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Reelin signalling in neuroblastoma: Migratory switch in metastatic stages

  • Authors:
    • Jürgen Becker
    • Johanna Fröhlich
    • Christina Perske
    • Helena Pavlakovic
    • Jörg Wilting
  • View Affiliations / Copyright

    Affiliations: Center of Anatomy, Department of Anatomy and Cell Biology, University Medicine Goettingen, Goettingen, Germany, Department of Pathology, University Medicine Goettingen, Goettingen, Germany, Center of Anatomy, Department of Neuroanatomy, University Medicine Goettingen, Goettingen, Germany
  • Pages: 681-689
    |
    Published online on: May 18, 2012
       https://doi.org/10.3892/ijo.2012.1488
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Abstract

The essential functions of Reelin for the migratory behaviour of neuroblasts in the central nervous system are well documented. Its role in the dissemination of neuronal tumours of the peripheral nervous system has not been studied in detail. Here, we examined neuroblastoma (NB), a tumour derived from sympathoadrenal cells of neural crest origin. We studied the expression of Reelin, its receptors VLDLR and LRP8 and the adapter protein DAB1 in primary tumour samples and cell lines. We used real-time RT-PCR, immunohistology and western blot analysis. In NB cell lines we studied effects of all-trans retinoic acid and the in vitro effects of Reelin. In primary tumour samples of untreated patients, a significant downregulation of Reelin and DAB1 mRNA was found in the metastatic stages 3, 4 and 4s. Immunohistochemical studies revealed expression of Reelin, LRP8 and DAB1 in differentiating-type low-grade NB. In vitro, western blot analysis of selected NB cell lines showed variable expression patterns. Differentiation induction with all-trans retinoic acid induced the upregulation of Reelin and DAB1. Reelin acted as a chemoattractant for various NB cell lines but inhibited migration when applied together with the NB cells. In normal tissue, we found Reelin in lymphatic endothelial cells (LECs) but not in blood vessel endothelium (BECs). In primary NB, both BECs and LECs were positive. Our data strongly suggest that Reelin has a dual role in NB. Autocrine expression marks low-grade differentiating tumour cells, whereas paracrine Reelin presented by LECs and BECs may act as a chemoattractant and promote hematogenic and lymphogenic dissemination in progressed stages.
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1 

Castleberry RP: Neuroblastoma. Eur J Cancer. 33:1430–1438. 1997. View Article : Google Scholar

2 

Maris JM: Recent advances in neuroblastoma. N Engl J Med. 362:2202–2211. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Maris JM, Hogarty MD, Bagatell R and Cohn SL: Neuroblastoma. Lancet. 369:2106–2120. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Brodeur GM: Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer. 3:203–216. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Weinstein JL, Katzenstein HM and Cohn SL: Advances in the diagnosis and treatment of neuroblastoma. Oncologist. 8:278–292. 2003. View Article : Google Scholar

6 

Westermann F and Schwab M: Genetic parameters of neuroblastomas. Cancer Lett. 184:127–147. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Becker J, Erdlenbruch B, Noskova I, et al: Keratoepithelin suppresses the progression of experimental human neuroblastomas. Cancer Res. 66:5314–5321. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Becker J, Pavlakovic H, Ludewig F, et al: Neuroblastoma progression correlates with downregulation of the lymphangiogenesis inhibitor sVEGFR-2. Clin Cancer Res. 16:1431–1441. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Becker J, Volland S, Noskova I, Schramm A, Schweigerer LL and Wilting J: Keratoepithelin reverts the suppression of tissue factor pathway inhibitor 2 by MYCN in human neuroblastoma: a mechanism to inhibit invasion. Int J Oncol. 32:235–240. 2008.PubMed/NCBI

10 

Volland S, Kugler W, Schweigerer L, Wilting J and Becker J: Stanniocalcin 2 promotes invasion and is associated with metastatic stages in neuroblastoma. Int J Cancer. 125:2049–2057. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Norgall S, Papoutsi M, Rossler J, Schweigerer L, Wilting J and Weich HA: Elevated expression of VEGFR-3 in lymphatic endothelial cells from lymphangiomas. BMC Cancer. 7:1052007. View Article : Google Scholar : PubMed/NCBI

12 

Petrova TV, Makinen T, Makela TP, et al: Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. EMBO J. 21:4593–4599. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Podgrabinska S, Braun P, Velasco P, Kloos B, Pepper MS and Skobe M: Molecular characterization of lymphatic endothelial cells. Proc Natl Acad Sci USA. 99:16069–16074. 2002. View Article : Google Scholar : PubMed/NCBI

14 

D’Arcangelo G, Miao GG, Chen SC, Soares HD, Morgan JI and Curran T: A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature. 374:719–723. 1995.

15 

Kohno T and Hattori M: Re-evaluation of protease activity of reelin. Biol Pharm Bull. 33:1047–1049. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Quattrocchi CC, Wannenes F, Persico AM, et al: Reelin is a serine protease of the extracellular matrix. J Biol Chem. 277:303–309. 2002. View Article : Google Scholar : PubMed/NCBI

17 

D’Arcangelo G, Homayouni R, Keshvara L, Rice DS, Sheldon M and Curran T: Reelin is a ligand for lipoprotein receptors. Neuron. 24:471–479. 1999.

