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September 2012 Volume 41 Issue 3

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Review Open Access

Epimutation and cancer: a new carcinogenic mechanism of Lynch syndrome (Review)

  • Authors:
    • Kouji Banno
    • Iori Kisu
    • Megumi Yanokura
    • Kosuke Tsuji
    • Kenta Masuda
    • Arisa Ueki
    • Yusuke Kobayashi
    • Wataru Yamagami
    • Hiroyuki Nomura
    • Eiichiro Tominaga
    • Nobuyuki Susumu
    • Daisuke Aoki
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan
    Copyright: © Banno et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 793-797
    |
    Published online on: June 25, 2012
       https://doi.org/10.3892/ijo.2012.1528
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Abstract

Epimutation is defined as abnormal transcriptional repression of active genes and/or abnormal activation of usually repressed genes caused by errors in epigenetic gene repression. Epimutation arises in somatic cells and the germline, and constitutional epimutation may also occur. Epimutation is the first step of tumorigenesis and can be a direct cause of carcinogenesis. Cancers associated with epimutation include Lynch syndrome (hereditary non-polyposis colorectal cancer, HNPCC), chronic lymphocytic leukemia, breast cancer and ovarian cancer. Epimutation has been shown for many tumor suppressor genes, including RB, VHL, hMLH1, APC and BRCA1, in sporadic cancers. Methylation has recently been shown in DNA from normal tissues and peripheral blood in cases of sporadic colorectal cancer and many studies show constitutive epimutation in cancers. Epimutation of DNA mismatch repair (MMR) genes (BRCA1, hMLH1 and hMSH2) involved in development familial cancers has also been found. These results have led to a focus on epimutation as a novel oncogenic mechanism.
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1 

Holliday R: The inheritance of epigenetic defects. Science. 238:163–170. 1987. View Article : Google Scholar : PubMed/NCBI

2 

Das OP and Messing J: Variegated phenotype and developmental methylation changes of a maize allele originating from epimutation. Genetics. 136:1121–1141. 1994.PubMed/NCBI

3 

Schofield PN, Joyce JA, Lam WK, Grandjean V, Ferguson-Smith A, Reik W and Maher ER: Genomic imprinting and cancer; new paradigms in the genetics of neoplasia. Toxicol Lett. 120:151–160. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Hitchins M, Williams R, Cheong K, et al: MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer. Gastroenterology. 129:1392–1399. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Hitchins MP, Wong JJ, Suthers G, Suter CM, Martin DI, Hawkins NJ and Ward RL: Inheritance of a cancer-associated MLH1 germ-line epimutation. N Engl J Med. 356:697–705. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Valle L, Carbonell P, Fernandez V, Dotor AM, Sanz M, Benitez J and Urioste M: MLH1 germline epimutations in selected patients with early-onset non-polyposis colorectal cancer. Clin Genet. 71:232–237. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Morak M, Schackert HK, Rahner N, et al: Further evidence for heritability of an epimutation in one of 12 cases with MLH1 promoter methylation in blood cells clinically displaying HNPCC. Eur J Hum Genet. 16:804–811. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Hitchins MP and Ward RL: Erasure of MLH1 methylation in spermatozoa-implications for epigenetic inheritance. Nat Genet. 39:12892007. View Article : Google Scholar : PubMed/NCBI

9 

Cooper WN, Luharia A, Evans GA, et al: Molecular subtypes and phenotypic expression of Beckwith-Wiedemann syndrome. Eur J Hum Genet. 13:1025–1032. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Schönherr N, Meyer E, Roos A, Schmidt A, Wollmann HA and Eggermann T: The centromeric 11p15 imprinting centre is also involved in Silver-Russell syndrome. J Med Genet. 44:59–63. 2007.PubMed/NCBI

11 

Conrad DF, Pinto D, Redon R, et al: Origins and functional impact of copy number variation in the human genome. Nature. 464:704–712. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Tufarelli C, Stanley JA, Garrick D, Sharpe JA, Ayyub H, Wood WG and Higgs DR: Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease. Nat Genet. 34:157–165. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Friend SH, Bernards R, Rogelj S, Weinberg RA, Rapaport JM, Albert DM and Dryja TP: A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature. 323:643–646. 1986. View Article : Google Scholar : PubMed/NCBI

14 

Nishisho I, Nakamura Y, Miyoshi Y, et al: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science. 253:665–669. 1991. View Article : Google Scholar : PubMed/NCBI

