|
1
|
Thiery JP and Sleeman JP: Complex networks
orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell
Biol. 7:131–142. 2006. View
Article : Google Scholar : PubMed/NCBI
|
|
2
|
Zavadil J and Böttinger EP: TGF-beta and
epithelial-to-mesenchymal transitions. Oncogene. 24:5764–5774.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Miettinen PJ, Ebner R, Lopez AR and
Derynck R: TGF-beta induced transdifferentiation of mammary
epithelial cells to mesenchymal cells: involvement of type I
receptors. J Cell Biol. 127:2021–2036. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Moustakas A and Heldin CH: Signaling
networks guiding epithelial-mesenchymal transitions during
embryogenesis and cancer progression. Cancer Sci. 98:1512–1520.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Miyazawa K, Shinozaki M, Hara T, et al:
Two major Smad pathways in TGF-beta superfamily signalling. Genes
Cells. 7:1191–1204. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Giehl K, Seidel B, Gierschik P, et al:
TGFbeta1 represses proliferation of pancreatic carcinoma cells
which correlates with Smad4-independent inhibition of ERK
activation. Oncogene. 19:4531–4541. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Hahn SA, Schutte M, Hoque AT, et al: DPC4,
a candidate tumor suppressor gene at human chromosome 18q21.1.
Science. 271:350–353. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Bartsch D, Hahn SA, Danichevski KD, et al:
Mutations of the DPC4/Smad4 gene in neuroendocrine pancreatic
tumors. Oncogene. 18:2367–2371. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Massagué J: How cells read TGF-beta
signals. Nat Rev Mol Cell Biol. 1:169–178. 2000.PubMed/NCBI
|
|
10
|
Zawel L, Dai JL, Buckhaults P, et al:
Human Smad3 and Smad4 are sequence-specific transcription
activators. Mol Cell. 1:611–617. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Ohashi S, Natsuizaka M, Naganuma S, et al:
A NOTCH3-mediated squamous cell differentiation program limits
expansion of EMT-competent cells that express the ZEB transcription
factors. Cancer Res. 71:6836–6847. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Dave N, Guaita-Esteruelas S, Gutarra S, et
al: Functional cooperation between Snail1 and twist in the
regulation of ZEB1 expression during epithelial to mesenchymal
transition. J Biol Chem. 286:12024–12032. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Gregory PA, Bracken CP, Smith E, et al: An
autocrine TGF-beta/ ZEB/miR-200 signaling network regulates
establishment and maintenance of epithelial-mesenchymal transition.
Mol Biol Cell. 22:1686–1698. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Hong J, Zhou J, Fu J, et al:
Phosphorylation of serine 68 of Twist1 by MAPKs stabilizes Twist1
protein and promotes breast cancer cell invasiveness. Cancer Res.
71:3980–3990. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Ikenouchi J, Matsuda M, Furuse M and
Tsukita S: Regulation of tight junctions during the
epithelium-mesenchyme transition: direct repression of the gene
expression of claudins/occludin by Snail. J Cell Sci.
116:1959–1967. 2003. View Article : Google Scholar
|
|
16
|
Ohkubo T and Ozawa M: The transcription
factor Snail downregulates the tight junction components
independently of E-cadherin downregulation. J Cell Sci.
117:1675–1685. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Zavadil J, Cermak L, Soto-Nieves N, et al:
Integration of TGF-beta/Smad and Jagged1/Notch signalling in
epithelial-to-mesenchymal transition. EMBO J. 23:1155–1165. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Wu Y, Sato F, Bhawal UK, et al: Basic
helix-loop-helix transcription factors DEC1 and DEC2 regulate the
paclitaxel-induced apoptotic pathway of MCF-7 human breast cancer
cells. Int J Mol Med. 27:491–495. 2011.PubMed/NCBI
|
|
19
|
Liu Y, Sato F, Kawamoto T, et al:
Anti-apoptotic effect of the basic helix-loop-helix (bHLH)
transcription factor DEC2 in human breast cancer cells. Genes
Cells. 15:315–325. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Bhawal UK, Sato F, Arakawa Y, et al: Basic
helix-loop-helix transcription factor DEC1 negatively regulates
cyclin D1. J Pathol. 224:420–429. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Li Y, Xie M, Yang J, et al: The expression
of antiapoptotic protein survivin is transcriptionally upregulated
by DEC1 primarily through multiple sp1 binding sites in the
proximal promoter. Oncogene. 25:3296–3306. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Turley H, Wykoff CC, Troup S, et al: The
hypoxia-regulated transcription factor DEC1 (Stra13, SHARP-2) and
its expression in human tissues and tumours. J Pathol. 203:808–813.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Chakrabarti J, Turley H, Campo L, et al:
The transcription factor DEC1 (stra13, SHARP2) is associated with
the hypoxic response and high tumour grade in human breast cancers.