18 

Benhayon D, Magdaleno S and Curran T: Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1. Brain Res Mol Brain Res. 112:33–45. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Hiesberger T, Trommsdorff M, Howell BW, et al: Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. Neuron. 24:481–489. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Howell BW, Hawkes R, Soriano P and Cooper JA: Neuronal position in the developing brain is regulated by mouse disabled-1. Nature. 389:733–737. 1997. View Article : Google Scholar : PubMed/NCBI

21 

Strasser V, Fasching D, Hauser C, et al: Receptor clustering is involved in Reelin signaling. Mol Cell Biol. 24:1378–1386. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Trommsdorff M, Gotthardt M, Hiesberger T, et al: Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell. 97:689–701. 1999. View Article : Google Scholar : PubMed/NCBI

23 

Dulabon L, Olson EC, Taglienti MG, et al: Reelin binds alpha-3beta1 integrin and inhibits neuronal migration. Neuron. 27:33–44. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Hoe HS, Lee KJ, Carney RS, et al: Interaction of reelin with amyloid precursor protein promotes neurite outgrowth. J Neurosci. 29:7459–7473. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Yip YP, Kronstadt-O’Brien P, Capriotti C, Cooper JA and Yip JW: Migration of sympathetic preganglionic neurons in the spinal cord is regulated by Reelin-dependent Dab1 tyrosine phosphorylation and CrkL. J Comp Neurol. 502:635–643. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Evangelisti C, Florian MC, Massimi I, et al: MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness. FASEB J. 23:4276–4287. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Hughes M, Marsden HB and Palmer MK: Histologic patterns of neuroblastoma related to prognosis and clinical staging. Cancer. 34:1706–1711. 1974. View Article : Google Scholar : PubMed/NCBI

28 

Peuchmaur M, d’Amore ES, Joshi VV, et al: Revision of the International Neuroblastoma Pathology Classification: confirmation of favorable and unfavorable prognostic subsets in ganglioneuroblastoma, nodular. Cancer. 98:2274–2281. 2003. View Article : Google Scholar

29 

Becker J, Wang B, Pavlakovic H, Buttler K and Wilting J: Homeobox transcription factor Prox1 in sympathetic ganglia of vertebrate embryos: correlation with human stage 4s neuroblastoma. Pediatr Res. 68:112–117. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Chen Y, Kundakovic M, Agis-Balboa RC, Pinna G and Grayson DR: Induction of the reelin promoter by retinoic acid is mediated by Sp1. J Neurochem. 103:650–665. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Pahlman S, Hoehner JC, Nanberg E, et al: Differentiation and survival influences of growth factors in human neuroblastoma. Eur J Cancer. 31A:453–458. 1995. View Article : Google Scholar : PubMed/NCBI

32 

Wilting J, Papoutsi M, Christ B, et al: The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues. FASEB J. 16:1271–1273. 2002.PubMed/NCBI

33 

Lagodny J, Juttner E, Kayser G, Niemeyer CM and Rossler J: Lymphangiogenesis and its regulation in human neuroblastoma. Biochem Biophys Res Commun. 352:571–577. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Falconer DS and Sierts-Roth U: Dreher, a new gene of the waltzer-shaker group in the house mouse. Z Indukt Abstamm Vererbungsl. 84:71–73. 1951.(In undetermined language).

35 

Fatemi SH: Reelin mutations in mouse and man: from reeler mouse to schizophrenia, mood disorders, autism and lissencephaly. Mol Psychiatry. 6:129–133. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Hourihane JO, Bennett CP, Chaudhuri R, Robb SA and Martin ND: A sibship with a neuronal migration defect, cerebellar hypoplasia and congenital lymphedema. Neuropediatrics. 24:43–46. 1993. View Article : Google Scholar : PubMed/NCBI

37 

Lorenzetto E, Panteri R, Marino R, Keller F and Buffelli M: Impaired nerve regeneration in reeler mice after peripheral nerve injury. Eur J Neurosci. 27:12–19. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Panteri R, Mey J, Zhelyaznik N, et al: Reelin is transiently expressed in the peripheral nerve during development and is upregulated following nerve crush. Mol Cell Neurosci. 32:133–142. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Smalheiser NR, Costa E, Guidotti A, et al: Expression of reelin in adult mammalian blood, liver, pituitary pars intermedia, and adrenal chromaffin cells. Proc Natl Acad Sci USA. 97:1281–1286. 2000. View Article : Google Scholar : PubMed/NCBI

40 

Kim DH, Iijima H, Goto K, et al: Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain. J Biol Chem. 271:8373–8380. 1996.PubMed/NCBI

41 

Koch S, Strasser V, Hauser C, et al: A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signaling. EMBO J. 21:5996–6004. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Brandes AA, Palmisano V, Pasetto LM, Basso U and Monfardini S: High-dose chemotherapy with bone marrow rescue for high-grade gliomas in adults. Cancer Invest. 19:41–48. 2001. View Article : Google Scholar : PubMed/NCBI

