The Hedgehog signaling pathway in ovarian teratoma is stimulated by Sonic Hedgehog which induces internalization of Patched

  • Authors:
    • Maja Sabol
    • Diana Car
    • Vesna Musani
    • Petar Ozretic
    • Slavko Oreskovic
    • Igor Weber
    • Sonja Levanat
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  • Published online on: July 13, 2012     https://doi.org/10.3892/ijo.2012.1554
  • Pages: 1411-1418
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Abstract

The Hedgehog-Gli (Hh-Gli) signaling pathway was examined in ovarian dermoids, which show characteristics of both tumors and developmental malformations. Dermoids are classified as mature teratomas that present differentiation into various tissues, mostly epidermal elements such as glands, multilayered epithelium, hair follicles and occasionally bone and cartilage. Their development is attributed to aberrant meiosis of germinal cells within the ovary. We showed activation of the Hh-Gli signaling in ovarian dermoid primary cultures. Cyclopamine treatment slows down cell proliferation, while the Sonic Hedgehog (Shh) protein stimulates cell proliferation and induces internalization of the Patched (Ptch) protein, which accumulates in the form of granules in the cytoplasm, colocalized with the Shh protein. Cyclopamine treatment decreases Gli1 localization in the nucleus compared to non-treated cells. Based on our observations, the mechanism of Hedgehog activation in the ovarian dermoids could be the ligand-dependent autocrine pathway, which can also be stimulated by paracrine signals.
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October 2012
Volume 41 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Sabol, M., Car, D., Musani, V., Ozretic, P., Oreskovic, S., Weber, I., & Levanat, S. (2012). The Hedgehog signaling pathway in ovarian teratoma is stimulated by Sonic Hedgehog which induces internalization of Patched. International Journal of Oncology, 41, 1411-1418. https://doi.org/10.3892/ijo.2012.1554
MLA
Sabol, M., Car, D., Musani, V., Ozretic, P., Oreskovic, S., Weber, I., Levanat, S."The Hedgehog signaling pathway in ovarian teratoma is stimulated by Sonic Hedgehog which induces internalization of Patched". International Journal of Oncology 41.4 (2012): 1411-1418.
Chicago
Sabol, M., Car, D., Musani, V., Ozretic, P., Oreskovic, S., Weber, I., Levanat, S."The Hedgehog signaling pathway in ovarian teratoma is stimulated by Sonic Hedgehog which induces internalization of Patched". International Journal of Oncology 41, no. 4 (2012): 1411-1418. https://doi.org/10.3892/ijo.2012.1554