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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2012 Volume 41 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Cytokine-like 1 is involved in the growth and metastasis of neuroblastoma cells

  • Authors:
    • Mingjie Wen
    • Huanmin Wang
    • Xulong Zhang
    • Jun Long
    • Zhe Lv
    • Qingli Kong
    • Yunqing An
  • View Affiliations / Copyright

    Affiliations: Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, P.R. China, Department of Surgery, Beijing Children's Hospital, Capital Medical University, Beijing 100045, P.R. China
  • Pages: 1419-1424
    |
    Published online on: July 13, 2012
       https://doi.org/10.3892/ijo.2012.1552
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Abstract

Cytokine-like 1 (CYTL1) was first identified in CD34+ cells derived from bone marrow and cord blood. The biological functions of CYTL1 remain largely unknown. Here, we reveal a relationship between CYTL1 expression and the biological characteristics of neuroblastoma (NB). The expression of CYTL1 was detected in 10 human tumor cell lines and human NB tissues by RT-PCR and real-time PCR. The inhibitory effect of CYTL1 knockdown on the proliferation, migration and invasion of SH-SY5Y human neuroblastoma cells was studied using the CCK-8 assay and Transwell chamber assays. Among the 10 human tumor cell lines that we examined, CYTL1 was expressed only in SH-SY5Y human neuroblastoma cells. Furthermore, we also observed high levels of CYTL1 expression in human NB tissues. When CYTL1 expression was blocked by siRNA, SH-SY5Y cells showed decreased proliferation, migration and invasion activities. Taken together, our results showed the first evidence of CYTL1 expression in SH-SY5Y neuroblastoma cells and human NB tissues, revealed a possible link between CYTL1 and NB development, and suggested CYTL1 as a potential therapeutic target and diagnosis biomarker for NB.
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Copy and paste a formatted citation
Spandidos Publications style
Wen M, Wang H, Zhang X, Long J, Lv Z, Kong Q and An Y: Cytokine-like 1 is involved in the growth and metastasis of neuroblastoma cells. Int J Oncol 41: 1419-1424, 2012.
APA
Wen, M., Wang, H., Zhang, X., Long, J., Lv, Z., Kong, Q., & An, Y. (2012). Cytokine-like 1 is involved in the growth and metastasis of neuroblastoma cells. International Journal of Oncology, 41, 1419-1424. https://doi.org/10.3892/ijo.2012.1552
MLA
Wen, M., Wang, H., Zhang, X., Long, J., Lv, Z., Kong, Q., An, Y."Cytokine-like 1 is involved in the growth and metastasis of neuroblastoma cells". International Journal of Oncology 41.4 (2012): 1419-1424.
Chicago
Wen, M., Wang, H., Zhang, X., Long, J., Lv, Z., Kong, Q., An, Y."Cytokine-like 1 is involved in the growth and metastasis of neuroblastoma cells". International Journal of Oncology 41, no. 4 (2012): 1419-1424. https://doi.org/10.3892/ijo.2012.1552
Copy and paste a formatted citation
x
Spandidos Publications style
Wen M, Wang H, Zhang X, Long J, Lv Z, Kong Q and An Y: Cytokine-like 1 is involved in the growth and metastasis of neuroblastoma cells. Int J Oncol 41: 1419-1424, 2012.
APA
Wen, M., Wang, H., Zhang, X., Long, J., Lv, Z., Kong, Q., & An, Y. (2012). Cytokine-like 1 is involved in the growth and metastasis of neuroblastoma cells. International Journal of Oncology, 41, 1419-1424. https://doi.org/10.3892/ijo.2012.1552
MLA
Wen, M., Wang, H., Zhang, X., Long, J., Lv, Z., Kong, Q., An, Y."Cytokine-like 1 is involved in the growth and metastasis of neuroblastoma cells". International Journal of Oncology 41.4 (2012): 1419-1424.
Chicago
Wen, M., Wang, H., Zhang, X., Long, J., Lv, Z., Kong, Q., An, Y."Cytokine-like 1 is involved in the growth and metastasis of neuroblastoma cells". International Journal of Oncology 41, no. 4 (2012): 1419-1424. https://doi.org/10.3892/ijo.2012.1552
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