43 

Brandes C, Novak S, Stockinger W, Herz J, Schneider WJ and Nimpf J: Avian and murine LR8B and human apolipoprotein E receptor 2: differentially spliced products from corresponding genes. Genomics. 42:185–191. 1997. View Article : Google Scholar : PubMed/NCBI

44 

Kim DH, Magoori K, Inoue TR, et al: Exon/intron organization, chromosome localization, alternative splicing, and transcription units of the human apolipoprotein E receptor 2 gene. J Biol Chem. 272:8498–8504. 1997. View Article : Google Scholar

45 

Bock HH, Jossin Y, Liu P, et al: Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination. J Biol Chem. 278:38772–38779. 2003. View Article : Google Scholar : PubMed/NCBI

46 

Thiele C: Neuroblastoma cell lines. Human Cell Culture. 1. Masters J: Kluwer Academic Publishers; Lancaster: pp. 21–53. 1998, View Article : Google Scholar

47 

Zhao S and Frotscher M: Go or stop? Divergent roles of Reelin in radial neuronal migration. Neuroscientist. 16:421–434. 2010. View Article : Google Scholar : PubMed/NCBI

48 

Meyer G and Goffinet AM: Prenatal development of reelin-immunoreactive neurons in the human neocortex. J Comp Neurol. 397:29–40. 1998. View Article : Google Scholar : PubMed/NCBI

49 

Senturk A, Pfennig S, Weiss A, Burk K and Acker-Palmer A: Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration. Nature. 472:356–360. 2011. View Article : Google Scholar : PubMed/NCBI

50 

Schmid RS, Jo R, Shelton S, Kreidberg JA and Anton ES: Reelin, integrin and DAB1 interactions during embryonic cerebral cortical development. Cereb Cortex. 15:1632–1636. 2005. View Article : Google Scholar : PubMed/NCBI

51 

Sato N, Fukushima N, Chang R, Matsubayashi H and Goggins M: Differential and epigenetic gene expression profiling identifies frequent disruption of the RELN pathway in pancreatic cancers. Gastroenterology. 130:548–565. 2006. View Article : Google Scholar : PubMed/NCBI

52 

Perrone G, Vincenzi B, Zagami M, et al: Reelin expression in human prostate cancer: a marker of tumor aggressiveness based on correlation with grade. Mod Pathol. 20:344–351. 2007. View Article : Google Scholar : PubMed/NCBI

53 

Seigel GM, Hackam AS, Ganguly A, Mandell LM and Gonzalez-Fernandez F: Human embryonic and neuronal stem cell markers in retinoblastoma. Mol Vis. 13:823–832. 2007.PubMed/NCBI

54 

Wang Q, Lu J, Yang C, et al: CASK and its target gene Reelin were co-upregulated in human esophageal carcinoma. Cancer Lett. 179:71–77. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Becker J, Fröhlich J, Perske C, Pavlakovic H and Wilting J: Reelin signalling in neuroblastoma: Migratory switch in metastatic stages. Int J Oncol 41: 681-689, 2012.
APA
Becker, J., Fröhlich, J., Perske, C., Pavlakovic, H., & Wilting, J. (2012). Reelin signalling in neuroblastoma: Migratory switch in metastatic stages. International Journal of Oncology, 41, 681-689. https://doi.org/10.3892/ijo.2012.1488
MLA
Becker, J., Fröhlich, J., Perske, C., Pavlakovic, H., Wilting, J."Reelin signalling in neuroblastoma: Migratory switch in metastatic stages". International Journal of Oncology 41.2 (2012): 681-689.
Chicago
Becker, J., Fröhlich, J., Perske, C., Pavlakovic, H., Wilting, J."Reelin signalling in neuroblastoma: Migratory switch in metastatic stages". International Journal of Oncology 41, no. 2 (2012): 681-689. https://doi.org/10.3892/ijo.2012.1488
Copy and paste a formatted citation
x
Spandidos Publications style
Becker J, Fröhlich J, Perske C, Pavlakovic H and Wilting J: Reelin signalling in neuroblastoma: Migratory switch in metastatic stages. Int J Oncol 41: 681-689, 2012.
APA
Becker, J., Fröhlich, J., Perske, C., Pavlakovic, H., & Wilting, J. (2012). Reelin signalling in neuroblastoma: Migratory switch in metastatic stages. International Journal of Oncology, 41, 681-689. https://doi.org/10.3892/ijo.2012.1488
MLA
Becker, J., Fröhlich, J., Perske, C., Pavlakovic, H., Wilting, J."Reelin signalling in neuroblastoma: Migratory switch in metastatic stages". International Journal of Oncology 41.2 (2012): 681-689.
Chicago
Becker, J., Fröhlich, J., Perske, C., Pavlakovic, H., Wilting, J."Reelin signalling in neuroblastoma: Migratory switch in metastatic stages". International Journal of Oncology 41, no. 2 (2012): 681-689. https://doi.org/10.3892/ijo.2012.1488
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