Transcriptomic study of dormant gastrointestinal cancer stem cells

Nishikawa,Shimpei; Dewi,Dyah  Laksmi; Ishii,Hideshi; Konno,Masamitsu; Haraguchi,Naotsugu; Kano,Yoshihiro; Fukusumi,Takahito; Ohta,Katsuya; Noguchi,Yuko; Ozaki,Miyuki; Sakai,Daisuke; Satoh,Taroh; Doki,Yuichiro; Mori,Masaki

doi:10.3892/ijo.2012.1531

September 2012 Volume 41 Issue 3

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September 2012 Volume 41 Issue 3

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Article

Transcriptomic study of dormant gastrointestinal cancer stem cells

Authors:
- Shimpei Nishikawa
- Dyah Laksmi Dewi
- Hideshi Ishii
- Masamitsu Konno
- Naotsugu Haraguchi
- Yoshihiro Kano
- Takahito Fukusumi
- Katsuya Ohta
- Yuko Noguchi
- Miyuki Ozaki
- Daisuke Sakai
- Taroh Satoh
- Yuichiro Doki
- Masaki Mori
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Affiliations: Department of Frontier Science for Cancer and Chemotherapy, Osaka University, Graduate School of Medicine, Suita, Osaka 565-0871, Japan, Department of Gastroenterological Surgery, Osaka University, Graduate School of Medicine, Suita, Osaka 565-0871, Japan
Pages: 979-984
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Published online on: June 25, 2012

https://doi.org/10.3892/ijo.2012.1531
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Abstract

We previously discovered the coexistence of dormant and proliferating cancer stem cells (CSCs) in gastrointestinal cancer, which leads to chemoradiation resistance. CD13-/CD90+ proliferating liver CSCs are sensitive to chemotherapy, and CD13+/CD90- dormant CSCs have a limited proliferation ability, survive in hypoxic areas with reduced oxidative stress, and relapse and metastasize to other organs. In such CD13+ dormant cells, non-homologous end-joining, an error-prone repair mechanism, is dominant after DNA damage, whereas high-fidelity homologous recombination is apparent in CD13- proliferating cells, suggesting the significance of dormancy as an essential protective mechanism of therapy resistance. However, this mechanism may also play a role in the generation and accumulation of heterogeneity during cancer progression, although the exact mechanism remains to be understood. Through transcriptomic study, we elucidated the underlying epigenetic mechanism for malignant behavior of dormant CSCs, i.e., simultaneous activation of several pathways including EZH2- and TP53-related proteins in response to microRNA101, suggesting that a pharmacogenomic approach would open an era to novel molecular targeting cancer therapy.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Transcriptomic study of dormant gastrointestinal cancer stem cells

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Abstract

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