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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2012 Volume 41 Issue 2

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Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade

  • Authors:
    • Miguel A. Fonseca-Sánchez
    • Sergio Rodríguez Cuevas
    • Guillermo Mendoza-Hernández
    • Veronica Bautista-Piña
    • Elena Arechaga Ocampo
    • Alfredo Hidalgo Miranda
    • Valeria Quintanar Jurado
    • Laurence A. Marchat
    • Elizbeth Álvarez-Sánchez
    • Carlos Pérez Plasencia
    • César López-Camarillo
  • View Affiliations / Copyright

    Affiliations: Genomics Sciences Program, Oncogenomics and Cancer Proteomics Laboratory, Autonomous University of Mexico city, 03100 Mexico City, Mexico, Institute of Breast Diseases-FUCAM, 04980 Mexico City, Mexico, Biochemistry Department, Medicine Faculty, Autonomous National University of Mexico, Mexico City, Mexico, Carcinogenesis Laboratory, National Institute of Cancerology, 14080 Mexico City, Mexico, National Institute of Genomic Medicine, Mexico City, Mexico, Biotechnology Program, Institutional Program of Molecular Biomedicine, National School of Medicine and Homeopathy of the National Polytechnic Institute, 07320 Mexico City, Mexico, Genomics Sciences Program, Oncogenomics and Cancer Proteomics Laboratory, Autonomous University of Mexico City, 03100 Mexico City, Mexico, Massive Sequencing Unit, National Institute of Cancerology, 14080 Mexico City, Mexico, Genomics Sciences Program, Oncogenomics and Cancer Proteomics Laboratory, Autonomous University of Mexico City, 03100 Mexico city, Mexico
  • Pages: 670-680
    |
    Published online on: May 14, 2012
       https://doi.org/10.3892/ijo.2012.1478
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Abstract

Breast cancer is the neoplasia with the highest incidence in women worldwide. Proteomics approaches have accelerated the discovery of diagnostic and prognostic biomarkers. Here, we compared the proteomic profiles of breast tumors versus non-tumoral tissues in order to identify modulated proteins, which could represent potential markers associated to clinical features. By two-dimensional electrophoresis, we detected 28 differentially expressed proteins. Among these, 21 proteins were up-regulated and 7 were down-regulated in tumors (p<0.05). Proteins were identified using LC/ESI-MS/MS tandem mass spectrometry. One protein was identified as glyoxalase 1 (GLO1), an enzyme involved in detoxification of methylglyoxal, a cytotoxic product of glycolysis. GLO1 overexpression was confirmed by western blot assays in paired normal and tumor breast tissues in clinical stages I-III, and by immunohistochemistry on tissue microarrays (TMA) comprising a cohort of 98 breast tumors and 20 healthy specimens. Results from TMA demonstrated that GLO1 is overexpressed in 79% of tumors. Interestingly, GLO1 up-regulation correlates with advanced tumor grade (p<0.05). These findings demonstrate the association of GLO1 overexpression with tumor grade and pointed out for additional studies to establish the importance of GLO1 in breast cancer.
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1 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T and Thun MJ: Cancer Statistics, 2008. CA Cancer J Clin. 58:71–96. 2008. View Article : Google Scholar

3 

Schnitt SJ: Classification and prognosis of invasive breast cancer: from morphology to molecular taxonomy. Mod Pathol. 23:S60–S64. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Rakha EA and Ellis IO: Modern classification of breast cancer: should we stick with morphology or convert to molecular profile characteristics. Adv Anat Pathol. 18:255–267. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Rakha EA, Reis-Filho JS, Baehner F, et al: Breast cancer prognostic classification in the molecular era: the role of histological grade. Breast Cancer Res. 12:2072010.PubMed/NCBI

6 

Perou CM, Sørlie T, Eisen MB, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Murphy N, Millar E and Lee CS: Gene expression profiling in breast cancer: towards individualising patient management. Pathology. 37:271–277. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Correa Geyer F and Reis-Filho JS: Microarray-based gene expression profiling as a clinical tool for breast cancer management: are we there yet? Int J Surg Pathol. 17:285–302. 2009.PubMed/NCBI

9 

Tyers M and Mann M: From genomics to proteomics. Nature. 422:193–197. 2003. View Article : Google Scholar

10 

Bertucci F, Birnbaum D and Goncalves A: Proteomics of breast cancer: principles and potential clinical applications. Mol Cell Proteomics. 5:1772–1786. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Westley B and Rochefort H: A secreted glycoprotein induced by estrogen in human breast cancer cell lines. Cell. 20:353–362. 1980. View Article : Google Scholar : PubMed/NCBI

12 

Trask DK, Band V, Zajchowski DA, Yaswen P, Suh T and Sager R: Keratins as markers that distinguish normal and tumor-derived mammary epithelial cells. Proc Natl Acad Sci USA. 87:2319–2323. 1990. View Article : Google Scholar : PubMed/NCBI