Br J Cancer. 91:954–958. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Giatromanolaki A, Koukourakis MI, Sivridis
E, et al: DEC1 (STRA13) protein expression relates to hypoxia-
inducible factor 1-alpha and carbonic anhydrase-9 overexpression in
non-small cell lung cancer. J Pathol. 200:222–228. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Kondo J, Sato F, Kusumi T, et al:
Claudin-1 expression is induced by tumor necrosis factor-α in human
pancreatic cancer cells. Int J Mol Med. 22:645–649. 2008.
|
|
26
|
Suzuki T, Sato F, Kondo J, et al: Period
is involved in the proliferation of human pancreatic MIA-PaCa2
cancer cells by TNF-alpha. Biomed Res. 29:99–103. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Sato F, Wu Y, Bhawal UK, Liu Y, et al:
PERIOD1 (PER1) has anti-apoptotic effects, and PER3 has
pro-apoptotic effects during cisplatin (CDDP) treatment in human
gingival cancer CA9-22 cells. Eur J Cancer. 47:1747–1758. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Li Y, Zhang H, Xie M, et al: Abundant
expression of Dec1/stra13/sharp2 in colon carcinoma: its
antagonizing role in serum deprivation-induced apoptosis and
selective inhibition of procaspase activation. Biochem J.
367:413–422. 2002. View Article : Google Scholar
|
|
29
|
Wang W, Reiser-Erkan C, Michalski CW, et
al: Hypoxia inducible BHLHB2 is a novel and independent prognostic
marker in pancreatic ductal adenocarcinoma. Biochem Biophys Res
Commun. 401:422–428. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Kon N, Hirota T, Kawamoto T, et al:
Activation of TGF-beta/ activin signalling resets the circadian
clock through rapid induction of Dec1 transcripts. Nat Cell Biol.
10:1463–1469. 2008. View
Article : Google Scholar : PubMed/NCBI
|
|
31
|
Nicolás FJ and Hill CS: Attenuation of the
TGF-beta-Smad signaling pathway in pancreatic tumor cells confers
resistance to TGF-beta-induced growth arrest. Oncogene.
22:3698–3711. 2003.PubMed/NCBI
|
|
32
|
Sato F, Kawamoto T, Fujimoto K, et al:
Functional analysis of the basic helix-loop-helix transcription
factor DEC1 in circadian regulation. Interaction with BMAL1. Eur J
Biochem. 271:4409–4419. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Kawamoto T, Noshiro M, Sato F, et al: A
novel autofeedback loop of Dec1 transcription involved in circadian
rhythm regulation. Biochem Biophys Res Commun. 313:117–124. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Bloom BB, Humphries DE, Kuang PP, et al:
Structure and expression of the promoter for the R4/ALK5 human type
I transforming growth factor-beta receptor: regulation by TGF-beta.
Biochim Biophys Acta. 1312:243–248. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Mulder KM: Role of ras and Mapks in
TGF-beta signaling. Cytokine Growth Factor Rev. 11:23–35. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Michl P, Barth C, Buchholz M, et al:
Claudin-4 expression decreases invasiveness and metastatic
potential of pancreatic cancer. Cancer Res. 63:6265–6271.
2003.PubMed/NCBI
|
|
37
|
Turksen K and Troy TC: Junctions gone bad:
Claudins and loss of the barrier in cancer. Biochim Biophys Acta.
1816:73–79. 2011.PubMed/NCBI
|
|
38
|
Berx G and Van Roy F: The
E-cadherin/catenin complex: an important gatekeeper in breast
cancer tumorigenesis and malignant progression. Breast Cancer Res.
3:289–293. 2001. View
Article : Google Scholar : PubMed/NCBI
|
|
39
|
Wells A, Yates C and Shepard CR:
E-cadherin as an indicator of mesenchymal to epithelial reverting
transitions during the metastatic seeding of disseminated
carcinomas. Clin Exp Metastasis. 25:621–628. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Martínez-Estrada OM, Cullerés A, Soriano
FX, et al: The transcription factors Slug and Snail act as
repressors of Claudin-1 expression in epithelial cells. Biochem J.
394:449–457. 2006.PubMed/NCBI
|
|
41
|
Batlle E, Sancho E, Francí C, et al: The
transcription factor snail is a repressor of E-cadherin gene
expression in epithelial tumour cells. Nat Cell Biol. 2:84–89.
2002. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Reka AK, Kurapati H, Narala VR, et al:
Peroxisome proliferator-activated receptor-gamma activation
inhibits tumor metastasis by antagonizing Smad3-mediated
epithelial-mesenchymal transition. Mol Cancer Ther. 9:3221–3232.
2010. View Article : Google Scholar
|
