a colon cancer cell line with high expression of the MUC2 gene, the cell death rate from heat and anticancer agents increased 40% in comparison with colon cancer cells in which scrambled siRNA had not been introduced. HIPEC therapy is thought to be effective in prolonging survival in patients with peritoneal dissemination of colon cancer, and MUC2 expression is thought to be useful as an indicator to assess its effectiveness in colon cancer cells.
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Copy and paste a formatted citation
Spandidos Publications style
Fujishima Y, Goi T, Kimura Y, Hirono Y, Katayama K and Yamaguchi A: MUC2 protein expression status is useful in assessing the effects of hyperthermic intraperitoneal chemotherapy for peritoneal dissemination of colon cancer. Int J Oncol 40: 960-964, 2012.
APA
Fujishima, Y., Goi, T., Kimura, Y., Hirono, Y., Katayama, K., & Yamaguchi, A. (2012). MUC2 protein expression status is useful in assessing the effects of hyperthermic intraperitoneal chemotherapy for peritoneal dissemination of colon cancer. International Journal of Oncology, 40, 960-964. https://doi.org/10.3892/ijo.2012.1334
MLA
Fujishima, Y., Goi, T., Kimura, Y., Hirono, Y., Katayama, K., Yamaguchi, A."MUC2 protein expression status is useful in assessing the effects of hyperthermic intraperitoneal chemotherapy for peritoneal dissemination of colon cancer". International Journal of Oncology 40.4 (2012): 960-964.
Chicago
Fujishima, Y., Goi, T., Kimura, Y., Hirono, Y., Katayama, K., Yamaguchi, A."MUC2 protein expression status is useful in assessing the effects of hyperthermic intraperitoneal chemotherapy for peritoneal dissemination of colon cancer". International Journal of Oncology 40, no. 4 (2012): 960-964. https://doi.org/10.3892/ijo.2012.1334
Copy and paste a formatted citation
x
Spandidos Publications style
Fujishima Y, Goi T, Kimura Y, Hirono Y, Katayama K and Yamaguchi A: MUC2 protein expression status is useful in assessing the effects of hyperthermic intraperitoneal chemotherapy for peritoneal dissemination of colon cancer. Int J Oncol 40: 960-964, 2012.
APA
Fujishima, Y., Goi, T., Kimura, Y., Hirono, Y., Katayama, K., & Yamaguchi, A. (2012). MUC2 protein expression status is useful in assessing the effects of hyperthermic intraperitoneal chemotherapy for peritoneal dissemination of colon cancer. International Journal of Oncology, 40, 960-964. https://doi.org/10.3892/ijo.2012.1334
MLA
Fujishima, Y., Goi, T., Kimura, Y., Hirono, Y., Katayama, K., Yamaguchi, A."MUC2 protein expression status is useful in assessing the effects of hyperthermic intraperitoneal chemotherapy for peritoneal dissemination of colon cancer". International Journal of Oncology 40.4 (2012): 960-964.
Chicago
Fujishima, Y., Goi, T., Kimura, Y., Hirono, Y., Katayama, K., Yamaguchi, A."MUC2 protein expression status is useful in assessing the effects of hyperthermic intraperitoneal chemotherapy for peritoneal dissemination of colon cancer". International Journal of Oncology 40, no. 4 (2012): 960-964. https://doi.org/10.3892/ijo.2012.1334
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