13 

Stein RC and Zvelebil MJ: The application of 2-D gel-based proteomics methods to the study of breast cancer. J Mammary Gland Biol Neoplasia. 7:385–393. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Umar A, Kang H, Timmermans AM, et al: Identification of a putative protein profile associated with tamoxifen therapy resistance in breast cancer. Mol Cell Proteomics. 8:1278–1294. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Besada V, Diaz M, Becker M, Ramos Y, Castellanos-Serra L and Fichtner I: Proteomics of xenografted human breast cancer indicates novel targets related to tamoxifen resistance. Proteomics. 6:1038–1048. 2006. View Article : Google Scholar : PubMed/NCBI

16 

González-Zamorano M, Mendoza-Hernández G, Xolalpa W, Parada C, Vallecillo AJ, Bigi F and Espitia C: Mycobacterium tuberculosis glycoproteomics based on ConA-lectin affinity capture of mannosylated proteins. J Proteome Res. 8:721–733. 2009.

17 

Zhang D, Tai LK, Wong LL, Chiu LL, Sethi SK and Koay ES: Proteomic study reveals that proteins involved in metabolic and detoxification pathways are highly expressed in HER-2/neu-positive breast cancer. Mol Cell Proteomics. 4:1686–1696. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Chang XZ, Li DQ, Hou YF, Wu J, Lu JS, Di GH, Jin W, Ou ZL, Shen ZZ and Shao ZM: Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer. Breast Cancer Res. 9:R762007. View Article : Google Scholar : PubMed/NCBI

19 

Le Naour F, Misek DE, Krause MC, Deneux L, Giordano TJ, Scholl S and Hanash SM: Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer. Clin Cancer Res. 7:3328–3335. 2001.PubMed/NCBI

20 

Bianchi MS, Bianchi NO and Bolzán AD: Superoxide dismutase activity and superoxide dismutase-1 gene methylation in normal and tumoral human breast tissues. Cancer Genet Cytogenet. 59:26–29. 1992. View Article : Google Scholar : PubMed/NCBI

21 

Wei L, Liu TT, Wang HH, Hong HM, Yu AL, Feng HP and Chang WW: Hsp27 participates in the maintenance of breast cancer stem cells through regulation of epithelial-mesenchymal transition and nuclear factor-kappa B. Breast Cancer Res. 13:R1012011. View Article : Google Scholar : PubMed/NCBI

22 

Sims JD, McCready J and Jay DG: Extracellular heat shock protein (Hsp)70 and Hsp90α assist in matrix metalloproteinase-2 activation and breast cancer cell migration and invasion. PLoS One. 6:e188482011.

23 

Wang LP, Bi J, Yao C, Xu XD, Li XX, Wang SM, Li ZL, Zhang DY, Wang M and Chang GQ: Annexin A1 expression and its prognostic significance in human breast cancer. Neoplasma. 57:253–259. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Porter D, Weremowicz S, Chin K, et al: A neural survival factor is a candidate oncogene in breast cancer. Proc Natl Acad Sci USA. 100:10931–10936. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Sahni A, Arévalo MT, Sahni SK and Simpson-Haidaris PJ: The VE-cadherin binding domain of fibrinogen induces endothelial barrier permeability and enhances transendothelial migration of malignant breast epithelial cells. Int J Cancer. 125:577–584. 2009. View Article : Google Scholar

26 

Moon HG, Jeong SH, Ju YT, Jeong CY, Lee JS, Lee YJ, Hong SC, Choi SK, Ha WS, Park ST and Jung EJ: Up-regulation of RhoGDI2 in human breast cancer and its prognostic implications. Cancer Res Treat. 42:151–156. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Steeg PS, De la Rosa A, Flatow U, MacDonald NJ, Benedict M and Leone A: Nm23 and breast cancer metastasis. Breast Cancer Res Treat. 25:175–187. 1993. View Article : Google Scholar : PubMed/NCBI

28 

Thornalley PJ: Protecting the genome: defence against nucleotide glycation and emerging role of glyoxalase I overexpression in multidrug resistance in cancer chemotherapy. Biochem Soc Trans. 31:1372–1377. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Knauer M, Cardoso F, Wesseling J, Bedard PL, Linn SC, Rutgers EJ and van’t Veer LJ: Identification of a low-risk subgroup of HER-2-positive breast cancer by the 70-gene prognosis signature. Br J Cancer. 103:1788–1793. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Toi M, Iwata H, Yamanaka T, et al Japan Breast Cancer Research Group-Translational Research Group: Clinical significance of the 21-gene signature (Oncotype DX) in hormone receptor-positive early stage primary breast cancer in the Japanese population. Cancer. 116:3112–3118. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Pitkanen-Arsiola T, Tillman J, Gu G, et al: Androgen and anti-androgen treatment modulates androgen receptor activity and DJ-1 stability. Prostate. 66:1177–1193. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Tillman J, Yuan J, Gu G, et al: DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells. Cancer Res. 67:4630–4637. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Ranganathan S and Tew KD: Analysis of glyoxalase-I from normal and tumor tissue from human colon. Biochim Biophys Acta. 1182:311–316. 1993. View Article : Google Scholar : PubMed/NCBI

