Crucial cross-talk of interleukin-1β and progesterone in human choriocarcinoma

Zachariades,Elena; Mparmpakas,Dionisis; Thomas,Peter; Rand-Weaver,Mariann; Karteris,Emmanouil

doi:10.3892/ijo.2012.1349

May 2012 Volume 40 Issue 5

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May 2012 Volume 40 Issue 5

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Crucial cross-talk of interleukin-1β and progesterone in human choriocarcinoma

Authors:
- Elena Zachariades
- Dionisis Mparmpakas
- Peter Thomas
- Mariann Rand-Weaver
- Emmanouil Karteris
View Affiliations / Copyright

Affiliations: Centre for Cell Chromosome Biology, Biosciences, Centre for Cell and Chromosome Biology, School of Health Sciences and Social Care, Brunel University, Uxbridge, UB8 3PH, UK, Marine Science Institute, University of Texas at Austin, Port Aransas, Texas, TX 78373, USA
Pages: 1358-1364
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Published online on: January 27, 2012

https://doi.org/10.3892/ijo.2012.1349
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Abstract

Choriocarcinoma is a highly malignant epithelial tumour that is most often associated with hydatidiform mole and presents the most common emergency medical problem in the management of trophoblast disease. We hypothesise that the hormones/cytokines present within the tumour microenvironment play key roles in the development of choriocarcinoma. In this study we assessed the effects of interleukin-1β (IL-1β) on cell death in the presence or absence of the sex hormone progesterone using two choriocarcinoma cell lines (BeWo and JEG-3) as in vitro experimental models. Although IL-1β induced cell death in both cell lines, the effect was more pronounced in JEG-3 cells, where cell death reached 40% compared to 15% in BeWo cells. Cell death of JEG-3 cells in response to IL-1β was significantly decreased by co-treatment with 100 nM and 1000 nM progesterone and completely abolished at a progesterone concentration of 1000 nM. Progesterone was also able to induce phosphorylation of ERK1/2 in these cells. Pretreatment of JEG-3 cells with a specific MAPK inhibitor (UO126) inhibited progesterone's inhibitory effect on cell death. Collectively, these data provide evidence of cross-talk between progesterone and IL-1β in this aggressive and poorly understood tumour that involves activation of a MAPK pathway and involvement of numerous progesterone receptors.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Crucial cross-talk of interleukin-1β and progesterone in human choriocarcinoma

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Abstract

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