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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
August 2012 Volume 41 Issue 2

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Review

Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: Potential prospects for combined targeted therapeutics (Review)

Drazen B. Zimonjic, Nicholas C. Popescu
Pages: 393-406
Published online on: 10 May 2012

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Review

Cannabinoid-associated cell death mechanisms in tumor models (Review)

Giuseppe Calvaruso, Ornella Pellerito, Antonietta Notaro, Michela Giuliano
Pages: 407-413
Published online on: 14 May 2012

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Article

Barrett's esophagus and esophageal cancer: An overview

Vincenza Conteduca, Domenico Sansonno, Giuseppe Ingravallo, Stefania Marangi, Sabino Russi, Gianfranco Lauletta, Franco Dammacco
Pages: 414-424
Published online on: 17 May 2012

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Article Open Access

Synergistic activity of the mTOR inhibitor ridaforolimus and the antiandrogen bicalutamide in prostate cancer models

Rachel M. Squillace, David Miller, Scott D. Wardwell, Frank Wang, Tim Clackson, Victor M. Rivera
Pages: 425-432
Published online on: 18 May 2012

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Article Open Access

Endothelial protein C receptor expressed by ovarian cancer cells as a possible biomarker of cancer onset

Elodie Ducros, Shahsoltan Mirshahi, Dalel Azzazene, Sophie Camilleri-Broët, Eliane Mery, Halema Al Farsi, Hamda Althawadi, Samaher Besbess, Jean Chidiac, Eric Pujade-Lauraine, Amu Therwath, Jeannette Soria, Massoud Mirshahi
Pages: 433-440
Published online on: 18 May 2012

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Article Open Access

Expression and role of nestin in human cervical intraepithelial neoplasia and cervical cancer

Atsuki Sato, Toshiyuki Ishiwata, Yoko Matsuda, Tetsushi Yamamoto, Hirobumi Asakura, Toshiyuki Takeshita, Zenya Naito
Pages: 441-448
Published online on: 10 May 2012

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Article Open Access

Antitumor activity of MEK and PI3K inhibitors against malignant pleural mesothelioma cells in vitro and in vivo

Seigo Miyoshi, Hironobu Hamada, Naohiko Hamaguchi, Aki Kato, Hitoshi Katayama, Kazunori Irifune, Ryoji Ito, Tatsuhiko Miyazaki, Takafumi Okura, Jitsuo Higaki
Pages: 449-456
Published online on: 08 May 2012

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Article Open Access

The role of hepatic stellate cells in the regulation of T-cell function and the promotion of hepatocellular carcinoma

Wenxiu Zhao, Weixue Su, Penghao Kuang, Lei  Zhang, Jianming  Liu, Zhenyu Yin, Xiaomin  Wang
Pages: 457-464
Published online on: 24 May 2012

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Article Open Access

Depolarization potentiates TRAIL-induced apoptosis in human melanoma cells: Role for ATP-sensitive K+ channels and endoplasmic reticulum stress

Yoshihiro Suzuki, Toshio Inoue, Mayumi Murai, Miki  Suzuki‑Karasaki, Toyoko Ochiai, Chisei  Ra
Pages: 465-475
Published online on: 17 May 2012

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Article Open Access

The role of human peritoneal mesothelial cells in the fibrosis and progression of gastric cancer

Tomoya Tsukada, Sachio Fushida, Shinichi Harada, Yasumichi  Yagi, Jun  Kinoshita, Katsunobu Oyama, Hidehiro Tajima, Hideto  Fujita, Itasu Ninomiya, Takashi Fujimura, Tetsuo Ohta
Pages: 476-482
Published online on: 18 May 2012

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Article

The clinical impact of breast scintigraphy acquired with a breast specific γ-camera (BSGC) in the diagnosis of breast cancer: Incremental value versus mammography

Angela Spanu, Daniela Sanna, Francesca Chessa, Alessandra Manca, Pierina Cottu, Alessandro Fancellu, Susanna Nuvoli, Giuseppe Madeddu
Pages: 483-489
Published online on: 24 May 2012

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Article

Genome-wide screening for methylation-silenced genes in colorectal cancer

Ahmed Khamas, Toshiaki Ishikawa, Kaoru Mogushi, Satoru Iida, Megumi Ishiguro, Hiroshi Tanaka, Hiroyuki Uetake, Kenichi Sugihara
Pages: 490-496
Published online on: 30 May 2012

