Cannabinoid-associated cell death mechanisms in tumor models (Review)

  • Authors:
    • Giuseppe Calvaruso
    • Ornella Pellerito
    • Antonietta Notaro
    • Michela Giuliano
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  • Published online on: May 14, 2012     https://doi.org/10.3892/ijo.2012.1476
  • Pages: 407-413
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Abstract

In recent years, cannabinoids (the active components of Cannabis sativa) and their derivatives have received considerable interest due to findings that they can affect the viability and invasiveness of a variety of different cancer cells. Moreover, in addition to their inhibitory effects on tumor growth and migration, angiogenesis and metastasis, the ability of these compounds to induce different pathways of cell death has been highlighted. Here, we review the most recent results generating interest in the field of death mechanisms induced by cannabinoids in cancer cells. In particular, we analyze the pathways triggered by cannabinoids to induce apoptosis or autophagy and investigate the interplay between the two processes. Overall, the results reported here suggest that the exploration of molecular mechanisms induced by cannabinoids in cancer cells can contribute to the development of safe and effective treatments in cancer therapy.
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August 2012
Volume 41 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Calvaruso G, Pellerito O, Notaro A and Giuliano M: Cannabinoid-associated cell death mechanisms in tumor models (Review). Int J Oncol 41: 407-413, 2012
APA
Calvaruso, G., Pellerito, O., Notaro, A., & Giuliano, M. (2012). Cannabinoid-associated cell death mechanisms in tumor models (Review). International Journal of Oncology, 41, 407-413. https://doi.org/10.3892/ijo.2012.1476
MLA
Calvaruso, G., Pellerito, O., Notaro, A., Giuliano, M."Cannabinoid-associated cell death mechanisms in tumor models (Review)". International Journal of Oncology 41.2 (2012): 407-413.
Chicago
Calvaruso, G., Pellerito, O., Notaro, A., Giuliano, M."Cannabinoid-associated cell death mechanisms in tumor models (Review)". International Journal of Oncology 41, no. 2 (2012): 407-413. https://doi.org/10.3892/ijo.2012.1476