Open Access

ETS transcription factors and prostate cancer: The role of the family prototype ETS-1 (Review)

  • Authors:
    • David Adler
    • Nicolas Wernert
  • View Affiliations

  • Published online on: February 21, 2012     https://doi.org/10.3892/ijo.2012.1380
  • Pages: 1748-1754
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Abstract

The ETS family of transcription factors is known to play important roles in various biological processes such as development, differentiation, proliferation, apoptosis, migra­tion, tissue remodeling, invasion and angiogenesis in various cell types including B cells, endothelial cells, fibroblasts as well as diverse neoplastic cells. In prostate cancer, recurrent gene fusions involving members of the ETS family are frequently reported. ETS-1, the prototype of the ETS family, is expressed in different cell types and is known to play various roles during both physiological and pathological conditions. In this review, we focus on studies investigating the role of ETS-1 in prostate cancer.

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June 2012
Volume 40 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Adler D and Wernert N: ETS transcription factors and prostate cancer: The role of the family prototype ETS-1 (Review). Int J Oncol 40: 1748-1754, 2012.
APA
Adler, D., & Wernert, N. (2012). ETS transcription factors and prostate cancer: The role of the family prototype ETS-1 (Review). International Journal of Oncology, 40, 1748-1754. https://doi.org/10.3892/ijo.2012.1380
MLA
Adler, D., Wernert, N."ETS transcription factors and prostate cancer: The role of the family prototype ETS-1 (Review)". International Journal of Oncology 40.6 (2012): 1748-1754.
Chicago
Adler, D., Wernert, N."ETS transcription factors and prostate cancer: The role of the family prototype ETS-1 (Review)". International Journal of Oncology 40, no. 6 (2012): 1748-1754. https://doi.org/10.3892/ijo.2012.1380