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Article

Association between common genetic variant of HRH2 and gastric cancer risk

Tomiyasu Arisawa, Tomomitsu Tahara, Kazuaki Ozaki, Yasuhiro Matsue, Takahiro Minato, Hideto Yamada, Tomoe Nomura, Ranji Hayashi, Kazuhiro Matsunaga, Atsushi Fukumura, Masakatsu Nakamura, Nobuyuki Toshikuni, Hisakazu Shiroeda, Tomoyuki Shibata
Pages: 497-503
Published online on: 17 May 2012

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Article

Diaminobenzene schiff base, a novel class of DNA minor groove binder

Muath H. Helal, Zena A. Al-Mudaris, Mohammed H. Al-Douh, Hasnah Osman, Habibah A. Wahab, Belal O. AlNajjar, Hassan H. Abdallah, Amin M.S. Abdul Majid
Pages: 504-510
Published online on: 18 May 2012

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Article

Association of stem cell marker expression pattern and survival in human biliary tract cancer

Ralf Kemmerling, Beate Alinger, Otto Dietze, Hans-Christian Bösmüller, Matthias Ocker, Gernot W. Wolkersdörfer, Frieder Berr, Daniel Neureiter, Tobias Kiesslich
Pages: 511-522
Published online on: 14 May 2012

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Article

Orlistat, a novel potent antitumor agent for ovarian cancer: proteomic analysis of ovarian cancer cells treated with Orlistat

Hui-Qiong Huang, Jing Tang, Sheng-Tao Zhou, Tao Yi, Hong-Ling Peng, Guo-Bo  Shen, Na Xie, Kai Huang, Tao Yang, Jin-Hua Wu, Can-Hua Huang, Yu-Quan Wei, Xia  Zhao
Pages: 523-532
Published online on: 08 May 2012

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Article

ZGDHu-1 promotes apoptosis of chronic lymphocytic leukemia cells

Lian-Nv Qiu, Yong-Lie Zhou, Zhen-Ni Wang, Qiang Huang, Wei-Xiao Hu
Pages: 533-540
Published online on: 08 May 2012

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Article

Fibroblast activation protein regulates tumor-associated fibroblasts and epithelial ovarian cancer cells

Dongmei Lai, Li Ma, Fangyuan Wang
Pages: 541-550
Published online on: 14 May 2012

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Article

Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification

Hideo Tomioka, Toru Mukohara, Yu Kataoka, Roudy Chiminch Ekyalongo, Yohei  Funakoshi, Yasuo Imai, Naomi Kiyota, Yutaka Fujiwara, Hironobu Minami
Pages: 551-558
Published online on: 17 May 2012

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Article

REIC/Dkk-3-encoding adenoviral vector as a potentially effective therapeutic agent for bladder cancer

Takeshi Hirata, Masami Watanabe, Haruki Kaku, Yasuyuki Kobayashi, Hiroshi Yamada, Masakiyo Sakaguchi, Kohji Takei, Nam-Ho Huh, Yasutomo Nasu, Hiromi Kumon
Pages: 559-564
Published online on: 31 May 2012

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Article

The enhancement of tumor radioresponse by combined treatment with cepharanthine is accompanied by the inhibition of DNA damage repair and the induction of apoptosis in oral squamous cell carcinoma

Toyoko Harada, Koji Harada, Yoshiya Ueyama
Pages: 565-572
Published online on: 31 May 2012

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Article

Angiotensin II enhances epithelial-to-mesenchymal transition through the interaction between activated hepatic stellate cells and the stromal cell-derived factor-1/CXCR4 axis in intrahepatic cholangiocarcinoma

Koichi Okamoto, Hidehiro Tajima, Shinichi Nakanuma, Seisho Sakai, Isamu Makino, Jun Kinoshita, Hironori Hayashi, Keishi Nakamura, Katsunobu Oyama, Hisatoshi Nakagawara, Hideto Fujita, Hiroyuki Takamura, Itasu Ninomiya, Hirohisa Kitagawa, Sachio Fushida, Takashi Fujimura, Shinichi Harada, Tomohiko Wakayama, Shoichi Iseki, Tetsuo Ohta
Pages: 573-582
Published online on: 29 May 2012

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Article

Differential response to EGFR- and VEGF-targeted therapies in patient-derived tumor tissue xenograft models of colon carcinoma and related metastases

Ketao Jin, Huanrong Lan, Feilin Cao, Na Han, Zhenzhen  Xu, Guangliang Li, Kuifeng He, Lisong Teng
Pages: 583-588
Published online on: 10 May 2012