34 

Di Ilio C, Angelucci S, Pennelli A, Zezza A, Tenaglia R and Sacchetta P: Glyoxalase activities in tumor and non-tumor human urogenital tissues. Cancer Lett. 96:189–193. 1995.PubMed/NCBI

35 

Davidson SD, Cherry JP, Choudhury MS, Tazaki H, Mallouh C and Konno S: Glyoxalase I activity in human prostate cancer: a potential marker and importance in chemotherapy. J Urol. 161:690–691. 1999. View Article : Google Scholar : PubMed/NCBI

36 

Rulli A, Carli L, Romani R, Baroni T, Giovannini E, Rosi G and Talesa V: Expression of glyoxalase I and II in normal and breast cancer tissues. Breast Cancer Res Treat. 66:67–72. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Bair WB III, Cabello CM, Uchida K, Bause AS and Wondra GT: GLO1 overexpression in human malignant melanoma. Melanoma Res. 20:85–96. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Sakamoto H, Mashima T, Kizaki A, Dan S, Hashimoto Y, Naito M and Tsuruo T: Glyoxalase I is involved in resistance of human leukemia cells to antitumor agent-induced apoptosis. Blood. 95:3214–3218. 2000.PubMed/NCBI

39 

Santarius T, Bignell GR, Greenman CD, et al: GLO1 - a novel amplified gene in human cancer. Genes Chromosomes Cancer. 49:711–725. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Van der Heiden MG, Cantley LC and Thompson CB: Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 324:1029–1033. 2009.PubMed/NCBI

41 

Ross JS and Harbeck N: Prognostic and predictive factors overview. Molecular Oncology of Breast Cancer. Ross JS and Hortobagyi GN: Jones and Bartlett Publishers; Sudbury, MA: 2005

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Copy and paste a formatted citation
Spandidos Publications style
Fonseca-Sánchez MA, Rodríguez Cuevas S, Mendoza-Hernández G, Bautista-Piña V, Arechaga Ocampo E, Hidalgo Miranda A, Quintanar Jurado V, Marchat LA, Álvarez-Sánchez E, Pérez Plasencia C, Pérez Plasencia C, et al: Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade. Int J Oncol 41: 670-680, 2012.
APA
Fonseca-Sánchez, M.A., Rodríguez Cuevas, S., Mendoza-Hernández, G., Bautista-Piña, V., Arechaga Ocampo, E., Hidalgo Miranda, A. ... López-Camarillo, C. (2012). Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade. International Journal of Oncology, 41, 670-680. https://doi.org/10.3892/ijo.2012.1478
MLA
Fonseca-Sánchez, M. A., Rodríguez Cuevas, S., Mendoza-Hernández, G., Bautista-Piña, V., Arechaga Ocampo, E., Hidalgo Miranda, A., Quintanar Jurado, V., Marchat, L. A., Álvarez-Sánchez, E., Pérez Plasencia, C., López-Camarillo, C."Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade". International Journal of Oncology 41.2 (2012): 670-680.
Chicago
Fonseca-Sánchez, M. A., Rodríguez Cuevas, S., Mendoza-Hernández, G., Bautista-Piña, V., Arechaga Ocampo, E., Hidalgo Miranda, A., Quintanar Jurado, V., Marchat, L. A., Álvarez-Sánchez, E., Pérez Plasencia, C., López-Camarillo, C."Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade". International Journal of Oncology 41, no. 2 (2012): 670-680. https://doi.org/10.3892/ijo.2012.1478
Copy and paste a formatted citation
x
Spandidos Publications style
Fonseca-Sánchez MA, Rodríguez Cuevas S, Mendoza-Hernández G, Bautista-Piña V, Arechaga Ocampo E, Hidalgo Miranda A, Quintanar Jurado V, Marchat LA, Álvarez-Sánchez E, Pérez Plasencia C, Pérez Plasencia C, et al: Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade. Int J Oncol 41: 670-680, 2012.
APA
Fonseca-Sánchez, M.A., Rodríguez Cuevas, S., Mendoza-Hernández, G., Bautista-Piña, V., Arechaga Ocampo, E., Hidalgo Miranda, A. ... López-Camarillo, C. (2012). Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade. International Journal of Oncology, 41, 670-680. https://doi.org/10.3892/ijo.2012.1478
MLA
Fonseca-Sánchez, M. A., Rodríguez Cuevas, S., Mendoza-Hernández, G., Bautista-Piña, V., Arechaga Ocampo, E., Hidalgo Miranda, A., Quintanar Jurado, V., Marchat, L. A., Álvarez-Sánchez, E., Pérez Plasencia, C., López-Camarillo, C."Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade". International Journal of Oncology 41.2 (2012): 670-680.
Chicago
Fonseca-Sánchez, M. A., Rodríguez Cuevas, S., Mendoza-Hernández, G., Bautista-Piña, V., Arechaga Ocampo, E., Hidalgo Miranda, A., Quintanar Jurado, V., Marchat, L. A., Álvarez-Sánchez, E., Pérez Plasencia, C., López-Camarillo, C."Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade". International Journal of Oncology 41, no. 2 (2012): 670-680. https://doi.org/10.3892/ijo.2012.1478
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