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Article

Evaluation of MAGE-A expression and grade of dysplasia for predicting malignant progression of oral leukoplakia

  • Authors:
    • Jutta Ries
    • Abbas Agaimy
    • Elefterios Vairaktaris
    • Yeeun Kwon
    • Friedrich W. Neukam
    • Lei H. Strassburg
    • Emeka Nkenke
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Erlangen University Hospital, Erlangen, Germany, Institute of Pathology, Erlangen University Hospital, Erlangen, Germany, Department of Oral and Maxillofacial Surgery, University of Athens, Athens, Greece
  • Pages: 1085-1093
    |
    Published online on: June 26, 2012
       https://doi.org/10.3892/ijo.2012.1532
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Abstract

The risk of the malignant transformation of oral leukoplakia (OLP) is difficult to predict by histopathology. Melanoma-associated antigen-A (MAGE-A) expression is restricted to malignant cells and may be useful for the more accurate estimation of the potential malignant transformation of pre-malignant lesions. The aim of the present study was to investigate whether the expression of MAGE-A can be used to predict the malignant transformation of OLP. Paraffin-embedded tissue samples of OLP from 74 patients followed-up for at least 5 years were included. A total of 24 progressing and 50 non-progressing OLP, 18 corresponding tumor and 30 healthy mucosa specimens were analysed for MAGE-A 1, 3, 4, 6 10 and 12 expression by nested real‑time RT-PCR and graded for dysplasia. In total, 46% of the progressing lesions expressed at least 1 out of the examined MAGE-A antigens, whereas no expression was detected in any of the non-progressing OLP and normal specimens. The correlation between malignant transformation and MAGE-A expression was statistically significant (p=0.00001). Furthermore, 42% of the progressing OLPs without dysplasia (D0) expressed at least 1 antigen. The correlation between the grade of dysplasia and MAGE-A staining in the malignant transformation group was not significant (p=0.08). The detection of at least 1 MAGE-A antigen may allow the identification of high-risk lesions that may progress into carcinoma with time. Therefore, the investigation of MAGE-A expression should be assessed in order to obtain a more accurate evaluation of the potential cancer risk of OLP.
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Copy and paste a formatted citation
Spandidos Publications style
Ries J, Agaimy A, Vairaktaris E, Kwon Y, Neukam FW, Strassburg LH and Nkenke E: Evaluation of MAGE-A expression and grade of dysplasia for predicting malignant progression of oral leukoplakia. Int J Oncol 41: 1085-1093, 2012.
APA
Ries, J., Agaimy, A., Vairaktaris, E., Kwon, Y., Neukam, F.W., Strassburg, L.H., & Nkenke, E. (2012). Evaluation of MAGE-A expression and grade of dysplasia for predicting malignant progression of oral leukoplakia. International Journal of Oncology, 41, 1085-1093. https://doi.org/10.3892/ijo.2012.1532
MLA
Ries, J., Agaimy, A., Vairaktaris, E., Kwon, Y., Neukam, F. W., Strassburg, L. H., Nkenke, E."Evaluation of MAGE-A expression and grade of dysplasia for predicting malignant progression of oral leukoplakia". International Journal of Oncology 41.3 (2012): 1085-1093.
Chicago
Ries, J., Agaimy, A., Vairaktaris, E., Kwon, Y., Neukam, F. W., Strassburg, L. H., Nkenke, E."Evaluation of MAGE-A expression and grade of dysplasia for predicting malignant progression of oral leukoplakia". International Journal of Oncology 41, no. 3 (2012): 1085-1093. https://doi.org/10.3892/ijo.2012.1532
Copy and paste a formatted citation
x
Spandidos Publications style
Ries J, Agaimy A, Vairaktaris E, Kwon Y, Neukam FW, Strassburg LH and Nkenke E: Evaluation of MAGE-A expression and grade of dysplasia for predicting malignant progression of oral leukoplakia. Int J Oncol 41: 1085-1093, 2012.
APA
Ries, J., Agaimy, A., Vairaktaris, E., Kwon, Y., Neukam, F.W., Strassburg, L.H., & Nkenke, E. (2012). Evaluation of MAGE-A expression and grade of dysplasia for predicting malignant progression of oral leukoplakia. International Journal of Oncology, 41, 1085-1093. https://doi.org/10.3892/ijo.2012.1532
MLA
Ries, J., Agaimy, A., Vairaktaris, E., Kwon, Y., Neukam, F. W., Strassburg, L. H., Nkenke, E."Evaluation of MAGE-A expression and grade of dysplasia for predicting malignant progression of oral leukoplakia". International Journal of Oncology 41.3 (2012): 1085-1093.
Chicago
Ries, J., Agaimy, A., Vairaktaris, E., Kwon, Y., Neukam, F. W., Strassburg, L. H., Nkenke, E."Evaluation of MAGE-A expression and grade of dysplasia for predicting malignant progression of oral leukoplakia". International Journal of Oncology 41, no. 3 (2012): 1085-1093. https://doi.org/10.3892/ijo.2012.1532
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