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Article

N-acetylglucosaminyltransferase V negatively regulates integrin α5β1-mediated monocyte adhesion and transmigration through vascular endothelium

Huo-Mei Yang, Chao Yu, Zhu Yang
Pages: 589-598
Published online on: 17 May 2012

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Article

uPAR and cathepsin B knockdown inhibits radiation-induced PKC integrated integrin signaling to the cytoskeleton of glioma-initiating cells

Kiranmai Alapati, Sreelatha Gopinath, Rama Rao Malla, Venkata Ramesh Dasari, Jasti S. Rao
Pages: 599-610
Published online on: 24 May 2012

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Article

Promoter methylation of RASSF1A modulates the effect of the microtubule-targeting agent docetaxel in breast cancer Retraction in /10.3892/ijo.2025.5745

Eun Young Gil, Uk Hyun Jo, Hoiseon Jeong, Young Mi Whang, Ok Hee Woo, Kyu Ran Cho, Jae Hong Seo, Aeree Kim, Eun Sook Lee, Insong Koh, Yeul Hong Kim, Kyong Hwa Park
Pages: 611-620
Published online on: 10 May 2012

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Article

Generation and characterization of bioluminescent xenograft mouse models of MLL-related acute leukemias and in vivo evaluation of luciferase-targeting siRNA nanoparticles

Raffaella Fazzina, Lorenza Lombardini, Laura  Mezzanotte, Aldo  Roda, Patrizia Hrelia, Andrea Pession, Roberto  Tonelli
Pages: 621-628
Published online on: 31 May 2012

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Article

Screening of significantly hypermethylated genes in breast cancer using microarray-based methylated-CpG island recovery assay and identification of their expression levels

Zhen-Qiang Lian, Qi Wang, Wen-Ping Li, An-Qin Zhang, Ling  Wu
Pages: 629-638
Published online on: 08 May 2012

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Article

Development and characterization of a preclinical ovarian carcinoma model to investigate the mechanism of acquired resistance to trastuzumab

Leopoldo L. Luistro, James A. Rosinski, Hongjin Bian, Subal Bishayee, Pranela Rameshwar, Nicholas M. Ponzio, Steve R. Ritland
Pages: 639-651
Published online on: 08 May 2012

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Article

Co-silencing of Birc5 (survivin) and Hspa5 (Grp78) induces apoptosis in hepatoma cells more efficiently than single gene interference

Qiang Wang, Rong Shu, Huijun He, Li Wang, Yuan Ma, Huifen Zhu, Zhihua Wang, Shuo Wang, Guanxin Shen, Ping Lei
Pages: 652-660
Published online on: 10 May 2012

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Article

An IL-12/Shh-C domain fusion protein-based IL-12 autocrine loop for sustained natural killer cell activation

Lining Zhu, Zhihui Zhao, Yanzhang Wei, William Marcotte , Thomas E. Wagner, Xianzhong Yu
Pages: 661-669
Published online on: 08 May 2012

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Article

Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade

Miguel A. Fonseca-Sánchez, Sergio Rodríguez Cuevas, Guillermo Mendoza-Hernández, Veronica Bautista-Piña, Elena Arechaga Ocampo, Alfredo Hidalgo Miranda, Valeria Quintanar Jurado, Laurence A. Marchat, Elizbeth Álvarez-Sánchez, Carlos Pérez Plasencia, César López-Camarillo
Pages: 670-680
Published online on: 14 May 2012

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Article

Reelin signalling in neuroblastoma: Migratory switch in metastatic stages

Jürgen Becker, Johanna Fröhlich, Christina Perske, Helena Pavlakovic, Jörg Wilting
Pages: 681-689
Published online on: 18 May 2012

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Article

Transcriptional silencing of the inhibin-α gene in human gastric carcinoma cells

Young Il Kim, Jaejun Shim, Byung-Ho Kim, Sung Jae Lee, Ha Kyu Lee, Chunghee Cho, Byung-Nam Cho
Pages: 690-700
Published online on: 10 May 2012

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Article

Characterization of sarcoma-like cells derived from endarterectomized tissues from patients with CTEPH and establishment of a mouse model of pulmonary artery intimal sarcoma

Takayuki Jujo, Seiichiro Sakao, Masashi Kantake, Miki Maruoka, Nobuhiro Tanabe, Yasunori Kasahara, Katsushi Kurosu, Masahisa Masuda, Kenichi Harigaya, Koichiro Tatsumi
Pages: 701-711
Published online on: 22 May 2012