15 

Hussussian CJ, Struewing JP, Goldstein AM, et al: Germline p16 mutations in familial melanoma. Nat Genet. 8:15–21. 1994. View Article : Google Scholar : PubMed/NCBI

16 

Greger V, Passarge E, Höpping W, Messmer E and Horsthemke B: Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma. Hum Genet. 83:155–158. 1989. View Article : Google Scholar : PubMed/NCBI

17 

Sakai T, Toguchida J, Ohtani N, Yandell DW, Rapaport JM and Dryja TP: Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene. Am J Hum Genet. 48:880–888. 1991.PubMed/NCBI

18 

Herman JG, Latif F, Weng Y, et al: Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA. 91:9700–9704. 1994. View Article : Google Scholar : PubMed/NCBI

19 

Kane MF, Loda M, Gaida GM, Lipman J, Mishra R, Goldman H, Jessup JM and Kolodner R: Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res. 57:808–811. 1997.PubMed/NCBI

20 

Dobrovic A and Simpfendorfer D: Methylation of the BRCA1 gene in sporadic breast cancer. Cancer Res. 57:3347–3350. 1997.PubMed/NCBI

21 

de la Chapelle A: Genetic predisposition to human disease: allele-specific expression and low-penetrance regulatory loci. Oncogene. 28:3345–3348. 2009.PubMed/NCBI

22 

Weisenberger DJ, Siegmund KD, Campan M, et al: CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet. 38:787–793. 2006. View Article : Google Scholar

23 

Gazzoli I, Loda M, Garber J, Syngal S and Kolodner RD: A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor. Cancer Res. 62:3925–3928. 2002.

24 

Suter CM, Martin DI and Ward RL: Germline epimutation of MLH1 in individuals with multiple cancers. Nat Genet. 36:497–501. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Miyakura Y, Sugano K, Konishi F, et al: Extensive methylation of hMLH1 promoter region predominates in proximal colon cancer with microsatellite instability. Gastroenterology. 121:1300–1309. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Miyakura Y, Sugano K, Konishi F, et al: Methylation profile of the MLH1 promoter region and their relationship to colorectal carcinogenesis. Genes Chromosomes Cancer. 36:17–25. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Miyakura Y, Sugano K, Akasu T, et al: Extensive but hemiallelic methylation of the hMLH1 promoter region in early-onset sporadic colon cancers with microsatellite instability. Clin Gastroenterol Hepatol. 2:147–156. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Chan TL, Yuen ST, Kong CK, et al: Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer. Nat Genet. 38:1178–1183. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Raval A, Tanner SM, Byrd JC, et al: Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia. Cell. 129:879–890. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Reddy AN, Jiang WW, Kim M, Benoit N, Taylor R, Clinger J, Sidransky D and Califano JA: Death-associated protein kinase promoter hypermethylation in normal human lymphocytes. Cancer Res. 63:7694–7698. 2003.PubMed/NCBI

31 

Armes JE and Venter DJ: The pathology of inherited breast cancer. Pathology. 34:309–314. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Lakhani SR, Van De Vijver MJ, Jacquemier J, Anderson TJ, Osin PP, MaGuffog L and Easton DF: The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2. J Clin Oncol. 20:2310–2318. 2002. View Article : Google Scholar

33 

Foulkes WD, Stefansson IM, Chappuis PO, Bégin LR, Goffin JR, Wong N, Trudel M and Akslen LA: Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer. J Natl Cancer Inst. 95:1482–1485. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Esteller M, Silva JM, Dominguez G, et al: Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. J Natl Cancer Inst. 92:564–569. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Catteau A and Morris JR: BRCA1 methylation: a significant role in tumour development? Semin Cancer Biol. 12:359–371. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Hedenfalk I, Duggan D, Chen Y, et al: Gene-expression profiles in hereditary breast cancer. N Engl J Med. 344:539–548. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Snell C, Krypuy M, Wong EM; kConFab investigators; Loughrey MB and Dobrovic A: BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotype. Breast Cancer Res. 10:R122008. View Article : Google Scholar : PubMed/NCBI

38 

Hampel H, Frankel WL, Martin E, et al: Feasibility of screening for Lynch syndrome among patients with colorectal cancer. J Clin Oncol. 26:5783–5788. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Peltomäki P and Vasen H: Mutations associated with HNPCC predisposition - Update of ICG-HNPCC/INSiGHT mutation database. Dis Markers. 20:269–276. 2004.PubMed/NCBI

