Anti-HuC and -HuD autoantibodies are differential sero-diagnostic markers for small cell carcinoma from large cell neuroendocrine carcinoma of the lung

Matsumoto,Toshihide; Ryuge,Shinichiro; Kobayashi,Makoto; Kageyama,Taihei; Hattori,Manabu; Goshima,Naoki; Jiang,Shi-Xu; Saegusa,Makoto; Iyoda,Akira; Satoh,Yukitoshi; Masuda,Noriyuki; Sato,Yuichi

doi:10.3892/ijo.2012.1405

June 2012 Volume 40 Issue 6

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June 2012 Volume 40 Issue 6

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Article

Anti-HuC and -HuD autoantibodies are differential sero-diagnostic markers for small cell carcinoma from large cell neuroendocrine carcinoma of the lung

Authors:
- Toshihide Matsumoto
- Shinichiro Ryuge
- Makoto Kobayashi
- Taihei Kageyama
- Manabu Hattori
- Naoki Goshima
- Shi-Xu Jiang
- Makoto Saegusa
- Akira Iyoda
- Yukitoshi Satoh
- Noriyuki Masuda
- Yuichi Sato
View Affiliations / Copyright

Affiliations: Department of Applied Tumor Pathology, Kitasato University Graduate School of Medical Sciences, Kanagawa, Japan, Department of Respiratory Medicine, Kitasato University School of Medicine, Kanagawa, Japan, Biomedicinal Information Research Center (BIRC), National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan, Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan, Department of Thoracic Surgery, Kitasato University School of Medicine, Kanagawa, Japan, Department of Molecular Diagnostics, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan
Pages: 1957-1962
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Published online on: March 16, 2012

https://doi.org/10.3892/ijo.2012.1405
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Abstract

Aiming to identify novel sero-diagnostic markers for neuroendocrine carcinomas of the lung, the two-dimensional gel electrophoresis-immunoblot method was used to analyze tumor-associated autoantibodies in patients with small cell lung carcinoma (SCLC) and large cell neuroendocrine carcinoma (LCNEC). Several autoantigens were revealed and anti-HuC autoantibody was detected only in sera of SCLC patients. Since Hu family proteins including HuC are well-known causes of paraneoplastic encephalomyelitis/sensory neuronopathy (PEM/SN), the expression of HuC as well as HuD mRNAs and their proteins was studied in 11 lung cancer cell lines. The expression of HuC and HuD mRNAs and proteins was only detected in SCLC- and LCNEC-derived cells. To validate the existence of anti-HuC and -HuD auto-antibodies, we studied a large number of sera including those from lung cancer patients employing dot blot analysis. Anti-HuC and -HuD autoantibodies were detected only in SCLC cases with or without PEM/SN, and not in the sera of LCNEC patients. The mechanism leading to different anti-HuC and -HuD autoantibody production between SCLC and LCNEC is unclear; however, the results from the present and previous studies suggest that anti-HuC and -HuD auto-antibodies are novel differential sero-diagnostic markers for SCLC from LCNEC.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Anti-HuC and -HuD autoantibodies are differential sero-diagnostic markers for small cell carcinoma from large cell neuroendocrine carcinoma of the lung

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