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Article

Combination of the ERK inhibitor AZD6244 and low-dose sorafenib in a xenograft model of human renal cell carcinoma

John Shyi Peng Yuen, Mei Yi Sim, Hong Gee Sim, Tsung Wen Chong, Weber  Kam On Lau, Christopher  Wai Sam Cheng, Richard Weijie Ong, Hung  Huynh
Pages: 712-720
Published online on: 23 May 2012

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Article

Loss of post-transcriptional regulation of DNMT3b by microRNAs: A possible molecular mechanism for the hypermethylation defect observed in a subset of breast cancer cell lines

Rupninder Sandhu, Ashley G. Rivenbark, William B. Coleman
Pages: 721-732
Published online on: 31 May 2012

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Article

Association of amphiregulin with the cetuximab sensitivity of gastric cancer cell lines

Julia Kneissl, Simone Keller, Thomas Lorber, Stefan Heindl, Gisela Keller, Ingo Drexler, Alexander Hapfelmeier, Heinz Höfler, Birgit Luber
Pages: 733-744
Published online on: 14 May 2012

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Article

A novel role for insulin resistance in the connection between obesity and postmenopausal breast cancer

Michael Weichhaus, John Broom, Klaus Wahle, Giovanna Bermano
Pages: 745-752
Published online on: 16 May 2012

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Article

Combined administration of EGCG and IL-1 receptor antagonist efficiently downregulates IL-1-induced tumorigenic factors in U-2 OS human osteosarcoma cells

Anne-Sophie Hönicke, Stephan Albrecht Ender, Jürgen Radons
Pages: 753-758
Published online on: 28 May 2012

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Article

Interleukin 11 regulates endometrial cancer cell adhesion and migration via STAT3

Virginia Lay, Joanne Yap, Stefan Sonderegger, Evdokia Dimitriadis
Pages: 759-764
Published online on: 18 May 2012

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Article

A tumor-derived population (SCCOHT-1) as cellular model for a small cell ovarian carcinoma of the hypercalcemic type

Anna Otte, Gudrun Göhring, Doris Steinemann, Brigitte Schlegelberger, Stephanie Groos, Florian Länger, Hans-Heinrich Kreipe, Axel Schambach, Thomas Neumann, Peter Hillemanns, Tjoung-Won Park-Simon, Ralf Hass
Pages: 765-775
Published online on: 08 May 2012

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Article

Casein kinase 2 inhibition modulates the DNA damage response but fails to radiosensitize malignant glioma cells

Jérôme Kroonen, Maria Artesi, Valérie Capraro, Minh-Tuan Nguyen-Khac, Marie Willems, Arnab Chakravarti, Vincent Bours, Pierre A. Robe
Pages: 776-782
Published online on: 18 May 2012

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Journal Cover
January-2026 Volume 68 Issue 1

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Article Open Access

c‑Myc‑regulated RPLP0 via the ROS‑mediated JAK2/STAT3 positive feedback loop facilitates hepatocellular carcinoma malignancy progression

Yanqiu Meng, Lebin Yuan, Gangrui Meng, Hongxiang Huang, Xianbin Huang, Xinping Xu, Xiaodong Peng
Article Number: 13
Published online on: 27 November 2025

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Review Open Access

Obesity, chronic breast inflammation and carcinogenesis: Molecular pathways and clinical implications (Review)

Fangying Li, Zhenhua Gao
Article Number: 12
Published online on: 27 November 2025

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Review Open Access

The tumor microenvironment in lung cancer: Heterogeneity, therapeutic resistance and emerging treatment strategies (Review)

Li Liu, Li Yang, Hongmin Li, Tianlu Shang, Lihan Liu
Article Number: 11
Published online on: 26 November 2025

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Article Open Access

Discovery of the late autophagy inhibitor FZU‑0045‑053 and its anti‑breast cancer and immunomodulatory effects

Jinlan Luo, Yi Yang, Lulu Cheng, Fangting Cheng, Huangwenlong Zhuang, Shanshan Chen, Panpan Qiao, Yinbin Liang, Li Chen, Yang Sun, Haijun Chen, Qinying Liu
Article Number: 10
Published online on: 26 November 2025

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Correction Open Access

[Corrigendum] RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling

Zi-Hao Qi, Hua-Xiang Xu, Shi-Rong Zhang, Jin-Zhi Xu, Shuo Li, He-Li Gao, Wei Jin, Wen-Quan Wang, Chun-Tao Wu, Quan-Xing Ni, Xian-Jun Yu, Liang Liu
Article Number: 9
Published online on: 24 November 2025