40 

Hirata K, Kanemitsu S, Nakayama Y, Nagata N, Itoh H, Ohnishi H, Ishikawa H and Furukawa Y; HNPCC registry and genetic testing project of the Japanese Society for Cancer of the Colon and Rectum (JSCCR): A novel germline mutation of MSH2 in a hereditary nonpolyposis colorectal cancer patient with liposarcoma. Am J Gastroenterol. 101:193–196. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Naruse H, Ikawa N, Yamaguchi K, et al: Determination of splice-site mutations in Lynch syndrome (hereditary nonpolyposis colorectal cancer) patients using functional splicing assay. Fam Cancer. 8:509–517. 2009. View Article : Google Scholar

42 

Winter MJ, Nagtegaal ID, van Krieken JH and Litvinov SV: The epithelial cell adhesion molecule (Ep-CAM) as a morpho-regulatory molecule is a tool in surgical pathology. Am J Pathol. 163:2139–2148. 2003. View Article : Google Scholar : PubMed/NCBI

43 

Ligtenberg MJ, Kuiper RP, Chan TL, et al: Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1. Nat Genet. 41:112–117. 2009.PubMed/NCBI

44 

Fraga MF, Ballestar E, Paz MF, et al: Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA. 102:10604–10609. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Issa JP, Ottaviano YL, Celano P, Hamilton SR, Davidson NE and Baylin SB: Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet. 7:536–540. 1994. View Article : Google Scholar : PubMed/NCBI

46 

Rose MG: Hematology: azacitidine improves survival in myelodysplastic syndromes. Nat Rev Clin Oncol. 6:502–503. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Banno K, Kisu I, Yanokura M, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Nomura H, Tominaga E, Tominaga E, et al: Epimutation and cancer: a new carcinogenic mechanism of Lynch syndrome (Review). Int J Oncol 41: 793-797, 2012.
APA
Banno, K., Kisu, I., Yanokura, M., Tsuji, K., Masuda, K., Ueki, A. ... Aoki, D. (2012). Epimutation and cancer: a new carcinogenic mechanism of Lynch syndrome (Review). International Journal of Oncology, 41, 793-797. https://doi.org/10.3892/ijo.2012.1528
MLA
Banno, K., Kisu, I., Yanokura, M., Tsuji, K., Masuda, K., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Tominaga, E., Susumu, N., Aoki, D."Epimutation and cancer: a new carcinogenic mechanism of Lynch syndrome (Review)". International Journal of Oncology 41.3 (2012): 793-797.
Chicago
Banno, K., Kisu, I., Yanokura, M., Tsuji, K., Masuda, K., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Tominaga, E., Susumu, N., Aoki, D."Epimutation and cancer: a new carcinogenic mechanism of Lynch syndrome (Review)". International Journal of Oncology 41, no. 3 (2012): 793-797. https://doi.org/10.3892/ijo.2012.1528
Copy and paste a formatted citation
x
Spandidos Publications style
Banno K, Kisu I, Yanokura M, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Nomura H, Tominaga E, Tominaga E, et al: Epimutation and cancer: a new carcinogenic mechanism of Lynch syndrome (Review). Int J Oncol 41: 793-797, 2012.
APA
Banno, K., Kisu, I., Yanokura, M., Tsuji, K., Masuda, K., Ueki, A. ... Aoki, D. (2012). Epimutation and cancer: a new carcinogenic mechanism of Lynch syndrome (Review). International Journal of Oncology, 41, 793-797. https://doi.org/10.3892/ijo.2012.1528
MLA
Banno, K., Kisu, I., Yanokura, M., Tsuji, K., Masuda, K., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Tominaga, E., Susumu, N., Aoki, D."Epimutation and cancer: a new carcinogenic mechanism of Lynch syndrome (Review)". International Journal of Oncology 41.3 (2012): 793-797.
Chicago
Banno, K., Kisu, I., Yanokura, M., Tsuji, K., Masuda, K., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Tominaga, E., Susumu, N., Aoki, D."Epimutation and cancer: a new carcinogenic mechanism of Lynch syndrome (Review)". International Journal of Oncology 41, no. 3 (2012): 793-797. https://doi.org/10.3892/ijo.2012.1528
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