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Article Open Access

Ephrin‑B2 promotes gastric cancer growth by inhibiting apoptosis and regulating the cell cycle via the Wnt/β‑catenin signaling pathway

Ding Ding, Xiaoshan Wang, Ran Xuan, Rui Li, Yalu Zhang, Zhengguang Wang
Article Number: 8
Published online on: 18 November 2025

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Expression of Concern Open Access

[Expression of Concern] Gene therapy for human colorectal cancer cell lines with recombinant adenovirus 5 based on loss of the insulin‑like growth factor 2 imprinting

Huiling Sun, Yuqin Pan, Bangshun He, Qiwen Deng, Rui Li, Yeqiong Xu, Jie Chen, Tianyi Gao, Houqun Ying, Feng Wang, Xian Liu, Shukui Wang
Article Number: 7
Published online on: 18 November 2025

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Review Open Access

Ferroptosis in biliary tract cancer: Molecular mechanisms and therapeutic applications (Review)

Ruiqi Zou, Yushi Dai, Siqi Yang, Haijie Hu, Fuyu Li, Fei Liu
Article Number: 6
Published online on: 14 November 2025

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Expression of Concern Open Access

[Expression of Concern] Radiosensitization of esophageal carcinoma cells by knockdown of RNF2 expression

Xing-Xiao Yang, Ming Ma, Mei-Xiang Sang, Xue-Xiao Wang, Heng Song, Zhi-Kun Liu, Shu-Chai Zhu
Article Number: 5
Published online on: 10 November 2025

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Review Open Access

Targeting ferroptosis in Helicobacter pylori‑associated gastric cancer development: From molecular mechanisms to application prospects (Review)

Chen-Yi Wang, Meng-Hui Wang, Chuan Xie
Article Number: 4
Published online on: 05 November 2025

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Expression of Concern Open Access

[Expression of Concern] Leptin promotes breast cancer cell migration and invasion via IL‑18 expression and secretion

Kuangfa Li, Lan Wei, Yunxiu Huang, Yang Wu, Min Su, Xueli Pang, Nian Wang, Feihu Ji, Changli Zhong, Tingmei Chen
Article Number: 3
Published online on: 04 November 2025

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Review Open Access

Cancer immunotherapy strategies based on transition‑metal medical materials: Still a long way to go (Review)

Zhefei Du, Zhenyu Cao, Chao Fang, Daihan Xie, Lixin Xie, Chunxia Su, Yu Huo
Article Number: 2
Published online on: 04 November 2025

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Expression of Concern Open Access

[Expression of Concern] Regulation of NADPH oxidase (Nox2) by lipid rafts in breast carcinoma cells

Rama Rao Malla, Hari Raghu, Jasti S. Rao
Article Number: 1
Published online on: 23 October 2025

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February-2026 Volume 68 Issue 2

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Review

Cancer stem cell heterogeneity‑inspired therapeutics for enhancing tumor treatment outcomes (Review)

Hanning Xu, Qunchao Si, Yongyao Song, Shengping Sun, Xianghong Wei, Hui Long, Xiaomei Wang
Article Number: 18
Published online on: 04 December 2025

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Review Open Access

Roles of interleukins in spasmolytic polypeptide‑expressing metaplasia (Review)

Jiale Ma, Tiancheng Zhan, Xinyuan Zhang, Wang Gao, Shuangmei Zhao, Huizhen Li
Article Number: 17
Published online on: 03 December 2025

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Expression of Concern Open Access

[Expression of Concern] MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion

Jingchun Gao, Matthew J. Mcconnell, Bin Yu, Jiannong Li, Justin M. Balko, Esther P. Black, Joseph O. Johnson, Mark C. Lloyd, Soner Altiok, Eric B. Haura
Article Number: 16
Published online on: 03 December 2025

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Review Open Access

Emerging biomarkers in prostate cancer diagnosis and treatment: Insights into genetic, RNA and metabolic markers (Review)

Yuanshe Huang, Jingxin Mao, Xiaobing Li
Article Number: 15
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] GDC‑0152 attenuates the malignant progression of osteosarcoma promoted by ANGPTL2 via PI3K/AKT but not p38MAPK signaling pathway

Lin Yang, Taipengfei Shu, Yingjian Liang, Wenguang Gu, Chunlei Wang, Xuanhe Song, Changdong Fan, Wenbo Wang
Article Number: 14
Published online on: 01 December 2025

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